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Conserved domains on  [gi|1907177005|ref|XP_036008518|]
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battenin isoform X3 [Mus musculus]

Protein Classification

nucleoside transporter family protein( domain architecture ID 68369)

nucleoside transporter family protein is involved in transport, similar to equilibrative nucleoside transporters and battenin

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CLN3 super family cl47738
CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of ...
29-222 1.30e-67

CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease). Batten disease is characterized by the accumulation of autofluorescent material in the lysosomes of most cells. Members of this family are transmembrane proteins functional in pre-vacuolar compartments. The protein in Sch.pombe is found to be localized to the vacuolar membrane, and a lack of functional protein clearly affects the size and pH of the vacuole. Thus the protein is necessary for vacuolar homeostasis. It is important for localization of late endosomal/lysosomal compartments, and it interacts with motor components driving both plus and minus end microtubular trafficking: tubulin, dynactin, dynein and kinesin-2.


The actual alignment was detected with superfamily member pfam02487:

Pssm-ID: 460570  Cd Length: 383  Bit Score: 212.37  E-value: 1.30e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177005  29 EAETAARQPLIGTETPESKPGASWDLSLQERWTVFKGL-LWYIIPLVLVYFAEYFINQGLFELLFFRNTS---LSHAQQY 104
Cdd:pfam02487 185 SDGLLEYTPASASEDASAESSSSLKLHFREKLRRIKPLfLPYMLPLFLVYLAEYTINQGVSPTLLFPLDEspfLSYRDQY 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177005 105 RWYQMLYQAGVFASRSSLQCCRIRFTWVLALLQCLNLALLLADVCLNF-LPSIYLIFIIILYEGLLGGAAYVNTFHNIAL 183
Cdd:pfam02487 265 RWYQVLYQLGVFISRSSVPFIRIRNLYLLSVLQFLNLVLLTLQSLYDFfIPSIWIIFLLIFYEGLLGGAAYVNTFYNISE 344
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907177005 184 ETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHL 222
Cdd:pfam02487 345 EVPPEEREFSLGAVSVSDSLGILLAGLLAMPLENALCSL 383
 
Name Accession Description Interval E-value
CLN3 pfam02487
CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of ...
29-222 1.30e-67

CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease). Batten disease is characterized by the accumulation of autofluorescent material in the lysosomes of most cells. Members of this family are transmembrane proteins functional in pre-vacuolar compartments. The protein in Sch.pombe is found to be localized to the vacuolar membrane, and a lack of functional protein clearly affects the size and pH of the vacuole. Thus the protein is necessary for vacuolar homeostasis. It is important for localization of late endosomal/lysosomal compartments, and it interacts with motor components driving both plus and minus end microtubular trafficking: tubulin, dynactin, dynein and kinesin-2.


Pssm-ID: 460570  Cd Length: 383  Bit Score: 212.37  E-value: 1.30e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177005  29 EAETAARQPLIGTETPESKPGASWDLSLQERWTVFKGL-LWYIIPLVLVYFAEYFINQGLFELLFFRNTS---LSHAQQY 104
Cdd:pfam02487 185 SDGLLEYTPASASEDASAESSSSLKLHFREKLRRIKPLfLPYMLPLFLVYLAEYTINQGVSPTLLFPLDEspfLSYRDQY 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177005 105 RWYQMLYQAGVFASRSSLQCCRIRFTWVLALLQCLNLALLLADVCLNF-LPSIYLIFIIILYEGLLGGAAYVNTFHNIAL 183
Cdd:pfam02487 265 RWYQVLYQLGVFISRSSVPFIRIRNLYLLSVLQFLNLVLLTLQSLYDFfIPSIWIIFLLIFYEGLLGGAAYVNTFYNISE 344
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907177005 184 ETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHL 222
Cdd:pfam02487 345 EVPPEEREFSLGAVSVSDSLGILLAGLLAMPLENALCSL 383
 
Name Accession Description Interval E-value
CLN3 pfam02487
CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of ...
29-222 1.30e-67

CLN3 protein; This is a family of proteins from the CLN3 gene. A mis-sense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein has been implicated in Juvenile neuronal ceroid lipofuscinosis (Batten disease). Batten disease is characterized by the accumulation of autofluorescent material in the lysosomes of most cells. Members of this family are transmembrane proteins functional in pre-vacuolar compartments. The protein in Sch.pombe is found to be localized to the vacuolar membrane, and a lack of functional protein clearly affects the size and pH of the vacuole. Thus the protein is necessary for vacuolar homeostasis. It is important for localization of late endosomal/lysosomal compartments, and it interacts with motor components driving both plus and minus end microtubular trafficking: tubulin, dynactin, dynein and kinesin-2.


Pssm-ID: 460570  Cd Length: 383  Bit Score: 212.37  E-value: 1.30e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177005  29 EAETAARQPLIGTETPESKPGASWDLSLQERWTVFKGL-LWYIIPLVLVYFAEYFINQGLFELLFFRNTS---LSHAQQY 104
Cdd:pfam02487 185 SDGLLEYTPASASEDASAESSSSLKLHFREKLRRIKPLfLPYMLPLFLVYLAEYTINQGVSPTLLFPLDEspfLSYRDQY 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177005 105 RWYQMLYQAGVFASRSSLQCCRIRFTWVLALLQCLNLALLLADVCLNF-LPSIYLIFIIILYEGLLGGAAYVNTFHNIAL 183
Cdd:pfam02487 265 RWYQVLYQLGVFISRSSVPFIRIRNLYLLSVLQFLNLVLLTLQSLYDFfIPSIWIIFLLIFYEGLLGGAAYVNTFYNISE 344
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907177005 184 ETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHL 222
Cdd:pfam02487 345 EVPPEEREFSLGAVSVSDSLGILLAGLLAMPLENALCSL 383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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