NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907176477|ref|XP_036008456|]
View 

latent-transforming growth factor beta-binding protein 4 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 386-427 4.66e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.66e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907176477  386 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 427
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
889-925 1.74e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.74e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907176477   889 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 925
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1371-1413 2.28e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.28e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907176477 1371 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1413
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1204-1246 4.76e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.76e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907176477 1204 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1246
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 846-878 8.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 8.65e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907176477  846 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 878
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1060-1101 1.04e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907176477  1060 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1101
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
931-966 6.75e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.75e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907176477   931 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 966
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 683-720 2.45e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907176477  683 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 720
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
325-355 2.94e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.94e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907176477   325 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 355
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
764-805 1.26e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.26e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907176477   764 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 805
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
599-635 1.34e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907176477   599 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 635
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
641-682 2.71e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907176477   641 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 682
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1585-1619 1.02e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.02e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907176477  1585 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1619
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 722-756 1.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907176477  722 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 756
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
972-1010 1.64e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.64e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907176477   972 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 1010
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1307-1336 1.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.86e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907176477 1307 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1336
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1102-1130 8.55e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam07645:

Pssm-ID: 473889  Cd Length: 32  Bit Score: 35.29  E-value: 8.55e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907176477 1102 DVNECETLQGVC-GSALCENVEGSFLCVCP 1130
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 581-602 8.64e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


:

Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 8.64e-03
                           10        20
                   ....*....|....*....|..
gi 1907176477  581 TCACDPGFRLGPQGTRCIDIDE 602
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 386-427 4.66e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.66e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907176477  386 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 427
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
889-925 1.74e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.74e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907176477   889 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 925
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1371-1413 2.28e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.28e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907176477 1371 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1413
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1204-1246 4.76e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.76e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907176477 1204 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1246
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 846-878 8.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 8.65e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907176477  846 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 878
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1060-1101 1.04e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907176477  1060 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1101
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
846-878 2.25e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.25e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907176477   846 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 878
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 889-921 2.57e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.57e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907176477  889 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 921
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
931-966 6.75e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.75e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907176477   931 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 966
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1060-1095 6.85e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907176477 1060 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1095
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 683-720 2.45e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907176477  683 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 720
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
325-355 2.94e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.94e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907176477   325 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 355
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 931-962 6.30e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.30e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907176477  931 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 962
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
683-720 1.01e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.01e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907176477   683 DVDECtQSPGLCGRG-VCENLPGSFRCVCPAGFR-GSACE 720
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 325-359 1.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907176477  325 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 359
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
764-805 1.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.26e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907176477   764 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 805
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
599-635 1.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907176477   599 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 635
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
641-682 2.71e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907176477   641 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 682
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
931-960 7.83e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 7.83e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  931 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 960
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 641-682 8.44e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 8.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907176477  641 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 682
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1070-1100 8.89e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.35  E-value: 8.89e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907176477 1070 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1100
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 764-796 9.41e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.41e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907176477  764 DVDECSrSPSPCAY-GRCENTEGSFKCVCPTGFQ 796
Cdd:cd00054      1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1585-1619 1.02e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.02e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907176477  1585 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1619
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 722-756 1.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907176477  722 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 756
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
722-756 1.58e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.58e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907176477   722 DVDECAQqPPPCGPG-RCDNTAGSFHCACPAGFRSR 756
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
972-1010 1.64e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.64e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907176477   972 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 1010
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1307-1336 1.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.86e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907176477 1307 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1336
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1307-1336 2.06e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.06e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907176477  1307 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1336
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
325-354 2.11e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.11e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  325 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 354
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1585-1623 3.01e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.01e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907176477 1585 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGFAPTH 1623
Cdd:cd00054      1 DIDEC----ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
683-713 3.23e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.23e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  683 DVDECTQSPGLCGR-GVCENLPGSFRCVCPAG 713
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 850-878 3.39e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 3.39e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907176477  850 CSSGT-PCGLHGQCTNTKGSFHCSCSTGYR 878
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYT 30
EGF_CA pfam07645
Calcium-binding EGF domain;
1585-1618 3.93e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907176477 1585 DVNECDEAEATSPlcVNARCVNTDGSFRCICRPG 1618
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 599-631 4.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907176477  599 DIDECRRvPTPCAP-GRCENTPGSFRCVCGTGFQ 631
Cdd:cd00054      1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
641-671 4.74e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.74e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  641 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 671
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
764-794 7.52e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 7.52e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  764 DVDECSRSPSPCAY-GRCENTEGSFKCVCPTG 794
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1102-1130 8.55e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.55e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907176477 1102 DVNECETLQGVC-GSALCENVEGSFLCVCP 1130
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 581-602 8.64e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 8.64e-03
                           10        20
                   ....*....|....*....|..
gi 1907176477  581 TCACDPGFRLGPQGTRCIDIDE 602
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 386-427 4.66e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 59.21  E-value: 4.66e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907176477  386 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREIC 427
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
889-925 1.74e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.74e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907176477   889 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYRPGPR 925
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1371-1413 2.28e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 2.28e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907176477 1371 VCSRPrLDRQATYTECCCLY-GEAWGMDCALCPAQDSDDFEALC 1413
Cdd:pfam00683    2 RCSNP-LPGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1204-1246 4.76e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 4.76e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907176477 1204 CDNILARNVTWQECCC-TVGEGWGSGCriQQCPGTETAEYQSLC 1246
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPC--ELCPPPGTDEFRELC 44
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 846-878 8.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 8.65e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907176477  846 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 878
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1060-1101 1.04e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907176477  1060 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEgarDGRHCV 1101
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
846-878 2.25e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.25e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907176477   846 DVDECSSGTPCGLHGQCTNTKGSFHCSCSTGYR 878
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 889-921 2.57e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 2.57e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907176477  889 DINECLEGDFCFPHGECLNTDGSFTCTCAPGYR 921
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
931-966 6.75e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 6.75e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1907176477   931 DVDECSEEDLCQSG-ICTNTDGSFECICPPGHRAGPD 966
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1060-1095 6.85e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907176477 1060 DVDECRNRSFCGAHAMCQNLPGSFQCVCDQGYEGAR 1095
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 683-720 2.45e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907176477  683 DVDECtQSPGLCGR-GVCENLPGSFRCVCPAGFRGSACE 720
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
325-355 2.94e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.94e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907176477   325 DVDECATGGRCQHG-ECANTRGGYTCVCPDGF 355
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 931-962 6.30e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 6.30e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907176477  931 DVDECSEEDLCQ-SGICTNTDGSFECICPPGHR 962
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
683-720 1.01e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.01e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907176477   683 DVDECtQSPGLCGRG-VCENLPGSFRCVCPAGFR-GSACE 720
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 325-359 1.12e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907176477  325 DVDECATGGRCQ-HGECANTRGGYTCVCPDGFLLDS 359
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
764-805 1.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.26e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907176477   764 DVDECSrSPSPCAYG-RCENTEGSFKCVCPTGFQPnaaGSECE 805
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
599-635 1.34e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907176477   599 DIDECRRvPTPCAPG-RCENTPGSFRCVCGTGFQAGPR 635
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
641-682 2.71e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907176477   641 DVDECRRvPPPCDRG-RCENTPGSFLCVCPAGYQAaphGASCQ 682
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTD---GRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
931-960 7.83e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 7.83e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  931 DVDEC-SEEDLC-QSGICTNTDGSFECICPPG 960
Cdd:pfam07645    1 DVDECaTGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 641-682 8.44e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 8.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907176477  641 DVDECRRVPPPCDRGRCENTPGSFLCVCPAGYqaapHGASCQ 682
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY----TGRNCE 38
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1070-1100 8.89e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.35  E-value: 8.89e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907176477 1070 CGAHAMCQNLPGSFQCVCDQGYEGarDGRHC 1100
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 764-796 9.41e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 9.41e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907176477  764 DVDECSrSPSPCAY-GRCENTEGSFKCVCPTGFQ 796
Cdd:cd00054      1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1585-1619 1.02e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.02e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907176477  1585 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGF 1619
Cdd:smart00179    1 DIDEC----ASGNPCQNgGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 722-756 1.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907176477  722 DVDECAQQPPPCGPGRCDNTAGSFHCACPAGFRSR 756
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF smart00181
Epidermal growth factor-like domain;
328-360 1.55e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 1.55e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907176477   328 ECATGGRCQHGECANTRGGYTCVCPDGFLLDSS 360
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
722-756 1.58e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.58e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907176477   722 DVDECAQqPPPCGPG-RCDNTAGSFHCACPAGFRSR 756
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
972-1010 1.64e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.64e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907176477   972 DIDECRERGPALCGSqRCENSPGSYRCvrDCDPGYHPGP 1010
Cdd:smart00179    1 DIDECASGNPCQNGG-TCVNTVGSYRC--ECPPGYTDGR 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1307-1336 1.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.86e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907176477 1307 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1336
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
1307-1336 2.06e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.06e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1907176477  1307 DNDECADEEPACEGGRCVNTVGSYHCTCEP 1336
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
325-354 2.11e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.11e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  325 DVDECATGGR-CQHGE-CANTRGGYTCVCPDG 354
Cdd:pfam07645    1 DVDECATGTHnCPANTvCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1585-1623 3.01e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.01e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907176477 1585 DVNECdeaeATSPLCVN-ARCVNTDGSFRCICRPGFAPTH 1623
Cdd:cd00054      1 DIDEC----ASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
683-713 3.23e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.23e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  683 DVDECTQSPGLCGR-GVCENLPGSFRCVCPAG 713
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 850-878 3.39e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 3.39e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907176477  850 CSSGT-PCGLHGQCTNTKGSFHCSCSTGYR 878
Cdd:pfam12947    1 CSDNNgGCHPNATCTNTGGSFTCTCNDGYT 30
EGF_CA pfam07645
Calcium-binding EGF domain;
1585-1618 3.93e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 3.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907176477 1585 DVNECDEAEATSPlcVNARCVNTDGSFRCICRPG 1618
Cdd:pfam07645    1 DVDECATGTHNCP--ANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 599-631 4.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 4.54e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907176477  599 DIDECRRvPTPCAP-GRCENTPGSFRCVCGTGFQ 631
Cdd:cd00054      1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
641-671 4.74e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 4.74e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  641 DVDECRRVPPPCDR-GRCENTPGSFLCVCPAG 671
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
764-794 7.52e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 7.52e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907176477  764 DVDECSRSPSPCAY-GRCENTEGSFKCVCPTG 794
Cdd:pfam07645    1 DVDECATGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1102-1130 8.55e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 8.55e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907176477 1102 DVNECETLQGVC-GSALCENVEGSFLCVCP 1130
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCP 30
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 581-602 8.64e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 8.64e-03
                           10        20
                   ....*....|....*....|..
gi 1907176477  581 TCACDPGFRLGPQGTRCIDIDE 602
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH