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Conserved domains on  [gi|1907189407|ref|XP_036009950|]
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long-chain fatty acid transport protein 1 isoform X1 [Mus musculus]

Protein Classification

acyl-CoA synthetase family protein( domain architecture ID 102275)

acyl-CoA synthetase family protein functions in fatty acid synthesis, and may catalyze the ATP-dependent activation of fatty acids in a two-step reaction to form acyl-CoA esters; belongs to the class I adenylate-forming enzyme superfamily

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AFD_class_I super family cl17068
Adenylate forming domain, Class I superfamily; This family includes acyl- and aryl-CoA ligases, ...
115-622 0e+00

Adenylate forming domain, Class I superfamily; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


The actual alignment was detected with superfamily member cd05939:

Pssm-ID: 473059 [Multi-domain]  Cd Length: 474  Bit Score: 860.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYgg 194
Cdd:cd05939     4 WTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKALIF-- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 emaaavaevseqlgksllkfcsgdlgpesilpdtQLLDPMLAEAPTTPLAQaPGKGMDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:cd05939    82 ----------------------------------NLLDPLLTQSSTEPPSQ-DDVNFRDKLFYIYTSGTTGLPKAAVIVH 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 SRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRY 354
Cdd:cd05939   127 SRYYRIAAGAYYAFGMRPEDVVYDCLPLYHSAGGIMGVGQALLHGSTVVIRKKFSASNFWDDCVKYNCTIVQYIGEICRY 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 355 LLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVK 434
Cdd:cd05939   207 LLAQPPSEEEQKHNVRLAVGNGLRPQIWEQFVRRFGIPQIGEFYGATEGNSSLVNIDNHVGACGFNSRILPSVYPIRLIK 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 435 VNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMY 514
Cdd:cd05939   287 VDEDTGELIRDSDGLCIPCQPGEPGLLVGKIIQNDPLRRFDGYVNEGATNKKIARDVFKKGDSAFLSGDVLVMDELGYLY 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 515 FRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPI 594
Cdd:cd05939   367 FKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGVEVPGVEGRAGMAAIVDPERKVDLDRFSAVLAKSLPPYARPQ 446
                         490       500
                  ....*....|....*....|....*...
gi 1907189407 595 FLRLLPQVDTTGTFKIQKTRLQREGFDP 622
Cdd:cd05939   447 FIRLLPEVDKTGTFKLQKTDLQKEGYDP 474
 
Name Accession Description Interval E-value
hsFATP4_like cd05939
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ...
115-622 0e+00

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341262 [Multi-domain]  Cd Length: 474  Bit Score: 860.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYgg 194
Cdd:cd05939     4 WTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKALIF-- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 emaaavaevseqlgksllkfcsgdlgpesilpdtQLLDPMLAEAPTTPLAQaPGKGMDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:cd05939    82 ----------------------------------NLLDPLLTQSSTEPPSQ-DDVNFRDKLFYIYTSGTTGLPKAAVIVH 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 SRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRY 354
Cdd:cd05939   127 SRYYRIAAGAYYAFGMRPEDVVYDCLPLYHSAGGIMGVGQALLHGSTVVIRKKFSASNFWDDCVKYNCTIVQYIGEICRY 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 355 LLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVK 434
Cdd:cd05939   207 LLAQPPSEEEQKHNVRLAVGNGLRPQIWEQFVRRFGIPQIGEFYGATEGNSSLVNIDNHVGACGFNSRILPSVYPIRLIK 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 435 VNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMY 514
Cdd:cd05939   287 VDEDTGELIRDSDGLCIPCQPGEPGLLVGKIIQNDPLRRFDGYVNEGATNKKIARDVFKKGDSAFLSGDVLVMDELGYLY 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 515 FRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPI 594
Cdd:cd05939   367 FKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGVEVPGVEGRAGMAAIVDPERKVDLDRFSAVLAKSLPPYARPQ 446
                         490       500
                  ....*....|....*....|....*...
gi 1907189407 595 FLRLLPQVDTTGTFKIQKTRLQREGFDP 622
Cdd:cd05939   447 FIRLLPEVDKTGTFKLQKTDLQKEGYDP 474
PRK08279 PRK08279
long-chain-acyl-CoA synthetase; Validated
53-657 0e+00

long-chain-acyl-CoA synthetase; Validated


Pssm-ID: 236217 [Multi-domain]  Cd Length: 600  Bit Score: 691.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  53 RFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFR 132
Cdd:PRK08279    3 TLMDLAARLPRRLPDLPGILRGLKRTALITPDSKRSLGDVFEEAAARHPDRPALLFEDQSI--SYAELNARANRYAHWAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 133 QLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLL 212
Cdd:PRK08279   81 ARGVGKGDVVALLMENRPEYLAAWLGLAKLGAVVALLNTQQRGAVLAHSLNLVDAKHLIVGEELVEAFEEARADLARPPR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 213 kFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYR-IAAFGHhSYSMR 291
Cdd:PRK08279  161 -LWVAGGDTLDDPEGYEDLAAAAAGAPTTNPASRSGVTAKDTAFYIYTSGTTGLPKAAVMSHMRWLKaMGGFGG-LLRLT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 292 AADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRL 371
Cdd:PRK08279  239 PDDVLYCCLPLYHNTGGTVAWSSVLAAGATLALRRKFSASRFWDDVRRYRATAFQYIGELCRYLLNQPPKPTDRDHRLRL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 372 AVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHvyPIRLVKVNEDTMEPLRDSEGLCI 451
Cdd:PRK08279  319 MIGNGLRPDIWDEFQQRFGIPRILEFYAASEGNVGFINVFNFDGTVGRVPLWLAH--PYAIVKYDVDTGEPVRDADGRCI 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 452 PCQPGEPGLLVGQINqqdPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVS 531
Cdd:PRK08279  397 KVKPGEVGLLIGRIT---DRGPFDGYTDPEASEKKILRDVFKKGDAWFNTGDLMRDDGFGHAQFVDRLGDTFRWKGENVA 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 532 TTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAI-ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKI 610
Cdd:PRK08279  474 TTEVENALSGFPGVEEAVVYGVEVPGTDGRAGMAAIvLADGAEFDLAALAAHLYERLPAYAVPLFVRLVPELETTGTFKY 553
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 1907189407 611 QKTRLQREGFDPRQTSDRLFFLDLKQGRYVPLDERVHARICAGDFSL 657
Cdd:PRK08279  554 RKVDLRKEGFDPSKVDDPLYVLDPGSGGYVPLTAELYAEIAAGKFRL 600
MenE/FadK COG0318
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...
92-618 3.39e-87

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440087 [Multi-domain]  Cd Length: 452  Bit Score: 279.77  E-value: 3.39e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:COG0318     4 LLRRAAARHPDRPALVFG--GRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLNP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLRREPLAFCLGTSAAKALIYggemaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgm 251
Cdd:COG0318    82 RLTAEELAYILEDSGARALVT----------------------------------------------------------- 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 ddrLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSAS 331
Cdd:COG0318   103 ---ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLTPGDVVLVALPLFHVFGLTVGLLAPLLAGATLVLLPRFDPE 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 332 RFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPqIGEFYGATECNCSIA- 408
Cdd:COG0318   180 RVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVsgGAPLPPELLERFEERFGVR-IVEGYGLTETSPVVTv 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 409 ----NMDGKVGSCGfnsRILTHVyPIRLVkvnedtmeplrDSEGlcIPCQPGEPGLLVGQINQQdplrrFDGYVSD-SAT 483
Cdd:COG0318   259 npedPGERRPGSVG---RPLPGV-EVRIV-----------DEDG--RELPPGEVGEIVVRGPNV-----MKGYWNDpEAT 316
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 484 NKKIAHSVFRkgdsaylSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgVEGKAG 563
Cdd:COG0318   317 AEAFRDGWLR-------TGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDE-KWGERV 388
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189407 564 MAAI-ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQRE 618
Cdd:COG0318   389 VAFVvLRPGAELDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRER 444
AMP-binding pfam00501
AMP-binding enzyme;
93-526 4.33e-64

AMP-binding enzyme;


Pssm-ID: 459834 [Multi-domain]  Cd Length: 417  Bit Score: 217.57  E-value: 4.33e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  93 FQAVARRQPERLALVDASsGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVN 172
Cdd:pfam00501   1 LERQAARTPDKTALEVGE-GRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 173 LRREPLAFCLGTSAAKALIYGGE-MAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQApgkgm 251
Cdd:pfam00501  80 LPAEELAYILEDSGAKVLITDDAlKLEELLEALGKLEVVKLVLVLDRDPVLKEEPLPEEAKPADVPPPPPPPPDP----- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVH----SRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKK 327
Cdd:pfam00501 155 DDLAYIIYTSGTTGKPKGVMLTHrnlvANVLSIKRVRPRGFGLGPDDRVLSTLPLFHDFGLSLGLLGPLLAGATVVLPPG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 328 FSA---SRFWDDCVKYNCTVVQYIGEICRYLLRQPV--RDVEQRHRVRLAVGNGLRPAIWEEFTQRFGvPQIGEFYGATE 402
Cdd:pfam00501 235 FPAldpAALLELIERYKVTVLYGVPTLLNMLLEAGApkRALLSSLRLVLSGGAPLPPELARRFRELFG-GALVNGYGLTE 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CNCSIANMD------GKVGSCGfnsRILTHVypiRLVKVNEDTMEPLRdseglcipcqPGEPG-LLVGQINQqdplrrFD 475
Cdd:pfam00501 314 TTGVVTTPLpldedlRSLGSVG---RPLPGT---EVKIVDDETGEPVP----------PGEPGeLCVRGPGV------MK 371
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 476 GYVSD-SATNKKIahsvfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWR 526
Cdd:pfam00501 372 GYLNDpELTAEAF------DEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
AA-adenyl-dom TIGR01733
amino acid adenylation domain; This model represents a domain responsible for the specific ...
116-550 1.53e-20

amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.


Pssm-ID: 273779 [Multi-domain]  Cd Length: 409  Bit Score: 94.25  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFA-PGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGG 194
Cdd:TIGR01733   1 TYRELDERANRLARHLRAAGGVgPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 EMAAAVAEVseqlgksllkfcsgdlgPESILPDTQLLDPMLAEAPTTPLAQAPGKGmDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:TIGR01733  81 ALASRLAGL-----------------VLPVILLDPLELAALDDAPAPPPPDAPSGP-DDLAYVIYTSGSTGRPKGVVVTH 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 ----------SRYY------RIAAFghHSYSMRAAdVLYDCLPLYHsagnimGVGQCVIYGltVVLRKKFSASRFWDDcv 338
Cdd:TIGR01733 143 rslvnllawlARRYgldpddRVLQF--ASLSFDAS-VEEIFGALLA------GATLVVPPE--DEERDDAALLAALIA-- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 339 KYNCTVVQYIGEICRYLLRQPVRDVEQRHRVrLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECN--CSIANMDGKVGS 416
Cdd:TIGR01733 210 EHPVTVLNLTPSLLALLAAALPPALASLRLV-ILGGEALTPALVDRWRARGPGARLINLYGPTETTvwSTATLVDPDDAP 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 417 CGFNSRI---LTHVypiRLVKVNEDTMeplrdseglciPCQPGEPG-LLVGQINqqdpLRRfdGYVSDSA-TNKKIAHSV 491
Cdd:TIGR01733 289 RESPVPIgrpLANT---RLYVLDDDLR-----------PVPVGVVGeLYIGGPG----VAR--GYLNRPElTAERFVPDP 348
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907189407 492 FRKGDSA--YLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAV 550
Cdd:TIGR01733 349 FAGGDGArlYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHPGVREAVV 409
 
Name Accession Description Interval E-value
hsFATP4_like cd05939
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ...
115-622 0e+00

Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341262 [Multi-domain]  Cd Length: 474  Bit Score: 860.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYgg 194
Cdd:cd05939     4 WTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKALIF-- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 emaaavaevseqlgksllkfcsgdlgpesilpdtQLLDPMLAEAPTTPLAQaPGKGMDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:cd05939    82 ----------------------------------NLLDPLLTQSSTEPPSQ-DDVNFRDKLFYIYTSGTTGLPKAAVIVH 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 SRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRY 354
Cdd:cd05939   127 SRYYRIAAGAYYAFGMRPEDVVYDCLPLYHSAGGIMGVGQALLHGSTVVIRKKFSASNFWDDCVKYNCTIVQYIGEICRY 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 355 LLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVK 434
Cdd:cd05939   207 LLAQPPSEEEQKHNVRLAVGNGLRPQIWEQFVRRFGIPQIGEFYGATEGNSSLVNIDNHVGACGFNSRILPSVYPIRLIK 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 435 VNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMY 514
Cdd:cd05939   287 VDEDTGELIRDSDGLCIPCQPGEPGLLVGKIIQNDPLRRFDGYVNEGATNKKIARDVFKKGDSAFLSGDVLVMDELGYLY 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 515 FRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPI 594
Cdd:cd05939   367 FKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGVEVPGVEGRAGMAAIVDPERKVDLDRFSAVLAKSLPPYARPQ 446
                         490       500
                  ....*....|....*....|....*...
gi 1907189407 595 FLRLLPQVDTTGTFKIQKTRLQREGFDP 622
Cdd:cd05939   447 FIRLLPEVDKTGTFKLQKTDLQKEGYDP 474
PRK08279 PRK08279
long-chain-acyl-CoA synthetase; Validated
53-657 0e+00

long-chain-acyl-CoA synthetase; Validated


Pssm-ID: 236217 [Multi-domain]  Cd Length: 600  Bit Score: 691.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  53 RFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFR 132
Cdd:PRK08279    3 TLMDLAARLPRRLPDLPGILRGLKRTALITPDSKRSLGDVFEEAAARHPDRPALLFEDQSI--SYAELNARANRYAHWAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 133 QLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLL 212
Cdd:PRK08279   81 ARGVGKGDVVALLMENRPEYLAAWLGLAKLGAVVALLNTQQRGAVLAHSLNLVDAKHLIVGEELVEAFEEARADLARPPR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 213 kFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYR-IAAFGHhSYSMR 291
Cdd:PRK08279  161 -LWVAGGDTLDDPEGYEDLAAAAAGAPTTNPASRSGVTAKDTAFYIYTSGTTGLPKAAVMSHMRWLKaMGGFGG-LLRLT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 292 AADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRL 371
Cdd:PRK08279  239 PDDVLYCCLPLYHNTGGTVAWSSVLAAGATLALRRKFSASRFWDDVRRYRATAFQYIGELCRYLLNQPPKPTDRDHRLRL 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 372 AVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHvyPIRLVKVNEDTMEPLRDSEGLCI 451
Cdd:PRK08279  319 MIGNGLRPDIWDEFQQRFGIPRILEFYAASEGNVGFINVFNFDGTVGRVPLWLAH--PYAIVKYDVDTGEPVRDADGRCI 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 452 PCQPGEPGLLVGQINqqdPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVS 531
Cdd:PRK08279  397 KVKPGEVGLLIGRIT---DRGPFDGYTDPEASEKKILRDVFKKGDAWFNTGDLMRDDGFGHAQFVDRLGDTFRWKGENVA 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 532 TTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAI-ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKI 610
Cdd:PRK08279  474 TTEVENALSGFPGVEEAVVYGVEVPGTDGRAGMAAIvLADGAEFDLAALAAHLYERLPAYAVPLFVRLVPELETTGTFKY 553
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 1907189407 611 QKTRLQREGFDPRQTSDRLFFLDLKQGRYVPLDERVHARICAGDFSL 657
Cdd:PRK08279  554 RKVDLRKEGFDPSKVDDPLYVLDPGSGGYVPLTAELYAEIAAGKFRL 600
FATP_FACS cd05940
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ...
115-622 0e+00

Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341263 [Multi-domain]  Cd Length: 449  Bit Score: 649.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYgg 194
Cdd:cd05940     4 LTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESLAHCLNVSSAKHLVV-- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 emaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgmdDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:cd05940    82 ----------------------------------------------------------DAALYIYTSGTTGLPKAAIISH 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 SRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRY 354
Cdd:cd05940   104 RRAWRGGAFFAGSGGALPSDVLYTCLPLYHSTALIVGWSACLASGATLVIRKKFSASNFWDDIRKYQATIFQYIGELCRY 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 355 LLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVK 434
Cdd:cd05940   184 LLNQPPKPTERKHKVRMIFGNGLRPDIWEEFKERFGVPRIAEFYAATEGNSGFINFFGKPGAIGRNPSLLRKVAPLALVK 263
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 435 VNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINqqdPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMY 514
Cdd:cd05940   264 YDLESGEPIRDAEGRCIKVPRGEPGLLISRIN---PLEPFDGYTDPAATEKKILRDVFKKGDAWFNTGDLMRLDGEGFWY 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 515 FRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQ-LDPNSMYQELQKVLASYARP 593
Cdd:cd05940   341 FVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQVPGTDGRAGMAAIVLQPNEeFDLSALAAHLEKNLPGYARP 420
                         490       500
                  ....*....|....*....|....*....
gi 1907189407 594 IFLRLLPQVDTTGTFKIQKTRLQREGFDP 622
Cdd:cd05940   421 LFLRLQPEMEITGTFKQQKVDLRNEGFDP 449
hsFATP2a_ACSVL_like cd05938
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ...
116-644 0e+00

Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.


Pssm-ID: 341261 [Multi-domain]  Cd Length: 537  Bit Score: 597.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVAN-LFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGG 194
Cdd:cd05938     7 TYRDVDRRSNQAARaLLAHAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAKVLVVAP 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 EMAAAVAEVSEQLGKSLLKFcsGDLGPESILPDTQLLDPMLAEAPTTPLAQ---APGKGMDDRLfYIYTSGTTGLPKAAI 271
Cdd:cd05938    87 ELQEAVEEVLPALRADGVSV--WYLSHTSNTEGVISLLDKVDAASDEPVPAslrAHVTIKSPAL-YIYTSGTTGLPKAAR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 272 VVHSRYYRIAAFgHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEI 351
Cdd:cd05938   164 ISHLRVLQCSGF-LSLCGVTADDVIYITLPLYHSSGFLLGIGGCIELGATCVLKPKFSASQFWDDCRKHNVTVIQYIGEL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 352 CRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIR 431
Cdd:cd05938   243 LRYLCNQPQSPNDRDHKVRLAIGNGLRADVWREFLRRFGPIRIREFYGSTEGNIGFFNYTGKIGAVGRVSYLYKLLFPFE 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 432 LVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPlrrFDGYVSDSA-TNKKIAHSVFRKGDSAYLSGDVLVMDEL 510
Cdd:cd05938   323 LIKFDVEKEEPVRDAQGFCIPVAKGEPGLLVAKITQQSP---FLGYAGDKEqTEKKLLRDVFKKGDVYFNTGDLLVQDQQ 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 511 GYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAI--ADPHsQLDPNSMYQELQKVLA 588
Cdd:cd05938   400 NFLYFHDRVGDTFRWKGENVATTEVADVLGLLDFLQEVNVYGVTVPGHEGRIGMAAVklKPGH-EFDGKKLYQHVREYLP 478
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189407 589 SYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGRYVPLDE 644
Cdd:cd05938   479 AYARPRFLRIQDSLEITGTFKQQKVRLVEEGFNPSIISDPLYFLDETQKTYVPLTP 534
FATP_chFAT1_like cd05937
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ...
115-622 1.68e-139

Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.


Pssm-ID: 341260 [Multi-domain]  Cd Length: 468  Bit Score: 415.68  E-value: 1.68e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFR-QLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYg 193
Cdd:cd05937     6 WTYSETYDLVLRYAHWLHdDLGVQAGDFVAIDLTNSPEFVFLWLGLWSIGAAPAFINYNLSGDPLIHCLKLSGSRFVIV- 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 194 gemaaavaevseqlgksllkfcsgdlgpesilpdtqllDPmlaeapttplaqapgkgmDDRLFYIYTSGTTGLPKAAIVV 273
Cdd:cd05937    85 --------------------------------------DP------------------DDPAILIYTSGTTGLPKAAAIS 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 274 HSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICR 353
Cdd:cd05937   109 WRRTLVTSNLLSHDLNLKNGDRTYTCMPLYHGTAAFLGACNCLMSGGTLALSRKFSASQFWKDVRDSGATIIQYVGELCR 188
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 354 YLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANM---DGKVGSCGFNSRILTHVY-- 428
Cdd:cd05937   189 YLLSTPPSPYDRDHKVRVAWGNGLRPDIWERFRERFNVPEIGEFYAATEGVFALTNHnvgDFGAGAIGHHGLIRRWKFen 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 429 PIRLVKVNEDTMEPLRD-SEGLCIPCQPGEPGLLVGQINqQDPLRRFDGYVSDS-ATNKKIAHSVFRKGDSAYLSGDVLV 506
Cdd:cd05937   269 QVVLVKMDPETDDPIRDpKTGFCVRAPVGEPGEMLGRVP-FKNREAFQGYLHNEdATESKLVRDVFRKGDIYFRTGDLLR 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 507 MDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAI-----ADPHSQLDPNSMYQ 581
Cdd:cd05937   348 QDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYGVKVPGHDGRAGCAAItleesSAVPTEFTKSLLAS 427
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1907189407 582 ELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDP 622
Cdd:cd05937   428 LARKNLPSYAVPLFLRLTEEVATTDNHKQQKGVLRDEGVDP 468
MenE/FadK COG0318
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ...
92-618 3.39e-87

O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440087 [Multi-domain]  Cd Length: 452  Bit Score: 279.77  E-value: 3.39e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:COG0318     4 LLRRAAARHPDRPALVFG--GRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLNP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLRREPLAFCLGTSAAKALIYggemaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgm 251
Cdd:COG0318    82 RLTAEELAYILEDSGARALVT----------------------------------------------------------- 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 ddrLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSAS 331
Cdd:COG0318   103 ---ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLTPGDVVLVALPLFHVFGLTVGLLAPLLAGATLVLLPRFDPE 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 332 RFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPqIGEFYGATECNCSIA- 408
Cdd:COG0318   180 RVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVsgGAPLPPELLERFEERFGVR-IVEGYGLTETSPVVTv 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 409 ----NMDGKVGSCGfnsRILTHVyPIRLVkvnedtmeplrDSEGlcIPCQPGEPGLLVGQINQQdplrrFDGYVSD-SAT 483
Cdd:COG0318   259 npedPGERRPGSVG---RPLPGV-EVRIV-----------DEDG--RELPPGEVGEIVVRGPNV-----MKGYWNDpEAT 316
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 484 NKKIAHSVFRkgdsaylSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgVEGKAG 563
Cdd:COG0318   317 AEAFRDGWLR-------TGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDE-KWGERV 388
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189407 564 MAAI-ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQRE 618
Cdd:COG0318   389 VAFVvLRPGAELDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRER 444
FACL_DitJ_like cd05934
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
114-616 1.93e-81

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.


Pssm-ID: 341257 [Multi-domain]  Cd Length: 422  Bit Score: 263.77  E-value: 1.93e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 114 CWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREplafclgtsaakaliyg 193
Cdd:cd05934     3 RWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGD----------------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 194 gEMAAAVAEVseqlgksllkfcsgdlGPESILPDTQLLdpmlaeapttplaqapgkgmddrlfyIYTSGTTGLPKAAIVV 273
Cdd:cd05934    66 -ELAYIIDHS----------------GAQLVVVDPASI--------------------------LYTSGTTGPPKGVVIT 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 274 HSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICR 353
Cdd:cd05934   103 HANLTFAGYYSARRFGLGEDDVYLTVLPLFHINAQAVSVLAALSVGATLVLLPRFSASRFWSDVRRYGATVTNYLGAMLS 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 354 YLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPqIGEFYGATECNCSIAN---MDGKVGSCGfnsrilthvYPI 430
Cdd:cd05934   183 YLLAQPPSPDDRAHRLRAAYGAPNPPELHEEFEERFGVR-LLEGYGMTETIVGVIGprdEPRRPGSIG---------RPA 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 431 RLVKVNedtmepLRDSEGLciPCQPGEPGLLVgqINQQDPLRRFDGYVSD-SATNKKIAHSVFRKGDSAYlsgdvlvMDE 509
Cdd:cd05934   253 PGYEVR------IVDDDGQ--ELPAGEPGELV--IRGLRGWGFFKGYYNMpEATAEAMRNGWFHTGDLGY-------RDA 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 510 LGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLAS 589
Cdd:cd05934   316 DGFFYFVDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPDEVGEDEVKAVVVLRPGETLDPEELFAFCEGQLAY 395
                         490       500
                  ....*....|....*....|....*..
gi 1907189407 590 YARPIFLRLLPQVDTTGTFKIQKTRLQ 616
Cdd:cd05934   396 FKVPRYIRFVDDLPKTPTEKVAKAQLR 422
PRK06155 PRK06155
crotonobetaine/carnitine-CoA ligase; Provisional
85-628 4.53e-78

crotonobetaine/carnitine-CoA ligase; Provisional


Pssm-ID: 235719 [Multi-domain]  Cd Length: 542  Bit Score: 258.53  E-value: 4.53e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  85 AGDTIPCIFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGV 164
Cdd:PRK06155   19 SERTLPAMLARQAERYPDRPLLVFG--GTRWTYAEAARAAAAAAHALAAAGVKRGDRVALMCGNRIEFLDVFLGCAWLGA 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 165 VAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVseqlgksllkfcsgDLGPESiLPDTQLLD------------ 232
Cdd:PRK06155   97 IAVPINTALRGPQLEHILRNSGARLLVVEAALLAALEAA--------------DPGDLP-LPAVWLLDapasvsvpagws 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 233 --PMLA-EAPTTPLAQAPGkgmdDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNI 309
Cdd:PRK06155  162 taPLPPlDAPAPAAAVQPG----DTAAILYTSGTTGPSKGVCCPHAQFYWWGRNSAEDLEIGADDVLYTTLPLFHTNALN 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 310 MGVgQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRF 389
Cdd:PRK06155  238 AFF-QALLAGATYVLEPRFSASGFWPAVRRHGATVTYLLGAMVSILLSQPARESDRAHRVRVALGPGVPAALHAAFRERF 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 390 GVPQIgEFYGATECNCSIANM--DGKVGSC-----GFNSRILthvypirlvkvnedtmeplrDSEGLCIPcqPGEPGLLV 462
Cdd:PRK06155  317 GVDLL-DGYGSTETNFVIAVThgSQRPGSMgrlapGFEARVV--------------------DEHDQELP--DGEPGELL 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 463 GQINQqdPLRRFDGYVSDSATnkkiahSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRL 542
Cdd:PRK06155  374 LRADE--PFAFATGYFGMPEK------TVEAWRNLWFHTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVEQVLLSH 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 543 LGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDP 622
Cdd:PRK06155  446 PAVAAAAVFPVPSELGEDEVMAAVVLRDGTALEPVALVRHCEPRLAYFAVPRYVEFVAALPKTENGKVQKFVLREQGVTA 525

                  ....*.
gi 1907189407 623 rQTSDR 628
Cdd:PRK06155  526 -DTWDR 530
AMP-binding pfam00501
AMP-binding enzyme;
93-526 4.33e-64

AMP-binding enzyme;


Pssm-ID: 459834 [Multi-domain]  Cd Length: 417  Bit Score: 217.57  E-value: 4.33e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  93 FQAVARRQPERLALVDASsGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVN 172
Cdd:pfam00501   1 LERQAARTPDKTALEVGE-GRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 173 LRREPLAFCLGTSAAKALIYGGE-MAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQApgkgm 251
Cdd:pfam00501  80 LPAEELAYILEDSGAKVLITDDAlKLEELLEALGKLEVVKLVLVLDRDPVLKEEPLPEEAKPADVPPPPPPPPDP----- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVH----SRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKK 327
Cdd:pfam00501 155 DDLAYIIYTSGTTGKPKGVMLTHrnlvANVLSIKRVRPRGFGLGPDDRVLSTLPLFHDFGLSLGLLGPLLAGATVVLPPG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 328 FSA---SRFWDDCVKYNCTVVQYIGEICRYLLRQPV--RDVEQRHRVRLAVGNGLRPAIWEEFTQRFGvPQIGEFYGATE 402
Cdd:pfam00501 235 FPAldpAALLELIERYKVTVLYGVPTLLNMLLEAGApkRALLSSLRLVLSGGAPLPPELARRFRELFG-GALVNGYGLTE 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CNCSIANMD------GKVGSCGfnsRILTHVypiRLVKVNEDTMEPLRdseglcipcqPGEPG-LLVGQINQqdplrrFD 475
Cdd:pfam00501 314 TTGVVTTPLpldedlRSLGSVG---RPLPGT---EVKIVDDETGEPVP----------PGEPGeLCVRGPGV------MK 371
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 476 GYVSD-SATNKKIahsvfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWR 526
Cdd:pfam00501 372 GYLNDpELTAEAF------DEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
AFD_class_I cd04433
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ...
253-611 1.00e-59

Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341228 [Multi-domain]  Cd Length: 336  Bit Score: 203.29  E-value: 1.00e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 DRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGnIMGVGQCVIYGLTVVLRKKFSASR 332
Cdd:cd04433     1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGDVFLSTLPLFHIGG-LFGLLGALLAGGTVVLLPKFDPEA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 333 FWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNG--LRPAIWEEFTQRFGVPqIGEFYGATECNCSIA-- 408
Cdd:cd04433    80 ALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGapLPPELLERFEEAPGIK-LVNGYGLTETGGTVAtg 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 409 ---NMDGKVGSCGFnsrilthvyPIRLVKVNedtmepLRDSEGlcIPCQPGEPGLLVGQINQqdplrRFDGYVSDSATNK 485
Cdd:cd04433   159 ppdDDARKPGSVGR---------PVPGVEVR------IVDPDG--GELPPGEIGELVVRGPS-----VMKGYWNNPEATA 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 486 kiahsvFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgVEGKAGMA 565
Cdd:cd04433   217 ------AVDEDGWYRTGDLGRLDEDGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDP-EWGERVVA 289
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1907189407 566 AI-ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQ 611
Cdd:cd04433   290 VVvLRPGADLDAEELRAHVRERLAPYKVPRRVVFVDALPRTASGKID 336
PRK13388 PRK13388
acyl-CoA synthetase; Provisional
97-653 2.20e-59

acyl-CoA synthetase; Provisional


Pssm-ID: 237374 [Multi-domain]  Cd Length: 540  Bit Score: 208.34  E-value: 2.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALvdASSGICWTFAQLDTYSNAVANLFRQLGFAPGDV-VAVFLEGRPEFVgLWLGLAK-AGVVAALLNvNLR 174
Cdd:PRK13388   11 DRAGDDTIAV--RYGDRTWTWREVLAEAAARAAALIALADPDRPLhVGVLLGNTPEML-FWLAAAAlGGYVLVGLN-TTR 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 175 ReplafclgtsaakaliyGGEMAAAVAEVSEQL------GKSLLKfcsgDLGpesiLPDTQLLD---PMLAE--APTTPL 243
Cdd:PRK13388   87 R-----------------GAALAADIRRADCQLlvtdaeHRPLLD----GLD----LPGVRVLDvdtPAYAElvAAAGAL 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 244 AQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVV 323
Cdd:PRK13388  142 TPHREVDAMDPFMLIFTSGTTGAPKAVRCSHGRLAFAGRALTERFGLTRDDVCYVSMPLFHSNAVMAGWAPAVASGAAVA 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 324 LRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVpQIGEFYGATEC 403
Cdd:PRK13388  222 LPAKFSASGFLDDVRRYGATYFNYVGKPLAYILATPERPDDADNPLRVAFGNEASPRDIAEFSRRFGC-QVEDGYGSSEG 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 404 NCSIANMDGK-VGSCGfnsrilthvypiR----LVKVNEDTMEPlrdseglCIPCQPGEPGLL------VGQINQQDPLR 472
Cdd:PRK13388  301 AVIVVREPGTpPGSIG------------RgapgVAIYNPETLTE-------CAVARFDAHGALlnadeaIGELVNTAGAG 361
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 473 RFDGYVSD-SATNKKIAHSVFRKGDSAYLSGDvlvmdelGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVY 551
Cdd:PRK13388  362 FFEGYYNNpEATAERMRHGMYWSGDLAYRDAD-------GWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVY 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 552 GVAVPGVeGKAGMAAI--ADPHSqLDPNSMYQEL--QKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFdpRQTSD 627
Cdd:PRK13388  435 AVPDERV-GDQVMAALvlRDGAT-FDPDAFAAFLaaQPDLGTKAWPRYVRIAADLPSTATNKVLKRELIAQGW--ATGDP 510
                         570       580
                  ....*....|....*....|....*.
gi 1907189407 628 RLFFLDLKQGRYVPLDERVHARICAG 653
Cdd:PRK13388  511 VTLWVRRGGPAYRLMSEPAKAALAAE 536
PRK07867 PRK07867
acyl-CoA synthetase; Validated
142-621 1.92e-54

acyl-CoA synthetase; Validated


Pssm-ID: 236120 [Multi-domain]  Cd Length: 529  Bit Score: 194.51  E-value: 1.92e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 142 VAVFLEGRPEFvGLWLGLAK-AGVVAALLNVNLRREPLA---------FCLGTSAAKALIYGGEMAAAVAEVSEQlgksl 211
Cdd:PRK07867   57 VGVLLDNTPEF-SLLLGAAAlSGIVPVGLNPTRRGAALArdiahadcqLVLTESAHAELLDGLDPGVRVINVDSP----- 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 212 lkfcsgdlgpesilPDTQLLDPmLAEAPTTPLAQAPgkgmDDRLFYIYTSGTTGLPKAAIVVHSRyyrIAAFGH---HSY 288
Cdd:PRK07867  131 --------------AWADELAA-HRDAEPPFRVADP----DDLFMLIFTSGTSGDPKAVRCTHRK---VASAGVmlaQRF 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 289 SMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHR 368
Cdd:PRK07867  189 GLGPDDVCYVSMPLFHSNAVMAGWAVALAAGASIALRRKFSASGFLPDVRRYGATYANYVGKPLSYVLATPERPDDADNP 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 369 VRLAVGNGLRPAIWEEFTQRFGVpQIGEFYGATECNCSIANM-DGKVGSCGfnsrilthVYPIRLVKVNEDTMEPlrdse 447
Cdd:PRK07867  269 LRIVYGNEGAPGDIARFARRFGC-VVVDGFGSTEGGVAITRTpDTPPGALG--------PLPPGVAIVDPDTGTE----- 334
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 448 glCIPCQPGEPGLL-----VGQ-INQQDPlRRFDGYVSDS-ATNKKIAHSVFRKGDSAYlsgdvlvMDELGYMYFRDRSG 520
Cdd:PRK07867  335 --CPPAEDADGRLLnadeaIGElVNTAGP-GGFEGYYNDPeADAERMRGGVYWSGDLAY-------RDADGYAYFAGRLG 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 521 DTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVeGKAGMAAIA-DPHSQLDPNSMYQEL--QKVLASYARPIFLR 597
Cdd:PRK07867  405 DWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVV-GDQVMAALVlAPGAKFDPDAFAEFLaaQPDLGPKQWPSYVR 483
                         490       500
                  ....*....|....*....|....
gi 1907189407 598 LLPQVDTTGTFKIQKTRLQREGFD 621
Cdd:PRK07867  484 VCAELPRTATFKVLKRQLSAEGVD 507
caiC PRK08008
putative crotonobetaine/carnitine-CoA ligase; Validated
86-616 1.46e-50

putative crotonobetaine/carnitine-CoA ligase; Validated


Pssm-ID: 181195 [Multi-domain]  Cd Length: 517  Bit Score: 183.73  E-value: 1.46e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  86 GDTIPCIFQAVARRQPERLALV-DASSGIC--WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKA 162
Cdd:PRK08008    6 GQHLRQMWDDLADVYGHKTALIfESSGGVVrrYSYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 163 GVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESIlPDTQLLDPMLAEAPTTp 242
Cdd:PRK08008   86 GAIMVPINARLLREESAWILQNSQASLLVTSAQFYPMYRQIQQEDATPLRHICLTRVALPAD-DGVSSFTQLKAQQPAT- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 243 LAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHsryYRIAAFGHHSY---SMRAADVLYDCLPLYHSAGNIMGVGQCVIYG 319
Cdd:PRK08008  164 LCYAPPLSTDDTAEILFTSGTTSRPKGVVITH---YNLRFAGYYSAwqcALRDDDVYLTVMPAFHIDCQCTAAMAAFSAG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 320 LTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVR-----LAVGNGLRpaiwEEFTQRFGVpQI 394
Cdd:PRK08008  241 ATFVLLEKYSARAFWGQVCKYRATITECIPMMIRTLMVQPPSANDRQHCLRevmfyLNLSDQEK----DAFEERFGV-RL 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 395 GEFYGATEcncSIANMDG----------KVGSCGFNsrilthvYPIRLVKVNEDTMEPLRDSEgLCIpcqPGEPGLLVgq 464
Cdd:PRK08008  316 LTSYGMTE---TIVGIIGdrpgdkrrwpSIGRPGFC-------YEAEIRDDHNRPLPAGEIGE-ICI---KGVPGKTI-- 379
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 465 inqqdplrrFDGYVSD-SATNKKI-AHSVFRKGDSAYlsgdvlvMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRL 542
Cdd:PRK08008  380 ---------FKEYYLDpKATAKVLeADGWLHTGDTGY-------VDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATH 443
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189407 543 LGQTDVAVYGVAVPgVEGKAGMA-AIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQ 616
Cdd:PRK08008  444 PKIQDIVVVGIKDS-IRDEAIKAfVVLNEGETLSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIKKNLK 517
FACL_FadD13-like cd17631
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ...
97-612 3.17e-50

fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.


Pssm-ID: 341286 [Multi-domain]  Cd Length: 435  Bit Score: 180.50  E-value: 3.17e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRRE 176
Cdd:cd17631     5 ARRHPDRTALVFG--GRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRLTPP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLAFCLGTSAAKALIyggemaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgmDDRLF 256
Cdd:cd17631    83 EVAYILADSGAKVLF------------------------------------------------------------DDLAL 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 257 YIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDD 336
Cdd:cd17631   103 LMYTSGTTGRPKGAMLTHRNLLWNAVNALAALDLGPDDVLLVVAPLFHIGGLGVFTLPTLLRGGTVVILRKFDPETVLDL 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 337 CVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNG--LRPAIWEEFtQRFGVpQIGEFYGATECNCSIANMD--- 411
Cdd:cd17631   183 IERHRVTSFFLVPTMIQALLQHPRFATTDLSSLRAVIYGGapMPERLLRAL-QARGV-KFVQGYGMTETSPGVTFLSped 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 412 --GKVGSCGfnsRILTHVyPIRLVKVNEDtmeplrdseglciPCQPGEpgllVGQINQQDPLrRFDGYVSDSATNKKiah 489
Cdd:cd17631   261 hrRKLGSAG---RPVFFV-EVRIVDPDGR-------------EVPPGE----VGEIVVRGPH-VMAGYWNRPEATAA--- 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 490 sVFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGvaVPGVE-GKAGMAAIA 568
Cdd:cd17631   316 -AFRDG--WFHTGDLGRLDEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVIG--VPDEKwGEAVVAVVV 390
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1907189407 569 -DPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQK 612
Cdd:cd17631   391 pRPGAELDEDELIAHCRERLARYKIPKSVEFVDALPRNATGKILK 435
Firefly_Luc_like cd05911
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ...
105-611 8.36e-49

Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.


Pssm-ID: 341237 [Multi-domain]  Cd Length: 486  Bit Score: 178.18  E-value: 8.36e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 105 ALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGT 184
Cdd:cd05911     1 AQIDADTGKELTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 185 SAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLgPESILPDTQLLDPmLAEAPTTPLAQAPGKGMDDRLFYIYTSGTT 264
Cdd:cd05911    81 SKPKVIFTDPDGLEKVKEAAKELGPKDKIIVLDDK-PDGVLSIEDLLSP-TLGEEDEDLPPPLKDGKDDTAAILYSSGTT 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 265 GLPKAAIVVHSRYyrIA----AFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGqCVIYGLTVVLRKKFSASRFWDDCVKY 340
Cdd:cd05911   159 GLPKGVCLSHRNL--IAnlsqVQTFLYGNDGSNDVILGFLPLYHIYGLFTTLA-SLLNGATVIIMPKFDSELFLDLIEKY 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 341 NCTVVQYIGEICRYLLRQPVRDVEQRHRVR-LAVGNG-LRPAIWEEFTQRFGVPQIGEFYGATECNCSIA---NMDGKVG 415
Cdd:cd05911   236 KITFLYLVPPIAAALAKSPLLDKYDLSSLRvILSGGApLSKELQELLAKRFPNATIKQGYGMTETGGILTvnpDGDDKPG 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 416 SCGfnsrILTHVYPIRLvkVNEDTMEPLrdseglcipcQPGEPG-LLV--GQInqqdplrrFDGYVSD-SATNKKIAHSV 491
Cdd:cd05911   316 SVG----RLLPNVEAKI--VDDDGKDSL----------GPNEPGeICVrgPQV--------MKGYYNNpEATKETFDEDG 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 492 FRKgdsaylSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgVEGKAGMAAIA-DP 570
Cdd:cd05911   372 WLH------TGDIGYFDEDGYLYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDE-VSGELPRAYVVrKP 444
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1907189407 571 HSQLDPNSMYQELQKVLASY----ARPIFLRLLPQvdtTGTFKIQ 611
Cdd:cd05911   445 GEKLTEKEVKDYVAKKVASYkqlrGGVVFVDEIPK---SASGKIL 486
PRK06187 PRK06187
long-chain-fatty-acid--CoA ligase; Validated
88-618 4.37e-47

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235730 [Multi-domain]  Cd Length: 521  Bit Score: 173.83  E-value: 4.37e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  88 TIPCIFQAVARRQPERLALVDASSGicWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAA 167
Cdd:PRK06187    7 TIGRILRHGARKHPDKEAVYFDGRR--TTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPKIGAVLH 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 168 LLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGksLLKFC--SGDLGPESILPDTQLLDPMLAEAPTTPLaq 245
Cdd:PRK06187   85 PINIRLKPEEIAYILNDAEDRVVLVDSEFVPLLAAILPQLP--TVRTVivEGDGPAAPLAPEVGEYEELLAAASDTFD-- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 246 APGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGniMGVGQCVIY-GLTVVL 324
Cdd:PRK06187  161 FPDIDENDAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRDDVYLVIVPMFHVHA--WGLPYLALMaGAKQVI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 325 RKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVpQIGEFYGATE 402
Cdd:PRK06187  239 PRRFDPENLLDLIETERVTFFFAVPTIWQMLLKAPRAYFVDFSSLRLVIygGAALPPALLREFKEKFGI-DLVQGYGMTE 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CncsianmdGKVGSCGFNSRILTHVYPIRL----------VKVNEDTMEPLrdseglciPCQPGEPGLLV--GQINQQdp 470
Cdd:PRK06187  318 T--------SPVVSVLPPEDQLPGQWTKRRsagrplpgveARIVDDDGDEL--------PPDGGEVGEIIvrGPWLMQ-- 379
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 471 lrrfdGYVSD-SATNKKIAhsvfrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVA 549
Cdd:PRK06187  380 -----GYWNRpEATAETID-------GGWLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVA 447
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 550 VYGV----------AVpgVEGKAGMaaiadphsQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLqRE 618
Cdd:PRK06187  448 VIGVpdekwgerpvAV--VVLKPGA--------TLDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVL-RE 515
Acs COG0365
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
97-626 1.07e-46

Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];


Pssm-ID: 440134 [Multi-domain]  Cd Length: 565  Bit Score: 173.76  E-value: 1.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDAS---SGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNL 173
Cdd:COG0365    19 AEGRGDKVALIWEGedgEERTLTYAELRREVNRFANALRALGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHSPVFPGF 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 174 RREPLAFCLGTSAAKALI------YGG---EMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTT-PL 243
Cdd:COG0365    99 GAEALADRIEDAEAKVLItadgglRGGkviDLKEKVDEALEELPSLEHVIVVGRTGADVPMEGDLDWDELLAAASAEfEP 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 244 AQAPGkgmDDRLFYIYTSGTTGLPKAaiVVHS-RYYRIAA--FGHHSYSMRAADVLY---DClplyhsaGNIMGVGQCVI 317
Cdd:COG0365   179 EPTDA---DDPLFILYTSGTTGKPKG--VVHThGGYLVHAatTAKYVLDLKPGDVFWctaDI-------GWATGHSYIVY 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 318 YGL----TVVL---RKKF-SASRFWDDCVKYNCTVvqyigeIC------RYLLRQPVRDVEQRHRVRL----AVGNGLRP 379
Cdd:COG0365   247 GPLlngaTVVLyegRPDFpDPGRLWELIEKYGVTV------FFtaptaiRALMKAGDEPLKKYDLSSLrllgSAGEPLNP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 380 AIWEEFTQRFGVPqIGEFYGATECNCSIAN----MDGKVGSCGFnsrilthvyPIRLVKVNedtmepLRDSEGlcIPCQP 455
Cdd:COG0365   321 EVWEWWYEAVGVP-IVDGWGQTETGGIFISnlpgLPVKPGSMGK---------PVPGYDVA------VVDEDG--NPVPP 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 456 GEPGLLVgqinqqdpLRR-----FDGYVSDSATNKKiahSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENV 530
Cdd:COG0365   383 GEEGELV--------IKGpwpgmFRGYWNDPERYRE---TYFGRFPGWYRTGDGARRDEDGYFWILGRSDDVINVSGHRI 451
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 531 STTEVEAVLSRLLGQTDVAVygVAVPGVEGKAGMAA--IADPHSQLDPNsMYQELQ----KVLASYARP---IFLRLLPq 601
Cdd:COG0365   452 GTAEIESALVSHPAVAEAAV--VGVPDEIRGQVVKAfvVLKPGVEPSDE-LAKELQahvrEELGPYAYPreiEFVDELP- 527
                         570       580
                  ....*....|....*....|....*..
gi 1907189407 602 vdTTGTFKIQKTRLQR--EGFDPRQTS 626
Cdd:COG0365   528 --KTRSGKIMRRLLRKiaEGRPLGDTS 552
PRK08316 PRK08316
acyl-CoA synthetase; Validated
78-553 3.68e-43

acyl-CoA synthetase; Validated


Pssm-ID: 181381 [Multi-domain]  Cd Length: 523  Bit Score: 162.79  E-value: 3.68e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  78 ELRRHRRagDTIPCIFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWL 157
Cdd:PRK08316    4 RSTRARR--QTIGDILRRSARRYPDKTALVFG--DRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 158 GLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKS---LLKFCSGDLGPESILPDTQLLDpm 234
Cdd:PRK08316   80 ACARAGAVHVPVNFMLTGEELAYILDHSGARAFLVDPALAPTAEAALALLPVDtliLSLVLGGREAPGGWLDFADWAE-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 235 lAEAPTTPLAQAPGkgmDDRLFYIYTSGTTGLPKAAIVVH----SRYYR-IAAFGhhsysMRAADVLYDCLPLYHSAGni 309
Cdd:PRK08316  158 -AGSVAEPDVELAD---DDLAQILYTSGTESLPKGAMLTHraliAEYVScIVAGD-----MSADDIPLHALPLYHCAQ-- 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 310 MGV--GQCVIYGLTVVLRKKFSASRFWDDCVKYNC-------TVvqYIGeicryLLRQPVRDveqrhRVRLAvgnGLRPA 380
Cdd:PRK08316  227 LDVflGPYLYVGATNVILDAPDPELILRTIEAERItsffappTV--WIS-----LLRHPDFD-----TRDLS---SLRKG 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 381 ----------IWEEFTQRFgvPQIG--EFYGATEcncsIA---------NMDGKVGSCG---FN--SRIlthvypirlvk 434
Cdd:PRK08316  292 yygasimpveVLKELRERL--PGLRfyNCYGQTE----IAplatvlgpeEHLRRPGSAGrpvLNveTRV----------- 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 435 VNEDtMEPLrdseglcipcQPGEPGLLVGQINQQdplrrFDGYVSDSAtnkKIAHSvFRKGdsAYLSGDVLVMDELGYMY 514
Cdd:PRK08316  355 VDDD-GNDV----------APGEVGEIVHRSPQL-----MLGYWDDPE---KTAEA-FRGG--WFHSGDLGVMDEEGYIT 412
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 1907189407 515 FRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGV 553
Cdd:PRK08316  413 VVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVIGL 451
FACL_fum10p_like cd05926
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ...
101-615 5.43e-43

Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.


Pssm-ID: 341249 [Multi-domain]  Cd Length: 493  Bit Score: 161.71  E-value: 5.43e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAF 180
Cdd:cd05926     1 PDAPALVVPGSTPALTYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 181 CLGTSAAKALI--YGGEMAA---------AVAEVSEQLGKSLLKFCSGDLGPesilpdtqlLDPMLAEAPTTPLAQAPgk 249
Cdd:cd05926    81 YLADLGSKLVLtpKGELGPAsraasklglAILELALDVGVLIRAPSAESLSN---------LLADKKNAKSEGVPLPD-- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 250 gmDDRLFyIYTSGTTGLPKAAIVVHSryyRIAAFGHH---SYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRK 326
Cdd:cd05926   150 --DLALI-LHTSGTTGRPKGVPLTHR---NLAASATNitnTYKLTPDDRTLVVMPLFHVHGLVASLLSTLAAGGSVVLPP 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 327 KFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRH---RVRLAVGNGLRPAIWEEFTQRFGVPQIgEFYGATE- 402
Cdd:cd05926   224 RFSASTFWPDVRDYNATWYTAVPTIHQILLNRPEPNPESPPpklRFIRSCSASLPPAVLEALEATFGAPVL-EAYGMTEa 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 -----CNCSIANMDgKVGSCGFNS----RILthvypirlvkvnedtmeplrDSEGLciPCQPGEpgllVGQINQQDPlRR 473
Cdd:cd05926   303 ahqmtSNPLPPGPR-KPGSVGKPVgvevRIL--------------------DEDGE--ILPPGV----VGEICLRGP-NV 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 474 FDGYVSDSATNKKIAHSV--FRKGDSAYLsgdvlvmDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVY 551
Cdd:cd05926   355 TRGYLNNPEANAEAAFKDgwFRTGDLGYL-------DADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAF 427
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907189407 552 GVAVPgVEGKAGMAAI-ADPHSQLDPNSMYQELQKVLASYARP---IFLRLLPQvdtTGTFKIQKTRL 615
Cdd:cd05926   428 GVPDE-KYGEEVAAAVvLREGASVTEEELRAFCRKHLAAFKVPkkvYFVDELPK---TATGKIQRRKV 491
PRK07656 PRK07656
long-chain-fatty-acid--CoA ligase; Validated
88-616 4.37e-42

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236072 [Multi-domain]  Cd Length: 513  Bit Score: 159.68  E-value: 4.37e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  88 TIPCIFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGvvAA 167
Cdd:PRK07656    6 TLPELLARAARRFGDKEAYVFGDQRL--TYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAG--AV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 168 LLNVNLRREP--LAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLaeAPTTPLAQ 245
Cdd:PRK07656   82 VVPLNTRYTAdeAAYILARGDAKALFVLGLFLGVDYSATTRLPALEHVVICETEEDDPHTEKMKTFTDFL--AAGDPAER 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 246 APGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLR 325
Cdd:PRK07656  160 APEVDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEGDRYLAANPFFHVFGYKAGVNAPLMRGATILPL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 326 KKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNG--LRPAIWEEFTQRFGVPQIGEFYGATEC 403
Cdd:PRK07656  240 PVFDPDEVFRLIETERITVLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAasMPVALLERFESELGVDIVLTGYGLSEA 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 404 nCSIANM-----DGKV--GSCGfnsrilthvYPIRLVKvnedtmepLRDSEGLCIPCQPGEPGLLVgqinqqdpLRRFD- 475
Cdd:PRK07656  320 -SGVTTFnrlddDRKTvaGTIG---------TAIAGVE--------NKIVNELGEEVPVGEVGELL--------VRGPNv 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 476 --GYVSDS-ATnkkiAHSVfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYG 552
Cdd:PRK07656  374 mkGYYDDPeAT----AAAI--DADGWLHTGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIG 447
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907189407 553 VAVPGVeGKAGMA-AIADPHSQLDPNSMYQELQKVLASYARP---IFLRLLPqVDTTGtfKIQKTRLQ 616
Cdd:PRK07656  448 VPDERL-GEVGKAyVVLKPGAELTEEELIAYCREHLAKYKVPrsiEFLDELP-KNATG--KVLKRALR 511
MACS_like cd05972
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ...
115-615 5.60e-41

Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.


Pssm-ID: 341276 [Multi-domain]  Cd Length: 428  Bit Score: 154.80  E-value: 5.60e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGG 194
Cdd:cd05972     1 WSFRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 EmaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgmdDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:cd05972    81 E---------------------------------------------------------DPALIYFTSGTTGLPKGVLHTH 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 SryyriAAFGHHSYS-----MRAADVLY---DCLPLYHSAGNIMGVgqcVIYGLTVVL--RKKFSASRFWDDCVKYNCTV 344
Cdd:cd05972   104 S-----YPLGHIPTAaywlgLRPDDIHWniaDPGWAKGAWSSFFGP---WLLGATVFVyeGPRFDAERILELLERYGVTS 175
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 345 VQYIGEICRYLLRQpvrDVEQRHRVRL----AVGNGLRPAIWEEFTQRFGVPqIGEFYGATECNCSIAN---MDGKVGSC 417
Cdd:cd05972   176 FCGPPTAYRMLIKQ---DLSSYKFSHLrlvvSAGEPLNPEVIEWWRAATGLP-IRDGYGQTETGLTVGNfpdMPVKPGSM 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 418 GFNsrilTHVYPIRLVkvnedtmeplrDSEGLciPCQPGEPGLLVGQINqqdPLRRFDGYVSDSATNKKiahsVFRKGds 497
Cdd:cd05972   252 GRP----TPGYDVAII-----------DDDGR--ELPPGEEGDIAIKLP---PPGLFLGYVGDPEKTEA----SIRGD-- 305
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 498 AYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgVEGKAGMAAIADPHSQLDPN 577
Cdd:cd05972   306 YYLTGDRAYRDEDGYFWFVGRADDIIKSSGYRIGPFEVESALLEHPAVAEAAVVGSPDP-VRGEVVKAFVVLTSGYEPSE 384
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1907189407 578 SMYQELQ----KVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd05972   385 ELAEELQghvkKVLAPYKYPREIEFVEELPKTISGKIRRVEL 426
MACS_AAE_MA_like cd05970
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ...
92-612 2.48e-40

Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.


Pssm-ID: 341274 [Multi-domain]  Cd Length: 537  Bit Score: 154.96  E-value: 2.48e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALV---DASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAAL 168
Cdd:cd05970    22 VVDAMAKEYPDKLALVwcdDAGEERIFTFAELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEFWYSLLALHKLGAIAIP 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 169 LNVNLRREPLAFCLGTSAAKALIYGGE--MAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMlAEAPTTPLAQA 246
Cdd:cd05970   102 ATHQLTAKDIVYRIESADIKMIVAIAEdnIPEEIEKAAPECPSKPKLVWVGDPVPEGWIDFRKLIKNA-SPDFERPTANS 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 247 PGKGMDDRLFYiYTSGTTGLPKaaIVVHSRYYriaAFGHHSYSMRAADVLYDCLplyHSAGNIMGVGQCV---IYG---- 319
Cdd:cd05970   181 YPCGEDILLVY-FSSGTTGMPK--MVEHDFTY---PLGHIVTAKYWQNVREGGL---HLTVADTGWGKAVwgkIYGqwia 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 320 ---LTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRhRVRLAV--GNGLRPAIWEEFTQRFGVpQI 394
Cdd:cd05970   252 gaaVFVYDYDKFDPKALLEKLSKYGVTTFCAPPTIYRFLIREDLSRYDLS-SLRYCTtaGEALNPEVFNTFKEKTGI-KL 329
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 395 GEFYGATECNCSIAN---MDGKVGSCGFNsrilTHVYPIRLVkvnedtmeplrDSEGLciPCQPGEPGLLVGQINQQDPL 471
Cdd:cd05970   330 MEGFGQTETTLTIATfpwMEPKPGSMGKP----APGYEIDLI-----------DREGR--SCEAGEEGEIVIRTSKGKPV 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 472 RRFDGYVSDSATNKKIAHsvfrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVY 551
Cdd:cd05970   393 GLFGGYYKDAEKTAEVWH------DGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQHPAVLECAVT 466
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189407 552 GVAVPgVEGKAGMAAIADPHSQLDPNSMYQELQ----KVLASYARPIFLRLLPQVDTTGTFKIQK 612
Cdd:cd05970   467 GVPDP-IRGQVVKATIVLAKGYEPSEELKKELQdhvkKVTAPYKYPRIVEFVDELPKTISGKIRR 530
FC-FACS_FadD_like cd05936
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ...
92-616 1.05e-39

Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341259 [Multi-domain]  Cd Length: 468  Bit Score: 151.95  E-value: 1.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALVDasSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:cd05936     4 LLEEAARRFPDKTALIF--MGRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLNP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLRREPLAFCLGTSAAKALIyggemaaaVAEVSEQLGKSLLkfcsgdlgpesilpdtqlldPMLAEAPTTPlaqapgkgm 251
Cdd:cd05936    82 LYTPRELEHILNDSGAKALI--------VAVSFTDLLAAGA--------------------PLGERVALTP--------- 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSY--SMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFS 329
Cdd:cd05936   125 EDVAVLQYTSGTTGVPKGAMLTHRNLVANALQIKAWLedLLEGDDVVLAALPLFHVFGLTVALLLPLALGATIVLIPRFR 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 330 ASRFWDDCVKYNCTVVQ-----YIGeicryLLRQPVRDVEQRHRVRLAVGNG--LRPAIWEEFTQRFGVPqIGEFYGATE 402
Cdd:cd05936   205 PIGVLKEIRKHRVTIFPgvptmYIA-----LLNAPEFKKRDFSSLRLCISGGapLPVEVAERFEELTGVP-IVEGYGLTE 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CNCSIA-N-MDG--KVGSCGfnsrilthvYPIRLVKVNedtmepLRDSEGLCIPcqPGEPGLLVgqinqqdpLR---RFD 475
Cdd:cd05936   279 TSPVVAvNpLDGprKPGSIG---------IPLPGTEVK------IVDDDGEELP--PGEVGELW--------VRgpqVMK 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 476 GYVSDSATNKKiahsVFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAV 555
Cdd:cd05936   334 GYWNRPEETAE----AFVDG--WLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPD 407
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189407 556 P--GVEGKAgmAAIADPHSQLDPNSMYQELQKVLASYARP---IFLRLLPQvDTTGtfKIQKTRLQ 616
Cdd:cd05936   408 PysGEAVKA--FVVLKEGASLTEEEIIAFCREQLAGYKVPrqvEFRDELPK-SAVG--KILRRELR 468
BCL_like cd05919
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ...
116-616 1.08e-34

Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.


Pssm-ID: 341243 [Multi-domain]  Cd Length: 436  Bit Score: 136.82  E-value: 1.08e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGE 195
Cdd:cd05919    12 TYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARDCEARLVVTSAD 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 MAAavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgmddrlFYIYTSGTTGLPKAAIVVHS 275
Cdd:cd05919    92 DIA---------------------------------------------------------YLLYSSGTTGPPKGVMHAHR 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 276 RYYRIA-AFGHHSYSMRAADVLYDCLPLYHSAG---NIMGVGQCviyGLTVVLRKKF-SASRFWDDCVKYNCTVVQYIGE 350
Cdd:cd05919   115 DPLLFAdAMAREALGLTPGDRVFSSAKMFFGYGlgnSLWFPLAV---GASAVLNPGWpTAERVLATLARFRPTVLYGVPT 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 351 ICRYLLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPqIGEFYGATEC-NCSIANMDGKV--GSCGfnsRILT 425
Cdd:cd05919   192 FYANLLDSCAGSPDALRSLRLCVsaGEALPRGLGERWMEHFGGP-ILDGIGATEVgHIFLSNRPGAWrlGSTG---RPVP 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 426 HvYPIRLVkvnedtmeplrDSEGLCIPcqPGEPGLLVGQINQQDPlrrfdGYVSDSATNKKiahsVFRKGdsAYLSGDVL 505
Cdd:cd05919   268 G-YEIRLV-----------DEEGHTIP--PGEEGDLLVRGPSAAV-----GYWNNPEKSRA----TFNGG--WYRTGDKF 322
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 506 VMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVygVAVPGVEGKAGMAAIADPHSQLDPN-----SMY 580
Cdd:cd05919   323 CRDADGWYTHAGRADDMLKVGGQWVSPVEVESLIIQHPAVAEAAV--VAVPESTGLSRLTAFVVLKSPAAPQeslarDIH 400
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 1907189407 581 QELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQ 616
Cdd:cd05919   401 RHLLERLSAHKVPRRIAFVDELPRTATGKLQRFKLR 436
PRK07788 PRK07788
acyl-CoA synthetase; Validated
53-604 3.06e-34

acyl-CoA synthetase; Validated


Pssm-ID: 236097 [Multi-domain]  Cd Length: 549  Bit Score: 137.37  E-value: 3.06e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  53 RFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGdTIPcifQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFR 132
Cdd:PRK07788   19 HYLRVMIRSGAVDLERPDNGLRLAADIRRYGPFA-GLV---AHAARRAPDRAALIDERGTL--TYAELDEQSNALARGLL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 133 QLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLL 212
Cdd:PRK07788   93 ALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIILLNTGFSGPQLAEVAAREGVKALVYDDEFTDLLSALPPDLGRLRA 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 213 KFCSGDLGPESIlPDTQLLDPMLAEAPTTPLAQAPGKGMddrlFYIYTSGTTGLPKAAIVVH-SRYYRIAAFGHHsYSMR 291
Cdd:PRK07788  173 WGGNPDDDEPSG-STDETLDDLIAGSSTAPLPKPPKPGG----IVILTSGTTGTPKGAPRPEpSPLAPLAGLLSR-VPFR 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 292 AADVLYDCLPLYHSagniMGVGQCVI---YGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPvRDVEQRH- 367
Cdd:PRK07788  247 AGETTLLPAPMFHA----TGWAHLTLamaLGSTVVLRRRFDPEATLEDIAKHKATALVVVPVMLSRILDLG-PEVLAKYd 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 368 ----RVRLAVGNGLRPAIWEEFTQRFGvPQIGEFYGATECN-CSIANMD------GKVGScgfnsrilthvyPIRLVKVN 436
Cdd:PRK07788  322 tsslKIIFVSGSALSPELATRALEAFG-PVLYNLYGSTEVAfATIATPEdlaeapGTVGR------------PPKGVTVK 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 437 edtmepLRDSEGLCIPcqPGEPG-LLVGQINQqdplrrFDGYVSDSatNKKIAHSVFRKGDSAYLsgdvlvmDELGYMYF 515
Cdd:PRK07788  389 ------ILDENGNEVP--RGVVGrIFVGNGFP------FEGYTDGR--DKQIIDGLLSSGDVGYF-------DEDGLLFV 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 516 RDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGvaVPGVEGKAGMAA--IADPHSQLDPNSMYQELQKVLASYARP 593
Cdd:PRK07788  446 DGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIG--VDDEEFGQRLRAfvVKAPGAALDEDAIKDYVRDNLARYKVP 523
                         570
                  ....*....|....
gi 1907189407 594 ---IFLRLLPQVDT 604
Cdd:PRK07788  524 rdvVFLDELPRNPT 537
PRK03640 PRK03640
o-succinylbenzoate--CoA ligase;
97-618 3.34e-33

o-succinylbenzoate--CoA ligase;


Pssm-ID: 235146 [Multi-domain]  Cd Length: 483  Bit Score: 133.55  E-value: 3.34e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGicWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRRE 176
Cdd:PRK03640   12 AFLTPDRTAIEFEEKK--VTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSRE 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKfcsgdlgpesilpdtqlldpmLAEAPTTPLAQAPgkgmDDRLF 256
Cdd:PRK03640   90 ELLWQLDDAEVKCLITDDDFEAKLIPGISVKFAELMN---------------------GPKEEAEIQEEFD----LDEVA 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 257 YI-YTSGTTGLPKAAivvhsryyrIAAFGHHSYS---------MRAADVLYDCLPLYHSAG-NIMGVGqcVIYGLTVVLR 325
Cdd:PRK03640  145 TImYTSGTTGKPKGV---------IQTYGNHWWSavgsalnlgLTEDDCWLAAVPIFHISGlSILMRS--VIYGMRVVLV 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 326 KKFSASRFWDDCVKYNCT---VVQyigeicrYLLRQPVRDVEQRH-----RVRLaVGNGLRPAIWEEFTQRFGVPQIgEF 397
Cdd:PRK03640  214 EKFDAEKINKLLQTGGVTiisVVS-------TMLQRLLERLGEGTypssfRCML-LGGGPAPKPLLEQCKEKGIPVY-QS 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 398 YGATECNCSIANMD-----GKVGSCG---FNSRIlthvypirlvKVNEDTMEplrdseglCIPCQPGE-----PGLLVGQ 464
Cdd:PRK03640  285 YGMTETASQIVTLSpedalTKLGSAGkplFPCEL----------KIEKDGVV--------VPPFEEGEivvkgPNVTKGY 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 465 INQQDplrrfdgyvsdsATNKKIAHSVFRKGDSAYLsgdvlvmDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLG 544
Cdd:PRK03640  347 LNRED------------ATRETFQDGWFKTGDIGYL-------DEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPG 407
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 545 QTDVAVYGVAvpgvEGKAGMAAIAD--PHSQLDPNSMYQELQKVLASYARP---IFLRLLPQvdtTGTFKIQKTRLQRE 618
Cdd:PRK03640  408 VAEAGVVGVP----DDKWGQVPVAFvvKSGEVTEEELRHFCEEKLAKYKVPkrfYFVEELPR---NASGKLLRHELKQL 479
BCL_4HBCL cd05959
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ...
92-615 4.25e-33

Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.


Pssm-ID: 341269 [Multi-domain]  Cd Length: 508  Bit Score: 133.65  E-value: 4.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:cd05959     9 VDLNLNEGRGDKTAFIDDAGSL--TYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVPVNT 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKF-CSGDLGPESILPD-TQLLD---PMLAEAPTTPlaqa 246
Cdd:cd05959    87 LLTPDDYAYYLEDSRARVVVVSGELAPVLAAALTKSEHTLVVLiVSGGAGPEAGALLlAELVAaeaEQLKPAATHA---- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 247 pgkgmDDRLFYIYTSGTTGLPKAAIVVHSRYYRIA-AFGHHSYSMRAADVLYDCLPLYHSagniMGVGQCVIY----GLT 321
Cdd:cd05959   163 -----DDPAFWLYSSGSTGRPKGVVHLHADIYWTAeLYARNVLGIREDDVCFSAAKLFFA----YGLGNSLTFplsvGAT 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 322 VVLRKKF-SASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVpQIGEFY 398
Cdd:cd05959   234 TVLMPERpTPAAVFKRIRRYRPTVFFGVPTLYAAMLAAPNLPSRDLSSLRLCVsaGEALPAEVGERWKARFGL-DILDGI 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 399 GATEC-NCSIANMDGKV--GSCGfnsrILTHVYPIRLVkvnEDTMEPLRDSEglcipcqPGE-----PGLLVGQINQQDP 470
Cdd:cd05959   313 GSTEMlHIFLSNRPGRVryGTTG----KPVPGYEVELR---DEDGGDVADGE-------PGElyvrgPSSATMYWNNRDK 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 471 LRR-FDGYvsdsatnkkiahsvfrkgdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLsrllgQTDVA 549
Cdd:cd05959   379 TRDtFQGE--------------------WTRTGDKYVRDDDGFYTYAGRADDMLKVSGIWVSPFEVESAL-----VQHPA 433
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407 550 VYGVAVPGVEGKAGM----AAIADPHSQLDPNSMYQELQK----VLASYARP---IFLRLLPQvdtTGTFKIQKTRL 615
Cdd:cd05959   434 VLEAAVVGVEDEDGLtkpkAFVVLRPGYEDSEALEEELKEfvkdRLAPYKYPrwiVFVDELPK---TATGKIQRFKL 507
PRK13391 PRK13391
acyl-CoA synthetase; Provisional
97-566 3.42e-31

acyl-CoA synthetase; Provisional


Pssm-ID: 184022 [Multi-domain]  Cd Length: 511  Bit Score: 127.89  E-value: 3.42e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRRE 176
Cdd:PRK13391    7 AQTTPDKPAVIMASTGEVVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFcsgDLGPESILPDTQLLDPMLAEAPTTPLAQAP-GKGMddrl 255
Cdd:PRK13391   87 EAAYIVDDSGARALITSAAKLDVARALLKQCPGVRHRL---VLDGDGELEGFVGYAEAVAGLPATPIADESlGTDM---- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 256 fyIYTSGTTGLPKAAivvhsryYR------------IAAFGHHSYSMRAADVLYDCLPLYHSA-GNIMGVGQCViyGLTV 322
Cdd:PRK13391  160 --LYSSGTTGRPKGI-------KRplpeqppdtplpLTAFLQRLWGFRSDMVYLSPAPLYHSApQRAVMLVIRL--GGTV 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 323 VLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPvRDVEQRHRVrlavgNGLRPAIW----------EEFTQRFGvP 392
Cdd:PRK13391  229 IVMEHFDAEQYLALIEEYGVTHTQLVPTMFSRMLKLP-EEVRDKYDL-----SSLEVAIHaaapcppqvkEQMIDWWG-P 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 393 QIGEFYGATECN----CSIANMDGKVGSCGfnsRILTHVYPIRlvkvnEDTMEplrdseglciPCQPGEPgllvGQINQQ 468
Cdd:PRK13391  302 IIHEYYAATEGLgftaCDSEEWLAHPGTVG---RAMFGDLHIL-----DDDGA----------ELPPGEP----GTIWFE 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 469 DPlRRFDgYVSDSAtnkKIAHSvfRKGDSAY-LSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTD 547
Cdd:PRK13391  360 GG-RPFE-YLNDPA---KTAEA--RHPDGTWsTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVAD 432
                         490       500       510
                  ....*....|....*....|....*....|...
gi 1907189407 548 VAVYGV--------------AVPGVEGKAGMAA 566
Cdd:PRK13391  433 AAVFGVpnedlgeevkavvqPVDGVDPGPALAA 465
MACS_like_3 cd05971
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
115-617 7.52e-31

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341275 [Multi-domain]  Cd Length: 439  Bit Score: 125.62  E-value: 7.52e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIygg 194
Cdd:cd05971     7 VTFKELKTASNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALV--- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 emaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeaptTPLAqapgkgmDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:cd05971    84 ----------------------------------------------TDGS-------DDPALIIYTSGTTGPPKGALHAH 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 sryyRIaAFGHhsysmraADVLYDCLPLYHSAGNIM----------GVGQCVI----YGLTVVLRK--KFSASRFWDDCV 338
Cdd:cd05971   111 ----RV-LLGH-------LPGVQFPFNLFPRDGDLYwtpadwawigGLLDVLLpslyFGVPVLAHRmtKFDPKAALDLMS 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 339 KYNCTVVqYIGEICRYLLRQpVRDVEQRHRVRL-AVGNGLRPAIWEEF---TQRFGVPqIGEFYGATECNCSIAN----M 410
Cdd:cd05971   179 RYGVTTA-FLPPTALKMMRQ-QGEQLKHAQVKLrAIATGGESLGEELLgwaREQFGVE-VNEFYGQTECNLVIGNcsalF 255
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 411 DGKVGSCGfnsriltHVYPIRLVKVNEDTMEPLrdseglcipcQPGEPGLLVgqINQQDPLrRFDGYVSD-SATNKKIAH 489
Cdd:cd05971   256 PIKPGSMG-------KPIPGHRVAIVDDNGTPL----------PPGEVGEIA--VELPDPV-AFLGYWNNpSATEKKMAG 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 490 SVFRKGDSAYLSGDvlvmdelGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgVEGKAGMAAIAD 569
Cdd:cd05971   316 DWLLTGDLGRKDSD-------GYFWYVGRDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIPDP-IRGEIVKAFVVL 387
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 570 PHSQLDPNSMYQELQKV----LASYARPIFLRLLPQVDTTGTFKIQKTRLQR 617
Cdd:cd05971   388 NPGETPSDALAREIQELvktrLAAHEYPREIEFVNELPRTATGKIRRRELRA 439
PRK08276 PRK08276
long-chain-fatty-acid--CoA ligase; Validated
105-553 1.03e-30

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236215 [Multi-domain]  Cd Length: 502  Bit Score: 126.56  E-value: 1.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 105 ALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGT 184
Cdd:PRK08276    2 AVIMAPSGEVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 185 SAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPdtqlLDPMLAEAPTTPLA-QAPGKGMddrlfyIYTSGT 263
Cdd:PRK08276   82 SGAKVLIVSAALADTAAELAAELPAGVPLLLVVAGPVPGFRS----YEEALAAQPDTPIAdETAGADM------LYSSGT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 264 TGLPK---------AAIVVHSRYYRIAAFGHHSYsmrAADVLYDCLPLYHSAGN--IMGVGQCviyGLTVVLRKKFSASR 332
Cdd:PRK08276  152 TGRPKgikrplpglDPDEAPGMMLALLGFGMYGG---PDSVYLSPAPLYHTAPLrfGMSALAL---GGTVVVMEKFDAEE 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 333 FWDDCVKYNCTVVQYIGEICRYLLRQPvRDVEQRHRVRlavgnGLRPAI----------------WeeftqrFGvPQIGE 396
Cdd:PRK08276  226 ALALIERYRVTHSQLVPTMFVRMLKLP-EEVRARYDVS-----SLRVAIhaaapcpvevkramidW------WG-PIIHE 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 397 FYGATECN----CSIANMDGKVGSCGfnsRILTHVypirlVKVNEDTMEPLrdseglciPcqPGEPGLLVGQINQQDplr 472
Cdd:PRK08276  293 YYASSEGGgvtvITSEDWLAHPGSVG---KAVLGE-----VRILDEDGNEL--------P--PGEIGTVYFEMDGYP--- 351
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 473 rFDgYVSDSATNKKIAHsvfRKGDSAYlsGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYG 552
Cdd:PRK08276  352 -FE-YHNDPEKTAAARN---PHGWVTV--GDVGYLDEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFG 424

                  .
gi 1907189407 553 V 553
Cdd:PRK08276  425 V 425
PRK09088 PRK09088
acyl-CoA synthetase; Validated
97-616 1.04e-30

acyl-CoA synthetase; Validated


Pssm-ID: 181644 [Multi-domain]  Cd Length: 488  Bit Score: 126.07  E-value: 1.04e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRre 176
Cdd:PRK09088    5 ARLQPQRLAAVDLALGRRWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLS-- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 plafclgtsaakaliyGGEMAAAVAEVSEQLgksLLkfcsGDLGPESILPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLF 256
Cdd:PRK09088   83 ----------------ASELDALLQDAEPRL---LL----GDDAVAAGRTDVEDLAAFIASADALEPADTPSIPPERVSL 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 257 YIYTSGTTGLPKAAIVVHSRYYRIAA-FGHHSYSMRAADVLYDClPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWD 335
Cdd:PRK09088  140 ILFTSGTSGQPKGVMLSERNLQQTAHnFGVLGRVDAHSSFLCDA-PMFHIIGLITSVRPVLAVGGSILVSNGFEPKRTLG 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 336 DCVKYNCTVVQYIG--EICRYLLRQPVRDVEQ-RHRVRLAVGNGLRPAI----WEE----FTQRFGVPQIGEFYGATeCN 404
Cdd:PRK09088  219 RLGDPALGITHYFCvpQMAQAFRAQPGFDAAAlRHLTALFTGGAPHAAEdilgWLDdgipMVDGFGMSEAGTVFGMS-VD 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 405 CSIanMDGKVGSCGfnsrILTHVYPIRLVKVNEdtmeplRDseglcipCQPGEPG--LLVGQinqqdplRRFDGYVSDSA 482
Cdd:PRK09088  298 CDV--IRAKAGAAG----IPTPTVQTRVVDDQG------ND-------CPAGVPGelLLRGP-------NLSPGYWRRPQ 351
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 483 TNKKIahsvfRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGvEGKA 562
Cdd:PRK09088  352 ATARA-----FTGDGWFRTGDIARRDADGFFWVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQ-WGEV 425
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907189407 563 GMAAIA-DPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQ 616
Cdd:PRK09088  426 GYLAIVpADGAPLDLERIRSHLSTRLAKYKVPKHLRLVDALPRTASGKLQKARLR 480
PRK07868 PRK07868
acyl-CoA synthetase; Validated
116-650 9.02e-30

acyl-CoA synthetase; Validated


Pssm-ID: 236121 [Multi-domain]  Cd Length: 994  Bit Score: 125.99  E-value: 9.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLnvnlrrEPlafclgtsaakaliyGGE 195
Cdd:PRK07868  474 TYEAVNRRINNVVRGLIAVGVRQGDRVGVLMETRPSALVAIAALSRLGAVAVLM------PP---------------DTD 532
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 MAAAV--AEVSE------------QLGKSLLKFCSGD-----LGPESILPDTQLLDPMLAEAPTTplaQAPGKGMDDRLF 256
Cdd:PRK07868  533 LAAAVrlGGVTEiitdptnleaarQLPGRVLVLGGGEsrdldLPDDADVIDMEKIDPDAVELPGW---YRPNPGLARDLA 609
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 257 YIYTSGTTGLPKAAIVVHSRYyRIAAFGHHSY-SMRAADVLYdCL-PLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFW 334
Cdd:PRK07868  610 FIAFSTAGGELVAKQITNYRW-ALSAFGTASAaALDRRDTVY-CLtPLHHESGLLVSLGGAVVGGSRIALSRGLDPDRFV 687
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 335 DDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDG-K 413
Cdd:PRK07868  688 QEVRQYGVTVVSYTWAMLREVVDDPAFVLHGNHPVRLFIGSGMPTGLWERVVEAFAPAHVVEFFATTDGQAVLANVSGaK 767
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 414 VGSCGfnsRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGqinqqdplrRFDGYVSDSATNKKiahSVFR 493
Cdd:PRK07868  768 IGSKG---RPLPGAGRVELAAYDPEHDLILEDDRGFVRRAEVNEVGVLLA---------RARGPIDPTASVKR---GVFA 832
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 494 KGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRlLGQTDVAV-YGVAVPGVEgkAGMAAIA-DPH 571
Cdd:PRK07868  833 PADTWISTEYLFRRDDDGDYWLVDRRGSVIRTARGPVYTEPVTDALGR-IGGVDLAVtYGVEVGGRQ--LAVAAVTlRPG 909
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 572 SQLDPnsmyQELQKVLASYA---RPIFLRLLPQVDTTGTFKIQKTRLQREGFdPRqTSDRLFFLDLKQGRYVPLDERVHA 648
Cdd:PRK07868  910 AAITA----ADLTEALASLPvglGPDIVHVVPEIPLSATYRPTVSALRAAGI-PK-PGRQAWYFDPETNRYRRLTPAVRA 983

                  ..
gi 1907189407 649 RI 650
Cdd:PRK07868  984 EL 985
CBAL cd05923
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ...
90-554 3.45e-29

4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.


Pssm-ID: 341247 [Multi-domain]  Cd Length: 493  Bit Score: 121.85  E-value: 3.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  90 PCIFQAVAR---RQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVA 166
Cdd:cd05923     1 QTVFEMLRRaasRAPDACAIADPARGLRLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 167 ALLNVNLRREPLAFClgtsaakalIYGGEMAAAVAEVSEQlgksllkfcsgdLGPESILPDTQLL----DPMLAEAPT-T 241
Cdd:cd05923    81 ALINPRLKAAELAEL---------IERGEMTAAVIAVDAQ------------VMDAIFQSGVRVLalsdLVGLGEPESaG 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 242 PLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVH-SRYYRIAAFGHHS-YSMRAADVLYDCLPLYHSAGNIMGVGQCVIYG 319
Cdd:cd05923   140 PLIEDPPREPEQPAFVFYTSGTTGLPKGAVIPQrAAESRVLFMSTQAgLRHGRHNVVLGLMPLYHVIGFFAVLVAALALD 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 320 LTVVLRKKFSASRfwddcvkynctVVQYIGE---ICRYL-----------LRQPVRDVEQRHRVRLAvGNGLRPAIWEEF 385
Cdd:cd05923   220 GTYVVVEEFDPAD-----------ALKLIEQervTSLFAtpthldalaaaAEFAGLKLSSLRHVTFA-GATMPDAVLERV 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 386 TQRFGVPQIgEFYGATECNCSIANMDGKVGSC---GFNSRilthvypIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLLV 462
Cdd:cd05923   288 NQHLPGEKV-NIYGTTEAMNSLYMRDARTGTEmrpGFFSE-------VRIVRIGGSPDEALANGEEGELIVAAAADAAFT 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 463 GQINQQDplrrfdgyvsdsATNKKIAHSVFRKGDSAYL--SGDVLVMDELGYMYFrdrSGdtfrwrGENVSTTEVEAVLS 540
Cdd:cd05923   360 GYLNQPE------------ATAKKLQDGWYRTGDVGYVdpSGDVRILGRVDDMII---SG------GENIHPSEIERVLS 418
                         490
                  ....*....|....
gi 1907189407 541 RLLGQTDVAVYGVA 554
Cdd:cd05923   419 RHPGVTEVVVIGVA 432
PRK12583 PRK12583
acyl-CoA synthetase; Provisional
86-618 6.81e-28

acyl-CoA synthetase; Provisional


Pssm-ID: 237145 [Multi-domain]  Cd Length: 558  Bit Score: 118.34  E-value: 6.81e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  86 GDTIPCIFQAVARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGvv 165
Cdd:PRK12583   17 TQTIGDAFDATVARFPDREALVVRHQALRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAEWLLTQFATARIG-- 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 166 AALLNVN--LRREPLAFCLGTSAAKALIYGGEMAAA--VAEVSEqLGKSLLKFCSGDLGPESiLPDTQLLDPMLAEAPTT 241
Cdd:PRK12583   95 AILVNINpaYRASELEYALGQSGVRWVICADAFKTSdyHAMLQE-LLPGLAEGQPGALACER-LPELRGVVSLAPAPPPG 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 242 PLA----QAPGKGM--------------DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLY 303
Cdd:PRK12583  173 FLAwhelQARGETVsrealaerqasldrDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLGLTEHDRLCVPVPLY 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 304 HSAGNIMGVGQCVIYGLTVVL-RKKFSASRFWDDCVKYNCTVVQ-----YIGEicrylLRQPVRDVEQRHRVRLAV--GN 375
Cdd:PRK12583  253 HCFGMVLANLGCMTVGACLVYpNEAFDPLATLQAVEEERCTALYgvptmFIAE-----LDHPQRGNFDLSSLRTGImaGA 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 376 GLRPAIWEEFTQRFGVPQIGEFYGATECN------CSIANMDGKVGSCGfnsRILTHVYpirlVKVnedtmeplRDSEGL 449
Cdd:PRK12583  328 PCPIEVMRRVMDEMHMAEVQIAYGMTETSpvslqtTAADDLERRVETVG---RTQPHLE----VKV--------VDPDGA 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 450 CIPcqPGEPGLLVgqinqqdplrrFDGYV-------SDSATNKKIahsvfrKGDSAYLSGDVLVMDELGYMYFRDRSGDT 522
Cdd:PRK12583  393 TVP--RGEIGELC-----------TRGYSvmkgywnNPEATAESI------DEDGWMHTGDLATMDEQGYVRIVGRSKDM 453
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 523 FRWRGENVSTTEVEAVLSRLLGQTDVAVYGvaVPGVE-GKAGMAAIA-DPHSQLDPNSMYQELQKVLASYARPIFLRLLP 600
Cdd:PRK12583  454 IIRGGENIYPREIEEFLFTHPAVADVQVFG--VPDEKyGEEIVAWVRlHPGHAASEEELREFCKARIAHFKVPRYFRFVD 531
                         570
                  ....*....|....*...
gi 1907189407 601 QVDTTGTFKIQKTRLqRE 618
Cdd:PRK12583  532 EFPMTVTGKVQKFRM-RE 548
PRK07529 PRK07529
AMP-binding domain protein; Validated
97-617 1.54e-27

AMP-binding domain protein; Validated


Pssm-ID: 236043 [Multi-domain]  Cd Length: 632  Bit Score: 118.13  E-value: 1.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALV------DASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAAlLN 170
Cdd:PRK07529   35 AARHPDAPALSflldadPLDRPETWTYAELLADVTRTANLLHSLGVGPGDVVAFLLPNLPETHFALWGGEAAGIANP-IN 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 171 VNLRREPLAFCLGTSAAKALIYGGEMAAA-----VAEVSEQL--GKSLLK-FCSGDLGPESILPDTQL----------LD 232
Cdd:PRK07529  114 PLLEPEQIAELLRAAGAKVLVTLGPFPGTdiwqkVAEVLAALpeLRTVVEvDLARYLPGPKRLAVPLIrrkaharildFD 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 233 PMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGV 312
Cdd:PRK07529  194 AELARQPGDRLFSGRPIGPDDVAAYFHTGGTTGMPKLAQHTHGNEVANAWLGALLLGLGPGDTVFCGLPLFHVNALLVTG 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 313 GQCVIYGLTVVL------RKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPV--RDVEQrhrVRLAVGNG--LRPAIW 382
Cdd:PRK07529  274 LAPLARGAHVVLatpqgyRGPGVIANFWKIVERYRINFLSGVPTVYAALLQVPVdgHDISS---LRYALCGAapLPVEVF 350
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 383 EEFTQRFGVPqIGEFYGATECNC--SIANMDG--KVGSCGFnsRI-LTHVypiRLVKVNEDTmEPLRDseglcipCQPGE 457
Cdd:PRK07529  351 RRFEAATGVR-IVEGYGLTEATCvsSVNPPDGerRIGSVGL--RLpYQRV---RVVILDDAG-RYLRD-------CAVDE 416
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 458 PGLLVgqinQQDPlRRFDGYVsDSATNKKIahsvfRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEA 537
Cdd:PRK07529  417 VGVLC----IAGP-NVFSGYL-EAAHNKGL-----WLEDGWLNTGDLGRIDADGYFWLTGRAKDLIIRGGHNIDPAAIEE 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 538 VLSRLlgqtdvavygvavPGVegkAGMAAIA--DPHS--------QLDPNSMYQELQkvLASYAR---------PIFLRL 598
Cdd:PRK07529  486 ALLRH-------------PAV---ALAAAVGrpDAHAgelpvayvQLKPGASATEAE--LLAFARdhiaeraavPKHVRI 547
                         570
                  ....*....|....*....
gi 1907189407 599 LPQVDTTGTFKIQKTRLQR 617
Cdd:PRK07529  548 LDALPKTAVGKIFKPALRR 566
PRK07514 PRK07514
malonyl-CoA synthase; Validated
93-620 2.50e-27

malonyl-CoA synthase; Validated


Pssm-ID: 181011 [Multi-domain]  Cd Length: 504  Bit Score: 116.13  E-value: 2.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  93 FQAVARRQPERLAL-VDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:PRK07514    6 FDALRAAFADRDAPfIETPDGLRYTYGDLDAASARLANLLVALGVKPGDRVAVQVEKSPEALALYLATLRAGAVFLPLNT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLkFCSGDLGPESilpdtqLLDpmLAEAPTTPLAQAPgKGM 251
Cdd:PRK07514   86 AYTLAELDYFIGDAEPALVVCDPANFAWLSKIAAAAGAPHV-ETLDADGTGS------LLE--AAAAAPDDFETVP-RGA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSAs 331
Cdd:PRK07514  156 DDLAAILYTSGTTGRSKGAMLSHGNLLSNALTLVDYWRFTPDDVLIHALPIFHTHGLFVATNVALLAGASMIFLPKFDP- 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 332 rfwDDCVKY--NCTVVqyIGEICRY--LLRQPVRDVEQRHRVRLAVgNGLRPAIWE---EFTQRFGVPqIGEFYGATECN 404
Cdd:PRK07514  235 ---DAVLALmpRATVM--MGVPTFYtrLLQEPRLTREAAAHMRLFI-SGSAPLLAEthrEFQERTGHA-ILERYGMTETN 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 405 CSIAN-MDGK--VGSCGFnsrilthvyPIRLVKV---NEDTMEPLrdseglcipcQPGEpgllVGQINQQDPlRRFDGY- 477
Cdd:PRK07514  308 MNTSNpYDGErrAGTVGF---------PLPGVSLrvtDPETGAEL----------PPGE----IGMIEVKGP-NVFKGYw 363
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 478 -VSDsatnkKIAHSvFRkGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVP 556
Cdd:PRK07514  364 rMPE-----KTAEE-FR-ADGFFITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVIGVPHP 436
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907189407 557 GVeGKAGMAA-IADPHSQLDPNSMYQELQKVLASYARP---IFLRLLPQvDTTGtfKIQKTRLqREGF 620
Cdd:PRK07514  437 DF-GEGVTAVvVPKPGAALDEAAILAALKGRLARFKQPkrvFFVDELPR-NTMG--KVQKNLL-REQY 499
PRK06178 PRK06178
acyl-CoA synthetase; Validated
97-616 2.96e-27

acyl-CoA synthetase; Validated


Pssm-ID: 235724 [Multi-domain]  Cd Length: 567  Bit Score: 116.68  E-value: 2.96e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRRE 176
Cdd:PRK06178   43 ARERPQRPAIIFYGHVI--TYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGILKLGAVHVPVSPLFREH 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLAFCLGTSAAKALIYGGEMAAAVAEVSEQLG-KSLLKFCSGDLGPESI---LPD---------TQLLDPMLAEAPTTPL 243
Cdd:PRK06178  121 ELSYELNDAGAEVLLALDQLAPVVEQVRAETSlRHVIVTSLADVLPAEPtlpLPDslraprlaaAGAIDLLPALRACTAP 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 244 AQAPGKGMDDRLFYIYTSGTTGLPKAaiVVHSR---YYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGL 320
Cdd:PRK06178  201 VPLPPPALDALAALNYTGGTTGMPKG--CEHTQrdmVYTAAAAYAVAVVGGEDSVFLSFLPEFWIAGENFGLLFPLFSGA 278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 321 TVVLRKKFSASRFWDDCVKYNCT----VVQYIGEIC------RYLLR--QPVR--------DVEQRHRVRLAVGNGLRPA 380
Cdd:PRK06178  279 TLVLLARWDAVAFMAAVERYRVTrtvmLVDNAVELMdhprfaEYDLSslRQVRvvsfvkklNPDYRQRWRALTGSVLAEA 358
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 381 IWeeftqrfgvpqigefyGATE---CNCSIANMdgKVGSCGFNSRILTHVYPI---RLVKVNEDTMEPLrdseglciPC- 453
Cdd:PRK06178  359 AW----------------GMTEthtCDTFTAGF--QDDDFDLLSQPVFVGLPVpgtEFKICDFETGELL--------PLg 412
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 454 QPGE-----PGLLVGQINQQDplrrfdgyvsdsATnkkiAHSvFRkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGE 528
Cdd:PRK06178  413 AEGEivvrtPSLLKGYWNKPE------------AT----AEA-LR--DGWLHTGDIGKIDEQGFLHYLGRRKEMLKVNGM 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 529 NVSTTEVEAvlsrLLGQTDvAVYGVAVPGV--EGKaGMAAIA----DPHSQLDPNSMYQELQKVLASYARPIfLRLLPQV 602
Cdd:PRK06178  474 SVFPSEVEA----LLGQHP-AVLGSAVVGRpdPDK-GQVPVAfvqlKPGADLTAAALQAWCRENMAVYKVPE-IRIVDAL 546
                         570
                  ....*....|....
gi 1907189407 603 DTTGTFKIQKTRLQ 616
Cdd:PRK06178  547 PMTATGKVRKQDLQ 560
OSB_CoA_lg cd05912
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ...
115-617 6.15e-27

O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.


Pssm-ID: 341238 [Multi-domain]  Cd Length: 411  Bit Score: 113.60  E-value: 6.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFclgtsaakaliygg 194
Cdd:cd05912     2 YTFAELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAF-------------- 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 emaaavaevseqlgksllkfcsgdlgpesilpdtQLLDpmlAEApttplaqapgkGMDDRLFYIYTSGTTGLPKAAIVvh 274
Cdd:cd05912    68 ----------------------------------QLKD---SDV-----------KLDDIATIMYTSGTTGKPKGVQQ-- 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 sryyriaAFGHHSYSMRAADV---LYD------CLPLYHSAG-NIMGVGqcVIYGLTVVLRKKFSASRFWDDCVKYNCTV 344
Cdd:cd05912    98 -------TFGNHWWSAIGSALnlgLTEddnwlcALPLFHISGlSILMRS--VIYGMTVYLVDKFDAEQVLHLINSGKVTI 168
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 345 VQYIGEICRYLLRQPVRDVEQRHRVRLaVGNGLRPAIWEEFTQRFGVPqIGEFYGATE-----CNCSIANMDGKVGSCG- 418
Cdd:cd05912   169 ISVVPTMLQRLLEILGEGYPNNLRCIL-LGGGPAPKPLLEQCKEKGIP-VYQSYGMTEtcsqiVTLSPEDALNKIGSAGk 246
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 419 --FNSRilthvypIRLVKVNEDtmeplrdseglciPCQPGE-----PGLLVGQINQQDplrrfdgyvsdsATNKKIAHSV 491
Cdd:cd05912   247 plFPVE-------LKIEDDGQP-------------PYEVGEillkgPNVTKGYLNRPD------------ATEESFENGW 294
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 492 FRKGDSAYLsgdvlvmDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVygVAVPgvEGKAGMAAIA--D 569
Cdd:cd05912   295 FKTGDIGYL-------DEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPAIKEAGV--VGIP--DDKWGQVPVAfvV 363
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907189407 570 PHSQLDPNSMYQELQKVLASYARP---IFLRLLPQvdtTGTFKIQKTRLQR 617
Cdd:cd05912   364 SERPISEEELIAYCSEKLAKYKVPkkiYFVDELPR---TASGKLLRHELKQ 411
PRK06839 PRK06839
o-succinylbenzoate--CoA ligase;
94-617 1.05e-26

o-succinylbenzoate--CoA ligase;


Pssm-ID: 168698 [Multi-domain]  Cd Length: 496  Bit Score: 114.19  E-value: 1.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  94 QAVARRQPERLALVdaSSGICWTFAQLDTYSNAVANLFR-QLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVN 172
Cdd:PRK06839    9 EKRAYLHPDRIAII--TEEEEMTYKQLHEYVSKVAAYLIyELNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIR 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 173 LRREPLAFCLGTSAAKALIYGGEMAAAVAEVSeqlgksllkfcsgdlGPESILPDTQLLDPmlAEAPTTPLAQAPGKGMD 252
Cdd:PRK06839   87 LTENELIFQLKDSGTTVLFVEKTFQNMALSMQ---------------KVSYVQRVISITSL--KEIEDRKIDNFVEKNES 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 DRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASR 332
Cdd:PRK06839  150 ASFIICYTSGTTGKPKGAVLTQENMFWNALNNTFAIDLTMHDRSIVLLPLFHIGGIGLFAFPTLFAGGVIIVPRKFEPTK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 333 FWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVgNGLRPA---IWEEFTQRfGVPqIGEFYGATECNCS--- 406
Cdd:PRK06839  230 ALSMIEKHKVTVVMGVPTIHQALINCSKFETTNLQSVRWFY-NGGAPCpeeLMREFIDR-GFL-FGQGFGMTETSPTvfm 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 407 IANMDG--KVGSCG----FNSrilthvypIRLVKVNEDTMEplrdseglcipcqPGEpgllVGQINQQDPLRRFDGYVSD 480
Cdd:PRK06839  307 LSEEDArrKVGSIGkpvlFCD--------YELIDENKNKVE-------------VGE----VGELLIRGPNVMKEYWNRP 361
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 481 SATNKKIAhsvfrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGvaVPGVE- 559
Cdd:PRK06839  362 DATEETIQ-------DGWLCTGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVG--RQHVKw 432
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 560 GKAGMAAIA-DPHSQLDPNSMYQELQKVLASYARP---IFLRLLPQvDTTGtfKIQKTRLQR 617
Cdd:PRK06839  433 GEIPIAFIVkKSSSVLIEKDVIEHCRLFLAKYKIPkeiVFLKELPK-NATG--KIQKAQLVN 491
PRK06145 PRK06145
acyl-CoA synthetase; Validated
97-618 2.67e-26

acyl-CoA synthetase; Validated


Pssm-ID: 102207 [Multi-domain]  Cd Length: 497  Bit Score: 113.06  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRRE 176
Cdd:PRK06145   12 ARRTPDRAALVYRDQEI--SYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAAD 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGksllkfcsgdLGPESILPDTQLLDPMLAEAPTTPLAQapgkgmDDRLF 256
Cdd:PRK06145   90 EVAYILGDAGAKLLLVDEEFDAIVALETPKIV----------IDAAAQADSRRLAQGGLEIPPQAAVAP------TDLVR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 257 YIYTSGTTGLPKAAIVVHSRYY-----RIAAFGhhsysMRAADVLYDCLPLYHsagnimgVGQCVIYGLTVV-------L 324
Cdd:PRK06145  154 LMYTSGTTDRPKGVMHSYGNLHwksidHVIALG-----LTASERLLVVGPLYH-------VGAFDLPGIAVLwvggtlrI 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 325 RKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLR-PAI-WEEFTQRFGVPQIGEFYGATE 402
Cdd:PRK06145  222 HREFDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRFDLDSLAWCIGGGEKtPESrIRDFTRVFTRARYIDAYGLTE 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CNCSIANMDG-----KVGSCGfnsRILTHVyPIRLvkvnedtmeplRDSEGLCIPcqPGEPGllvgQINQQDPlRRFDGY 477
Cdd:PRK06145  302 TCSGDTLMEAgreieKIGSTG---RALAHV-EIRI-----------ADGAGRWLP--PNMKG----EICMRGP-KVTKGY 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 478 VSDSatnKKIAHSVFrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPG 557
Cdd:PRK06145  360 WKDP---EKTAEAFY---GDWFRSGDVGYLDEEGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDR 433
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907189407 558 VEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQRE 618
Cdd:PRK06145  434 WGERITAVVVLNPGATLTLEALDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVLRDE 494
PRK06164 PRK06164
acyl-CoA synthetase; Validated
87-615 1.49e-25

acyl-CoA synthetase; Validated


Pssm-ID: 235722 [Multi-domain]  Cd Length: 540  Bit Score: 110.99  E-value: 1.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  87 DTIPCIFQAVARRQPERLALVDasSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVA 166
Cdd:PRK06164   10 DTLASLLDAHARARPDAVALID--EDRPLSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACARLGATV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 167 ALLNVNLRREPLAFCLGTSAAKALIY-----GGEMAAAVAEVSEQLGKSLLKFCSGDLGPESIlPDTQLLDPMLA---EA 238
Cdd:PRK06164   88 IAVNTRYRSHEVAHILGRGRARWLVVwpgfkGIDFAAILAAVPPDALPPLRAIAVVDDAADAT-PAPAPGARVQLfalPD 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 239 PTTPLAQAPGKGMDDRLFYIY-TSGTTGLPKaaIVVHS-----RYYRIAAfghHSYSMRAADVLYDCLPLYHSAGNIMGV 312
Cdd:PRK06164  167 PAPPAAAGERAADPDAGALLFtTSGTTSGPK--LVLHRqatllRHARAIA---RAYGYDPGAVLLAALPFCGVFGFSTLL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 313 GqCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNgLRPAiWEEFTQRF--- 389
Cdd:PRK06164  242 G-ALAGGAPLVCEPVFDAARTARALRRHRVTHTFGNDEMLRRILDTAGERADFPSARLFGFAS-FAPA-LGELAALArar 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 390 GVPQIGeFYGATECncsIANMDGKVGSCGFNSRIL---THVYPIRLVKVnedtmeplRDSEGLCIpCQPGEPgllvGQIN 466
Cdd:PRK06164  319 GVPLTG-LYGSSEV---QALVALQPATDPVSVRIEgggRPASPEARVRA--------RDPQDGAL-LPDGES----GEIE 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 467 QQDPlRRFDGYVSD-SATNKKI-AHSVFRKGDSAYLSGDvlvmdelGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLG 544
Cdd:PRK06164  382 IRAP-SLMRGYLDNpDATARALtDDGYFRTGDLGYTRGD-------GQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPG 453
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189407 545 QTDVAVYGVAvpgVEGKAGMAA--IADPHSQLDPNSMYQELQKVLASY---ARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:PRK06164  454 VAAAQVVGAT---RDGKTVPVAfvIPTDGASPDEAGLMAACREALAGFkvpARVQVVEAFPVTESANGAKIQKHRL 526
PRK06087 PRK06087
medium-chain fatty-acid--CoA ligase;
80-618 1.65e-25

medium-chain fatty-acid--CoA ligase;


Pssm-ID: 180393 [Multi-domain]  Cd Length: 547  Bit Score: 110.99  E-value: 1.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  80 RRHRRAG----DTIPCIFQAVARRQPERLALVDaSSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGL 155
Cdd:PRK06087   12 AAYRQQGywgdASLADYWQQTARAMPDKIAVVD-NHGASYTYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTII 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 156 WLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGG--------EMAAAVAEVSEQLGKSLLkfcSGDLGPE-SILP 226
Cdd:PRK06087   91 YLACLKVGAVSVPLLPSWREAELVWVLNKCQAKMFFAPTlfkqtrpvDLILPLQNQLPQLQQIVG---VDKLAPAtSSLS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 227 DTQLLdpmlaeAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYriaaFGHHSYSMR----AADVLYDCLPL 302
Cdd:PRK06087  168 LSQII------ADYEPLTTAITTHGDELAAVLFTSGTEGLPKGVMLTHNNIL----ASERAYCARlnltWQDVFMMPAPL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 303 YHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQ----YIGEICRYLLRQPVrDVEQRhRVRLAVGNGLR 378
Cdd:PRK06087  238 GHATGFLHGVTAPFLIGARSVLLDIFTPDACLALLEQQRCTCMLgatpFIYDLLNLLEKQPA-DLSAL-RFFLCGGTTIP 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 379 PAIWEEfTQRFGVpQIGEFYGATE-CNCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTmeplrdseglcIPCqpGE 457
Cdd:PRK06087  316 KKVARE-CQQRGI-KLLSVYGSTEsSPHAVVNLDDPLSRFMHTDGYAAAGVEIKVVDEARKT-----------LPP--GC 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 458 PGLLVGQINQQdplrrFDGYVSD-SATNKKIahsvfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVE 536
Cdd:PRK06087  381 EGEEASRGPNV-----FMGYLDEpELTARAL------DEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVE 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 537 AVLSRLLGQTDVAVygVAVP----GvEGKAGMAAIADPHSQLdpnsmyqELQKVLASYAR--------PIFLRLLPQVDT 604
Cdd:PRK06087  450 DILLQHPKIHDACV--VAMPderlG-ERSCAYVVLKAPHHSL-------TLEEVVAFFSRkrvakykyPEHIVVIDKLPR 519
                         570
                  ....*....|....
gi 1907189407 605 TGTFKIQKTRLQRE 618
Cdd:PRK06087  520 TASGKIQKFLLRKD 533
PRK13295 PRK13295
cyclohexanecarboxylate-CoA ligase; Reviewed
70-618 1.91e-25

cyclohexanecarboxylate-CoA ligase; Reviewed


Pssm-ID: 171961 [Multi-domain]  Cd Length: 547  Bit Score: 110.91  E-value: 1.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  70 SVLIRVRLElrRHRRAG----DTIPCIFQAVARRQPERLALVDASSGIC----WTFAQLDTYSNAVANLFRQLGFAPGDV 141
Cdd:PRK13295    5 AVLLPPRRA--ASIAAGhwhdRTINDDLDACVASCPDKTAVTAVRLGTGaprrFTYRELAALVDRVAVGLARLGVGRGDV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 142 VAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIY-----GGEMAAAVAEVSEQLGK-SLLKFC 215
Cdd:PRK13295   83 VSCQLPNWWEFTVLYLACSRIGAVLNPLMPIFRERELSFMLKHAESKVLVVpktfrGFDHAAMARRLRPELPAlRHVVVV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 216 SGDlGPESIlpDTQLLDPMLAEAP-TTPLAQAPGKGMDDRLFYIYTSGTTGLPKAaiVVHSRYYRIAAFghHSYSMR--- 291
Cdd:PRK13295  163 GGD-GADSF--EALLITPAWEQEPdAPAILARLRPGPDDVTQLIYTSGTTGEPKG--VMHTANTLMANI--VPYAERlgl 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 292 -AADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWD----DCVKYNCTVVQYIGEICRyLLRQPVRDVEQR 366
Cdd:PRK13295  236 gADDVILMASPMAHQTGFMYGLMMPVMLGATAVLQDIWDPARAAElirtEGVTFTMASTPFLTDLTR-AVKESGRPVSSL 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 367 hRVRLAVGNGLRPAIWEEFTQRFGVpQIGEFYGATECNC----SIANMDGKVGScgfnsrilTHVYPIRLVKVNedtmep 442
Cdd:PRK13295  315 -RTFLCAGAPIPGALVERARAALGA-KIVSAWGMTENGAvtltKLDDPDERAST--------TDGCPLPGVEVR------ 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 443 LRDSEGLCIPcqPGEPGLLV--GQINqqdplrrFDGYVSDSATNKKIAHSVFRKGDSAYLSGDvlvmdelGYMYFRDRSG 520
Cdd:PRK13295  379 VVDADGAPLP--AGQIGRLQvrGCSN-------FGGYLKRPQLNGTDADGWFDTGDLARIDAD-------GYIRISGRSK 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 521 DTFRWRGENVSTTEVEAVLSRLLGQTDVAVygVAVPgvEGKAGMAAIA----DPHSQLDPNSM--YQELQKVLASYArPI 594
Cdd:PRK13295  443 DVIIRGGENIPVVEIEALLYRHPAIAQVAI--VAYP--DERLGERACAfvvpRPGQSLDFEEMveFLKAQKVAKQYI-PE 517
                         570       580
                  ....*....|....*....|....
gi 1907189407 595 FLRLLPQVDTTGTFKIQKTRLQRE 618
Cdd:PRK13295  518 RLVVRDALPRTPSGKIQKFRLREM 541
CHC_CoA_lg cd05903
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ...
116-615 3.08e-25

Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.


Pssm-ID: 341229 [Multi-domain]  Cd Length: 437  Bit Score: 109.01  E-value: 3.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIygge 195
Cdd:cd05903     3 TYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFV---- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 maaavaeVSEQLGKsllkfcsgdlgpesilpdtqlldpmlaeapTTPLAQApgkgmDDRLFYIYTSGTTGLPKAAIVVHS 275
Cdd:cd05903    79 -------VPERFRQ------------------------------FDPAAMP-----DAVALLLFTSGTTGEPKGVMHSHN 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 276 R-YYRIAAFGHHsYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQ----YIGE 350
Cdd:cd05903   117 TlSASIRQYAER-LGLGPGDVFLVASPMAHQTGFVYGFTLPLLLGAPVVLQDIWDPDKALALMREHGVTFMMgatpFLTD 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 351 ICRYLLRQPvrDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVpQIGEFYGATECNcsianmdGKVGSC--GFNSRIL-THV 427
Cdd:cd05903   196 LLNAVEEAG--EPLSRLRTFVCGGATVPRSLARRAAELLGA-KVCSAYGSTECP-------GAVTSItpAPEDRRLyTDG 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 428 YPIRLVKVNedtmepLRDSEGLCIPcqPGEpgllVGQINQQDPlRRFDGYVSDSATNKKIAHSVFrkgdsaYLSGDVLVM 507
Cdd:cd05903   266 RPLPGVEIK------VVDDTGATLA--PGV----EGELLSRGP-SVFLGYLDRPDLTADAAPEGW------FRTGDLARL 326
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 508 DELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVygVAVPgvEGKAGMAAIA-----DPHSqLDPNSMYQE 582
Cdd:cd05903   327 DEDGYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPGVIEAAV--VALP--DERLGERACAvvvtkSGAL-LTFDELVAY 401
                         490       500       510
                  ....*....|....*....|....*....|....
gi 1907189407 583 LQKV-LASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd05903   402 LDRQgVAKQYWPERLVHVDDLPRTPSGKVQKFRL 435
A_NRPS cd05930
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ...
101-615 6.09e-25

The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341253 [Multi-domain]  Cd Length: 444  Bit Score: 108.38  E-value: 6.09e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASSgiCWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGvvAALLNVNLR--REPL 178
Cdd:cd05930     1 PDAVAVVDGDQ--SLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAG--AAYVPLDPSypAERL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 179 AFCLGTSAAKALIYGGEMAAAVaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgmddrlfyI 258
Cdd:cd05930    77 AYILEDSGAKLVLTDPDDLAYV---------------------------------------------------------I 99
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 259 YTSGTTGLPKAAIVVHsryyriAAFGHHSYSMRAAdvlY-----DCLPLYHSAGNIMGVGQ---CVIYGLTVVLRKK--- 327
Cdd:cd05930   100 YTSGSTGKPKGVMVEH------RGLVNLLLWMQEA---YpltpgDRVLQFTSFSFDVSVWEifgALLAGATLVVLPEevr 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 328 FSASRFWDDCVKYNCTVVQYIGEICRYLLRQPvrDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPQIGEFYGATECNc 405
Cdd:cd05930   171 KDPEALADLLAEEGITVLHLTPSLLRLLLQEL--ELAALPSLRLVLvgGEALPPDLVRRWRELLPGARLVNLYGPTEAT- 247
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 406 sianmdgkvgscgfnsrILTHVYPIRLVKVNEDTM---EPLRDSEGL-----CIPCQPGEPG-LLVG--QINQqdplrrf 474
Cdd:cd05930   248 -----------------VDATYYRVPPDDEEDGRVpigRPIPNTRVYvldenLRPVPPGVPGeLYIGgaGLAR------- 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 475 dGYVSDSA-TNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVygV 553
Cdd:cd05930   304 -GYLNRPElTAERFVPNPFGPGERMYRTGDLVRWLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLAHPGVREAAV--V 380
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907189407 554 AVPGVEGKAGMAA--IADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd05930   381 AREDGDGEKRLVAyvVPDEGGELDEEELRAHLAERLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444
A_NRPS_VisG_like cd17651
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ...
93-610 9.15e-25

similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341306 [Multi-domain]  Cd Length: 491  Bit Score: 108.20  E-value: 9.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  93 FQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVN 172
Cdd:cd17651     1 FERQAARTPDAPALVAE--GRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 173 LRREPLAFCLGTSAAKALIyggemAAAVAevseqlgksllkfcSGDLGPESIlPDTQLLDPMLAEAPTTPLaqAPGKGMD 252
Cdd:cd17651    79 YPAERLAFMLADAGPVLVL-----THPAL--------------AGELAVELV-AVTLLDQPGAAAGADAEP--DPALDAD 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 DRLFYIYTSGTTGLPKAAIVVHS----------RYYRIAAFGHHS-YSMRAADVlydclplyhSAGNIMGVgqcVIYGLT 321
Cdd:cd17651   137 DLAYVIYTSGSTGRPKGVVMPHRslanlvawqaRASSLGPGARTLqFAGLGFDV---------SVQEIFST---LCAGAT 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 322 VVLRK---KFSASRFWDDCVKYNCTVV----QYIGEICRYLLRQPVRDVEQRHRV----RLAVGNGLRpaiweEFTQRFG 390
Cdd:cd17651   205 LVLPPeevRTDPPALAAWLDEQRISRVflptVALRALAEHGRPLGVRLAALRYLLtggeQLVLTEDLR-----EFCAGLP 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 391 VPQIGEFYGATECNCSIA-NMDGKVGSCGFNSRILTHVYPIRLVKVNEDtmepLRdseglciPCQPGEPG-LLVGqinqQ 468
Cdd:cd17651   280 GLRLHNHYGPTETHVVTAlSLPGDPAAWPAPPPIGRPIDNTRVYVLDAA----LR-------PVPPGVPGeLYIG----G 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 469 DPLRRfdGYVSDSA-TNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTD 547
Cdd:cd17651   345 AGLAR--GYLNRPElTAERFVPDPFVPGARMYRTGDLARWLPDGELEFLGRADDQVKIRGFRIELGEIEAALARHPGVRE 422
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189407 548 VAVygVAVPGVEGKAGMAA--IADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKI 610
Cdd:cd17651   423 AVV--LAREDRPGEKRLVAyvVGDPEAPVDAAELRAALATHLPEYMVPSAFVLLDALPLTPNGKL 485
4CL cd05904
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ...
97-550 1.10e-24

4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.


Pssm-ID: 341230 [Multi-domain]  Cd Length: 505  Bit Score: 108.09  E-value: 1.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLN-VNLRR 175
Cdd:cd05904    15 ASAHPSRPALIDAATGRALTYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANpLSTPA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 176 EpLAFCLGTSAAKALIyggeMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPmlAEAPTTPLAQapgkgmDDRL 255
Cdd:cd05904    95 E-IAKQVKDSGAKLAF----TTAELAEKLASLALPVVLLDSAEFDSLSFSDLLFEADE--AEPPVVVIKQ------DDVA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 256 FYIYTSGTTGLPKAAIVVHSRYyrIAAF-GHHSY--SMRAADVLYDC-LPLYHSAGnIMGVGQCVI-YGLTVVLRKKFSA 330
Cdd:cd05904   162 ALLYSSGTTGRSKGVMLTHRNL--IAMVaQFVAGegSNSDSEDVFLCvLPMFHIYG-LSSFALGLLrLGATVVVMPRFDL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 331 SRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRlAVGNG---LRPAIWEEFTQRFGVPQIGEFYGATECNCSI 407
Cdd:cd05904   239 EELLAAIERYKVTHLPVVPPIVLALVKSPIVDKYDLSSLR-QIMSGaapLGKELIEAFRAKFPNVDLGQGYGMTESTGVV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 408 ANMD------GKVGSCGFnsrilthVYPIRLVK-VNEDTMEPLRdseglciPCQPGEpgLLV-G-QINQqdplrrfdGYV 478
Cdd:cd05904   318 AMCFapekdrAKYGSVGR-------LVPNVEAKiVDPETGESLP-------PNQTGE--LWIrGpSIMK--------GYL 373
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907189407 479 SD-SATNKKIahsvfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAV 550
Cdd:cd05904   374 NNpEATAATI------DKEGWLHTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAV 440
PRK12406 PRK12406
long-chain-fatty-acid--CoA ligase; Provisional
117-615 1.13e-24

long-chain-fatty-acid--CoA ligase; Provisional


Pssm-ID: 183506 [Multi-domain]  Cd Length: 509  Bit Score: 108.25  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 117 FAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEM 196
Cdd:PRK12406   14 FDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSGARVLIAHADL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 197 AAAVAEVSEQlGKSLLKFCSgdlgPESIL-------------PDTQLLDPMLA--EAPTTPLAQAPGKgmddrlfYIYTS 261
Cdd:PRK12406   94 LHGLASALPA-GVTVLSVPT----PPEIAaayrispalltppAGAIDWEGWLAqqEPYDGPPVPQPQS-------MIYTS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 262 GTTGLPK-----AAIVVHSRYY---RIAAFGHHSySMRAadVLYDclPLYHSAGNIMGVgQCVIYGLTVVLRKKFSASRF 333
Cdd:PRK12406  162 GTTGHPKgvrraAPTPEQAAAAeqmRALIYGLKP-GIRA--LLTG--PLYHSAPNAYGL-RAGRLGGVLVLQPRFDPEEL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 334 WDDCVKYNCTVVQYIGEICRYLLRQP--VR---DVEQ-RHRVRLAvgnGLRPA-IWEEFTQRFGvPQIGEFYGATECncs 406
Cdd:PRK12406  236 LQLIERHRITHMHMVPTMFIRLLKLPeeVRakyDVSSlRHVIHAA---APCPAdVKRAMIEWWG-PVIYEYYGSTES--- 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 407 ianmdGKVGSCGfNSRILTHvyPIRLVKVNEDTMEPLRDSEGLCIPcqPGEPGllvgqinqqDPLRRFDGYVSDSATNKK 486
Cdd:PRK12406  309 -----GAVTFAT-SEDALSH--PGTVGKAAPGAELRFVDEDGRPLP--QGEIG---------EIYSRIAGNPDFTYHNKP 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 487 IAHSVFRKGDsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGvaVPGVE-GKAGMA 565
Cdd:PRK12406  370 EKRAEIDRGG-FITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFG--IPDAEfGEALMA 446
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907189407 566 AI-ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:PRK12406  447 VVePQPGATLDEADIRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRL 497
PRK07470 PRK07470
acyl-CoA synthetase; Validated
96-623 1.22e-24

acyl-CoA synthetase; Validated


Pssm-ID: 180988 [Multi-domain]  Cd Length: 528  Bit Score: 108.20  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  96 VARRQPERLALVDASSgiCWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPE-FVGLWLGLaKAGVVaaLLNVNLR 174
Cdd:PRK07470   16 AARRFPDRIALVWGDR--SWTWREIDARVDALAAALAARGVRKGDRILVHSRNCNQmFESMFAAF-RLGAV--WVPTNFR 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 175 REP--LAFCLGTSAAKALIYGG---EMAAAVAEVSEQLgKSLLKFCSGDLGPEsilpdtqlLDPMLAEAPTTPLAQAPGK 249
Cdd:PRK07470   91 QTPdeVAYLAEASGARAMICHAdfpEHAAAVRAASPDL-THVVAIGGARAGLD--------YEALVARHLGARVANAAVD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 250 gMDDRLFYIYTSGTTGLPKAAIVVHSRYyriaAF-------------GHHSYSMRAAdvlydclPLYHSAGnIMGVGQcV 316
Cdd:PRK07470  162 -HDDPCWFFFTSGTTGRPKAAVLTHGQM----AFvitnhladlmpgtTEQDASLVVA-------PLSHGAG-IHQLCQ-V 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 317 IYGLTVVL--RKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGlRPAIWEEftQRFGVPQI 394
Cdd:PRK07470  228 ARGAATVLlpSERFDPAEVWALVERHRVTNLFTVPTILKMLVEHPAVDRYDHSSLRYVIYAG-APMYRAD--QKRALAKL 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 395 G----EFYGATECNCSIANM--------DG---KVGSCGFnsrilthvypirlvkvnEDT-ME-PLRDSEGLciPCQPGE 457
Cdd:PRK07470  305 GkvlvQYFGLGEVTGNITVLppalhdaeDGpdaRIGTCGF-----------------ERTgMEvQIQDDEGR--ELPPGE 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 458 pgllVGQINQQDPlRRFDGYVSDSATNKKiahsVFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEA 537
Cdd:PRK07470  366 ----TGEICVIGP-AVFAGYYNNPEANAK----AFRDG--WFRTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEE 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 538 VLSRLLGQTDVAVYGVAVPgVEGKAGMAA-IADPHSQLDPNSMYQELQKVLASYARP---IFLRLLPQvdtTGTFKIQKt 613
Cdd:PRK07470  435 KLLTHPAVSEVAVLGVPDP-VWGEVGVAVcVARDGAPVDEAELLAWLDGKVARYKLPkrfFFWDALPK---SGYGKITK- 509
                         570
                  ....*....|
gi 1907189407 614 RLQREGFDPR 623
Cdd:PRK07470  510 KMVREELEER 519
PRK05852 PRK05852
fatty acid--CoA ligase family protein;
85-553 6.16e-24

fatty acid--CoA ligase family protein;


Pssm-ID: 235625 [Multi-domain]  Cd Length: 534  Bit Score: 106.12  E-value: 6.16e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  85 AGDTIPCIFQAVARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGV 164
Cdd:PRK05852   14 FGPRIADLVEVAATRLPEAPALVVTADRIAISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 165 VAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTqlLDpmlAEAPTTPLA 244
Cdd:PRK05852   94 VVVPLDPALPIAEQRVRSQAAGARVVLIDADGPHDRAEPTTRWWPLTVNVGGDSGPSGGTLSVH--LD---AATEPTPAT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 245 QAP-GKGMDDRLFyIYTSGTTGLPKAAIVVHSryyRIAAFGHH---SYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGL 320
Cdd:PRK05852  169 STPeGLRPDDAMI-MFTGGTTGLPKMVPWTHA---NIASSVRAiitGYRLSPRDATVAVMPLYHGHGLIAALLATLASGG 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 321 TVVL--RKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRL----AVGNGLRPAIWEEFTQRFGVPQI 394
Cdd:PRK05852  245 AVLLpaRGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERAATEPSGRKPAALrfirSCSAPLTAETAQALQTEFAAPVV 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 395 gEFYGATECNCSIANMDGKVGSCGFNSRILTHVypirlvkVNEDTMEPLR--DSEGLciPCQPGEpgllVGQINQQDP-- 470
Cdd:PRK05852  325 -CAFGMTEATHQVTTTQIEGIGQTENPVVSTGL-------VGRSTGAQIRivGSDGL--PLPAGA----VGEVWLRGTtv 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 471 LRrfdGYVSDSA-TNKKIAHSVFRKGDSAYLSGDvlvmdelGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVA 549
Cdd:PRK05852  391 VR---GYLGDPTiTAANFTDGWLRTGDLGSLSAA-------GDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAA 460

                  ....
gi 1907189407 550 VYGV 553
Cdd:PRK05852  461 VFGV 464
MCS cd05941
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ...
102-615 1.82e-23

Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.


Pssm-ID: 341264 [Multi-domain]  Cd Length: 442  Bit Score: 103.91  E-value: 1.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 102 ERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGF-APGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAF 180
Cdd:cd05941     1 DRIAIVDDGDSI--TYADLVARAARLANRLLALGKdLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 181 CLGTSAAKALIYGGEMaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgmddrlfyIYT 260
Cdd:cd05941    79 VITDSEPSLVLDPALI-------------------------------------------------------------LYT 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 261 SGTTGLPKAaiVVHSRyYRIAAFGH---HSYSMRAADVLYDCLPLYHSAGNIMGVgQCVIY-GLTVVLRKKFSASRFWDD 336
Cdd:cd05941    98 SGTTGRPKG--VVLTH-ANLAANVRalvDAWRWTEDDVLLHVLPLHHVHGLVNAL-LCPLFaGASVEFLPKFDPKEVAIS 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 337 CVKYNCTVVQYIGEICRYLLRQPVRDVEQR--------HRVRLAV-GNG-LRPAIWEEFTQRFGVPqIGEFYGATECNCS 406
Cdd:cd05941   174 RLMPSITVFMGVPTIYTRLLQYYEAHFTDPqfaraaaaERLRLMVsGSAaLPVPTLEEWEAITGHT-LLERYGMTEIGMA 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 407 IAN-MDG--KVGSCGFnsrilthvyPIRLVK---VNEDTMEPL-RDSEG-LCIPcqpgEPGLlvgqinqqdplrrFDGYV 478
Cdd:cd05941   253 LSNpLDGerRPGTVGM---------PLPGVQariVDEETGEPLpRGEVGeIQVR----GPSV-------------FKEYW 306
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 479 SDSATNKKiahsVFRkGDSAYLSGDVLVMDELGYMYFRDR-SGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPg 557
Cdd:cd05941   307 NKPEATKE----EFT-DDGWFKTGDLGVVDEDGYYWILGRsSVDIIKSGGYKVSALEIERVLLAHPGVSECAVIGVPDP- 380
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 558 VEGKAGMAAIA--DPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd05941   381 DWGERVVAVVVlrAGAAALSLEELKEWAKQRLAPYKRPRRLILVDELPRNAMGKVNKKEL 440
MACS_like_4 cd05969
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ...
115-556 2.50e-23

Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.


Pssm-ID: 341273 [Multi-domain]  Cd Length: 442  Bit Score: 103.35  E-value: 2.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIygg 194
Cdd:cd05969     1 YTFAQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVICPLFSAFGPEAIRDRLENSEAKVLI--- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 emaaavaevseqlgksllkfcsgdlgpesilpdtqlLDPMLAEAPTtplaqapgkgMDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:cd05969    78 ------------------------------------TTEELYERTD----------PEDPTLLHYTSGTTGTPKGVLHVH 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 SRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRK-KFSASRFWDDCVKYNCTVVQYIGEICR 353
Cdd:cd05969   112 DAMIFYYFTGKYVLDLHPDDIYWCTADPGWVTGTVYGIWAPWLNGVTNVVYEgRFDAESWYGIIERVKVTVWYTAPTAIR 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 354 YLLR---QPVRDVEQRH-RVRLAVGNGLRPAI--WEEftQRFGVPqIGEFYGATECNC-SIAN---MDGKVGSCGfnsri 423
Cdd:cd05969   192 MLMKegdELARKYDLSSlRFIHSVGEPLNPEAirWGM--EVFGVP-IHDTWWQTETGSiMIANypcMPIKPGSMG----- 263
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 424 lthvYPIRLVK--VNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDplrRFDGYvsdsatnkkiahsvFRKGdsAYLS 501
Cdd:cd05969   264 ----KPLPGVKaaVVDENGNELPPGTKGILALKPGWPSMFRGIWNDEE---RYKNS--------------FIDG--WYLT 320
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907189407 502 GDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVP 556
Cdd:cd05969   321 GDLAYRDEDGYFWFVGRADDIIKTSGHRVGPFEVESALMEHPAVAEAGVIGKPDP 375
PRK07798 PRK07798
acyl-CoA synthetase; Validated
88-349 2.96e-23

acyl-CoA synthetase; Validated


Pssm-ID: 236100 [Multi-domain]  Cd Length: 533  Bit Score: 104.20  E-value: 2.96e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  88 TIPCIFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVaa 167
Cdd:PRK07798    4 NIADLFEAVADAVPDRVALVCGDRRL--TYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAV-- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 168 LLNVNLR--REPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLaq 245
Cdd:PRK07798   80 PVNVNYRyvEDELRYLLDDSDAVALVYEREFAPRVAEVLPRLPKLRTLVVVEDGSGNDLLPGAVDYEDALAAGSPERD-- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 246 aPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRiAAFG------------HHSYSMRAAD----VLYDCLPLYHSAGnI 309
Cdd:PRK07798  158 -FGERSPDDLYLLYTGGTTGMPKGVMWRQEDIFR-VLLGgrdfatgepiedEEELAKRAAAgpgmRRFPAPPLMHGAG-Q 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1907189407 310 MGVGQCVIYGLTVVL--RKKFSASRFWDDCVKYNCTVVQYIG 349
Cdd:PRK07798  235 WAAFAALFSGQTVVLlpDVRFDADEVWRTIEREKVNVITIVG 276
A_NRPS_GliP_like cd17653
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ...
92-617 3.44e-23

nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341308 [Multi-domain]  Cd Length: 433  Bit Score: 102.77  E-value: 3.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGvvAALLNV 171
Cdd:cd17653     2 AFERIAAAHPDAVAVESLGGSL--TYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAG--AAYVPL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NlrreplafclgtsaakaliyGGEMAAAVAEVSEQLGKSLLkfcsgdlgpesILPDTQlldpmlaeapttplaqapgkgm 251
Cdd:cd17653    78 D--------------------AKLPSARIQAILRTSGATLL-----------LTTDSP---------------------- 104
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAAD-------VLYDClplyhSAGNIMGvgqCVIYGLTVVL 324
Cdd:cd17653   105 DDLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPARLDVGPGSrvaqvlsIAFDA-----CIGEIFS---TLCNGGTLVL 176
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 325 RkkfSASRFWDDcVKYNCTVVQYIGEICRYLlrqPVRDVEQRHRVRLAvGNGLRPAIWEEFTqrfGVPQIGEFYGATECN 404
Cdd:cd17653   177 A---DPSDPFAH-VARTVDALMSTPSILSTL---SPQDFPNLKTIFLG-GEAVPPSLLDRWS---PGRRLYNAYGPTECT 245
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 405 CSIAN---MDGKVGSCGfnsrilthvYPIRLVKV---NEDTMEPLRDSEG-LCIpcqpGEPGLLVGQINQQdplrrfdgy 477
Cdd:cd17653   246 ISSTMtelLPGQPVTIG---------KPIPNSTCyilDADLQPVPEGVVGeICI----SGVQVARGYLGNP--------- 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 478 vsdSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQtdvaVYGVAVPG 557
Cdd:cd17653   304 ---ALTASKFVPDPFWPGSRMYRTGDYGRWTEDGGLEFLGREDNQVKVRGFRINLEEIEEVVLQSQPE----VTQAAAIV 376
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 558 VEGKagMAAIADPHSqLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQR 617
Cdd:cd17653   377 VNGR--LVAFVTPET-VDVDGLRSELAKHLPSYAVPDRIIALDSFPLTANGKVDRKALRE 433
PRK13382 PRK13382
bile acid CoA ligase;
83-617 3.66e-23

bile acid CoA ligase;


Pssm-ID: 172019 [Multi-domain]  Cd Length: 537  Bit Score: 103.68  E-value: 3.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  83 RRAGDTIPCIFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKA 162
Cdd:PRK13382   39 RREGMGPTSGFAIAAQRCPDRPGLIDELGTL--TWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAANRI 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 163 GVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAevseqlgksllKFCSGDLGPESILPDTQLLDPMLAEA-PTT 241
Cdd:PRK13382  117 GADILLLNTSFAGPALAEVVTREGVDTVIYDEEFSATVD-----------RALADCPQATRIVAWTDEDHDLTVEVlIAA 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 242 PLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSagniMGVGQCVIYGL- 320
Cdd:PRK13382  186 HAGQRPEPTGRKGRVILLTSGTTGTPKGARRSGPGGIGTLKAILDRTPWRAEEPTVIVAPMFHA----WGFSQLVLAASl 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 321 --TVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQP--VRDVEQRHRVRLAVGNG--LRPAIWEEFTQRFGvPQI 394
Cdd:PRK13382  262 acTIVTRRRFDPEATLDLIDRHRATGLAVVPVMFDRIMDLPaeVRNRYSGRSLRFAAASGsrMRPDVVIAFMDQFG-DVI 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 395 GEFYGATECN-CSIANMDGkvgscgfnsrilTHVYPIRLVKVNEDTMEPLRDSEGLCIPcqPGEpgllVGQINQQDPLrR 473
Cdd:PRK13382  341 YNNYNATEAGmIATATPAD------------LRAAPDTAGRPAEGTEIRILDQDFREVP--TGE----VGTIFVRNDT-Q 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 474 FDGYVSDSATNkkiahsvFRKGDSAylSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGV 553
Cdd:PRK13382  402 FDGYTSGSTKD-------FHDGFMA--SGDVGYLDENGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAEAAVIGV 472
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907189407 554 AVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQR 617
Cdd:PRK13382  473 DDEQYGQRLAAFVVLKPGASATPETLKQHVRDNLANYKVPRDIVVLDELPRGATGKILRRELQA 536
PRK07786 PRK07786
long-chain-fatty-acid--CoA ligase; Validated
97-620 3.67e-23

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 169098 [Multi-domain]  Cd Length: 542  Bit Score: 103.70  E-value: 3.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGICWtfAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRRE 176
Cdd:PRK07786   27 ALMQPDAPALRFLGNTTTW--RELDDRVAALAGALSRRGVGFGDRVLILMLNRTEFVESVLAANMLGAIAVPVNFRLTPP 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPdtqlLDPMLAEA-PTTPLAQAPGkgmDDRL 255
Cdd:PRK07786  105 EIAFLVSDCGAHVVVTEAALAPVATAVRDIVPLLSTVVVAGGSSDDSVLG----YEDLLAEAgPAHAPVDIPN---DSPA 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 256 FYIYTSGTTGLPKAAIVVHSRYYRIAAfgHHSYSMRA---ADVLYDCLPLYHSAGnIMGVGQCVIYGLTVVLR--KKFSA 330
Cdd:PRK07786  178 LIMYTSGTTGRPKGAVLTHANLTGQAM--TCLRTNGAdinSDVGFVGVPLFHIAG-IGSMLPGLLLGAPTVIYplGAFDP 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 331 SRFWDDCVKYNCTVV-----QYIGeICRYLLRQPvRDVEQRhrvrlAVGNGLRPA---IWEEFTQRFGVPQIGEFYGATE 402
Cdd:PRK07786  255 GQLLDVLEAEKVTGIflvpaQWQA-VCAEQQARP-RDLALR-----VLSWGAAPAsdtLLRQMAATFPEAQILAAFGQTE 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CNCSIANMDG-----KVGSCGfnsriltHVYPIRLVKVNEDTMEPLrdseglcipcQPGEpgllVGQINQQDPlrrfdGY 477
Cdd:PRK07786  328 MSPVTCMLLGedairKLGSVG-------KVIPTVAARVVDENMNDV----------PVGE----VGEIVYRAP-----TL 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 478 VSDSATNKKIAHSVFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPG 557
Cdd:PRK07786  382 MSGYWNNPEATAEAFAGG--WFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEK 459
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907189407 558 -VEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLqREGF 620
Cdd:PRK07786  460 wGEVPVAVAAVRNDDAALTLEDLAEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTEL-RERY 522
ACS-like cd17634
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ...
98-588 3.78e-23

acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.


Pssm-ID: 341289 [Multi-domain]  Cd Length: 587  Bit Score: 104.20  E-value: 3.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  98 RRQPERLALV----DASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNL 173
Cdd:cd17634    64 RENGDRTAIIyegdDTSQSRTISYRELHREVCRFAGTLLDLGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFGGF 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 174 RREPLAFCLGTSAAKALIYGGEMAAAVAEVSeqlgksLLKFCSGDLGPESILPDTQLL------------------DPML 235
Cdd:cd17634   144 APEAVAGRIIDSSSRLLITADGGVRAGRSVP------LKKNVDDALNPNVTSVEHVIVlkrtgsdidwqegrdlwwRDLI 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 236 AEAPT--TPLAQAPgkgmDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFG-HHSYSMRAADVLYdclpLYHSAGNIMGv 312
Cdd:cd17634   218 AKASPehQPEAMNA----EDPLFILYTSGTTGKPKGVLHTTGGYLVYAATTmKYVFDYGPGDIYW----CTADVGWVTG- 288
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 313 GQCVIY-----GLTVVLRKKF----SASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRL----AVGNGLRP 379
Cdd:cd17634   289 HSYLLYgplacGATTLLYEGVpnwpTPARMWQVVDKHGVNILYTAPTAIRALMAAGDDAIEGTDRSSLrilgSVGEPINP 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 380 AIWEEFTQRFG---VPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSE-GLCIPCQP 455
Cdd:cd17634   369 EAYEWYWKKIGkekCPVVDTWWQTETGGFMITPLPGAIELKAGSATRPVFGVQPAVVDNEGHPQPGGTEGNlVITDPWPG 448
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 456 GEPGLLvgqinqQDPLRRFDGYvsdsatnkkiahsvFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEV 535
Cdd:cd17634   449 QTRTLF------GDHERFEQTY--------------FSTFKGMYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGTAEI 508
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907189407 536 EAVLSRLLGQTDVAVYGVAVPgVEGKAGMAAIADPHSQLDPNSMYQELQKVLA 588
Cdd:cd17634   509 ESVLVAHPKVAEAAVVGIPHA-IKGQAPYAYVVLNHGVEPSPELYAELRNWVR 560
PRK13390 PRK13390
acyl-CoA synthetase; Provisional
97-616 4.84e-23

acyl-CoA synthetase; Provisional


Pssm-ID: 139538 [Multi-domain]  Cd Length: 501  Bit Score: 103.16  E-value: 4.84e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPE-FVGLWLGLaKAGVVAALLNVNLRR 175
Cdd:PRK13390    7 AQIAPDRPAVIVAETGEQVSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEaLVVLWAAL-RSGLYITAINHHLTA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 176 EPLAFCLGTSAAKALIYGGEMAAAVAEVSEQL------GKSLLKFcsGDLgpESILPDTqllDPMLAEAPTtplaqapGK 249
Cdd:PRK13390   86 PEADYIVGDSGARVLVASAALDGLAAKVGADLplrlsfGGEIDGF--GSF--EAALAGA---GPRLTEQPC-------GA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 250 GMddrlfyIYTSGTTGLPKA------AIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAgNIMGVGQCVIYGLTVV 323
Cdd:PRK13390  152 VM------LYSSGTTGFPKGiqpdlpGRDVDAPGDPIVAIARAFYDISESDIYYSSAPIYHAA-PLRWCSMVHALGGTVV 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 324 LRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQpvrDVEQRHRVRL----AVGNGLRPA---IWEEFTQRFGvPQIGE 396
Cdd:PRK13390  225 LAKRFDAQATLGHVERYRITVTQMVPTMFVRLLKL---DADVRTRYDVsslrAVIHAAAPCpvdVKHAMIDWLG-PIVYE 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 397 FYGATECNcSIANMD-----GKVGSCGFNSRILTHVYpirlvkvnedtmeplrDSEGLCIPCqpGEPGLLVGQINQQdPL 471
Cdd:PRK13390  301 YYSSTEAH-GMTFIDspdwlAHPGSVGRSVLGDLHIC----------------DDDGNELPA--GRIGTVYFERDRL-PF 360
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 472 RrfdgYVSD---SATNKKIAHSVFRKgdsaylSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDV 548
Cdd:PRK13390  361 R----YLNDpekTAAAQHPAHPFWTT------VGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDV 430
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 549 AVYGVAVP--GVEGKAGMAAIA--DPHSQLdPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQ 616
Cdd:PRK13390  431 AVIGVPDPemGEQVKAVIQLVEgiRGSDEL-ARELIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLLR 501
MACS_euk cd05928
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ...
115-618 6.63e-23

Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.


Pssm-ID: 341251 [Multi-domain]  Cd Length: 530  Bit Score: 102.93  E-value: 6.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQL-GFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYG 193
Cdd:cd05928    42 WSFRELGSLSRKAANVLSGAcGLQRGDRVAVILPRVPEWWLVNVACIRTGLVFIPGTIQLTAKDILYRLQASKAKCIVTS 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 194 GEMAAAVAEVSEQLG-------------------KSLLKFCSgdlgPESILPDTQLLDPMLaeapttplaqapgkgmddr 254
Cdd:cd05928   122 DELAPEVDSVASECPslktkllvseksrdgwlnfKELLNEAS----TEHHCVETGSQEPMA------------------- 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 255 lfyIY-TSGTTGLPKAAIVVHSRY-YRIAAFGHHSYSMRAADVLY---DCLPLYHSAGNIMG---VGQCVIygltVVLRK 326
Cdd:cd05928   179 ---IYfTSGTTGSPKMAEHSHSSLgLGLKVNGRYWLDLTASDIMWntsDTGWIKSAWSSLFEpwiQGACVF----VHHLP 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 327 KFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVE-QRHRVRLAVGNGLRPAIWEEFTQRFGVpQIGEFYGATECNC 405
Cdd:cd05928   252 RFDPLVILKTLSSYPITTFCGAPTVYRMLVQQDLSSYKfPSLQHCVTGGEPLNPEVLEKWKAQTGL-DIYEGYGQTETGL 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 406 SIANMDG---KVGSCGFNSRilthVYPIRLVkvnedtmeplrDSEGLCIPcqPGEPGLLVGQINQQDPLRRFDGYVSDSa 482
Cdd:cd05928   331 ICANFKGmkiKPGSMGKASP----PYDVQII-----------DDNGNVLP--PGTEGDIGIRVKPIRPFGLFSGYVDNP- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 483 tnKKIAHSvfRKGDsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgVEGKA 562
Cdd:cd05928   393 --EKTAAT--IRGD-FYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDP-IRGEV 466
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 563 GMAAI--ADPHSQLDPNSMYQELQ----KVLASYARPIFLRLLPQVDTTGTFKIQKTRLQRE 618
Cdd:cd05928   467 VKAFVvlAPQFLSHDPEQLTKELQqhvkSVTAPYKYPRKVEFVQELPKTVTGKIQRNELRDK 528
FACL_like_6 cd05922
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
124-610 1.37e-22

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341246 [Multi-domain]  Cd Length: 457  Bit Score: 101.36  E-value: 1.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 124 SNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVnlrrePLAFCLGTSAAKALIygGEMAAAVAEV 203
Cdd:cd05922     3 VSAAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGGRLGLVFV-----PLNPTLKESVLRYLV--ADAGGRIVLA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 204 SEQLGkSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQapgkgmDDRLFYIYTSGTTGLPKAAIVVHsRYYRIAAF 283
Cdd:cd05922    76 DAGAA-DRLRDALPASPDPGTVLDADGIRAARASAPAHEVSH------EDLALLLYTSGSTGSPKLVRLSH-QNLLANAR 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 284 GHHSY-SMRAADVLYDCLPLYHSAGnIMGVGQCVIYGLTVVLRKKFSASR-FWDDCVKYNCT---VVQYIGEICRYLLRQ 358
Cdd:cd05922   148 SIAEYlGITADDRALTVLPLSYDYG-LSVLNTHLLRGATLVLTNDGVLDDaFWEDLREHGATglaGVPSTYAMLTRLGFD 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 359 P-----VRDVEQrhrvrlaVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDG-----KVGSCGfnsrilthvy 428
Cdd:cd05922   227 PaklpsLRYLTQ-------AGGRLPQETIARLRELLPGAQVYVMYGQTEATRRMTYLPPerileKPGSIG---------- 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 429 pirlVKVNEDTMEPLRDSEGlciPCQPGEPGLLVgqinqqdpLRR---FDGYVSDSATNKKIAhsvfRKGDSAYlSGDVL 505
Cdd:cd05922   290 ----LAIPGGEFEILDDDGT---PTPPGEPGEIV--------HRGpnvMKGYWNDPPYRRKEG----RGGGVLH-TGDLA 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 506 VMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAgMAAIADPHSQLDPNSMYqeLQK 585
Cdd:cd05922   350 RRDEDGFLFIVGRRDRMIKLFGNRISPTEIEAAARSIGLIIEAAAVGLPDPLGEKLA-LFVTAPDKIDPKDVLRS--LAE 426
                         490       500
                  ....*....|....*....|....*
gi 1907189407 586 VLASYARPIFLRLLPQVDTTGTFKI 610
Cdd:cd05922   427 RLPPYKVPATVRVVDELPLTASGKV 451
AACS_like cd05968
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ...
115-562 6.02e-21

Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.


Pssm-ID: 341272 [Multi-domain]  Cd Length: 610  Bit Score: 97.18  E-value: 6.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGG 194
Cdd:cd05968    92 LTYGELLYEVKRLANGLRALGVGKGDRVGIYLPMIPEIVPAFLAVARIGGIVVPIFSGFGKEAAATRLQDAEAKALITAD 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 EMAAAVAEVSeqLGKSLLKFCSGDLGPESIL---------PDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTG 265
Cdd:cd05968   172 GFTRRGREVN--LKEEADKACAQCPTVEKVVvvrhlgndfTPAKGRDLSYDEEKETAGDGAERTESEDPLMIIYTSGTTG 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 266 LPKAAIVVHSRYYRIAAFG-HHSYSMRAADVLYdclpLYHSAGNIMG---VGQCVIYGLTVVLRKKF----SASRFWDDC 337
Cdd:cd05968   250 KPKGTVHVHAGFPLKAAQDmYFQFDLKPGDLLT----WFTDLGWMMGpwlIFGGLILGATMVLYDGApdhpKADRLWRMV 325
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 338 VKYNCTVVQYIGEICRYLL---RQPVRdVEQRHRVRLAVGNG--LRPAIWEEFTQRFG---VPqIGEFYGATECNCSI-- 407
Cdd:cd05968   326 EDHEITHLGLSPTLIRALKprgDAPVN-AHDLSSLRVLGSTGepWNPEPWNWLFETVGkgrNP-IINYSGGTEISGGIlg 403
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 408 ANMDGKVGSCGFNSrilthVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGePGLLVGqiNQQDPLRRFDGYvsdsatnkki 487
Cdd:cd05968   404 NVLIKPIKPSSFNG-----PVPGMKADVLDESGKPARPEVGELVLLAPW-PGMTRG--FWRDEDRYLETY---------- 465
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189407 488 ahsvFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgVEGKA 562
Cdd:cd05968   466 ----WSRFDNVWVHGDFAYYDEEGYFYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLESAAIGVPHP-VKGEA 535
AFD_YhfT-like cd17633
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ...
254-610 9.17e-21

fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain


Pssm-ID: 341288 [Multi-domain]  Cd Length: 320  Bit Score: 93.62  E-value: 9.17e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 254 RLFYI-YTSGTTGLPKAaivvhsrYYR-----IAAF--GHHSYSMRAADVLYDCLPLYHSaGNIMGVGQCVIYGLTVVLR 325
Cdd:cd17633     1 NPFYIgFTSGTTGLPKA-------YYRserswIESFvcNEDLFNISGEDAILAPGPLSHS-LFLYGAISALYLGGTFIGQ 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 326 KKFSASRFWDDCVKYNCTVVQYIGEicryLLRQPVRDVEQRHRVR--LAVGNGLRPAIWEEFTQRFGVPQIGEFYGATEC 403
Cdd:cd17633    73 RKFNPKSWIRKINQYNATVIYLVPT----MLQALARTLEPESKIKsiFSSGQKLFESTKKKLKNIFPKANLIEFYGTSEL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 404 NCSIANMDG---KVGSCGfnsRILTHVyPIRLvkvnedtmeplRDSEGlcipcqpGEPGLLVGQINQqdplrRFDGYVSD 480
Cdd:cd17633   149 SFITYNFNQesrPPNSVG---RPFPNV-EIEI-----------RNADG-------GEIGKIFVKSEM-----VFSGYVRG 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 481 SATNKkiaHSVFRKGDSAYLsgdvlvmDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGV------- 553
Cdd:cd17633   202 GFSNP---DGWMSVGDIGYV-------DEEGYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIpdarfge 271
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907189407 554 -AVPGVEGKagmaaiadphsQLDPNSMYQELQKVLASYARP---IFLRLLPQvdtTGTFKI 610
Cdd:cd17633   272 iAVALYSGD-----------KLTYKQLKRFLKQKLSRYEIPkkiIFVDSLPY---TSSGKI 318
EntF COG1020
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ...
88-403 9.98e-21

EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440643 [Multi-domain]  Cd Length: 1329  Bit Score: 97.62  E-value: 9.98e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   88 TIPCIFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGvvAA 167
Cdd:COG1020    477 TLHELFEAQAARTPDAVAVVFG--DQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAG--AA 552
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  168 L--LNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAevseqlgksllkfcsgDLGPESILPDTQLLDPMLAEAPTTPLAq 245
Cdd:COG1020    553 YvpLDPAYPAERLAYMLEDAGARLVLTQSALAARLP----------------ELGVPVLALDALALAAEPATNPPVPVT- 615
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  246 apgkgmDDRLFY-IYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVlydcLPLYH------SAGNIMGvgqCVIY 318
Cdd:COG1020    616 ------PDDLAYvIYTSGSTGRPKGVMVEHRALVNLLAWMQRRYGLGPGDR----VLQFAslsfdaSVWEIFG---ALLS 682
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  319 GLTVVLRKK---FSASRFWDDCVKYNCTVVQYIGEICRYLLRQPvrdVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPQ 393
Cdd:COG1020    683 GATLVLAPPearRDPAALAELLARHRVTVLNLTPSLLRALLDAA---PEALPSLRLVLvgGEALPPELVRRWRARLPGAR 759
                          330
                   ....*....|
gi 1907189407  394 IGEFYGATEC 403
Cdd:COG1020    760 LVNLYGPTET 769
ABCL cd05958
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ...
115-615 1.33e-20

2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.


Pssm-ID: 341268 [Multi-domain]  Cd Length: 439  Bit Score: 94.85  E-value: 1.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVAN-LFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLG-TSAAKALIY 192
Cdd:cd05958    11 WTYRDLLALANRIANvLVGELGIVPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELAYILDkARITVALCA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 193 GGEMAAavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgmDDRLFYIYTSGTTGLPKAAIV 272
Cdd:cd05958    91 HALTAS-----------------------------------------------------DDICILAFTSGTTGAPKATMH 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 273 VHSRYYRIA-AFGHHSYSMRAADVLYDCLPLYHSagniMGVGQCVIY----GLTVVLRKKFSASRFWDDCVKYNCTVVQY 347
Cdd:cd05958   118 FHRDPLASAdRYAVNVLRLREDDRFVGSPPLAFT----FGLGGVLLFpfgvGASGVLLEEATPDLLLSAIARYKPTVLFT 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 348 IGEICRYLLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPQIgEFYGATEC-NCSIANMDGkvgscgfnsril 424
Cdd:cd05958   194 APTAYRAMLAHPDAAGPDLSSLRKCVsaGEALPAALHRAWKEATGIPII-DGIGSTEMfHIFISARPG------------ 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 425 tHVYPIRLVKVNEDTMEPLRDSEGLCIPcqPGEPGLLVgqinqqdpLRRFDGYVSDSatnKKIAHSVFRKGDSAylSGDV 504
Cdd:cd05958   261 -DARPGATGKPVPGYEAKVVDDEGNPVP--DGTIGRLA--------VRGPTGCRYLA---DKRQRTYVQGGWNI--TGDT 324
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 505 LVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPG--------VEGKAGMAAIADPHSQLdp 576
Cdd:cd05958   325 YSRDPDGYFRHQGRSDDMIVSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESrgvvvkafVVLRPGVIPGPVLAREL-- 402
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1907189407 577 nsmyQELQK-VLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd05958   403 ----QDHAKaHIAPYKYPRAIEFVTELPRTATGKLQRFAL 438
AA-adenyl-dom TIGR01733
amino acid adenylation domain; This model represents a domain responsible for the specific ...
116-550 1.53e-20

amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.


Pssm-ID: 273779 [Multi-domain]  Cd Length: 409  Bit Score: 94.25  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFA-PGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGG 194
Cdd:TIGR01733   1 TYRELDERANRLARHLRAAGGVgPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 EMAAAVAEVseqlgksllkfcsgdlgPESILPDTQLLDPMLAEAPTTPLAQAPGKGmDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:TIGR01733  81 ALASRLAGL-----------------VLPVILLDPLELAALDDAPAPPPPDAPSGP-DDLAYVIYTSGSTGRPKGVVVTH 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 ----------SRYY------RIAAFghHSYSMRAAdVLYDCLPLYHsagnimGVGQCVIYGltVVLRKKFSASRFWDDcv 338
Cdd:TIGR01733 143 rslvnllawlARRYgldpddRVLQF--ASLSFDAS-VEEIFGALLA------GATLVVPPE--DEERDDAALLAALIA-- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 339 KYNCTVVQYIGEICRYLLRQPVRDVEQRHRVrLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECN--CSIANMDGKVGS 416
Cdd:TIGR01733 210 EHPVTVLNLTPSLLALLAAALPPALASLRLV-ILGGEALTPALVDRWRARGPGARLINLYGPTETTvwSTATLVDPDDAP 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 417 CGFNSRI---LTHVypiRLVKVNEDTMeplrdseglciPCQPGEPG-LLVGQINqqdpLRRfdGYVSDSA-TNKKIAHSV 491
Cdd:TIGR01733 289 RESPVPIgrpLANT---RLYVLDDDLR-----------PVPVGVVGeLYIGGPG----VAR--GYLNRPElTAERFVPDP 348
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907189407 492 FRKGDSA--YLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAV 550
Cdd:TIGR01733 349 FAGGDGArlYRTGDLVRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHPGVREAVV 409
FAA1 COG1022
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
85-322 2.26e-20

Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];


Pssm-ID: 440645 [Multi-domain]  Cd Length: 603  Bit Score: 95.55  E-value: 2.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  85 AGDTIPCIFQAVARRQPERLALVDASSGI--CWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKA 162
Cdd:COG1022     9 PADTLPDLLRRRAARFPDRVALREKEDGIwqSLTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVIADLAILAA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 163 GVVAALLNVNLRREPLAFCLGTSAAKALIYGG-EMAAAVAEVSEQLGkSLLKFCSGDLGPESILPDTQLLDPMLA----- 236
Cdd:COG1022    89 GAVTVPIYPTSSAEEVAYILNDSGAKVLFVEDqEQLDKLLEVRDELP-SLRHIVVLDPRGLRDDPRLLSLDELLAlgrev 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 237 EAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGqCV 316
Cdd:COG1022   168 ADPAELEARRAAVKPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGDRTLSFLPLAHVFERTVSYY-AL 246

                  ....*.
gi 1907189407 317 IYGLTV 322
Cdd:COG1022   247 AAGATV 252
A_NRPS_AB3403-like cd17646
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ...
93-615 3.09e-20

Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341301 [Multi-domain]  Cd Length: 488  Bit Score: 94.26  E-value: 3.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  93 FQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVN 172
Cdd:cd17646     4 VAEQAARTPDAPAVVDEGRTL--TYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDPG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 173 LRREPLAFCLGTSAAKALIYGGEMAAAVAEVseqlgksllkfcsgdlgpesiLPDTQLLDPMLAEAPTTPLAQAPGKgmD 252
Cdd:cd17646    82 YPADRLAYMLADAGPAVVLTTADLAARLPAG---------------------GDVALLGDEALAAPPATPPLVPPRP--D 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 DRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVL-------YDC------LPLYHSAGNIMGV--GQCVI 317
Cdd:cd17646   139 NLAYVIYTSGSTGRPKGVMVTHAGIVNRLLWMQDEYPLGPGDRVlqktplsFDVsvwelfWPLVAGARLVVARpgGHRDP 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 318 YGLTVVLRkkfsasrfwDDCVkyncTVVQYIGEICRYLLRQPvrDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPqIG 395
Cdd:cd17646   219 AYLAALIR---------EHGV----TTCHFVPSMLRVFLAEP--AAGSCASLRRVFcsGEALPPELAARFLALPGAE-LH 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 396 EFYGATE-------CNCSIANMDGKV--GSCGFNSRILthvypirlvkVNEDTMEplrdseglciPCQPGEPG-LLVGQI 465
Cdd:cd17646   283 NLYGPTEaaidvthWPVRGPAETPSVpiGRPVPNTRLY----------VLDDALR----------PVPVGVPGeLYLGGV 342
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 466 nqqdPLRRfdGYVSDSA-TNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLG 544
Cdd:cd17646   343 ----QLAR--GYLGRPAlTAERFVPDPFGPGSRMYRTGDLARWRPDGALEFLGRSDDQVKIRGFRVEPGEIEAALAAHPA 416
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907189407 545 QTDVAVygVAVPGVEGKAGMAA---IADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd17646   417 VTHAVV--VARAAPAGAARLVGyvvPAAGAAGPDTAALRAHLAERLPEYMVPAAFVVLDALPLTANGKLDRAAL 488
LC_FACS_like cd05935
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ...
116-610 3.33e-20

Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.


Pssm-ID: 341258 [Multi-domain]  Cd Length: 430  Bit Score: 93.70  E-value: 3.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGE 195
Cdd:cd05935     3 TYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVGSE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 MaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgkgmDDRLFYIYTSGTTGLPKAAIVVHS 275
Cdd:cd05935    83 L-------------------------------------------------------DDLALIPYTSGTTGLPKGCMHTHF 107
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 276 RYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYL 355
Cdd:cd05935   108 SAAANALQSAVWTGLTPSDVILACLPLFHVTGFVGSLNTAVYVGGTYVLMARWDRETALELIEKYKVTFWTNIPTMLVDL 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 356 LRQPvrDVEQRHRVRLAV----GNGLRPAIWEEFTQRFGVPQIgEFYGATEcNCSianmdgkvgscgfnsriLTHVYPIR 431
Cdd:cd05935   188 LATP--EFKTRDLSSLKVltggGAPMPPAVAEKLLKLTGLRFV-EGYGLTE-TMS-----------------QTHTNPPL 246
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 432 LVKVNEDTMePLRDSEGLCIPCQPGE--PGLLVGQINQQDPlRRFDGYVSDSATNKKIAhsVFRKGDSAYLSGDVLVMDE 509
Cdd:cd05935   247 RPKLQCLGI-P*FGVDARVIDIETGRelPPNEVGEIVVRGP-QIFKGYWNRPEETEESF--IEIKGRRFFRTGDLGYMDE 322
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 510 LGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVP--GVEGKAGMAAIADPHSQLDPNSMYQELQKVL 587
Cdd:cd05935   323 EGYFFFVDRVKRMINVSGFKVWPAEVEAKLYKHPAI*EVCVISVPDErvGEEVKAFIVLRPEYRGKVTEEDIIEWAREQM 402
                         490       500
                  ....*....|....*....|....*.
gi 1907189407 588 ASYARP---IFLRLLPQvdtTGTFKI 610
Cdd:cd05935   403 AAYKYPrevEFVDELPR---SASGKI 425
MACS_like_2 cd05973
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
116-617 6.96e-20

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341277 [Multi-domain]  Cd Length: 437  Bit Score: 92.97  E-value: 6.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVaallnvnlrREPL--AFclgtsaakaliyg 193
Cdd:cd05973     2 TFGELRALSARFANALQELGVGPGDVVAGLLPRTPELVVTILGIWRLGAV---------YQPLftAF------------- 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 194 gemaaavaevseqlgksllkfcsgdlGPESIlpdTQLLDPMLAEAPTTPLAQApGKGMDDRLFYIYTSGTTGLPKaAIVV 273
Cdd:cd05973    60 --------------------------GPKAI---EHRLRTSGARLVVTDAANR-HKLDSDPFVMMFTSGTTGLPK-GVPV 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 274 HSRYyrIAAFghHSYSMRAADVLYDclplyHSAGNIMGVGQCviYGL-------------TVVLRKKFSASRFWDDCVKY 340
Cdd:cd05973   109 PLRA--LAAF--GAYLRDAVDLRPE-----DSFWNAADPGWA--YGLyyaitgplalghpTILLEGGFSVESTWRVIERL 177
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 341 NCTVVQYIGEICRYLLRQPVrDVEQRHRVRLAV----GNGLRPAIWEEFTQRFGVPqIGEFYGATECNCSIANMDG---- 412
Cdd:cd05973   178 GVTNLAGSPTAYRLLMAAGA-EVPARPKGRLRRvssaGEPLTPEVIRWFDAALGVP-IHDHYGQTELGMVLANHHAlehp 255
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 413 -KVGSCGFnsrilthVYP-IRLVKVNEDTMEPLrdseglcipcqPGEPGLLVGQINQQdPLRRFDGYvsdsatnkkiahs 490
Cdd:cd05973   256 vHAGSAGR-------AMPgWRVAVLDDDGDELG-----------PGEPGRLAIDIANS-PLMWFRGY------------- 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 491 vFRKGDSA-----YLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPG----VEGK 561
Cdd:cd05973   304 -QLPDTPAidggyYLTGDTVEFDPDGSFSFIGRADDVITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPErtevVKAF 382
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189407 562 AGMAAIADPHSQLDpNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQR 617
Cdd:cd05973   383 VVLRGGHEGTPALA-DELQLHVKKRLSAHAYPRTIHFVDELPKTPSGKIQRFLLRR 437
A_NRPS_Srf_like cd12117
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ...
92-615 1.09e-19

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.


Pssm-ID: 341282 [Multi-domain]  Cd Length: 483  Bit Score: 92.65  E-value: 1.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:cd12117     2 LFEEQAARTPDAVAVVYG--DRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLRREPLAFCLGTSAAKALIYGGEMAAAVAEvseqlgksllkfcsgdlgpesiLPDTQLLDPMLAEAPTTPLAQAPGKgm 251
Cdd:cd12117    80 ELPAERLAFMLADAGAKVLLTDRSLAGRAGG----------------------LEVAVVIDEALDAGPAGNPAVPVSP-- 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIV--------VHSRYYriAAFGHHSYSMRAADVLYD--CLPLYhsaGNIMGVGQCVIYGLT 321
Cdd:cd12117   136 DDLAYVMYTSGSTGRPKGVAVthrgvvrlVKNTNY--VTLGPDDRVLQTSPLAFDasTFEIW---GALLNGARLVLAPKG 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 322 VVLrkkfSASRFWDDCVKYNCTVVQyigeICRYLLRQPVRDVEQRH---RVRLAVGNGLRPAIWEEFTQRFGVPQIGEFY 398
Cdd:cd12117   211 TLL----DPDALGALIAEEGVTVLW----LTAALFNQLADEDPECFaglRELLTGGEVVSPPHVRRVLAACPGLRLVNGY 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 399 GATE-----CNCSIANMDGKVGScgfnsrilthvYPI-------RLVKVNEDtmepLRdseglciPCQPGEPG-LLVGqi 465
Cdd:cd12117   283 GPTEnttftTSHVVTELDEVAGS-----------IPIgrpiantRVYVLDED----GR-------PVPPGVPGeLYVG-- 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 466 nqQDPLRRfdGYVSDSA-TNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLG 544
Cdd:cd12117   339 --GDGLAL--GYLNRPAlTAERFVADPFGPGERLYRTGDLARWLPDGRLEFLGRIDDQVKIRGFRIELGEIEAALRAHPG 414
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907189407 545 QTDVAVygVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd12117   415 VREAVV--VVREDAGGDKRLVAYVVAEGALDAAELRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483
EntE COG1021
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ...
80-268 4.28e-19

EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440644 [Multi-domain]  Cd Length: 533  Bit Score: 90.98  E-value: 4.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  80 RRHRRAG----DTIPCIFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGL 155
Cdd:COG1021    14 ARYREAGywrgETLGDLLRRRAERHPDRIAVVDG--ERRLSYAELDRRADRLAAGLLALGLRPGDRVVVQLPNVAEFVIV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 156 WLGLAKAGV--VAALlnVNLRR-EPLAFClGTSAAKALI----YGG----EMAAAVAEVSEQLGKSLLkfcSGDLGPESI 224
Cdd:COG1021    92 FFALFRAGAipVFAL--PAHRRaEISHFA-EQSEAVAYIipdrHRGfdyrALARELQAEVPSLRHVLV---VGDAGEFTS 165
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907189407 225 LPDtqlldpmLAEAPTTPLAQAPgkGMDDRLFYIYTSGTTGLPK 268
Cdd:COG1021   166 LDA-------LLAAPADLSEPRP--DPDDVAFFQLSGGTTGLPK 200
PRK06188 PRK06188
acyl-CoA synthetase; Validated
82-553 5.07e-19

acyl-CoA synthetase; Validated


Pssm-ID: 235731 [Multi-domain]  Cd Length: 524  Bit Score: 90.82  E-value: 5.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  82 HRRAGDTIPCIFQAVARRQPERLALVDasSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEfvgLWLGLAk 161
Cdd:PRK06188    7 LLHSGATYGHLLVSALKRYPDRPALVL--GDTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNRPE---VLMAIG- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 162 AGVVAALLNVNLrrEPL------AFCLGTSAAKALIY--------GGEMAAAVAEVseqlgKSLLKFCSGDLGPEsilpd 227
Cdd:PRK06188   81 AAQLAGLRRTAL--HPLgslddhAYVLEDAGISTLIVdpapfverALALLARVPSL-----KHVLTLGPVPDGVD----- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 228 tqlldpMLAEAPTTPLAQA-PGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSA 306
Cdd:PRK06188  149 ------LLAAAAKFGPAPLvAAALPPDIAGLAYTGGTTGKPKGVMGTHRSIATMAQIQLAEWEWPADPRFLMCTPLSHAG 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 307 GNImgVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPvrDVEQRHRVRLAV----GNGLRPAIW 382
Cdd:PRK06188  223 GAF--FLPTLLRGGTVIVLAKFDPAEVLRAIEEQRITATFLVPTMIYALLDHP--DLRTRDLSSLETvyygASPMSPVRL 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 383 EEFTQRFGvPQIGEFYGATECNCSIANMD---------GKVGSCGFnsrilthvyPIRLVKVNedtmepLRDSEGLCIPc 453
Cdd:PRK06188  299 AEAIERFG-PIFAQYYGQTEAPMVITYLRkrdhdpddpKRLTSCGR---------PTPGLRVA------LLDEDGREVA- 361
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 454 qPGEPgllvGQINQQDPLrRFDGYVSDSATNKKiahsVFRKGdsaYL-SGDVLVMDELGYMYFRDRSGDTFRWRGENVST 532
Cdd:PRK06188  362 -QGEV----GEICVRGPL-VMDGYWNRPEETAE----AFRDG---WLhTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFP 428
                         490       500
                  ....*....|....*....|.
gi 1907189407 533 TEVEAVLSRLLGQTDVAVYGV 553
Cdd:PRK06188  429 REVEDVLAEHPAVAQVAVIGV 449
FACL_like_2 cd05917
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
259-616 5.49e-19

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341241 [Multi-domain]  Cd Length: 349  Bit Score: 88.87  E-value: 5.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 259 YTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVL-RKKFSASRFWDDC 337
Cdd:cd05917     9 FTSGTTGSPKGATLTHHNIVNNGYFIGERLGLTEQDRLCIPVPLFHCFGSVLGVLACLTHGATMVFpSPSFDPLAVLEAI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 338 VKYNCTVVQ-----YIGEicrylLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIAN- 409
Cdd:cd05917    89 EKEKCTALHgvptmFIAE-----LEHPDFDKFDLSSLRTGImaGAPCPPELMKRVIEVMNMKDVTIAYGMTETSPVSTQt 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 410 -----MDGKVGSCGfnsRILTHVYpirlVKVnedtmeplRDSEGLCIPcQPGEPGLLVgqinqqdpLRRFD---GYVSD- 480
Cdd:cd05917   164 rtddsIEKRVNTVG---RIMPHTE----AKI--------VDPEGGIVP-PVGVPGELC--------IRGYSvmkGYWNDp 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 481 SATNKKIahsvfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVeG 560
Cdd:cd05917   220 EKTAEAI------DGDGWLHTGDLAVMDEDGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERY-G 292
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407 561 KAGMAAIA-DPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQ 616
Cdd:cd05917   293 EEVCAWIRlKEGAELTEEDIKAYCKGKIAHYKVPRYVFFVDEFPLTVSGKIQKFKLR 349
PRK04319 PRK04319
acetyl-CoA synthetase; Provisional
102-553 9.92e-19

acetyl-CoA synthetase; Provisional


Pssm-ID: 235279 [Multi-domain]  Cd Length: 570  Bit Score: 89.95  E-value: 9.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 102 ERLAL--VDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLeGR-PEFVGLWLGLAKAGVVAALLNVNLRREPL 178
Cdd:PRK04319   59 DKVALryLDASRKEKYTYKELKELSNKFANVLKELGVEKGDRVFIFM-PRiPELYFALLGALKNGAIVGPLFEAFMEEAV 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 179 AFCLGTSAAKALIYGGEMAAAVaeVSEQLGKslLK--FCSGDLGPESilPDTQLLDPMLAEAPTTplAQAPGKGMDDRLF 256
Cdd:PRK04319  138 RDRLEDSEAKVLITTPALLERK--PADDLPS--LKhvLLVGEDVEEG--PGTLDFNALMEQASDE--FDIEWTDREDGAI 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 257 YIYTSGTTGLPKAAIVVHSryyriAAFGHH---SYSM--RAADVlYDCL---------------PLYHSAGNimgvgqcv 316
Cdd:PRK04319  210 LHYTSGSTGKPKGVLHVHN-----AMLQHYqtgKYVLdlHEDDV-YWCTadpgwvtgtsygifaPWLNGATN-------- 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 317 iygltVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVrDVEQRH-----RVRLAVGNGLRP-AIWeeFTQR-F 389
Cdd:PRK04319  276 -----VIDGGRFSPERWYRILEDYKVTVWYTAPTAIRMLMGAGD-DLVKKYdlsslRHILSVGEPLNPeVVR--WGMKvF 347
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 390 GVPqIGEFYGATECNCS-IAN---MDGKVGSCGfnsRILTHVYpIRLVKVNEDTMEPLRDSEgLCIpcQPGEPGLLVGQI 465
Cdd:PRK04319  348 GLP-IHDNWWMTETGGImIANypaMDIKPGSMG---KPLPGIE-AAIVDDQGNELPPNRMGN-LAI--KKGWPSMMRGIW 419
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 466 NQQDplrRFDGYvsdsatnkkiahsvFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEavlSRLLGQ 545
Cdd:PRK04319  420 NNPE---KYESY--------------FAGD--WYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVE---SKLMEH 477

                  ....*...
gi 1907189407 546 TDVAVYGV 553
Cdd:PRK04319  478 PAVAEAGV 485
PRK08315 PRK08315
AMP-binding domain protein; Validated
86-323 1.48e-18

AMP-binding domain protein; Validated


Pssm-ID: 236236 [Multi-domain]  Cd Length: 559  Bit Score: 89.48  E-value: 1.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  86 GDTIPCIFQAVARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVV 165
Cdd:PRK08315   15 EQTIGQLLDRTAARYPDREALVYRDQGLRWTYREFNEEVDALAKGLLALGIEKGDRVGIWAPNVPEWVLTQFATAKIGAI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 166 aaLLNVN--LRREPLAFCLGTSAAKALIYGG--------EMAAAVA-EVSEQLGKSL-------LKF-CSgdLGPESIlP 226
Cdd:PRK08315   95 --LVTINpaYRLSELEYALNQSGCKALIAADgfkdsdyvAMLYELApELATCEPGQLqsarlpeLRRvIF--LGDEKH-P 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 227 DTQLLDPMLAEAPTTPLAQ--APGKGM--DDRLFYIYTSGTTGLPKAAIVVHsryYRIAAFGHH-SYSMR--AADVLYDC 299
Cdd:PRK08315  170 GMLNFDELLALGRAVDDAElaARQATLdpDDPINIQYTSGTTGFPKGATLTH---RNILNNGYFiGEAMKltEEDRLCIP 246
                         250       260
                  ....*....|....*....|....
gi 1907189407 300 LPLYHSAGNIMGVGQCVIYGLTVV 323
Cdd:PRK08315  247 VPLYHCFGMVLGNLACVTHGATMV 270
PRK08314 PRK08314
long-chain-fatty-acid--CoA ligase; Validated
97-541 2.06e-18

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236235 [Multi-domain]  Cd Length: 546  Bit Score: 88.86  E-value: 2.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGIcwTFAQLDTYSNAVAN-LFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRR 175
Cdd:PRK08314   20 ARRYPDKTAIVFYGRAI--SYRELLEEAERLAGyLQQECGVRKGDRVLLYMQNSPQFVIAYYAILRANAVVVPVNPMNRE 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 176 EPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLG-KSLLKFCSGDL---GPESILPD---TQLLDPMLAEAPTTPLAQA-- 246
Cdd:PRK08314   98 EELAHYVTDSGARVAIVGSELAPKVAPAVGNLRlRHVIVAQYSDYlpaEPEIAVPAwlrAEPPLQALAPGGVVAWKEAla 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 247 ----PGK---GMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYG 319
Cdd:PRK08314  178 aglaPPPhtaGPDDLAVLPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPESVVLAVLPLFHVTGMVHSMNAPIYAG 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 320 LTVVLrkkfsASRfWD-----DCV-KYNCTVVQYIGEICRYLLRQPvrDVEQRHRVRLA-VGNG---LRPAIWEEFTQRF 389
Cdd:PRK08314  258 ATVVL-----MPR-WDreaaaRLIeRYRVTHWTNIPTMVVDFLASP--GLAERDLSSLRyIGGGgaaMPEAVAERLKELT 329
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 390 GVPQIgEFYGATECNC-SIAN-MDGKVGSC------GFNSRIlthvypirlvkVNEDTMEPLrdseglcipcQPGEpgll 461
Cdd:PRK08314  330 GLDYV-EGYGLTETMAqTHSNpPDRPKLQClgiptfGVDARV-----------IDPETLEEL----------PPGE---- 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 462 VGQINQQDPlRRFDGYVSDSATNKKI-----AHSVFRKGDSAYlsgdvlvMDELGYMYFRDRSGDTFRWRGENVSTTEVE 536
Cdd:PRK08314  384 VGEIVVHGP-QVFKGYWNRPEATAEAfieidGKRFFRTGDLGR-------MDEEGYFFITDRLKRMINASGFKVWPAEVE 455

                  ....*
gi 1907189407 537 AVLSR 541
Cdd:PRK08314  456 NLLYK 460
PRK05605 PRK05605
long-chain-fatty-acid--CoA ligase; Validated
86-593 2.34e-17

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235531 [Multi-domain]  Cd Length: 573  Bit Score: 85.82  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  86 GDTIPCIFQAVARRQPERLALvdASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVV 165
Cdd:PRK05605   31 DTTLVDLYDNAVARFGDRPAL--DFFGATTTYAELGKQVRRAAAGLRALGVRPGDRVAIVLPNCPQHIVAFYAVLRLGAV 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 166 AALLNVNLRREPLAFCLGTSAAKALIYGGEmaaaVAEVSEQLgksllkfcSGDLGPESI--------LPDTQLL------ 231
Cdd:PRK05605  109 VVEHNPLYTAHELEHPFEDHGARVAIVWDK----VAPTVERL--------RRTTPLETIvsvnmiaaMPLLQRLalrlpi 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 232 -------DPMLAEAP-TTPLAQ-----APGKGM---------DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHH--S 287
Cdd:PRK05605  177 palrkarAALTGPAPgTVPWETlvdaaIGGDGSdvshprptpDDVALILYTSGTTGKPKGAQLTHRNLFANAAQGKAwvP 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 288 YSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEIcrYllrQPVRDVEQRH 367
Cdd:PRK05605  257 GLGDGPERVLAALPMFHAYGLTLCLTLAVSIGGELVLLPAPDIDLILDAMKKHPPTWLPGVPPL--Y---EKIAEAAEER 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 368 RVRLavgNGLRPAI-------------WEEFTQRFGVpqigEFYGATECN----CSIANMDGKVGSCG--FNSRIlthvy 428
Cdd:PRK05605  332 GVDL---SGVRNAFsgamalpvstvelWEKLTGGLLV----EGYGLTETSpiivGNPMSDDRRPGYVGvpFPDTE----- 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 429 pIRLVkvneDTMEPLRDseglcIPcqPGEPG-LLVgqinqQDPlRRFDGYVSDSATNKKIAHsvfrkgDSAYLSGDVLVM 507
Cdd:PRK05605  400 -VRIV----DPEDPDET-----MP--DGEEGeLLV-----RGP-QVFKGYWNRPEETAKSFL------DGWFRTGDVVVM 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 508 DELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVygVAVPGVEGKAGMAA--IADPHSQLDPNSMYQELQK 585
Cdd:PRK05605  456 EEDGFIRIVDRIKELIITGGFNVYPAEVEEVLREHPGVEDAAV--VGLPREDGSEEVVAavVLEPGAALDPEGLRAYCRE 533

                  ....*...
gi 1907189407 586 VLASYARP 593
Cdd:PRK05605  534 HLTRYKVP 541
PLN02246 PLN02246
4-coumarate--CoA ligase
92-568 2.97e-17

4-coumarate--CoA ligase


Pssm-ID: 215137 [Multi-domain]  Cd Length: 537  Bit Score: 85.42  E-value: 2.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRqPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:PLN02246   29 CFERLSEF-SDRPCLIDGATGRVYTYADVELLSRRVAAGLHKLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTANP 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLRREPLAFCLGTSAAKALIyggEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQapgkgm 251
Cdd:PLN02246  108 FYTPAEIAKQAKASGAKLII---TQSCYVDKLKGLAEDDGVTVVTIDDPPEGCLHFSELTQADENELPEVEISP------ 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVH-SRYYRIAAF--GHH-SYSMRAADVLYDCLPLYH--SAGNIMGVGQCViyGLTVVLR 325
Cdd:PLN02246  179 DDVVALPYSSGTTGLPKGVMLTHkGLVTSVAQQvdGENpNLYFHSDDVILCVLPMFHiySLNSVLLCGLRV--GAAILIM 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 326 KKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLaVGNGLRPAIWE-EFTQRFGVPQ--IGEFYGATE 402
Cdd:PLN02246  257 PKFEIGALLELIQRHKVTIAPFVPPIVLAIAKSPVVEKYDLSSIRM-VLSGAAPLGKElEDAFRAKLPNavLGQGYGMTE 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CNCSIAnM---------DGKVGSCGfnsrilTHVYPIRLVKVNEDTMEPLRDSeglcipcQPGEPGLLVGQInqqdplrr 473
Cdd:PLN02246  336 AGPVLA-MclafakepfPVKSGSCG------TVVRNAELKIVDPETGASLPRN-------QPGEICIRGPQI-------- 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 474 FDGYVSD-SATNKKI-----AHSvfrkGDSAYLSGDvlvmDElgyMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTD 547
Cdd:PLN02246  394 MKGYLNDpEATANTIdkdgwLHT----GDIGYIDDD----DE---LFIVDRLKELIKYKGFQVAPAELEALLISHPSIAD 462
                         490       500
                  ....*....|....*....|.
gi 1907189407 548 VAVygvaVPGVEGKAGMAAIA 568
Cdd:PLN02246  463 AAV----VPMKDEVAGEVPVA 479
PLN02574 PLN02574
4-coumarate--CoA ligase-like
87-553 4.55e-17

4-coumarate--CoA ligase-like


Pssm-ID: 215312 [Multi-domain]  Cd Length: 560  Bit Score: 84.89  E-value: 4.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  87 DTIPCIFQAVARrqPERLALVDASSGICWTFAQLDTYSNAVAN-LFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVV 165
Cdd:PLN02574   41 DAVSFIFSHHNH--NGDTALIDSSTGFSISYSELQPLVKSMAAgLYHVMGVRQGDVVLLLLPNSVYFPVIFLAVLSLGGI 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 166 AALLNvnlrrePLAfCLGTSAAKALIYGGEMAAAVAEVSEQLGKsllkfcsgdLG-PESILPDTQLLDPMLAEAPT---- 240
Cdd:PLN02574  119 VTTMN------PSS-SLGEIKKRVVDCSVGLAFTSPENVEKLSP---------LGvPVIGVPENYDFDSKRIEFPKfyel 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 241 ----TPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYyrIAA------FGHHSYSMRAADVLY-DCLPLYHSAGNI 309
Cdd:PLN02574  183 ikedFDFVPKPVIKQDDVAAIMYSSGTTGASKGVVLTHRNL--IAMvelfvrFEASQYEYPGSDNVYlAALPMFHIYGLS 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 310 MGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPA---IWEEFT 386
Cdd:PLN02574  261 LFVVGLLSLGSTIVVMRRFDASDMVKVIDRFKVTHFPVVPPILMALTKKAKGVCGEVLKSLKQVSCGAAPLsgkFIQDFV 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 387 QRFGVPQIGEFYGATEcncSIAnmdgkVGSCGFNSRILTHVYPIRLVKVNedtMEP--LRDSEGLCIPcqPGE------- 457
Cdd:PLN02574  341 QTLPHVDFIQGYGMTE---STA-----VGTRGFNTEKLSKYSSVGLLAPN---MQAkvVDWSTGCLLP--PGNcgelwiq 407
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 458 -PGLLVGQINqqdplrrfDGYVSDSATNKkiahsvfrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVE 536
Cdd:PLN02574  408 gPGVMKGYLN--------NPKATQSTIDK----------DGWLRTGDIAYFDEDGYLYIVDRLKEIIKYKGFQIAPADLE 469
                         490
                  ....*....|....*..
gi 1907189407 537 AVLSRLLGQTDVAVYGV 553
Cdd:PLN02574  470 AVLISHPEIIDAAVTAV 486
BACL_like cd05929
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ...
118-615 4.99e-17

Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.


Pssm-ID: 341252 [Multi-domain]  Cd Length: 473  Bit Score: 84.35  E-value: 4.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 118 AQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLakaGVVAALLNVNLRREPLAF---CLGTSAAKALIYGG 194
Cdd:cd05929     2 EARDLDRAQVFHQRRLLLLDVYSIALNRNARAAAAEGVWIAD---GVYIYLINSILTVFAAAAawkCGACPAYKSSRAPR 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 EMAAAVAEVseqlgKSLLKFCSGDLGPESILPDTQLlDPMLAEAPTTPLA-QAPGKGMddrlfyIYTSGTTGLPKA---- 269
Cdd:cd05929    79 AEACAIIEI-----KAAALVCGLFTGGGALDGLEDY-EAAEGGSPETPIEdEAAGWKM------LYSGGTTGRPKGikrg 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 270 --AIVVHSRYYRIAAFGhhsYSMRAADVLYDCLPLYHSAGNI--MGVgqcVIYGLTVVLRKKFSASRFWDDCVKYNCTVV 345
Cdd:cd05929   147 lpGGPPDNDTLMAAALG---FGPGADSVYLSPAPLYHAAPFRwsMTA---LFMGGTLVLMEKFDPEEFLRLIERYRVTFA 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 346 QYIGEICRYLLRQP--VRDVEQRHRVRLAVGNGLRPAIW-EEFTQRFGVPQIGEFYGATECNcsianmdgkvGSCGFNS- 421
Cdd:cd05929   221 QFVPTMFVRLLKLPeaVRNAYDLSSLKRVIHAAAPCPPWvKEQWIDWGGPIIWEYYGGTEGQ----------GLTIINGe 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 422 RILTHvyPIRLVKVNEDTMEpLRDSEGLciPCQPGEPGLLVgqinqqdplrrFDGYVSDSATNK--KIAHSVFRKGDSAY 499
Cdd:cd05929   291 EWLTH--PGSVGRAVLGKVH-ILDEDGN--EVPPGEIGEVY-----------FANGPGFEYTNDpeKTAAARNEGGWSTL 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 500 lsGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGvaVPGVE-GKAGMAAIaDPHSQLDPNS 578
Cdd:cd05929   355 --GDVGYLDEDGYLYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVVG--VPDEElGQRVHAVV-QPAPGADAGT 429
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 1907189407 579 MYQE-----LQKVLASYARP---IFLRLLPQVDTTgtfKIQKTRL 615
Cdd:cd05929   430 ALAEeliafLRDRLSRYKCPrsiEFVAELPRDDTG---KLYRRLL 471
ttLC_FACS_AEE21_like cd12118
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ...
101-556 6.29e-17

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.


Pssm-ID: 341283 [Multi-domain]  Cd Length: 486  Bit Score: 83.89  E-value: 6.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASsgICWTFAQldTYSNAV--ANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPL 178
Cdd:cd12118    18 PDRTSIVYGD--RRYTWRQ--TYDRCRrlASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTRLDAEEI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 179 AFCLGTSAAKALIyggemaaavaeVSEQL-GKSLLKfcSGDLGPESILPDTQlldpmlaeapttplaqapgkgmDDRLFY 257
Cdd:cd12118    94 AFILRHSEAKVLF-----------VDREFeYEDLLA--EGDPDFEWIPPADE----------------------WDPIAL 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 258 IYTSGTTGLPKAaIVVHSRYYRIAAFGH-HSYSMRAADVLYDCLPLYHSAG--NIMGVGqcVIYGLTVVLRKkFSASRFW 334
Cdd:cd12118   139 NYTSGTTGRPKG-VVYHHRGAYLNALANiLEWEMKQHPVYLWTLPMFHCNGwcFPWTVA--AVGGTNVCLRK-VDAKAIY 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 335 DDCVKYNCT-------VVQYIGEiCRYLLRQPVRdveqrHRVRLAVGNGLRPAIWEEFTQRFGVpQIGEFYGATECNcsi 407
Cdd:cd12118   215 DLIEKHKVThfcgaptVLNMLAN-APPSDARPLP-----HRVHVMTAGAPPPAAVLAKMEELGF-DVTHVYGLTETY--- 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 408 anmdGKVGSC---------------GFNSRI-LTHVYPIRLVKVNEDTMEPL-RDSEGLcipcqpGEPgLLVGQINQQdp 470
Cdd:cd12118   285 ----GPATVCawkpewdelpteeraRLKARQgVRYVGLEEVDVLDPETMKPVpRDGKTI------GEI-VFRGNIVMK-- 351
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 471 lrrfdGYVSDSATNKKiahsVFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAV 550
Cdd:cd12118   352 -----GYLKNPEATAE----AFRGG--WFHSGDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVLEAAV 420

                  ....*.
gi 1907189407 551 ygVAVP 556
Cdd:cd12118   421 --VARP 424
PRK06710 PRK06710
long-chain-fatty-acid--CoA ligase; Validated
82-618 2.24e-16

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 180666 [Multi-domain]  Cd Length: 563  Bit Score: 82.77  E-value: 2.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  82 HRRAGDTIPC--IFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGL 159
Cdd:PRK06710   17 STISYDIQPLhkYVEQMASRYPEKKALHFLGKDI--TFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGT 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 160 AKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLG---------KSLLKFCSGDLGPESILPDTQL 230
Cdd:PRK06710   95 LLAGGIVVQTNPLYTERELEYQLHDSGAKVILCLDLVFPRVTNVQSATKiehvivtriADFLPFPKNLLYPFVQKKQSNL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 231 LdPMLAEAPTTPLAQAPGKGMD-----------DRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFG-HHSYS-MRAADVLY 297
Cdd:PRK06710  175 V-VKVSESETIHLWNSVEKEVNtgvevpcdpenDLALLQYTGGTTGFPKGVMLTHKNLVSNTLMGvQWLYNcKEGEEVVL 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 298 DCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAV-GNG 376
Cdd:PRK06710  254 GVLPFFHVYGMTAVMNLSIMQGYKMVLIPKFDMKMVFEAIKKHKVTLFPGAPTIYIALLNSPLLKEYDISSIRACIsGSA 333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 377 LRPAIWEEFTQRFGVPQIGEFYGATEcncsianmdgkvgscgfnSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPG 456
Cdd:PRK06710  334 PLPVEVQEKFETVTGGKLVEGYGLTE------------------SSPVTHSNFLWEKRVPGSIGVPWPDTEAMIMSLETG 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 457 E---PGLlVGQINQQDPlRRFDGYVSDSATNKKIAHsvfrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTT 533
Cdd:PRK06710  396 EalpPGE-IGEIVVKGP-QIMKGYWNKPEETAAVLQ------DGWLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPR 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 534 EVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKT 613
Cdd:PRK06710  468 EVEEVLYEHEKVQEVVTIGVPDPYRGETVKAFVVLKEGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRR 547

                  ....*
gi 1907189407 614 RLQRE 618
Cdd:PRK06710  548 VLIEE 552
A_NRPS_TlmIV_like cd12114
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ...
101-615 2.59e-16

The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.


Pssm-ID: 341279 [Multi-domain]  Cd Length: 477  Bit Score: 81.93  E-value: 2.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAF 180
Cdd:cd12114     1 PDATAVICG--DGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 181 CLGTSAAKALIyggemaaavaevseqlgksllkFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPgkGMDDRLFYIYT 260
Cdd:cd12114    79 ILADAGARLVL----------------------TDGPDAQLDVAVFDVLILDLDALAAPAPPPPVDV--APDDLAYVIFT 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 261 SGTTGLPKAAIVVHSRYYR-IAAFGHHsYSMRAADVLYDCLPLYH--SAGNIMGVgqcVIYGLTVVL----RKKFSASrf 333
Cdd:cd12114   135 SGSTGTPKGVMISHRAALNtILDINRR-FAVGPDDRVLALSSLSFdlSVYDIFGA---LSAGATLVLpdeaRRRDPAH-- 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 334 WDDCV-KYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLA------VGNGLRPAIWeeftQRFGVPQIGEFYGATEcncs 406
Cdd:cd12114   209 WAELIeRHGVTLWNSVPALLEMLLDVLEAAQALLPSLRLVllsgdwIPLDLPARLR----ALAPDARLISLGGATE---- 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 407 ianmdgkvGScgfnsrILTHVYPIRlvKVNEDTME-----PLR-------DSEGLciPCQPGEPG-LLVGQIN-----QQ 468
Cdd:cd12114   281 --------AS------IWSIYHPID--EVPPDWRSipygrPLAnqryrvlDPRGR--DCPDWVPGeLWIGGRGvalgyLG 342
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 469 DPLRRFDGYVSDSAtnkkiAHSVFRKGDSAYLSGDvlvmdelGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDV 548
Cdd:cd12114   343 DPELTAARFVTHPD-----GERLYRTGDLGRYRPD-------GTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARA 410
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407 549 AVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd12114   411 VVVVLGDPGGKRLAAFVVPDNDGTPIAPDALRAFLAQTLPAYMIPSRVIALEALPLTANGKVDRAAL 477
AAS_C cd05909
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ...
252-556 1.07e-15

C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.


Pssm-ID: 341235 [Multi-domain]  Cd Length: 490  Bit Score: 80.07  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVH----SRYYRIAAFghhsYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLR-- 325
Cdd:cd05909   147 DDPAVILFTSGSEGLPKGVVLSHknllANVEQITAI----FDPNPEDVVFGALPFFHSFGLTGCLWLPLLSGIKVVFHpn 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 326 ----KKFSasRFWDDcvkYNCTVVQYIGEICRYLLR--QPvrdvEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPqIGEF 397
Cdd:cd05909   223 pldyKKIP--ELIYD---KKATILLGTPTFLRGYARaaHP----EDFSSLRLVVagAEKLKDTLRQEFQEKFGIR-ILEG 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 398 YGATEC----NCSIANMDGKVGSCGfnsRILTHVyPIRLVKVnedtmeplrdsEGLCiPCQPGEPGLLVGQINQqdplrR 473
Cdd:cd05909   293 YGTTECspviSVNTPQSPNKEGTVG---RPLPGM-EVKIVSV-----------ETHE-EVPIGEGGLLLVRGPN-----V 351
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 474 FDGYVSDSatnkkiAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQtDVAVYGV 553
Cdd:cd05909   352 MLGYLNEP------ELTSFAFGDGWYDTGDIGKIDGEGFLTITGRLSRFAKIAGEMVSLEAIEDILSEILPE-DNEVAVV 424

                  ...
gi 1907189407 554 AVP 556
Cdd:cd05909   425 SVP 427
PRK12316 PRK12316
peptide synthase; Provisional
53-624 1.34e-15

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 81.16  E-value: 1.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   53 RFLRIVCKTARRDLFGLSVLIRV--RLELRRHRRAGDTIPC------IFQAVARRQPERLALVdaSSGICWTFAQLDTYS 124
Cdd:PRK12316  1961 HLLEQMAEDAQAALGELALLDAGerQRILADWDRTPEAYPRgpgvhqRIAEQAARAPEAIAVV--FGDQHLSYAELDSRA 2038
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  125 NAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAavaevs 204
Cdd:PRK12316  2039 NRLAHRLRARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVPLDPNYPAERLAYMLEDSGAALLLTQRHLLE------ 2112
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  205 eqlgksllkfcsgDLGPESILPDTQLLDPM-LAEAPTT-PLAQAPGkgmDDRLFYIYTSGTTGLPKAAIVVHSRYY-RIA 281
Cdd:PRK12316  2113 -------------RLPLPAGVARLPLDRDAeWADYPDTaPAVQLAG---ENLAYVIYTSGSTGLPKGVAVSHGALVaHCQ 2176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  282 AFGhHSYSMRAADVLYDCLPLYHSaGNIMGVGQCVIYGLTVVLR--KKFSASRFWDDCVKYNCTVVQYIGEicrYLlrQP 359
Cdd:PRK12316  2177 AAG-ERYELSPADCELQFMSFSFD-GAHEQWFHPLLNGARVLIRddELWDPEQLYDEMERHGVTILDFPPV---YL--QQ 2249
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  360 VRDVEQRHRVRLAV------GNGLRPAIWEEFTQRFGVPQIGEFYGATEcncsiANMDGKVGSCGFNSRILTHVYPI--- 430
Cdd:PRK12316  2250 LAEHAERDGRPPAVrvycfgGEAVPAASLRLAWEALRPVYLFNGYGPTE-----AVVTPLLWKCRPQDPCGAAYVPIgra 2324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  431 ---RLVKVNEDTMEPLrdSEGLCIPCQPGEPGLLVGQINQqdPLRRFDGYVSDSATNkkiahsvfrKGDSAYLSGDVLVM 507
Cdd:PRK12316  2325 lgnRRAYILDADLNLL--APGMAGELYLGGEGLARGYLNR--PGLTAERFVPDPFSA---------SGERLYRTGDLARY 2391
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  508 DELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVygVAVPGVEGKAGMA-AIADPHSQLDPNSMYQELQKV 586
Cdd:PRK12316  2392 RADGVVEYLGRIDHQVKIRGFRIELGEIEARLQAHPAVREAVV--VAQDGASGKQLVAyVVPDDAAEDLLAELRAWLAAR 2469
                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1907189407  587 LASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQ 624
Cdd:PRK12316  2470 LPAYMVPAHWVVLERLPLNPNGKLDRKALPKPDVSQLR 2507
23DHB-AMP_lg cd05920
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ...
80-615 1.83e-15

2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.


Pssm-ID: 341244 [Multi-domain]  Cd Length: 482  Bit Score: 79.29  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  80 RRHRRAG----DTIPCIFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGL 155
Cdd:cd05920     4 RRYRAAGywqdEPLGDLLARSAARHPDRIAVVDG--DRRLTYRELDRRADRLAAGLRGLGIRPGDRVVVQLPNVAEFVVL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 156 WLGLAKAGVVAAL-LNVNLRREPLAFClGTSAAKALIyggemaaavaeVSEQLGksllKFCSGDLGPEsilpdtqlldpM 234
Cdd:cd05920    82 FFALLRLGAVPVLaLPSHRRSELSAFC-AHAEAVAYI-----------VPDRHA----GFDHRALARE-----------L 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 235 LAEAPTTPLAQAPGkgmddrlfyiytsGTTGLPKAAIVVHSRYyriaafghhSYSMRAA--------DVLYDC-LPLYH- 304
Cdd:cd05920   135 AESIPEVALFLLSG-------------GTTGTPKLIPRTHNDY---------AYNVRASaevcgldqDTVYLAvLPAAHn 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 305 ---SAGNIMGVGQCviyGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLL--RQPVRDVEQRHRVRLAVGNGLRP 379
Cdd:cd05920   193 fplACPGVLGTLLA---GGRVVLAPDPSPDAAFPLIEREGVTVTALVPALVSLWLdaAASRRADLSSLRLLQVGGARLSP 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 380 AIWEEFTQRFGvPQIGEFYGATE---CNCSIANMDGKVgsCGFNSRILTHVYPIRLVkvnedtmeplrDSEGLCIPcqPG 456
Cdd:cd05920   270 ALARRVPPVLG-CTLQQVFGMAEgllNYTRLDDPDEVI--IHTQGRPMSPDDEIRVV-----------DEEGNPVP--PG 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 457 EPGLLvgqinqqdpLRR----FDGYVSDSATNKKiahsVFRKgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVST 532
Cdd:cd05920   334 EEGEL---------LTRgpytIRGYYRAPEHNAR----AFTP-DGFYRTGDLVRRTPDGYLVVEGRIKDQINRGGEKIAA 399
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 533 TEVEAVLSRLLGQTDVAVygVAVPG-VEGKAGMAAIADPHSQLDPNSMYQEL-QKVLASYARPIFLRLLPQVDTTGTFKI 610
Cdd:cd05920   400 EEVENLLLRHPAVHDAAV--VAMPDeLLGERSCAFVVLRDPPPSAAQLRRFLrERGLAAYKLPDRIEFVDSLPLTAVGKI 477

                  ....*
gi 1907189407 611 QKTRL 615
Cdd:cd05920   478 DKKAL 482
FadD3 cd17638
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ...
258-612 4.51e-15

acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.


Pssm-ID: 341293 [Multi-domain]  Cd Length: 330  Bit Score: 76.77  E-value: 4.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 258 IYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDC 337
Cdd:cd17638     6 MFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDDRYLIINPFFHTFGYKAGIVACLLTGATVVPVAVFDVDAILEAI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 338 VKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAV-GNGLRPAIW-EEFTQRFGVPQIGEFYGATECNCSianmdgkvg 415
Cdd:cd17638    86 ERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVtGAATVPVELvRRMRSELGFETVLTAYGLTEAGVA--------- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 416 scgfnsrilthvypirlvkvnedTM-EPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRR----FDGYVSD-SATNKKIah 489
Cdd:cd17638   157 -----------------------TMcRPGDDAETVATTCGRACPGFEVRIADDGEVLVRgynvMQGYLDDpEATAEAI-- 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 490 svfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVeGKAGMA-AIA 568
Cdd:cd17638   212 ----DADGWLHTGDVGELDERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERM-GEVGKAfVVA 286
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1907189407 569 DPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQK 612
Cdd:cd17638   287 RPGVTLTEEDVIAWCRERLANYKVPRFVRFLDELPRNASGKVMK 330
A_NRPS_LgrA-like cd17645
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ...
92-615 4.64e-15

adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.


Pssm-ID: 341300 [Multi-domain]  Cd Length: 440  Bit Score: 77.98  E-value: 4.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALVDasSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:cd17645     3 LFEEQVERTPDHVAVVD--RGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLRREPLAFCLGTSAAKALIyggemaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttplaqapgKGM 251
Cdd:cd17645    81 DYPGERIAYMLADSSAKILL---------------------------------------------------------TNP 103
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAAD--VLYDCLPLYHSAGNIMgvgQCVIYGLTVVL---RK 326
Cdd:cd17645   104 DDLAYVIYTSGSTGLPKGVMIEHHNLVNLCEWHRPYFGVTPADksLVYASFSFDASAWEIF---PHLTAGAALHVvpsER 180
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 327 KFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPvrdvEQRHRVRLAVGNGLRPAIWEEFtqrfgvpQIGEFYGATECN-- 404
Cdd:cd17645   181 RLDLDALNDYFNQEGITISFLPTGAAEQFMQLD----NQSLRVLLTGGDKLKKIERKGY-------KLVNNYGPTENTvv 249
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 405 CSIANMDGKVGSCGFNSRILThvypIRLVKVNED-TMEPLRDSEGLCIPcqpGEpGLLVGQINQQDplrrfdgyvsdsAT 483
Cdd:cd17645   250 ATSFEIDKPYANIPIGKPIDN----TRVYILDEAlQLQPIGVAGELCIA---GE-GLARGYLNRPE------------LT 309
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 484 NKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVygVAVPGVEGKAG 563
Cdd:cd17645   310 AEKFIVHPFVPGERMYRTGDLAKFLPDGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAV--LAKEDADGRKY 387
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 564 MAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd17645   388 LVAYVTAPEEIPHEELREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKAL 439
VL_LC_FACS_like cd05907
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ...
115-552 5.33e-15

Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341233 [Multi-domain]  Cd Length: 452  Bit Score: 77.64  E-value: 5.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIygg 194
Cdd:cd05907     6 ITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPTSSAEQIAYILNDSEAKALF--- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 emaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlAEAPttplaqapgkgmDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:cd05907    83 -----------------------------------------VEDP------------DDLATIIYTSGTTGRPKGVMLSH 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 275 SRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVV-----------LRKK-----FSASRFWDdcv 338
Cdd:cd05907   110 RNILSNALALAERLPATEGDRHLSFLPLAHVFERRAGLYVPLLAGARIYfassaetllddLSEVrptvfLAVPRVWE--- 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 339 K-YNCTVVQYIGEICRYLLRQPVRDveqrhRVRLAVGNG--LRPAIwEEFTQRFGVPqIGEFYGATECnCSIANM----D 411
Cdd:cd05907   187 KvYAAIKVKAVPGLKRKLFDLAVGG-----RLRFAASGGapLPAEL-LHFFRALGIP-VYEGYGLTET-SAVVTLnppgD 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 412 GKVGSCGfnsriltHVYPIRLVKVNEDtmeplrdseglcipcqpGEpgLLV-GQINqqdplrrFDGYVSDSATNKKIAhs 490
Cdd:cd05907   259 NRIGTVG-------KPLPGVEVRIADD-----------------GE--ILVrGPNV-------MLGYYKNPEATAEAL-- 303
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189407 491 vfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWR-GENVSTTEVEAVL--SRLLGQtdVAVYG 552
Cdd:cd05907   304 ---DADGWLHTGDLGEIDEDGFLHITGRKKDLIITSgGKNISPEPIENALkaSPLISQ--AVVIG 363
A_NRPS_PpsD_like cd17650
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ...
101-615 8.32e-15

similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341305 [Multi-domain]  Cd Length: 447  Bit Score: 77.12  E-value: 8.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAF 180
Cdd:cd17650     1 PDAIAVSDATRQL--TYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 181 CLGTSAAKALiyggemaaavaevseqlgksllkfcsgdlgpesilpdtqLLDPmlaeapttplaqapgkgmDDRLFYIYT 260
Cdd:cd17650    79 MLEDSGAKLL---------------------------------------LTQP------------------EDLAYVIYT 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 261 SGTTGLPKAAIVVHS----------RYYRIAAFGHHSYSMR--AADVLYDCLPLYHSAGnimgvGQCVIygltVVLRKKF 328
Cdd:cd17650   102 SGTTGKPKGVMVEHRnvahaahawrREYELDSFPVRLLQMAsfSFDVFAGDFARSLLNG-----GTLVI----CPDEVKL 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 329 SASRFWDDCVKYNCTVVQYIGEICRyllrqPVRDVEQRHRVR------LAVGNGLRPAIW-EEFTQRFGVP-QIGEFYGA 400
Cdd:cd17650   173 DPAALYDLILKSRITLMESTPALIR-----PVMAYVYRNGLDlsamrlLIVGSDGCKAQDfKTLAARFGQGmRIINSYGV 247
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 401 TEcncsiANMDGKVGSCGFNSRILTHVYPI-------RLVKVNE-DTMEPLRDSEGLCIpcqpGEPGLLVGQINQQDplr 472
Cdd:cd17650   248 TE-----ATIDSTYYEEGRDPLGDSANVPIgrplpntAMYVLDErLQPQPVGVAGELYI----GGAGVARGYLNRPE--- 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 473 rfdgyvsdsATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVyg 552
Cdd:cd17650   316 ---------LTAERFVENPFAPGERMYRTGDLARWRADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDEAVV-- 384
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907189407 553 VAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd17650   385 AVREDKGGEARLCAYVVAAATLNTAELRAFLAKELPSYMIPSYYVQLDALPLTPNGKVDRRAL 447
FAAL cd05931
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ...
97-324 2.98e-14

Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.


Pssm-ID: 341254 [Multi-domain]  Cd Length: 547  Bit Score: 75.74  E-value: 2.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALV----DASSGICWTFAQLDTYSNAVANLFRQLGfAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALL--- 169
Cdd:cd05931     3 AAARPDRPAYTflddEGGREETLTYAELDRRARAIAARLQAVG-KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAVPLppp 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 170 --NVNLRRepLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKsllkfcsgdlgpesiLPDTQLLDPMLAEAPTTPLAQAP 247
Cdd:cd05931    82 tpGRHAER--LAAILADAGPRVVLTTAAALAAVRAFAASRPA---------------AGTPRLLVVDLLPDTSAADWPPP 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 248 GKGMDDRLFYIYTSGTTGLPKAAIVVHsryyriAAFGH------HSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLT 321
Cdd:cd05931   145 SPDPDDIAYLQYTSGSTGTPKGVVVTH------RNLLAnvrqirRAYGLDPGDVVVSWLPLYHDMGLIGGLLTPLYSGGP 218

                  ...
gi 1907189407 322 VVL 324
Cdd:cd05931   219 SVL 221
Firefly_Luc cd17642
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ...
101-553 5.60e-14

insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.


Pssm-ID: 341297 [Multi-domain]  Cd Length: 532  Bit Score: 74.87  E-value: 5.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAF 180
Cdd:cd17642    31 PGTIAFTDAHTGVNYSYAEYLEMSVRLAEALKKYGLKQNDRIAVCSENSLQFFLPVIAGLFIGVGVAPTNDIYNERELDH 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 181 CLGTSAAKALIYGGEMAAAVAEVseqlgKSLLKFCSG--------DLGPESILPD--TQLLDPMLAEAPTTPlaqaPGKG 250
Cdd:cd17642   111 SLNISKPTIVFCSKKGLQKVLNV-----QKKLKIIKTiiildskeDYKGYQCLYTfiTQNLPPGFNEYDFKP----PSFD 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 251 MDDRLFYI-YTSGTTGLPKAAIVVHSRYyrIAAFGHHSYSMRAADVLYD-----CLPLYHSAGNIMGVGQcVIYGLTVVL 324
Cdd:cd17642   182 RDEQVALImNSSGSTGLPKGVQLTHKNI--VARFSHARDPIFGNQIIPDtailtVIPFHHGFGMFTTLGY-LICGFRVVL 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 325 RKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRD-VEQRHRVRLAVGNG-LRPAIWEEFTQRFGVPQIGEFYGATE 402
Cdd:cd17642   259 MYKFEEELFLRSLQDYKVQSALLVPTLFAFFAKSTLVDkYDLSNLHEIASGGApLSKEVGEAVAKRFKLPGIRQGYGLTE 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CNCSI---ANMDGKVGSCGfnsriltHVYPIRLVKVnedtMEPlrDSEGLCIPCQPGE-----PGLLVGQINQQDplrrf 474
Cdd:cd17642   339 TTSAIlitPEGDDKPGAVG-------KVVPFFYAKV----VDL--DTGKTLGPNERGElcvkgPMIMKGYVNNPE----- 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 475 dgyvsdsATNKKIAHsvfrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGV 553
Cdd:cd17642   401 -------ATKALIDK------DGWLHSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPKIFDAGVAGI 466
A_NRPS_Cytc1-like cd17643
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ...
101-615 5.96e-14

similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341298 [Multi-domain]  Cd Length: 450  Bit Score: 74.65  E-value: 5.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGvvAALLNVNLR--REPL 178
Cdd:cd17643     1 PEAVAVVDEDRRL--TYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAG--GAYVPIDPAypVERI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 179 AFCLGTSAAKALIyggemaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapTTPlaqapgkgmDDRLFYI 258
Cdd:cd17643    77 AFILADSGPSLLL------------------------------------------------TDP---------DDLAYVI 99
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 259 YTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYdclpLYHSAG------NIMGVgqcVIYGLTVVLRKKF---S 329
Cdd:cd17643   100 YTSGSTGRPKGVVVSHANVLALFAATQRWFGFNEDDVWT----LFHSYAfdfsvwEIWGA---LLHGGRLVVVPYEvarS 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 330 ASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGV--PQIGEFYGATEcnc 405
Cdd:cd17643   173 PEDFARLLRDEGVTVLNQTPSAFYQLVEAADRDGRDPLALRYVIfgGEALEAAMLRPWAGRFGLdrPQLVNMYGITE--- 249
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 406 sianmdgkvgscgfnSRILTHVYPIRLVKVNEDTMEP-----------LRDSEGLCIPcqPGEPGLLV--------GQIN 466
Cdd:cd17643   250 ---------------TTVHVTFRPLDAADLPAAAASPigrplpglrvyVLDADGRPVP--PGVVGELYvsgagvarGYLG 312
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 467 QQD-PLRRFdgyVSDSATNkkiahsvfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQ 545
Cdd:cd17643   313 RPElTAERF---VANPFGG---------PGSRMYRTGDLARRLPDGELEYLGRADEQVKIRGFRIELGEIEAALATHPSV 380
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 546 TDVAVygVAVPGVEGKAGMAA--IADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd17643   381 RDAAV--IVREDEPGDTRLVAyvVADDGAAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDRAAL 450
PRK05691 PRK05691
peptide synthase; Validated
85-623 6.58e-14

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 75.98  E-value: 6.58e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   85 AGDTIPCIFQAVARRQPERLALVdaSSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEF-VGLwLGLAKAG 163
Cdd:PRK05691  1129 AQAWLPELLNEQARQTPERIALV--WDGGSLDYAELHAQANRLAHYLRDKGVGPDVCVAIAAERSPQLlVGL-LAILKAG 1205
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  164 VVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSeqlgksllkfcsgdlGPESILPDTQLLDPMLAEAPTTPL 243
Cdd:PRK05691  1206 GAYVPLDPDYPAERLAYMLADSGVELLLTQSHLLERLPQAE---------------GVSAIALDSLHLDSWPSQAPGLHL 1270
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  244 AqapgkgmDDRLFY-IYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSagniMGVGQC---VIYG 319
Cdd:PRK05691  1271 H-------GDNLAYvIYTSGSTGQPKGVGNTHAALAERLQWMQATYALDDSDVLMQKAPISFD----VSVWECfwpLITG 1339
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  320 LTVVLR---KKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPvrDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPQI 394
Cdd:PRK05691  1340 CRLVLAgpgEHRDPQRIAELVQQYGVTTLHFVPPLLQLFIDEP--LAAACTSLRRLFsgGEALPAELRNRVLQRLPQVQL 1417
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  395 GEFYGATEC-------NCSIAnmDGKVGSCGfnsRILTHVypirLVKVNEDTMEPLrdseglcipcQPGEPG-LLVGQIN 466
Cdd:PRK05691  1418 HNRYGPTETainvthwQCQAE--DGERSPIG---RPLGNV----LCRVLDAELNLL----------PPGVAGeLCIGGAG 1478
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  467 qqdpLRRfdGYVSDSATNKK--IAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAvlsRLLG 544
Cdd:PRK05691  1479 ----LAR--GYLGRPALTAErfVPDPLGEDGARLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQA---RLLA 1549
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  545 QTDVAVYGVAVPgvEGKAGMAAI----ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL----- 615
Cdd:PRK05691  1550 QPGVAQAAVLVR--EGAAGAQLVgyytGEAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALpepvw 1627

                   ....*....
gi 1907189407  616 -QREGFDPR 623
Cdd:PRK05691  1628 qQREHVEPR 1636
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
80-556 1.98e-13

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 73.80  E-value: 1.98e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   80 RRHRRAGDTIPCIFQAVARRQPERLALVDaSSGICWTFAQLDTYSNAVANLFRQLgFAPGDVVAVFLegrPEFVG---LW 156
Cdd:PRK08633   608 KSRKEALPPLAEAWIDTAKRNWSRLAVAD-STGGELSYGKALTGALALARLLKRE-LKDEENVGILL---PPSVAgalAN 682
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  157 LGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIyggemaaavaeVSEQ-LGKSLLKFCSGDLGP-------ESILPDT 228
Cdd:PRK08633   683 LALLLAGKVPVNLNYTASEAALKSAIEQAQIKTVI-----------TSRKfLEKLKNKGFDLELPEnvkviylEDLKAKI 751
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  229 QLLDPMLAE-----APTTPLAQA--PGKGMDDRLFYIYTSGTTGLPKAAIVVHsryYRIAA--------FGhhsysMRAA 293
Cdd:PRK08633   752 SKVDKLTALlaarlLPARLLKRLygPTFKPDDTATIIFSSGSEGEPKGVMLSH---HNILSnieqisdvFN-----LRND 823
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  294 DVLYDCLPLYHSagnimgvgqcviYGLTV----VLRKKFSASRFWDD---------CVKYNCTVVQYIGEICRYLLRQPV 360
Cdd:PRK08633   824 DVILSSLPFFHS------------FGLTVtlwlPLLEGIKVVYHPDPtdalgiaklVAKHRATILLGTPTFLRLYLRNKK 891
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  361 RDVEQRHRVRLAVGNG--LRPAIWEEFTQRFGVPqIGEFYGATEC------NCSIANMDG-------KVGSCGfnsrilt 425
Cdd:PRK08633   892 LHPLMFASLRLVVAGAekLKPEVADAFEEKFGIR-ILEGYGATETspvasvNLPDVLAADfkrqtgsKEGSVG------- 963
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  426 HVYPIRLVK-VNEDTMEPLrdseglcipcQPGEPGL-LVGQINqqdplrRFDGYVSDSA-TNKKIAHSvfrKGDSAYLSG 502
Cdd:PRK08633   964 MPLPGVAVRiVDPETFEEL----------PPGEDGLiLIGGPQ------VMKGYLGDPEkTAEVIKDI---DGIGWYVTG 1024
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907189407  503 DVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVP 556
Cdd:PRK08633  1025 DKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEEELAKALGGEEVVFAVTAVP 1078
MACS_like_1 cd05974
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ...
116-539 2.50e-13

Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.


Pssm-ID: 341278 [Multi-domain]  Cd Length: 432  Bit Score: 72.60  E-value: 2.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVaallnvnlrreplafclgtsaakaliygge 195
Cdd:cd05974     2 SFAEMSARSSRVANFLRSIGVGRGDRILLMLGNVVELWEAMLAAMKLGAV------------------------------ 51
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 maaavaevseqlgksllkfcsgdlgpesILPDTQLLDP-----MLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKaa 270
Cdd:cd05974    52 ----------------------------VIPATTLLTPddlrdRVDRGGAVYAAVDENTHADDPMLLYFTSGTTSKPK-- 101
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 271 IVVHSryYRIAAFGHHS----YSMRAADVLYD-CLPLY--HSAGNIMG---VGQCVIygltVVLRKKFSASRFWDDCVKY 340
Cdd:cd05974   102 LVEHT--HRSYPVGHLStmywIGLKPGDVHWNiSSPGWakHAWSCFFApwnAGATVF----LFNYARFDAKRVLAALVRY 175
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 341 NCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVpQIGEFYGATECNCSIANMDGKVGSCGFN 420
Cdd:cd05974   176 GVTTLCAPPTVWRMLIQQDLASFDVKLREVVGAGEPLNPEVIEQVRRAWGL-TIRDGYGQTETTALVGNSPGQPVKAGSM 254
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 421 SRILTHvYPIRLVkvnedtmeplrDSEGLciPCQPGEPGLLVGQINqqdPLRRFDGYVSDSAtnkKIAHSVfrkGDSAYL 500
Cdd:cd05974   255 GRPLPG-YRVALL-----------DPDGA--PATEGEVALDLGDTR---PVGLMKGYAGDPD---KTAHAM---RGGYYR 311
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1907189407 501 SGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVL 539
Cdd:cd05974   312 TGDIAMRDEDGYLTYVGRADDVFKSSDYRISPFELESVL 350
PRK07638 PRK07638
acyl-CoA synthetase; Validated
97-616 2.69e-13

acyl-CoA synthetase; Validated


Pssm-ID: 236071 [Multi-domain]  Cd Length: 487  Bit Score: 72.50  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPgDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRRE 176
Cdd:PRK07638   11 ASLQPNKIAIKENDRVL--TYKDWFESVCKVANWLNEKESKN-KTIAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQD 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLAFCLGTSAAKALIyggemaaavaevseqlgksLLKFCSGDLGPEsilpDTQLLD-----PMLAEAPTTPlaqAPGKGM 251
Cdd:PRK07638   88 ELKERLAISNADMIV-------------------TERYKLNDLPDE----EGRVIEidewkRMIEKYLPTY---APIENV 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYI-YTSGTTGLPKAAIVVHSRYyrIAAF--GHHSYSMRAADVLYDCLPLYHSAgNIMGVGQCVIYGLTVVLRKKF 328
Cdd:PRK07638  142 QNAPFYMgFTSGSTGKPKAFLRAQQSW--LHSFdcNVHDFHMKREDSVLIAGTLVHSL-FLYGAISTLYVGQTVHLMRKF 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 329 SASRFWDDCVKYNCTVVQYIGEICRYLLRQPvRDVEQRHRVrlaVGNGlrpAIW-----EEFTQRFGVPQIGEFYGATEC 403
Cdd:PRK07638  219 IPNQVLDKLETENISVMYTVPTMLESLYKEN-RVIENKMKI---ISSG---AKWeaeakEKIKNIFPYAKLYEFYGASEL 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 404 NCSIANMDG----KVGSCGfnsrilTHVYPIRLVKVNEDTMEplrdseglcipCQPGEpgllVGQINQQDPLRrFDGYVS 479
Cdd:PRK07638  292 SFVTALVDEeserRPNSVG------RPFHNVQVRICNEAGEE-----------VQKGE----IGTVYVKSPQF-FMGYII 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 480 DSATNKKIAhsvfrkgDSAYLS-GDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgv 558
Cdd:PRK07638  350 GGVLARELN-------ADGWMTvRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDS-- 420
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907189407 559 egKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQ 616
Cdd:PRK07638  421 --YWGEKPVAIIKGSATKQQLKSFCLQRLSSFKIPKEWHFVDEIPYTNSGKIARMEAK 476
PRK09274 PRK09274
peptide synthase; Provisional
93-303 2.71e-13

peptide synthase; Provisional


Pssm-ID: 236443 [Multi-domain]  Cd Length: 552  Bit Score: 73.01  E-value: 2.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  93 FQAVARRQPERLALV-----DASSGICW---TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGV 164
Cdd:PRK09274   12 LPRAAQERPDQLAVAvpggrGADGKLAYdelSFAELDARSDAIAHGLNAAGIGRGMRAVLMVTPSLEFFALTFALFKAGA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 165 VAALLNVNLRREPLAFCLGTSAAKALIygGEMAAAVAEVSEQLGKSLLKF---CSGDLGPESILPDTQLLDPMLAEAPTT 241
Cdd:PRK09274   92 VPVLVDPGMGIKNLKQCLAEAQPDAFI--GIPKAHLARRLFGWGKPSVRRlvtVGGRLLWGGTTLATLLRDGAAAPFPMA 169
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907189407 242 PLAQapgkgmDDRLFYIYTSGTTGLPKAAIVVHSRYYR-IAAFGHHsYSMRAADVLYDCLPLY 303
Cdd:PRK09274  170 DLAP------DDMAAILFTSGSTGTPKGVVYTHGMFEAqIEALRED-YGIEPGEIDLPTFPLF 225
PLN02860 PLN02860
o-succinylbenzoate-CoA ligase
133-553 2.90e-13

o-succinylbenzoate-CoA ligase


Pssm-ID: 215464 [Multi-domain]  Cd Length: 563  Bit Score: 72.91  E-value: 2.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 133 QLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREplafclgtSAAKALiyggEMAAAVAEVSEQLGKS-- 210
Cdd:PLN02860   51 RLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYRWSFE--------EAKSAM----LLVRPVMLVTDETCSSwy 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 211 ---------------LLKFCSGDLGPE--SILPDTQLLDPMLAEaPTTPLAQAPgkgmDDRLFYIYTSGTTGLPKAAIVV 273
Cdd:PLN02860  119 eelqndrlpslmwqvFLESPSSSVFIFlnSFLTTEMLKQRALGT-TELDYAWAP----DDAVLICFTSGTTGRPKGVTIS 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 274 HSRYY-----RIAAFGHHSysmraADVLYDCLPLYH-----SAGNIMGVGQCviygltVVLRKKFSASRFWD----DCVK 339
Cdd:PLN02860  194 HSALIvqslaKIAIVGYGE-----DDVYLHTAPLCHigglsSALAMLMVGAC------HVLLPKFDAKAALQaikqHNVT 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 340 YNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGF 419
Cdd:PLN02860  263 SMITVPAMMADLISLTRKSMTWKVFPSVRKILNGGGSLSSRLLPDAKKLFPNAKLFSAYGMTEACSSLTFMTLHDPTLES 342
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 420 NSRILTHVYPIRLVKVNEdtmeplrdSEGLCI----P------CQPGEPGllVGQINQQDP---LRRFDGYVSDSATnkk 486
Cdd:PLN02860  343 PKQTLQTVNQTKSSSVHQ--------PQGVCVgkpaPhvelkiGLDESSR--VGRILTRGPhvmLGYWGQNSETASV--- 409
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407 487 iahsvfRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGV 553
Cdd:PLN02860  410 ------LSNDGWLDTGDIGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAVLSQHPGVASVVVVGV 470
FACL_like_4 cd05944
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
252-617 3.09e-13

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341266 [Multi-domain]  Cd Length: 359  Bit Score: 71.74  E-value: 3.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVL------R 325
Cdd:cd05944     2 DDVAAYFHTGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDDVLLCGLPLFHVNGSVVTLLTPLASGAHVVLagpagyR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 326 KKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPV-RDVEQrhrVRLAVGNG--LRPAIWEEFTQRFGVPqIGEFYGATE 402
Cdd:cd05944    82 NPGLFDNFWKLVERYRITSLSTVPTVYAALLQVPVnADISS---LRFAMSGAapLPVELRARFEDATGLP-VVEGYGLTE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CNCSIA----NMDGKVGSCGFNsrilthvYPIRLVKVNEDtmeplrDSEGLCI-PCQPGEpgllVGQINQQDPlRRFDGY 477
Cdd:cd05944   158 ATCLVAvnppDGPKRPGSVGLR-------LPYARVRIKVL------DGVGRLLrDCAPDE----VGEICVAGP-GVFGGY 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 478 V-SDSATNKKIAHSVFRKGDSAYLsgdvlvmDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRllgQTDVAVYGvAVP 556
Cdd:cd05944   220 LyTEGNKNAFVADGWLNTGDLGRL-------DADGYLFITGRAKDLIIRGGHNIDPALIEEALLR---HPAVAFAG-AVG 288
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 557 GVEGKAGMAAIAdpHSQLDPNSMYQELQkvLASYAR---------PIFLRLLPQVDTTGTFKIQKTRLQR 617
Cdd:cd05944   289 QPDAHAGELPVA--YVQLKPGAVVEEEE--LLAWARdhvperaavPKHIEVLEELPVTAVGKVFKPALRA 354
PRK08162 PRK08162
acyl-CoA synthetase; Validated
101-618 3.69e-13

acyl-CoA synthetase; Validated


Pssm-ID: 236169 [Multi-domain]  Cd Length: 545  Bit Score: 72.29  E-value: 3.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASSGICWtfaqLDTYSNA--VANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPL 178
Cdd:PRK08162   32 PDRPAVIHGDRRRTW----AETYARCrrLASALARRGIGRGDTVAVLLPNIPAMVEAHFGVPMAGAVLNTLNTRLDAASI 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 179 AFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLkFCSGDLGPEsiLPDTQLL-----DPMLAEAPTTPLAQAPgkgmDD 253
Cdd:PRK08162  108 AFMLRHGEAKVLIVDTEFAEVAREALALLPGPKP-LVIDVDDPE--YPGGRFIgaldyEAFLASGDPDFAWTLP----AD 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 254 RLFYI---YTSGTTGLPKaAIVVHSRYYRIAAFGHH-SYSMRAADVLYDCLPLYHSagNimgvGQC------VIYGLTVV 323
Cdd:PRK08162  181 EWDAIalnYTSGTTGNPK-GVVYHHRGAYLNALSNIlAWGMPKHPVYLWTLPMFHC--N----GWCfpwtvaARAGTNVC 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 324 LRkKFSASRFWDDCVKYNctVVQYIGE-ICRYLL-------RQPVrdveqRHRVRLAVGNGLRPAIWEEFTQRFGVpQIG 395
Cdd:PRK08162  254 LR-KVDPKLIFDLIREHG--VTHYCGApIVLSALinapaewRAGI-----DHPVHAMVAGAAPPAAVIAKMEEIGF-DLT 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 396 EFYGATECNcsianmdGKVGSC---------------GFNSRilTHV-YPIR--LVKVNEDTMEPL-RDSEGLcipcqpG 456
Cdd:PRK08162  325 HVYGLTETY-------GPATVCawqpewdalplderaQLKAR--QGVrYPLQegVTVLDPDTMQPVpADGETI------G 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 457 E---PGLLVgqinqqdplrrFDGYVSdsatNKKIAHSVFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTT 533
Cdd:PRK08162  390 EimfRGNIV-----------MKGYLK----NPKATEEAFAGG--WFHTGDLAVLHPDGYIKIKDRSKDIIISGGENISSI 452
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 534 EVEAVLSRLLGQTDVAVygVAVPG----------VEGKAGMAAIADphsqldpnsmyqEL----QKVLASYARP--IFLR 597
Cdd:PRK08162  453 EVEDVLYRHPAVLVAAV--VAKPDpkwgevpcafVELKDGASATEE------------EIiahcREHLAGFKVPkaVVFG 518
                         570       580
                  ....*....|....*....|.
gi 1907189407 598 LLPQvdtTGTFKIQKTRLQRE 618
Cdd:PRK08162  519 ELPK---TSTGKIQKFVLREQ 536
OSB_MenE-like cd17630
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ...
253-617 1.04e-12

O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.


Pssm-ID: 341285 [Multi-domain]  Cd Length: 325  Bit Score: 69.67  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 DRLFYIYTSGTTGLPKAaiVVHSRYYRIAAF--GHHSYSMRAADVLYDCLPLYHSAGnIMGVGQCVIYGLTVVLRKKFSA 330
Cdd:cd17630     1 RLATVILTSGSTGTPKA--VVHTAANLLASAagLHSRLGFGGGDSWLLSLPLYHVGG-LAILVRSLLAGAELVLLERNQA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 331 SRfwDDCVKYNCTVVQYIGEICRYLLRQPVrDVEQRHRVR-LAVGNGlrpAIWEEFTQRF---GVPqIGEFYGATEcncs 406
Cdd:cd17630    78 LA--EDLAPPGVTHVSLVPTQLQRLLDSGQ-GPAALKSLRaVLLGGA---PIPPELLERAadrGIP-LYTTYGMTE---- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 407 ianMDGKVGSCGFNSRILTHVYPI---RLVKVNEDTMeplrdseglcipCQPGEPGLLVGQINQQDPLRRFDGyvsdsat 483
Cdd:cd17630   147 ---TASQVATKRPDGFGRGGVGVLlpgRELRIVEDGE------------IWVGGASLAMGYLRGQLVPEFNED------- 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 484 nkkiahSVFRKGDSAYLSGDvlvmdelGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgvegKAG 563
Cdd:cd17630   205 ------GWFTTKDLGELHAD-------GRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDE----ELG 267
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189407 564 MAAIA--DPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQR 617
Cdd:cd17630   268 QRPVAviVGRGPADPAELRAWLKDKLARFKLPKRIYPVPELPRTGGGKVDRRALRA 323
PRK12467 PRK12467
peptide synthase; Provisional
72-625 1.18e-12

peptide synthase; Provisional


Pssm-ID: 237108 [Multi-domain]  Cd Length: 3956  Bit Score: 71.73  E-value: 1.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   72 LIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVdaSSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPE 151
Cdd:PRK12467   497 RELVRWNAPATEYAPDCVHQLIEAQARQHPERPALV--FGEQVLSYAELNRQANRLAHVLIAAGVGPDVLVGIAVERSIE 574
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  152 FVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAavaevseqlgksLLKFCSGdlgpESILPDTQLL 231
Cdd:PRK12467   575 MVVGLLAVLKAGGAYVPLDPEYPQDRLAYMLDDSGVRLLLTQSHLLA------------QLPVPAG----LRSLCLDEPA 638
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  232 DPMLAEAP-TTPLAQAPgkgmdDRLFY-IYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNI 309
Cdd:PRK12467   639 DLLCGYSGhNPEVALDP-----DNLAYvIYTSGSTGQPKGVAISHGALANYVCVIAERLQLAADDSMLMVSTFAFDLGVT 713
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  310 MGVGQcVIYGLTVVLRKK---FSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAI---WE 383
Cdd:PRK12467   714 ELFGA-LASGATLHLLPPdcaRDAEAFAALMADQGVTVLKIVPSHLQALLQASRVALPRPQRALVCGGEALQVDLlarVR 792
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  384 EFTqrfgvPQIGEF--YGATEcncsiANMDGKVGSCGFNSRILTHVyPIRlvkvnedtmEPLRDSeGLCI------PCQP 455
Cdd:PRK12467   793 ALG-----PGARLInhYGPTE-----TTVGVSTYELSDEERDFGNV-PIG---------QPLANL-GLYIldhylnPVPV 851
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  456 GEPG-LLVGqinqQDPLRRfdGYVSDSA-TNKKIAHSVF-RKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVST 532
Cdd:PRK12467   852 GVVGeLYIG----GAGLAR--GYHRRPAlTAERFVPDPFgADGGRLYRTGDLARYRADGVIEYLGRMDHQVKIRGFRIEL 925
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  533 TEVEAvlsRLLGQTDV--AVYgVAVPGVEGK--------AGMAAIADPHSQLDpnSMYQELQKVLASYARPIFLRLLPQV 602
Cdd:PRK12467   926 GEIEA---RLLAQPGVreAVV-LAQPGDAGLqlvaylvpAAVADGAEHQATRD--ELKAQLRQVLPDYMVPAHLLLLDSL 999
                          570       580
                   ....*....|....*....|....
gi 1907189407  603 DTTGTFKIQKTRL-QREGFDPRQT 625
Cdd:PRK12467  1000 PLTPNGKLDRKALpKPDASAVQAT 1023
PRK13383 PRK13383
acyl-CoA synthetase; Provisional
58-615 2.88e-12

acyl-CoA synthetase; Provisional


Pssm-ID: 139531 [Multi-domain]  Cd Length: 516  Bit Score: 69.64  E-value: 2.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  58 VCKTARRDLFGLSVLI----RVRLELRRHRRAGDTIPCIFQAV-ARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFR 132
Cdd:PRK13383    1 VAPTAARALVRSGLLNppspRAVLRLLREASRGGTNPYTLLAVtAARWPGRTAIIDDDGAL--SYRELQRATESLARRLT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 133 QLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGksll 212
Cdd:PRK13383   79 RDGVAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVPISTEFRSDALAAALRAHHISTVVADNEFAERIAGADDAVA---- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 213 kfcsgdlgpesilpdtqLLDPMLA---EAPTTPLAQAPGKgmddrlFYIYTSGTTGLPKAaivVHSRYYRIAAFG----- 284
Cdd:PRK13383  155 -----------------VIDPATAgaeESGGRPAVAAPGR------IVLLTSGTTGKPKG---VPRAPQLRSAVGvwvti 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 285 HHSYSMRAADVLYDCLPLYHSagniMGVGQCVI---YGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVR 361
Cdd:PRK13383  209 LDRTRLRTGSRISVAMPMFHG----LGLGMLMLtiaLGGTVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPR 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 362 dVEQRH-----RVRLAVGNGLRPAIWEEFTQRFGvPQIGEFYGATECN----CSIANMD------GK-VGSCgfnsrilt 425
Cdd:PRK13383  285 -VRARNplpqlRVVMSSGDRLDPTLGQRFMDTYG-DILYNGYGSTEVGigalATPADLRdapetvGKpVAGC-------- 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 426 hvyPIRLVKVNEDtmeplrdseglciPCQPGEPGLLV--GQINQqdplrrfDGYVSDSAtnKKIAHSVFRKGDSAYLsgd 503
Cdd:PRK13383  355 ---PVRILDRNNR-------------PVGPRVTGRIFvgGELAG-------TRYTDGGG--KAVVDGMTSTGDMGYL--- 406
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 504 vlvmDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQEL 583
Cdd:PRK13383  407 ----DNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSGVDAAQLRDYL 482
                         570       580       590
                  ....*....|....*....|....*....|..
gi 1907189407 584 QKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:PRK13383  483 KDRVSRFEQPRDINIVSSIPRNPTGKVLRKEL 514
PRK07059 PRK07059
Long-chain-fatty-acid--CoA ligase; Validated
88-624 6.53e-12

Long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235923 [Multi-domain]  Cd Length: 557  Bit Score: 68.51  E-value: 6.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  88 TIPCIFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVaa 167
Cdd:PRK07059   24 SLADLLEESFRQYADRPAFICMGKAI--TYGELDELSRALAAWLQSRGLAKGARVAIMMPNVLQYPVAIAAVLRAGYV-- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 168 LLNVNLRREP--LAFCLGTSAAKALIYGGEMAAAVAEVseqLGKSLLKF----CSGD-LG-----------------PES 223
Cdd:PRK07059  100 VVNVNPLYTPreLEHQLKDSGAEAIVVLENFATTVQQV---LAKTAVKHvvvaSMGDlLGfkghivnfvvrrvkkmvPAW 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 224 ILPDTQLLDPMLAEAPTTPLaQAPGKGMDDRLFYIYTSGTTGLPKAAIVVH----SRYYRIAAFGHHSYSMRAAD--VLY 297
Cdd:PRK07059  177 SLPGHVRFNDALAEGARQTF-KPVKLGPDDVAFLQYTGGTTGVSKGATLLHrnivANVLQMEAWLQPAFEKKPRPdqLNF 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 298 DC-LPLYH----SAGNIMGVGQCviyGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLA 372
Cdd:PRK07059  256 VCaLPLYHifalTVCGLLGMRTG---GRNILIPNPRDIPGFIKELKKYQVHIFPAVNTLYNALLNNPDFDKLDFSKLIVA 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 373 VGNGL--RPAIWEEFTQRFGVPqIGEFYGATECN----CSIANMDGKVGSCGFnsrilthvyPIRLVKVNedtmepLRDS 446
Cdd:PRK07059  333 NGGGMavQRPVAERWLEMTGCP-ITEGYGLSETSpvatCNPVDATEFSGTIGL---------PLPSTEVS------IRDD 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 447 EGLCIPC-QPGE-----PGLLVGQINQQDPLRRF---DGYvsdsatnkkiahsvFRkgdsaylSGDVLVMDELGYMYFRD 517
Cdd:PRK07059  397 DGNDLPLgEPGEicirgPQVMAGYWNRPDETAKVmtaDGF--------------FR-------TGDVGVMDERGYTKIVD 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 518 RSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVavpgvegkagmaaiADPHS---------QLDPNSMYQELQKV-- 586
Cdd:PRK07059  456 RKKDMILVSGFNVYPNEIEEVVASHPGVLEVAAVGV--------------PDEHSgeavklfvvKKDPALTEEDVKAFck 521
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 1907189407 587 --LASYARPIFLRLLPQVDTTGTFKIqktrLQREGFDPRQ 624
Cdd:PRK07059  522 erLTNYKRPKFVEFRTELPKTNVGKI----LRRELRDGKA 557
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
88-295 7.53e-12

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 68.92  E-value: 7.53e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   88 TIPCIFQAVARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEgRPEFVGLWL-GLAKAGvvA 166
Cdd:PRK10252   459 TLSALVAQQAAKTPDAPALADA--RYQFSYREMREQVVALANLLRERGVKPGDSVAVALP-RSVFLTLALhAIVEAG--A 533
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  167 ALLNVNLRR--EPLAFCLGTSAAKALIyggemaaavaEVSEQLGKsllkfcsgdlgpesiLPDTQLLDPMLAEAPTTPLA 244
Cdd:PRK10252   534 AWLPLDTGYpdDRLKMMLEDARPSLLI----------TTADQLPR---------------FADVPDLTSLCYNAPLAPQG 588
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907189407  245 QAPGKGM--DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADV 295
Cdd:PRK10252   589 AAPLQLSqpHHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLTADDV 641
ttLC_FACS_AlkK_like cd12119
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...
116-618 1.47e-11

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.


Pssm-ID: 341284 [Multi-domain]  Cd Length: 518  Bit Score: 67.27  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGE 195
Cdd:cd12119    27 TYAEVAERARRLANALRRLGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTINPRLFPEQIAYIINHAEDRVVFVDRD 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 MAAAVAEVSEQL--GKSLLKFCSGDLGPESILPDTQLLDPMLAEAPttPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVV 273
Cdd:cd12119   107 FLPLLEAIAPRLptVEHVVVMTDDAAMPEPAGVGVLAYEELLAAES--PEYDWPDFDENTAAAICYTSGTTGNPKGVVYS 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 274 HSRYYriaafgHHSYSMRAADVLY----D----CLPLYHsaGNIMGVG-QCVIYGLTVVLRKKF----SASRFWDdcvKY 340
Cdd:cd12119   185 HRSLV------LHAMAALLTDGLGlsesDvvlpVVPMFH--VNAWGLPyAAAMVGAKLVLPGPYldpaSLAELIE---RE 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 341 NCTVVQYIGEICRYLLRQPVR-DVEQRHRVRLAVGNG-LRPAIWEEFTQRfGVPQIgEFYGATE-CNCSIAN-----MDG 412
Cdd:cd12119   254 GVTFAAGVPTVWQGLLDHLEAnGRDLSSLRRVVIGGSaVPRSLIEAFEER-GVRVI-HAWGMTEtSPLGTVArppseHSN 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 413 KVGSCGFNSRILTHvYPIRLVK---VNEDTMEPLRDSEGLcipcqpGE-----PGLLVGQINQQDPLRRF--DGYvsdsa 482
Cdd:cd12119   332 LSEDEQLALRAKQG-RPVPGVElriVDDDGRELPWDGKAV------GElqvrgPWVTKSYYKNDEESEALteDGW----- 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 483 tnkkiahsvFRkgdsaylSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPgvegKA 562
Cdd:cd12119   400 ---------LR-------TGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHP----KW 459
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 563 G---MAAI-ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLqRE 618
Cdd:cd12119   460 GerpLAVVvLKEGATVTAEELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKAL-RE 518
A_NRPS_Ta1_like cd12116
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ...
101-275 1.62e-11

The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.


Pssm-ID: 341281 [Multi-domain]  Cd Length: 470  Bit Score: 66.93  E-value: 1.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDasSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAF 180
Cdd:cd12116     1 PDATAVRD--DDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 181 CLGTSAAKALIYGGEMAAAvaevseqlgksllkfcsgdlgpesiLPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFY-IY 259
Cdd:cd12116    79 ILEDAEPALVLTDDALPDR-------------------------LPAGLPVLLLALAAAAAAPAAPRTPVSPDDLAYvIY 133
                         170
                  ....*....|....*.
gi 1907189407 260 TSGTTGLPKAAIVVHS 275
Cdd:cd12116   134 TSGSTGRPKGVVVSHR 149
PRK08974 PRK08974
long-chain-fatty-acid--CoA ligase FadD;
92-553 2.07e-11

long-chain-fatty-acid--CoA ligase FadD;


Pssm-ID: 236359 [Multi-domain]  Cd Length: 560  Bit Score: 67.00  E-value: 2.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALVDAssGICWTFAQLDTYSNA-VANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAalLN 170
Cdd:PRK08974   28 MFEQAVARYADQPAFINM--GEVMTFRKLEERSRAfAAYLQNGLGLKKGDRVALMMPNLLQYPIALFGILRAGMIV--VN 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 171 VNLRREP--LAFCLGTSAAKALIYGGEMAAAVAEVSEQ----------LGKSL-----------LKFCSGdLGPESILPD 227
Cdd:PRK08974  104 VNPLYTPreLEHQLNDSGAKAIVIVSNFAHTLEKVVFKtpvkhviltrMGDQLstakgtlvnfvVKYIKR-LVPKYHLPD 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 228 tqlldpmlaeAPTTPLAQAPGKGM---------DDRLFYIYTSGTTGLPKAAIVVHSRYyrIA----AFGHHSYSMR-AA 293
Cdd:PRK08974  183 ----------AISFRSALHKGRRMqyvkpelvpEDLAFLQYTGGTTGVAKGAMLTHRNM--LAnleqAKAAYGPLLHpGK 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 294 DVLYDCLPLYHsagnimgvgqcvIYGLTVvlrkkfsasrfwddcvkyNCTVVQYIGeICRYLLRQPvRDVE------QRH 367
Cdd:PRK08974  251 ELVVTALPLYH------------IFALTV------------------NCLLFIELG-GQNLLITNP-RDIPgfvkelKKY 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 368 RV---------------------------RLAVGNGL--RPAI---WEEFTQRFgvpqIGEFYGATECN----CSIANMD 411
Cdd:PRK08974  299 PFtaitgvntlfnallnneefqeldfsslKLSVGGGMavQQAVaerWVKLTGQY----LLEGYGLTECSplvsVNPYDLD 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 412 GKVGSCGFnsrilthvyPIrlvkvnEDTMEPLRDSEGLCIPcqPGEPGLLVG---QINQ---QDPlrrfdgyvsdSATNK 485
Cdd:PRK08974  375 YYSGSIGL---------PV------PSTEIKLVDDDGNEVP--PGEPGELWVkgpQVMLgywQRP----------EATDE 427
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 486 kiahsVFRKGdsaYLS-GDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGV 553
Cdd:PRK08974  428 -----VIKDG---WLAtGDIAVMDEEGFLRIVDRKKDMILVSGFNVYPNEIEDVVMLHPKVLEVAAVGV 488
PRK05857 PRK05857
fatty acid--CoA ligase;
97-615 2.64e-11

fatty acid--CoA ligase;


Pssm-ID: 180293 [Multi-domain]  Cd Length: 540  Bit Score: 66.57  E-value: 2.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLAL--VDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLR 174
Cdd:PRK05857   24 ARQQPEAIALrrCDGTSAL--RYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNLP 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 175 REPLA-FCLGTSAAKALIYGGEmaaavaevseQLGKSLLKfcSGDLGPESILPDTQLLDPMLAEAPTTP-LAQAPGKGMD 252
Cdd:PRK05857  102 IAAIErFCQITDPAAALVAPGS----------KMASSAVP--EALHSIPVIAVDIAAVTRESEHSLDAAsLAGNADQGSE 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 DRLFYIYTSGTTGLPKAAIVVHSRYYRIA----AFGHHSYSMRAADVLYDCLPLYHSAG------NIMGVGQCVIYG-LT 321
Cdd:PRK05857  170 DPLAMIFTSGTTGEPKAVLLANRTFFAVPdilqKEGLNWVTWVVGETTYSPLPATHIGGlwwiltCLMHGGLCVTGGeNT 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 322 VVLRKKFSASRfwddcVKYNCTVVQYIGEICrYLLRQPVRDVEQrhrVRLAVGNGLRpAIWEE--FTQRFGVpQIGEFYG 399
Cdd:PRK05857  250 TSLLEILTTNA-----VATTCLVPTLLSKLV-SELKSANATVPS---LRLVGYGGSR-AIAADvrFIEATGV-RTAQVYG 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 400 ATECNCSIANMDGKVGSCgfnSRI----LTHVYPirLVKVNedtmepLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFd 475
Cdd:PRK05857  319 LSETGCTALCLPTDDGSI---VKIeagaVGRPYP--GVDVY------LAATDGIGPTAPGAGPSASFGTLWIKSPANML- 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 476 GYVSDSATNKKIAhsvfrkGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAV 555
Cdd:PRK05857  387 GYWNNPERTAEVL------IDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPD 460
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407 556 PGVEGKAGMAAIadPHSQLDPNSMYQELQKVLASY-------ARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:PRK05857  461 EEFGALVGLAVV--ASAELDESAARALKHTIAARFrresepmARPSTIVIVTDIPRTQSGKVMRASL 525
LC_FACS_bac cd05932
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ...
115-616 3.32e-11

Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341255 [Multi-domain]  Cd Length: 508  Bit Score: 65.95  E-value: 3.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYG- 193
Cdd:cd05932     7 FTWGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKALFVGk 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 194 ----GEMAAAVAEvseqlgksllKFCSGDLGPESILPDTQLLDPMLAEAPttPLAQAPGKGMDDRLFYIYTSGTTGLPKA 269
Cdd:cd05932    87 lddwKAMAPGVPE----------GLISISLPPPSAANCQYQWDDLIAQHP--PLEERPTRFPEQLATLIYTSGTTGQPKG 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 270 AIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTV------------VLRKK----FSASRF 333
Cdd:cd05932   155 VMLTFGSFAWAAQAGIEHIGTEENDRMLSYLPLAHVTERVFVEGGSLYGGVLVafaesldtfvedVQRARptlfFSVPRL 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 334 WddcVKYNCTVVQYIG-EICRYLLRQPVRDVEQRHRV---------RLAVGNG--LRPAIWEEFtQRFGVPqIGEFYGAT 401
Cdd:cd05932   235 W---TKFQQGVQDKIPqQKLNLLLKIPVVNSLVKRKVlkglgldqcRLAGCGSapVPPALLEWY-RSLGLN-ILEAYGMT 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 402 EcNCSIANM----DGKVGSCGFNsrilthvYPIRLVKVNEDTmEPLRDSeglcipcqpgePGLLVGQinqqdplrrfdgY 477
Cdd:cd05932   310 E-NFAYSHLnypgRDKIGTVGNA-------GPGVEVRISEDG-EILVRS-----------PALMMGY------------Y 357
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 478 VSDSATNkkiahSVFRKgDSAYLSGDVLVMDELGYMYFRDRSGDTFRW-RGENVSTTEVEAVLSR--------LLGQTDV 548
Cdd:cd05932   358 KDPEATA-----EAFTA-DGFLRTGDKGELDADGNLTITGRVKDIFKTsKGKYVAPAPIENKLAEhdrvemvcVIGSGLP 431
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 549 AVYGVAVPGVEGKAGMAAIA-------------------DPHSQLDPNSMYQELQKVLASYARPiflrllpqvdttgTFK 609
Cdd:cd05932   432 APLALVVLSEEARLRADAFAraeleaslrahlarvnstlDSHEQLAGIVVVKDPWSIDNGILTP-------------TLK 498

                  ....*..
gi 1907189407 610 IQKTRLQ 616
Cdd:cd05932   499 IKRNVLE 505
PRK05691 PRK05691
peptide synthase; Validated
94-324 5.13e-11

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 66.35  E-value: 5.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   94 QAVARR---QPERLALV----DASSGICWTFAQLDTYSNAVANLFRQLGfAPGDVVAVFLEGRPEFVGLWLGLAKAGVVA 166
Cdd:PRK05691    13 QALQRRaaqTPDRLALRfladDPGEGVVLSYRDLDLRARTIAAALQARA-SFGDRAVLLFPSGPDYVAAFFGCLYAGVIA 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  167 A---------------LLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAevseqlgksllkfcsgdlgPESILPDTqlL 231
Cdd:PRK05691    92 VpayppesarrhhqerLLSIIADAEPRLLLTVADLRDSLLQMEELAAANA-------------------PELLCVDT--L 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  232 DPMLAEApttplAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAA--DVLYDCLPLYHSAGNI 309
Cdd:PRK05691   151 DPALAEA-----WQEPALQPDDIAFLQYTSGSTALPKGVQVSHGNLVANEQLIRHGFGIDLNpdDVIVSWLPLYHDMGLI 225
                          250
                   ....*....|....*
gi 1907189407  310 MGVGQCVIYGLTVVL 324
Cdd:PRK05691   226 GGLLQPIFSGVPCVL 240
PRK03584 PRK03584
acetoacetate--CoA ligase;
99-275 7.01e-11

acetoacetate--CoA ligase;


Pssm-ID: 235134 [Multi-domain]  Cd Length: 655  Bit Score: 65.20  E-value: 7.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  99 RQPERLALVDAS-SGI--CWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPE-FVGLwlgLAKA------------ 162
Cdd:PRK03584   96 RRDDRPAIIFRGeDGPrrELSWAELRRQVAALAAALRALGVGPGDRVAAYLPNIPEtVVAM---LATAslgaiwsscspd 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 163 -GVVAALlnvnlRReplafcLGTSAAKALI------YGG---EMAAAVAEVSEQLgKSLLKFCS----GDLGPESILPDT 228
Cdd:PRK03584  173 fGVQGVL-----DR------FGQIEPKVLIavdgyrYGGkafDRRAKVAELRAAL-PSLEHVVVvpylGPAAAAAALPGA 240
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1907189407 229 QLLDPMLAEAPTTPLAQAPGkGMDDRLFYIYTSGTTGLPKAaiVVHS 275
Cdd:PRK03584  241 LLWEDFLAPAEAAELEFEPV-PFDHPLWILYSSGTTGLPKC--IVHG 284
PLN03102 PLN03102
acyl-activating enzyme; Provisional
101-556 8.25e-11

acyl-activating enzyme; Provisional


Pssm-ID: 215576 [Multi-domain]  Cd Length: 579  Bit Score: 65.04  E-value: 8.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASSGICWTfaqlDTYSNA--VANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPL 178
Cdd:PLN03102   28 PNRTSIIYGKTRFTWP----QTYDRCcrLAASLISLNITKNDVVSVLAPNTPAMYEMHFAVPMAGAVLNPINTRLDATSI 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 179 AFCLGTSAAKALIYGGEMAAAVAEVSeqlgkSLLKFCSGDLGPESIL---------PDTQLLD--PMLAEAPTTPLAQAp 247
Cdd:PLN03102  104 AAILRHAKPKILFVDRSFEPLAREVL-----HLLSSEDSNLNLPVIFiheidfpkrPSSEELDyeCLIQRGEPTPSLVA- 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 248 gkgmddRLFYI----------YTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVI 317
Cdd:PLN03102  178 ------RMFRIqdehdpislnYTSGTTADPKGVVISHRGAYLSTLSAIIGWEMGTCPVYLWTLPMFHCNGWTFTWGTAAR 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 318 YGLTVVLRkKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDveQRHR---VRLAVGNGLRPAIWEEFTQRFGVpQI 394
Cdd:PLN03102  252 GGTSVCMR-HVTAPEIYKNIEMHNVTHMCCVPTVFNILLKGNSLD--LSPRsgpVHVLTGGSPPPAALVKKVQRLGF-QV 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 395 GEFYGATECNcsianmdGKVGSCGFN---SRILTH----------VYPIRLVKV---NEDTMEPL-RDSEGLcipcqpGE 457
Cdd:PLN03102  328 MHAYGLTEAT-------GPVLFCEWQdewNRLPENqqmelkarqgVSILGLADVdvkNKETQESVpRDGKTM------GE 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 458 PgLLVGQINQQdplrrfdGYVSdsatNKKIAHSVFRKGdsaYL-SGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVE 536
Cdd:PLN03102  395 I-VIKGSSIMK-------GYLK----NPKATSEAFKHG---WLnTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVE 459
                         490       500
                  ....*....|....*....|
gi 1907189407 537 AVLSRLLGQTDVAVygVAVP 556
Cdd:PLN03102  460 NVLYKYPKVLETAV--VAMP 477
A_NRPS_SidN3_like cd05918
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ...
92-291 8.89e-11

The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341242 [Multi-domain]  Cd Length: 481  Bit Score: 64.49  E-value: 8.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLAlVDASSGiCWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:cd05918     4 LIEERARSQPDAPA-VCAWDG-SLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLDP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 172 NLrrePLAFclgtsaakaliyggemaaaVAEVSEQLGKSLlkfcsgdlgpesilpdtqlldpMLAEAPttplaqapgkgm 251
Cdd:cd05918    82 SH---PLQR-------------------LQEILQDTGAKV----------------------VLTSSP------------ 105
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVHSRYyrIAAFGHHSYSMR 291
Cdd:cd05918   106 SDAAYVIFTSGSTGKPKGVVIEHRAL--STSALAHGRALG 143
ttLC_FACS_like cd05915
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ...
102-552 1.43e-10

Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.


Pssm-ID: 213283 [Multi-domain]  Cd Length: 509  Bit Score: 63.99  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 102 ERLALVDAS---SGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPL 178
Cdd:cd05915     9 GRKEVVSRLhtgEVHRTTYAEVYQRARRLMGGLRALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 179 AFCLGTSAAKALIYGGEMAAaVAEVSEQLGKSLLKfcsgdlGPESILPDTQLLDPMLAEAPTTplaqAPGKGMD--DRLF 256
Cdd:cd05915    89 AYILNHAEDKVLLFDPNLLP-LVEAIRGELKTVQH------FVVMDEKAPEGYLAYEEALGEE----ADPVRVPerAACG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 257 YIYTSGTTGLPKAAIVVH-SRYYRIAAFGHHSYSMRAADVLYDC-LPLYHSAGnimgvgQCVIY------GLTVVLRKKF 328
Cdd:cd05915   158 MAYTTGTTGLPKGVVYSHrALVLHSLAASLVDGTALSEKDVVLPvVPMFHVNA------WCLPYaatlvgAKQVLPGPRL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 329 SASRFWDDCVKYNCTvvQYIGEICRYLLRQPVRDVEQRH---RVRLAVGNGLRPAIWEEFtQRFGVPQIGEFYGATEcnc 405
Cdd:cd05915   232 DPASLVELFDGEGVT--FTAGVPTVWLALADYLESTGHRlktLRRLVVGGSAAPRSLIAR-FERMGVEVRQGYGLTE--- 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 406 sianMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGllVGQINQQDPLRR---FDGYVSDSA 482
Cdd:cd05915   306 ----TSPVVVQNFVKSHLESLSEEEKLTLKAKTGLPIPLVRLRVADEEGRPVPK--DGKALGEVQLKGpwiTGGYYGNEE 379
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 483 TNKKIAhsvFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYG 552
Cdd:cd05915   380 ATRSAL---TPDG--FFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVA 444
ACLS-CaiC cd17637
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ...
258-556 2.61e-10

acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341292 [Multi-domain]  Cd Length: 333  Bit Score: 62.29  E-value: 2.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 258 IYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGniMGVGQCVIY--GLTVVLRKkFSASRFWD 335
Cdd:cd17637     6 IHTAAVAGRPRGAVLSHGNLIAANLQLIHAMGLTEADVYLNMLPLFHIAG--LNLALATFHagGANVVMEK-FDPAEALE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 336 DCVKYNCTVVQYIGEICRYLLrqpvrDVEQRHRVRLAvgnGLR-------PaiweEFTQRFGVPQIGEF---YGATECNC 405
Cdd:cd17637    83 LIEEEKVTLMGSFPPILSNLL-----DAAEKSGVDLS---SLRhvlgldaP----ETIQRFEETTGATFwslYGQTETSG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 406 --SIANMDGKVGSCGfnsRILthvyPIRLVKVNEDTMEPLRdseglcipcqPGEPGllvgQINQQDPLRrFDGYVSDSAT 483
Cdd:cd17637   151 lvTLSPYRERPGSAG---RPG----PLVRVRIVDDNDRPVP----------AGETG----EIVVRGPLV-FQGYWNLPEL 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907189407 484 NkkiAHSvFRKGdsAYLSGDVLVMDELGYMYFRDRSG--DTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVP 556
Cdd:cd17637   209 T---AYT-FRNG--WHHTGDLGRFDEDGYLWYAGRKPekELIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDP 277
PRK06060 PRK06060
p-hydroxybenzoic acid--AMP ligase FadD22;
116-630 2.77e-10

p-hydroxybenzoic acid--AMP ligase FadD22;


Pssm-ID: 180374 [Multi-domain]  Cd Length: 705  Bit Score: 63.51  E-value: 2.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGE 195
Cdd:PRK06060   32 THGQIHDGAARLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPALVVTSDA 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 MAAAVAEvseqlgksllkfcSGDLGPESILPDTQLLDPmlaeAPTTPLaqapgkGMDDRLFYIYTSGTTGLPKAAIVVHS 275
Cdd:PRK06060  112 LRDRFQP-------------SRVAEAAELMSEAARVAP----GGYEPM------GGDALAYATYTSGTTGPPKAAIHRHA 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 276 RYYR-IAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGV-------GQCVIYGLTVVLRKKFSASRFWDDCVKYNctVVQY 347
Cdd:PRK06060  169 DPLTfVDAMCRKALRLTPEDTGLCSARMYFAYGLGNSVwfplatgGSAVINSAPVTPEAAAILSARFGPSVLYG--VPNF 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 348 IGEICRYLLRQPVRDVeqrhRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCS-IANM--DGKVGSCGfnsRIL 424
Cdd:PRK06060  247 FARVIDSCSPDSFRSL----RCVVSAGEALELGLAERLMEFFGGIPILDGIGSTEVGQTfVSNRvdEWRLGTLG---RVL 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 425 THvYPIRLVKVNEDTMEPlrdseglcipcqPGEPGLLVgqinqQDPlrrfdgyvsdsatnkKIAHSVFRKGDSAYLSGDV 504
Cdd:PRK06060  320 PP-YEIRVVAPDGTTAGP------------GVEGDLWV-----RGP---------------AIAKGYWNRPDSPVANEGW 366
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 505 L------VMDELGYMYFRDRSGDTFRWRGENVSTTEVEavlsRLLGQTDvAVYGVAVPGVEGKAGMAAIadpHSQLDPNS 578
Cdd:PRK06060  367 LdtrdrvCIDSDGWVTYRCRADDTEVIGGVNVDPREVE----RLIIEDE-AVAEAAVVAVRESTGASTL---QAFLVATS 438
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 579 MyqelQKVLASYARPIFLRLLPQVDttgTFKIQKTRLQREGFdPRQTSDRLF 630
Cdd:PRK06060  439 G----ATIDGSVMRDLHRGLLNRLS---AFKVPHRFAVVDRL-PRTPNGKLV 482
PRK12316 PRK12316
peptide synthase; Provisional
92-625 5.56e-10

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 63.05  E-value: 5.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   92 IFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:PRK12316  3062 LFEEQVERTPDAVALAFGEQRL--SYAELNRRANRLAHRLIERGVGPDVLVGVAVERSLEMVVGLLAILKAGGAYVPLDP 3139
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  172 NLRREPLAFCLGTSAAKALiyggemaaavaevseqLGKSLLKfcsgdlgpesiLPDTQLLDPMLAEAPTTPLAQA--PGK 249
Cdd:PRK12316  3140 EYPEERLAYMLEDSGAQLL----------------LSQSHLR-----------LPLAQGVQVLDLDRGDENYAEAnpAIR 3192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  250 GMDDRLFY-IYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLydclpLYHSAGNIMGVGQCVIYGLTVVLRKKF 328
Cdd:PRK12316  3193 TMPENLAYvIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYGLGVGDRV-----LQFTTFSFDVFVEELFWPLMSGARVVL 3267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  329 SASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVE----QRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECN 404
Cdd:PRK12316  3268 AGPEDWRDPALLVELINSEGVDVLHAYPSMLQAFLEeedaHRCTSLKRIVCGGEALPADLQQQVFAGLPLYNLYGPTEAT 3347
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  405 CSIANMDgkVGSCGFNSRILTHVYPIRLVKVNEDTMEPlrDSEGLCIPCQPGEPGLLVGQINQQDplrrfdgyvsdsATN 484
Cdd:PRK12316  3348 ITVTHWQ--CVEEGKDAVPIGRPIANRACYILDGSLEP--VPVGALGELYLGGEGLARGYHNRPG------------LTA 3411
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  485 KKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLsrllgQTDVAVYGVAVPGVEGKAGM 564
Cdd:PRK12316  3412 ERFVPDPFVPGERLYRTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEARL-----LEHPWVREAVVLAVDGRQLV 3486
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907189407  565 AAIADPHSQLD-PNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQT 625
Cdd:PRK12316  3487 AYVVPEDEAGDlREALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKALPRPDAALLQQ 3548
PRK12316 PRK12316
peptide synthase; Provisional
92-615 5.85e-10

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 63.05  E-value: 5.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   92 IFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:PRK12316  4556 LVAERARMTPDAVAVVFDEEKL--TYAELNRRANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDP 4633
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  172 NLRREPLAFCLGTSAAKALIyggemaaAVAEVSEQL----GKSLLkfcsgDLGPESILPDTQLLDPMLAEAPttplaqap 247
Cdd:PRK12316  4634 EYPRERLAYMMEDSGAALLL-------TQSHLLQRLpipdGLASL-----ALDRDEDWEGFPAHDPAVRLHP-------- 4693
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  248 gkgmdDRLFY-IYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPlYHSAGNIMGVGQCVIYGLTVVLRK 326
Cdd:PRK12316  4694 -----DNLAYvIYTSGSTGRPKGVAVSHGSLVNHLHATGERYELTPDDRVLQFMS-FSFDGSHEGLYHPLINGASVVIRD 4767
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  327 kfsaSRFWD------DCVKYNCTVVQYIGEICRYLLRQPVRDVE-QRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYG 399
Cdd:PRK12316  4768 ----DSLWDperlyaEIHEHRVTVLVFPPVYLQQLAEHAERDGEpPSLRVYCFGGEAVAQASYDLAWRALKPVYLFNGYG 4843
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  400 ATECNCSIANMDGKVGS-CGFNSRILTHVYPIRLVKVNEDTMEPLrdseglciPC-QPGEpgLLVGqinqQDPLRRfdGY 477
Cdd:PRK12316  4844 PTETTVTVLLWKARDGDaCGAAYMPIGTPLGNRSGYVLDGQLNPL--------PVgVAGE--LYLG----GEGVAR--GY 4907
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  478 VSDSA-TNKKIAHSVFRK-GDSAYLSGDVL------VMDELGymyfrdRSGDTFRWRGENVSTTEVEAvlsRLLGQTDV- 548
Cdd:PRK12316  4908 LERPAlTAERFVPDPFGApGGRLYRTGDLAryradgVIDYLG------RVDHQVKIRGFRIELGEIEA---RLREHPAVr 4978
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407  549 -AVYgVAVPGVEGK--AGMAAIADPHSQLDP-------NSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:PRK12316  4979 eAVV-IAQEGAVGKqlVGYVVPQDPALADADeaqaelrDELKAALRERLPEYMVPAHLVFLARMPLTPNGKLDRKAL 5054
DltA cd05945
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ...
97-615 8.84e-10

D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.


Pssm-ID: 341267 [Multi-domain]  Cd Length: 449  Bit Score: 61.49  E-value: 8.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDAssGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNvnlrre 176
Cdd:cd05945     1 AAANPDRPAVVEG--GRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLD------ 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 plafclGTSAAkaliyggEMAAAVAEVSeqlgksllkfcsgdlGPESILPDtqlldpmlaeapttplaqapgkgmDDRLF 256
Cdd:cd05945    73 ------ASSPA-------ERIREILDAA---------------KPALLIAD------------------------GDDNA 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 257 YI-YTSGTTGLPKAaiVVHSrYYRIAAFGHHS---YSMRAADVLYdCLPLYHSAGNIMGVGQCVIYGLTVV-LRKKFSAS 331
Cdd:cd05945   101 YIiFTSGSTGRPKG--VQIS-HDNLVSFTNWMlsdFPLGPGDVFL-NQAPFSFDLSVMDLYPALASGATLVpVPRDATAD 176
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 332 --RFWDDCVKYNCTV---VQYIGEICrylLRQPVRDVEQRHRVRLAVGNGlrpaiwEEFT--------QRFGVPQIGEFY 398
Cdd:cd05945   177 pkQLFRFLAEHGITVwvsTPSFAAMC---LLSPTFTPESLPSLRHFLFCG------EVLPhktaralqQRFPDARIYNTY 247
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 399 GATECN--CSIANMDGKVgsCGFNSRIlthvyPIRLVKVNEDTMepLRDSEGLCIPcqPGEPG--LLVGQinqqdplRRF 474
Cdd:cd05945   248 GPTEATvaVTYIEVTPEV--LDGYDRL-----PIGYAKPGAKLV--ILDEDGRPVP--PGEKGelVISGP-------SVS 309
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 475 DGYVSDSATNKKIAHSVfrKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVygVA 554
Cdd:cd05945   310 KGYLNNPEKTAAAFFPD--EGQRAYRTGDLVRLEADGLLFYRGRLDFQVKLNGYRIELEEIEAALRQVPGVKEAVV--VP 385
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907189407 555 VPGVEGKAGMAAIADPH---SQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd05945   386 KYKGEKVTELIAFVVPKpgaEAGLTKAIKAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449
LC_FACL_like cd05914
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ...
112-570 1.12e-09

Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341240 [Multi-domain]  Cd Length: 463  Bit Score: 60.92  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 112 GICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALi 191
Cdd:cd05914     5 GEPLTYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEAKAI- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 192 yggemaaavaevseqlgksllkFCSgdlgpesilpdtqllDPmlaeapttplaqapgkgmDDRLFYIYTSGTTGLPKAAI 271
Cdd:cd05914    84 ----------------------FVS---------------DE------------------DDVALINYTSGTTGNSKGVM 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 272 VVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFwDDCVKYNCTVV------ 345
Cdd:cd05914   109 LTYRNIVSNVDGVKEVVLLGKGDKILSILPLHHIYPLTFTLLLPLLNGAHVVFLDKIPSAKI-IALAFAQVTPTlgvpvp 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 346 -------------QYIGEICRYLLRQPVRDVEQRHRVRLAV--------------GNGLRPAIwEEFTQRFGVPQIgEFY 398
Cdd:cd05914   188 lviekifkmdiipKLTLKKFKFKLAKKINNRKIRKLAFKKVheafggnikefvigGAKINPDV-EEFLRTIGFPYT-IGY 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 399 GATECN---CSIANMDGKVGSCGFnsrilthvyPIRLVKVNEDTMEPlrdseglcipcQPGEPGLLVGQINQqdplrrFD 475
Cdd:cd05914   266 GMTETApiiSYSPPNRIRLGSAGK---------VIDGVEVRIDSPDP-----------ATGEGEIIVRGPNV------MK 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 476 GYVSdsatNKKIAHSVFRKgDSAYLSGDVLVMDELGYMYFRDRSGDTFRW-RGENVSTTEVEAVLSRLlgqTDVAVYGVA 554
Cdd:cd05914   320 GYYK----NPEATAEAFDK-DGWFHTGDLGKIDAEGYLYIRGRKKEMIVLsSGKNIYPEEIEAKINNM---PFVLESLVV 391
                         490
                  ....*....|....*.
gi 1907189407 555 VpgVEGKAGMAAIADP 570
Cdd:cd05914   392 V--QEKKLVALAYIDP 405
PRK09192 PRK09192
fatty acyl-AMP ligase;
134-307 2.89e-09

fatty acyl-AMP ligase;


Pssm-ID: 236403 [Multi-domain]  Cd Length: 579  Bit Score: 60.02  E-value: 2.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 134 LGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVnlrrePLAF------------CLGTSAAKALIYGGEMAAAVA 201
Cdd:PRK09192   69 LGLKPGDRVALIAETDGDFVEAFFACQYAGLVPVPLPL-----PMGFggresyiaqlrgMLASAQPAAIITPDELLPWVN 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 202 EVSEqlGKSLLKfcsgdlgpesILPDTQLldpMLAEAPTTPLAQA-PgkgmDDRLFYIYTSGTTGLPKAAIVVH-SRYYR 279
Cdd:PRK09192  144 EATH--GNPLLH----------VLSHAWF---KALPEADVALPRPtP----DDIAYLQYSSGSTRFPRGVIITHrALMAN 204
                         170       180
                  ....*....|....*....|....*...
gi 1907189407 280 IAAFGHHSYSMRAADVLYDCLPLYHSAG 307
Cdd:PRK09192  205 LRAISHDGLKVRPGDRCVSWLPFYHDMG 232
PRK05677 PRK05677
long-chain-fatty-acid--CoA ligase; Validated
94-618 6.59e-09

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 168170 [Multi-domain]  Cd Length: 562  Bit Score: 59.01  E-value: 6.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  94 QAVARRQPERLALVDASS--GICWTFAQLDTYSNAVANLFRQL-GFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVaaLLN 170
Cdd:PRK05677   27 QAVLKQSCQRFADKPAFSnlGKTLTYGELYKLSGAFAAWLQQHtDLKPGDRIAVQLPNVLQYPVAVFGAMRAGLI--VVN 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 171 VN---LRREpLAFCLGTSAAKALIYGGEMA--------------AAVAEVSEQLG-------KSLLKFCSgDLGPESILP 226
Cdd:PRK05677  105 TNplyTARE-MEHQFNDSGAKALVCLANMAhlaekvlpktgvkhVIVTEVADMLPplkrlliNAVVKHVK-KMVPAYHLP 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 227 DTQLLDPMLAEAPTTPLAQAPGKGmDDRLFYIYTSGTTGLPKAAIVVHSRyyrIAAFGHHSYSMRAADVLYDC------L 300
Cdd:PRK05677  183 QAVKFNDALAKGAGQPVTEANPQA-DDVAVLQYTGGTTGVAKGAMLTHRN---LVANMLQCRALMGSNLNEGCeiliapL 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 301 PLYH------SAGNIMGVGQCVIY--------GLTVVLRK-KFSAsrFwddcVKYNCTVVQyigeICRyllRQPVRDVE- 364
Cdd:PRK05677  259 PLYHiyaftfHCMAMMLIGNHNILisnprdlpAMVKELGKwKFSG--F----VGLNTLFVA----LCN---NEAFRKLDf 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 365 QRHRVRLAVGNGLRPAIWEEFTQRFGVPqIGEFYGATECN--CSIANMDG-KVGSCGFNsrilthvYPIRLVKVNEDTME 441
Cdd:PRK05677  326 SALKLTLSGGMALQLATAERWKEVTGCA-ICEGYGMTETSpvVSVNPSQAiQVGTIGIP-------VPSTLCKVIDDDGN 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 442 --PLRDSEGLCIPcqpgEPGLLVGQINQQDplrrfdgyvsdsATNKKIAHSVFRKgdsaylSGDVLVMDELGYMYFRDRS 519
Cdd:PRK05677  398 elPLGEVGELCVK----GPQVMKGYWQRPE------------ATDEILDSDGWLK------TGDIALIQEDGYMRIVDRK 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 520 GDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAvpgvEGKAGMA----AIADPHSQLDPNSMYQELQKVLASYARPIF 595
Cdd:PRK05677  456 KDMILVSGFNVYPNELEDVLAALPGVLQCAAIGVP----DEKSGEAikvfVVVKPGETLTKEQVMEHMRANLTGYKVPKA 531
                         570       580
                  ....*....|....*....|...
gi 1907189407 596 LRLLPQVDTTGTFKIQKTRLQRE 618
Cdd:PRK05677  532 VEFRDELPTTNVGKILRRELRDE 554
A_NRPS_CmdD_like cd17652
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ...
101-282 7.86e-09

similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).


Pssm-ID: 341307 [Multi-domain]  Cd Length: 436  Bit Score: 58.42  E-value: 7.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 101 PERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAF 180
Cdd:cd17652     1 PDAPAVVFGDETL--TYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 181 CLGTSAAKALIyggemaaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapTTPlaqapgkgmdDRLFY-IY 259
Cdd:cd17652    79 MLADARPALLL------------------------------------------------TTP----------DNLAYvIY 100
                         170       180
                  ....*....|....*....|...
gi 1907189407 260 TSGTTGLPKAAIVVHSRYYRIAA 282
Cdd:cd17652   101 TSGSTGRPKGVVVTHRGLANLAA 123
PrpE cd05967
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ...
116-600 8.12e-09

Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.


Pssm-ID: 341271 [Multi-domain]  Cd Length: 617  Bit Score: 58.48  E-value: 8.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGvvaallnvnlrreplafclgtsAAKALIYGGE 195
Cdd:cd05967    84 TYAELLDEVSRLAGVLRKLGVVKGDRVIIYMPMIPEAAIAMLACARIG----------------------AIHSVVFGGF 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 MAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPL-------------AQAPGKGMD---------- 252
Cdd:cd05967   142 AAKELASRIDDAKPKLIVTASCGIEPGKVVPYKPLLDKALELSGHKPHhvlvlnrpqvpadLTKPGRDLDwsellakaep 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 ---------DRLFYIYTSGTTGLPKAaIVVHSRYYRIAAfghhSYSMRAadvLYDCLP--LYHSAGNImG--VGQCVI-Y 318
Cdd:cd05967   222 vdcvpvaatDPLYILYTSGTTGKPKG-VVRDNGGHAVAL----NWSMRN---IYGIKPgdVWWAASDV-GwvVGHSYIvY 292
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 319 G------LTVVLRKKFS----ASRFWDDCVKYNCTVVQYIGEICRYLLRQP-----VRDVE-QRHRVRLAVGNGLRPAIW 382
Cdd:cd05967   293 GpllhgaTTVLYEGKPVgtpdPGAFWRVIEKYQVNALFTAPTAIRAIRKEDpdgkyIKKYDlSSLRTLFLAGERLDPPTL 372
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 383 EEFTQRFGVPQIgEFYGATE------CNCS-IANMDGKVGSC-----GFNsrilthvypirlVKVNEDTMEPLRDSE--G 448
Cdd:cd05967   373 EWAENTLGVPVI-DHWWQTEtgwpitANPVgLEPLPIKAGSPgkpvpGYQ------------VQVLDEDGEPVGPNElgN 439
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 449 LCIPCqPGEPGLLVGQINQQDplrRF-DGYVSDSatnkkiahsvfrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRG 527
Cdd:cd05967   440 IVIKL-PLPPGCLLTLWKNDE---RFkKLYLSKF--------------PGYYDTGDAGYKDEDGYLFIMGRTDDVINVAG 501
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 528 ENVSTTEVEAVLSRLLGQTDVAVYGVaVPGVEGKAGMA-AIADPHSQLDPNSMYQELQKV-------LASYARPIFLRLL 599
Cdd:cd05967   502 HRLSTGEMEESVLSHPAVAECAVVGV-RDELKGQVPLGlVVLKEGVKITAEELEKELVALvreqigpVAAFRLVIFVKRL 580

                  .
gi 1907189407 600 P 600
Cdd:cd05967   581 P 581
PRK08751 PRK08751
long-chain fatty acid--CoA ligase;
252-553 2.38e-08

long-chain fatty acid--CoA ligase;


Pssm-ID: 181546 [Multi-domain]  Cd Length: 560  Bit Score: 57.19  E-value: 2.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYS-----MRAADVLYDCLPLYH----SAGNI--MGVGqcviyGL 320
Cdd:PRK08751  208 DDIAFLQYTGGTTGVAKGAMLTHRNLVANMQQAHQWLAgtgklEEGCEVVITALPLYHifalTANGLvfMKIG-----GC 282
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 321 TVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGL--RPAIWEEFTQRFGVPQIgEFY 398
Cdd:PRK08751  283 NHLISNPRDMPGFVKELKKTRFTAFTGVNTLFNGLLNTPGFDQIDFSSLKMTLGGGMavQRSVAERWKQVTGLTLV-EAY 361
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 399 GATECNcsianmdgkVGSCgfnsrilthVYPIRLVKVNEDTMEPLrDSEGLCIPCQPGEpGLLVGQINQ---QDPlRRFD 475
Cdd:PRK08751  362 GLTETS---------PAAC---------INPLTLKEYNGSIGLPI-PSTDACIKDDAGT-VLAIGEIGElciKGP-QVMK 420
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907189407 476 GYVSDSATNKKIAHSvfrkgDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGV 553
Cdd:PRK08751  421 GYWKRPEETAKVMDA-----DGWLHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGVLEVAAVGV 493
PRK09029 PRK09029
O-succinylbenzoic acid--CoA ligase; Provisional
97-307 3.06e-08

O-succinylbenzoic acid--CoA ligase; Provisional


Pssm-ID: 236363 [Multi-domain]  Cd Length: 458  Bit Score: 56.42  E-value: 3.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVdaSSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRRE 176
Cdd:PRK09029   13 AQVRPQAIALR--LNDEVLTWQQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNPQLPQP 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLafclgtsaakaliyggemaaavAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPgkgMddrlf 256
Cdd:PRK09029   91 LL----------------------EELLPSLTLDFALVLEGENTFSALTSLHLQLVEGAHAVAWQPQRLAT---M----- 140
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907189407 257 yIYTSGTTGLPKAaiVVHSryyriaaFGHHSYSmrAADVL----YDC-------LPLYHSAG 307
Cdd:PRK09029  141 -TLTSGSTGLPKA--AVHT-------AQAHLAS--AEGVLslmpFTAqdswllsLPLFHVSG 190
PRK05691 PRK05691
peptide synthase; Validated
83-294 3.35e-08

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 57.10  E-value: 3.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   83 RRAGDTIPCIFQAVARRQPERLALVDASSGICwtFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKA 162
Cdd:PRK05691  2184 ARLDQTLHGLFAAQAARTPQAPALTFAGQTLS--YAELDARANRLARALRERGVGPQVRVGLALERSLEMVVGLLAILKA 2261
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  163 GVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEvseqLGKSLLKFCsgdlgpesiLPDTQlldPMLAEAPTTP 242
Cdd:PRK05691  2262 GGAYVPLDPEYPLERLHYMIEDSGIGLLLSDRALFEALGE----LPAGVARWC---------LEDDA---AALAAYSDAP 2325
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407  243 LAQAPGKgmDDRLFYIYTSGTTGLPKAAIVVHSRYYR-----IAAFGhhsysMRAAD 294
Cdd:PRK05691  2326 LPFLSLP--QHQAYLIYTSGSTGKPKGVVVSHGEIAMhcqavIERFG-----MRADD 2375
FADD10 cd17635
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ...
253-612 6.84e-08

adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.


Pssm-ID: 341290 [Multi-domain]  Cd Length: 340  Bit Score: 54.96  E-value: 6.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 DRLFYIYTSGTTGLPKAAIVVHSRYYriAAFGH---HSYSMRAADVLYDCLPLYHSAGN------IMGVGQCVIYGLTVV 323
Cdd:cd17635     2 DPLAVIFTSGTTGEPKAVLLANKTFF--AVPDIlqkEGLNWVVGDVTYLPLPATHIGGLwwiltcLIHGGLCVTGGENTT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 324 LRKKFSASRFWDdcVKYNCTVVQYIGEICRyLLRQPVRDVEQrhrVRLAVGNGLRP-AIWEEFTQRFGVPQIGEFYGATE 402
Cdd:cd17635    80 YKSLFKILTTNA--VTTTCLVPTLLSKLVS-ELKSANATVPS---LRLIGYGGSRAiAADVRFIEATGLTNTAQVYGLSE 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 403 CN--CSIANMDG--KVGSCGfnsriltHVYPIRLVKV-NEDTMEPLRDSEGLCIPCQPgepgllvgqinqqdplRRFDGY 477
Cdd:cd17635   154 TGtaLCLPTDDDsiEINAVG-------RPYPGVDVYLaATDGIAGPSASFGTIWIKSP----------------ANMLGY 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 478 VSdsatNKKIAHSVFRKGdsaYL-SGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYgvAVP 556
Cdd:cd17635   211 WN----NPERTAEVLIDG---WVnTGDLGERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACY--EIS 281
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 557 GVEGKAGMAAIADPHSQLDPNSMYQELQKV---LASYARPIFLRLLPQVDTTGTFKIQK 612
Cdd:cd17635   282 DEEFGELVGLAVVASAELDENAIRALKHTIrreLEPYARPSTIVIVTDIPRTQSGKVKR 340
AMP-binding_C pfam13193
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ...
534-609 7.01e-08

AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.


Pssm-ID: 463804 [Multi-domain]  Cd Length: 76  Bit Score: 49.85  E-value: 7.01e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407 534 EVEAVLSRLLGQTDVAVYGVAVPgVEGKAGMA-AIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFK 609
Cdd:pfam13193   1 EVESALVSHPAVAEAAVVGVPDE-LKGEAPVAfVVLKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76
PRK12316 PRK12316
peptide synthase; Provisional
92-275 7.07e-08

peptide synthase; Provisional


Pssm-ID: 237054 [Multi-domain]  Cd Length: 5163  Bit Score: 56.12  E-value: 7.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   92 IFQAVARRQPERLALVDASSGIcwTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNV 171
Cdd:PRK12316   516 LFEEQVERTPEAPALAFGEETL--DYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLDP 593
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  172 NLRREPLAFCLGTSAAKALIyggemaaavaevSEQlgkSLLKFCSGDLGPESILPD--TQLLDPMLAEAPTTPLAQapgk 249
Cdd:PRK12316   594 EYPAERLAYMLEDSGVQLLL------------SQS---HLGRKLPLAAGVQVLDLDrpAAWLEGYSEENPGTELNP---- 654
                          170       180
                   ....*....|....*....|....*..
gi 1907189407  250 gmdDRLFY-IYTSGTTGLPKAAIVVHS 275
Cdd:PRK12316   655 ---ENLAYvIYTSGSTGKPKGAGNRHR 678
FACL_like_5 cd05924
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
253-602 1.18e-07

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341248 [Multi-domain]  Cd Length: 364  Bit Score: 54.31  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 253 DRLFYIYTSGTTGLPKAAIVVHSRYYRI----AAFGHHSYSM---------RAAD-VLYDCLPLYHSAGNIMGVGQcVIY 318
Cdd:cd05924     4 DDLYILYTGGTTGMPKGVMWRQEDIFRMlmggADFGTGEFTPsedahkaaaAAAGtVMFPAPPLMHGTGSWTAFGG-LLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 319 GLTVVL-RKKFSASRFWDDCVKYNCTVVQYIGEIcryLLRQPVRDVEQRHRVRL----AVGNGlrPAIW-EEFTQRF--G 390
Cdd:cd05924    83 GQTVVLpDDRFDPEEVWRTIEKHKVTSMTIVGDA---MARPLIDALRDAGPYDLsslfAISSG--GALLsPEVKQGLleL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 391 VPQIG--EFYGATEcncSIANMDGKVGSCGFNSRILTHVYPiRLVKVNEDTMEPLRDSEGlcipcqpgepgllVGQINQQ 468
Cdd:cd05924   158 VPNITlvDAFGSSE---TGFTGSGHSAGSGPETGPFTRANP-DTVVLDDDGRVVPPGSGG-------------VGWIARR 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 469 D--PLrrfdGYVSDSatnKKIAHSVFRKGDSAY-LSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQ 545
Cdd:cd05924   221 GhiPL----GYYGDE---AKTAETFPEVDGVRYaVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAV 293
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907189407 546 TDVAVYGVAVP--GVEgkagMAAI--ADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQV 602
Cdd:cd05924   294 YDVLVVGRPDErwGQE----VVAVvqLREGAGVDLEELREHCRTRIARYKLPKQVVFVDEI 350
FACL_like_1 cd05910
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ...
116-615 2.24e-07

Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.


Pssm-ID: 341236 [Multi-domain]  Cd Length: 457  Bit Score: 53.62  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIygGE 195
Cdd:cd05910     4 SFRELDERSDRIAQGLTAYGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDPGMGRKNLKQCLQEAEPDAFI--GI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 maaavaevseqlgksllkfcsgdlgpesilpdtqlldpmlaeapttPLAqapgkgmDDRLFYIYTSGTTGLPKAAIVVHS 275
Cdd:cd05910    82 ----------------------------------------------PKA-------DEPAAILFTSGSTGTPKGVVYRHG 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 276 RYY-RIAAFgHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCV-----IYGLTVVLRKKFSASRfwddcvKYNCTVV---- 345
Cdd:cd05910   109 TFAaQIDAL-RQLYGIRPGEVDLATFPLFALFGPALGLTSVIpdmdpTRPARADPQKLVGAIR------QYGVSIVfgsp 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 346 QYIGEICRYLLRQPvRDVEQRHRVrLAVGNGLRPAIWEEFtqRFGVPQIGEF---YGATEC--NCSIANMD--------- 411
Cdd:cd05910   182 ALLERVARYCAQHG-ITLPSLRRV-LSAGAPVPIALAARL--RKMLSDEAEIltpYGATEAlpVSSIGSREllatttaat 257
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 412 -GKVGSCgfnsriLTHVYPIRLVKVNEDTMEPLRDSEG-LCIPcqPGEpgllVGQINQQDPLrrfdgyVSDSATNKKIAH 489
Cdd:cd05910   258 sGGAGTC------VGRPIPGVRVRIIEIDDEPIAEWDDtLELP--RGE----IGEITVTGPT------VTPTYVNRPVAT 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 490 SVFRKGDSA----YLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAG-- 563
Cdd:cd05910   320 ALAKIDDNSegfwHRMGDLGYLDDEGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGVGKPGCQLPVLcv 399
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 564 --MAAIADPHSQLdpnsmYQELQKVLASYA-----RPIFLRLLPQVDTTGTFKIQKTRL 615
Cdd:cd05910   400 epLPGTITPRARL-----EQELRALAKDYPhtqriGRFLIHPSFPVDIRHNAKIFREKL 453
alpha_am_amid TIGR03443
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ...
89-283 3.16e-07

L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.


Pssm-ID: 274582 [Multi-domain]  Cd Length: 1389  Bit Score: 53.92  E-value: 3.16e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   89 IPCIFQAVARRQPERLALVDASSGIC-------WTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAK 161
Cdd:TIGR03443  238 IHDIFADNAEKHPDRTCVVETPSFLDpssktrsFTYKQINEASNILAHYLLKTGIKRGDVVMIYAYRGVDLVVAVMGVLK 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  162 AGVVAALLNVNLRREPLAFCLGTSAAKALIyggemaaaVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAE---- 237
Cdd:TIGR03443  318 AGATFSVIDPAYPPARQTIYLSVAKPRALI--------VIEKAGTLDQLVRDYIDKELELRTEIPALALQDDGSLVggsl 389
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407  238 --------APTTPLAQAPGK---GMDDRLFYIYTSGTTGLPKAaivVHSRYYRIAAF 283
Cdd:TIGR03443  390 eggetdvlAPYQALKDTPTGvvvGPDSNPTLSFTSGSEGIPKG---VLGRHFSLAYY 443
PLN02479 PLN02479
acetate-CoA ligase
100-539 1.38e-06

acetate-CoA ligase


Pssm-ID: 178097 [Multi-domain]  Cd Length: 567  Bit Score: 51.38  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 100 QPERLALVDASSGICWtfaqLDTYSNA--VANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREP 177
Cdd:PLN02479   33 HPTRKSVVHGSVRYTW----AQTYQRCrrLASALAKRSIGPGSTVAVIAPNIPAMYEAHFGVPMAGAVVNCVNIRLNAPT 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 178 LAFCLGTSAAKALIYGGEMAAAVAE----VSEQLGKSL---LKFCSGD-----------LGPESILPDTQLL--DPMLAE 237
Cdd:PLN02479  109 IAFLLEHSKSEVVMVDQEFFTLAEEalkiLAEKKKSSFkppLLIVIGDptcdpkslqyaLGKGAIEYEKFLEtgDPEFAW 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 238 APTTPLAQAPGKGmddrlfyiYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVI 317
Cdd:PLN02479  189 KPPADEWQSIALG--------YTSGTTASPKGVVLHHRGAYLMALSNALIWGMNEGAVYLWTLPMFHCNGWCFTWTLAAL 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 318 YGLTVVLRKkFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRD--VEQRHRVRLAV-GNGLRPAIWEEFTQR-FGVPQ 393
Cdd:PLN02479  261 CGTNICLRQ-VTAKAIYSAIANYGVTHFCAAPVVLNTIVNAPKSEtiLPLPRVVHVMTaGAAPPPSVLFAMSEKgFRVTH 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 394 ---IGEFYG-ATECN----------CSIANMDGKVGscgfnsriLTHVYPIRLVKVNEDTMEPLrdseglcipcqPGEpG 459
Cdd:PLN02479  340 tygLSETYGpSTVCAwkpewdslppEEQARLNARQG--------VRYIGLEGLDVVDTKTMKPV-----------PAD-G 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 460 LLVGQInqqdpLRRFDGYVSDSATNKKIAHSVFRKGdsAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVL 539
Cdd:PLN02479  400 KTMGEI-----VMRGNMVMKGYLKNPKANEEAFANG--WFHSGDLGVKHPDGYIEIKDRSKDIIISGGENISSLEVENVV 472
PTZ00216 PTZ00216
acyl-CoA synthetase; Provisional
116-275 1.48e-06

acyl-CoA synthetase; Provisional


Pssm-ID: 240316 [Multi-domain]  Cd Length: 700  Bit Score: 51.52  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGE 195
Cdd:PTZ00216  123 TYAELWERIVNFGRGLAELGLTKGSNVAIYEETRWEWLASIYGIWSQSMVAATVYANLGEDALAYALRETECKAIVCNGK 202
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 maaAVAEVSEQLGKSLLKFCS----GDLgPES-------ILPDTQLLDPMLAEAPTTPLaqaPGKGMDDRLFYI-YTSGT 263
Cdd:PTZ00216  203 ---NVPNLLRLMKSGGMPNTTiiylDSL-PASvdtegcrLVAWTDVVAKGHSAGSHHPL---NIPENNDDLALImYTSGT 275
                         170
                  ....*....|..
gi 1907189407 264 TGLPKAaiVVHS 275
Cdd:PTZ00216  276 TGDPKG--VMHT 285
PLN02654 PLN02654
acetate-CoA ligase
252-617 1.61e-06

acetate-CoA ligase


Pssm-ID: 215353 [Multi-domain]  Cd Length: 666  Bit Score: 51.44  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 252 DDRLFYIYTSGTTGLPKAAIVVHSRY--YRIAAFgHHSYSMRAADVLY---DClplyhsaGNIMGvGQCVIYG-----LT 321
Cdd:PLN02654  275 EDPLFLLYTSGSTGKPKGVLHTTGGYmvYTATTF-KYAFDYKPTDVYWctaDC-------GWITG-HSYVTYGpmlngAT 345
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 322 VVLRKKF----SASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRL----AVGNGLRPAIWEEFTQRFGvpq 393
Cdd:PLN02654  346 VLVFEGApnypDSGRCWDIVDKYKVTIFYTAPTLVRSLMRDGDEYVTRHSRKSLrvlgSVGEPINPSAWRWFFNVVG--- 422
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 394 igefygatECNCSIANMDGKVGSCGFNSRILTHVYP------------IRLVKVNEDTMEPLRDSEG-LCIPCQ-PGEPG 459
Cdd:PLN02654  423 --------DSRCPISDTWWQTETGGFMITPLPGAWPqkpgsatfpffgVQPVIVDEKGKEIEGECSGyLCVKKSwPGAFR 494
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 460 LLVGQINQQDP--LRRFDGYvsdsatnkkiahsvfrkgdsaYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEA 537
Cdd:PLN02654  495 TLYGDHERYETtyFKPFAGY---------------------YFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVES 553
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 538 VLSRLLGQTDVAVYGV--AVPGvEGKAGMAAIAD--PHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKT 613
Cdd:PLN02654  554 ALVSHPQCAEAAVVGIehEVKG-QGIYAFVTLVEgvPYSEELRKSLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRR 632

                  ....
gi 1907189407 614 RLQR 617
Cdd:PLN02654  633 ILRK 636
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
92-307 2.79e-06

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 50.73  E-value: 2.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   92 IFQAV--ARRQ--PERLALVDASSGICwTFAQLDTYSNAVANLFRQlGFAPGDVVAVFLegrPEFVGL---WLGLAKAGV 164
Cdd:PRK06814   633 LFEALieAAKIhgFKKLAVEDPVNGPL-TYRKLLTGAFVLGRKLKK-NTPPGENVGVML---PNANGAavtFFALQSAGR 707
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  165 VAALLN-----VNLrrepLAFCLGTS-----AAKALIYGGEMAAAVAEVSEQLGKSLLkfcsgdlgpESILPDTQLLDPM 234
Cdd:PRK06814   708 VPAMINfsagiANI----LSACKAAQvktvlTSRAFIEKARLGPLIEALEFGIRIIYL---------EDVRAQIGLADKI 774
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  235 LAE-APTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVH----SRYYRIAA---FGhhsysmrAADVLYDCLPLYHSA 306
Cdd:PRK06814   775 KGLlAGRFPLVYFCNRDPDDPAVILFTSGSEGTPKGVVLSHrnllANRAQVAAridFS-------PEDKVFNALPVFHSF 847

                   .
gi 1907189407  307 G 307
Cdd:PRK06814   848 G 848
PRK06334 PRK06334
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
248-547 3.14e-06

long chain fatty acid--[acyl-carrier-protein] ligase; Validated


Pssm-ID: 180533 [Multi-domain]  Cd Length: 539  Bit Score: 50.20  E-value: 3.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 248 GKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAG-NIMGV-----GQCVIYGLT 321
Cdd:PRK06334  179 DKDPEDVAVILFTSGTEKLPKGVPLTHANLLANQRACLKFFSPKEDDVMMSFLPPFHAYGfNSCTLfpllsGVPVVFAYN 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 322 VVLRKKFsaSRFWDDcvkyncTVVQYIGE---ICRYLLRQPVRDVEQRHRVRLAV--GNGLRPAIWEEFTQRFGVPQIGE 396
Cdd:PRK06334  259 PLYPKKI--VEMIDE------AKVTFLGStpvFFDYILKTAKKQESCLPSLRFVVigGDAFKDSLYQEALKTFPHIQLRQ 330
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 397 FYGATECN--CSIANMDG-KVGSCgfnsrilthvypirlVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQdplrr 473
Cdd:PRK06334  331 GYGTTECSpvITINTVNSpKHESC---------------VGMPIRGMDVLIVSEETKVPVSSGETGLVLTRGTSL----- 390
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907189407 474 FDGYVSDSATNKKIAHSvfrkGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTD 547
Cdd:PRK06334  391 FSGYLGEDFGQGFVELG----GETWYVTGDLGYVDRHGELFLKGRLSRFVKIGAEMVSLEALESILMEGFGQNA 460
PLN02736 PLN02736
long-chain acyl-CoA synthetase
115-304 5.63e-06

long-chain acyl-CoA synthetase


Pssm-ID: 178337 [Multi-domain]  Cd Length: 651  Bit Score: 49.71  E-value: 5.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 W-TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEfvglWLGLAKAGVVAALLNVnlrrePLAFCLGTSAAKALIYG 193
Cdd:PLN02736   78 WmTYGEAGTARTAIGSGLVQHGIPKGACVGLYFINRPE----WLIVDHACSAYSYVSV-----PLYDTLGPDAVKFIVNH 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 194 GEMAAAVaeVSEQLGKSLLKFCSgDL----------GPESILPDTQL--------LDPMLAEAPTTPLAQAPGKGmDDRL 255
Cdd:PLN02736  149 AEVAAIF--CVPQTLNTLLSCLS-EIpsvrlivvvgGADEPLPSLPSgtgveivtYSKLLAQGRSSPQPFRPPKP-EDVA 224
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1907189407 256 FYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYH 304
Cdd:PLN02736  225 TICYTSGTTGTPKGVVLTHGNLIANVAGSSLSTKFYPSDVHISYLPLAH 273
ACS cd05966
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ...
97-571 6.36e-06

Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.


Pssm-ID: 341270 [Multi-domain]  Cd Length: 608  Bit Score: 49.48  E-value: 6.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALV----DASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVaallnvn 172
Cdd:cd05966    63 LKERGDKVAIIwegdEPDQSRTITYRELLREVCRFANVLKSLGVKKGDRVAIYMPMIPELVIAMLACARIGAV------- 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 173 lrreplafclgtsaaKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPT---------TPL 243
Cdd:cd05966   136 ---------------HSVVFAGFSAESLADRINDAQCKLVITADGGYRGGKVIPLKEIVDEALEKCPSvekvlvvkrTGG 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 244 AQAPGKGMD----------------------DRLFYIYTSGTTGLPKAaiVVHS----------------------RYYR 279
Cdd:cd05966   201 EVPMTEGRDlwwhdlmakqspecepewmdseDPLFILYTSGSTGKPKG--VVHTtggyllyaattfkyvfdyhpddIYWC 278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 280 IAAFG---HHSYsmraadVLYDclPLyhsagnimgvgqcvIYGLTVVLrkkF-------SASRFWDDCVKYNCTVVQYIG 349
Cdd:cd05966   279 TADIGwitGHSY------IVYG--PL--------------ANGATTVM---FegtptypDPGRYWDIVEKHKVTIFYTAP 333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 350 EICRYLLRQPvRDVEQRH-----RVRLAVGNGLRPAIWEEFTQRFG---VPqIGEFYGATEC-NCSIANMDG----KVGS 416
Cdd:cd05966   334 TAIRALMKFG-DEWVKKHdlsslRVLGSVGEPINPEAWMWYYEVIGkerCP-IVDTWWQTETgGIMITPLPGatplKPGS 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 417 CGFnsrilthvyP---IRLVKVNEDTMEPLRDSEG-LCIPcQPGePGLLVGQINqqDPLRRFDGYvsdsatnkkiahsvF 492
Cdd:cd05966   412 ATR---------PffgIEPAILDEEGNEVEGEVEGyLVIK-RPW-PGMARTIYG--DHERYEDTY--------------F 464
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 493 RKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLsrllgqtdvavygVAVPGVegkAGMAAIADPH 571
Cdd:cd05966   465 SKFPGYYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESAL-------------VAHPAV---AEAAVVGRPH 527
PRK12492 PRK12492
long-chain-fatty-acid--CoA ligase; Provisional
92-539 7.99e-06

long-chain-fatty-acid--CoA ligase; Provisional


Pssm-ID: 171539 [Multi-domain]  Cd Length: 562  Bit Score: 49.05  E-value: 7.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  92 IFQAVARRQPERLALvdASSGICWTFAQLDTYSNAVANLFRQ-LGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVaaLLN 170
Cdd:PRK12492   29 VFERSCKKFADRPAF--SNLGVTLSYAELERHSAAFAAYLQQhTDLVPGDRIAVQMPNVLQYPIAVFGALRAGLI--VVN 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 171 VN---LRREpLAFCLGTSAAKALIYGGEMAAAVAEVSEQLG-KSLLKFCSGDLGP--ESILPDTqLLDPMLAEAPTTPLA 244
Cdd:PRK12492  105 TNplyTARE-MRHQFKDSGARALVYLNMFGKLVQEVLPDTGiEYLIEAKMGDLLPaaKGWLVNT-VVDKVKKMVPAYHLP 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 245 QAPG-----------------KGMDDRLFYIYTSGTTGLPKAAIVVHSRYYR-----IAAFGH-----HSYSMRAADVLY 297
Cdd:PRK12492  183 QAVPfkqalrqgrglslkpvpVGLDDIAVLQYTGGTTGLAKGAMLTHGNLVAnmlqvRACLSQlgpdgQPLMKEGQEVMI 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 298 DCLPLYHsagnimgvgqcvIYGLT-------------VVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQP-VRDV 363
Cdd:PRK12492  263 APLPLYH------------IYAFTancmcmmvsgnhnVLITNPRDIPGFIKELGKWRFSALLGLNTLFVALMDHPgFKDL 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 364 EQRH-RVRLAVGNGLRPAIWEEFTQRFGVpQIGEFYGATECN-CSIANMDGKVgscgfnSRILTHVYPI--RLVKV-NED 438
Cdd:PRK12492  331 DFSAlKLTNSGGTALVKATAERWEQLTGC-TIVEGYGLTETSpVASTNPYGEL------ARLGTVGIPVpgTALKViDDD 403
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 439 TME-PLRDSEGLCIPcqpgEPGLLVGQINQQDplrrfdgyvsdsATNKKI-AHSVFRkgdsaylSGDVLVMDELGYMYFR 516
Cdd:PRK12492  404 GNElPLGERGELCIK----GPQVMKGYWQQPE------------ATAEALdAEGWFK-------TGDIAVIDPDGFVRIV 460
                         490       500
                  ....*....|....*....|...
gi 1907189407 517 DRSGDTFRWRGENVSTTEVEAVL 539
Cdd:PRK12492  461 DRKKDLIIVSGFNVYPNEIEDVV 483
PRK06018 PRK06018
putative acyl-CoA synthetase; Provisional
116-620 9.78e-06

putative acyl-CoA synthetase; Provisional


Pssm-ID: 235673 [Multi-domain]  Cd Length: 542  Bit Score: 48.59  E-value: 9.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGE 195
Cdd:PRK06018   41 TYAQIHDRALKVSQALDRDGIKLGDRVATIAWNTWRHLEAWYGIMGIGAICHTVNPRLFPEQIAWIINHAEDRVVITDLT 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 196 MAAAVAEVSEQLgKSLLKFCSgdLGPESILPDTQLLDpmlAEAPTTPLAQAPG----KGMDDRLF--YIYTSGTTGLPKA 269
Cdd:PRK06018  121 FVPILEKIADKL-PSVERYVV--LTDAAHMPQTTLKN---AVAYEEWIAEADGdfawKTFDENTAagMCYTSGTTGDPKG 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 270 AI------VVHSryyrIAAFGHHSYSMRAADVLYDCLPLYHSagNIMGVGqcviygltvvlrkkFSASRFWDDCVKYNCt 343
Cdd:PRK06018  195 VLyshrsnVLHA----LMANNGDALGTSAADTMLPVVPLFHA--NSWGIA--------------FSAPSMGTKLVMPGA- 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 344 vvQYIGEICRYLLrqpvrDVEQrhrVRLAVGnglRPAIWEEFTQ-----RFGVPQIGEFY-GATECNCSIANMDGKVGSC 417
Cdd:PRK06018  254 --KLDGASVYELL-----DTEK---VTFTAG---VPTVWLMLLQymekeGLKLPHLKMVVcGGSAMPRSMIKAFEDMGVE 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 418 GFNSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVgQINQQDPLRR---FDG------YVSDSAtnkkIA 488
Cdd:PRK06018  321 VRHAWGMTEMSPLGTLAALKPPFSKLPGDARLDVLQKQGYPPFGV-EMKITDDAGKelpWDGktfgrlKVRGPA----VA 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 489 HSVFRKGDSA------YLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVE--AVlsrllGQTDV---AVYGVAVPG 557
Cdd:PRK06018  396 AAYYRVDGEIldddgfFDTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLEnlAV-----GHPKVaeaAVIGVYHPK 470
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907189407 558 VEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARP---IFLRLLPQvdtTGTFKIQKTRLqREGF 620
Cdd:PRK06018  471 WDERPLLIVQLKPGETATREEILKYMDGKIAKWWMPddvAFVDAIPH---TATGKILKTAL-REQF 532
PRK05691 PRK05691
peptide synthase; Validated
92-272 2.70e-05

peptide synthase; Validated


Pssm-ID: 235564 [Multi-domain]  Cd Length: 4334  Bit Score: 47.86  E-value: 2.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407   92 IFQAVARRQPERLAL--VDASsgicWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALL 169
Cdd:PRK05691  3725 LFEAQVAAHPQRIAAscLDQQ----WSYAELNRAANRLGHALRAAGVGVDQPVALLAERGLDLLGMIVGSFKAGAGYLPL 3800
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  170 NVNLRREPLAFCLGTSAAKALIyggeMAAAVAEvseqLGKSLLKFCSGDLGPesilpdtQLLdpMLAEAPTTPLAQA-PG 248
Cdd:PRK05691  3801 DPGLPAQRLQRIIELSRTPVLV----CSAACRE----QARALLDELGCANRP-------RLL--VWEEVQAGEVASHnPG 3863
                          170       180
                   ....*....|....*....|....*.
gi 1907189407  249 --KGMDDRLFYIYTSGTTGLPKAAIV 272
Cdd:PRK05691  3864 iySGPDNLAYVIYTSGSTGLPKGVMV 3889
entE PRK10946
(2,3-dihydroxybenzoyl)adenylate synthase;
99-317 4.36e-05

(2,3-dihydroxybenzoyl)adenylate synthase;


Pssm-ID: 236803 [Multi-domain]  Cd Length: 536  Bit Score: 46.52  E-value: 4.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  99 RQPERLALVDASSGicWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGV--VAALLNVNlRRE 176
Cdd:PRK10946   35 AASDAIAVICGERQ--FSYRELNQASDNLACSLRRQGIKPGDTALVQLGNVAEFYITFFALLKLGVapVNALFSHQ-RSE 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 177 PLAFC-------LGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGpesilpdtqLLDPMLAEAPTTPLAQAPGk 249
Cdd:PRK10946  112 LNAYAsqiepalLIADRQHALFSDDDFLNTLVAEHSSLRVVLLLNDDGEHS---------LDDAINHPAEDFTATPSPA- 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 250 gmDDRLFYIYTSGTTGLPKAAIVVHSRYYriaafghhsYSMRA--------ADVLYDC-LPLYH----SAGNIMGV---G 313
Cdd:PRK10946  182 --DEVAFFQLSGGSTGTPKLIPRTHNDYY---------YSVRRsveicgftPQTRYLCaLPAAHnypmSSPGALGVflaG 250

                  ....
gi 1907189407 314 QCVI 317
Cdd:PRK10946  251 GTVV 254
PRK12582 PRK12582
acyl-CoA synthetase; Provisional
70-309 4.88e-05

acyl-CoA synthetase; Provisional


Pssm-ID: 237144 [Multi-domain]  Cd Length: 624  Bit Score: 46.58  E-value: 4.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  70 SVLIRVRLELRRHRRagdTIPCIFQAVARRQPER--LALVDASSGiCW---TFAQLDTYSNAVANLFRQLGFAPGDVVAV 144
Cdd:PRK12582   35 SIVIKSRHPLGPYPR---SIPHLLAKWAAEAPDRpwLAQREPGHG-QWrkvTYGEAKRAVDALAQALLDLGLDPGRPVMI 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 145 fLEGRP-EFVGLWLGLAKAGVVAA-------LLNVNLRRepLAFCLgTSAAKALIY---GGEMAAAVAEVSEQlGKSLLk 213
Cdd:PRK12582  111 -LSGNSiEHALMTLAAMQAGVPAApvspaysLMSHDHAK--LKHLF-DLVKPRVVFaqsGAPFARALAALDLL-DVTVV- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 214 FCSGDLGPESILPdtqlLDPMLAEAPTTPLAQAPGK-GMDDRLFYIYTSGTTGLPKAAIVVHsRYYRIAAFGHHSYSMRA 292
Cdd:PRK12582  185 HVTGPGEGIASIA----FADLAATPPTAAVAAAIAAiTPDTVAKYLFTSGSTGMPKAVINTQ-RMMCANIAMQEQLRPRE 259
                         250       260
                  ....*....|....*....|..
gi 1907189407 293 AD----VLYDCLPLYH-SAGNI 309
Cdd:PRK12582  260 PDppppVSLDWMPWNHtMGGNA 281
FCS cd05921
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ...
97-319 8.01e-05

Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.


Pssm-ID: 341245 [Multi-domain]  Cd Length: 561  Bit Score: 45.89  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407  97 ARRQPERLALVDASSGICW---TFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAA------ 167
Cdd:cd05921     5 ARQAPDRTWLAEREGNGGWrrvTYAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGVPAApvspay 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 168 -LLNVNLRRepLAFCLGTsAAKALIY---GGEMAAAVAEVsEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPttpl 243
Cdd:cd05921    85 sLMSQDLAK--LKHLFEL-LKPGLVFaqdAAPFARALAAI-FPLGTPLVVSRNAVAGRGAISFAELAATPPTAAVD---- 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907189407 244 AQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAAD--VLYDCLPLYHSAGNIMGVGqCVIYG 319
Cdd:cd05921   157 AAFAAVGPDTVAKFLFTSGSTGLPKAVINTQRMLCANQAMLEQTYPFFGEEppVLVDWLPWNHTFGGNHNFN-LVLYN 233
PLN02387 PLN02387
long-chain-fatty-acid-CoA ligase family protein
115-319 8.37e-05

long-chain-fatty-acid-CoA ligase family protein


Pssm-ID: 215217 [Multi-domain]  Cd Length: 696  Bit Score: 45.88  E-value: 8.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 115 W-TFAQ-LDTYSNAVANLFrQLGFAPGDVVAVFLEGRPEfvglWL----GLAKAGVVAALLNVNLRREPLAFCLGTSAAK 188
Cdd:PLN02387  106 WiTYGQvFERVCNFASGLV-ALGHNKEERVAIFADTRAE----WLialqGCFRQNITVVTIYASLGEEALCHSLNETEVT 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 189 ALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLA----------EAPTTPLAQAPgkgmDDRLFYI 258
Cdd:PLN02387  181 TVICDSKQLKKLIDISSQLETVKRVIYMDDEGVDSDSSLSGSSNWTVSsfseveklgkENPVDPDLPSP----NDIAVIM 256
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407 259 YTSGTTGLPKAAIVVHSRYY-RIAAFGHHSYSMRAADVLYDCLPLYH----SAGNIM-GVGQCVIYG 319
Cdd:PLN02387  257 YTSGSTGLPKGVMMTHGNIVaTVAGVMTVVPKLGKNDVYLAYLPLAHilelAAESVMaAVGAAIGYG 323
PRK08308 PRK08308
acyl-CoA synthetase; Validated
491-610 1.22e-04

acyl-CoA synthetase; Validated


Pssm-ID: 236231 [Multi-domain]  Cd Length: 414  Bit Score: 45.03  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 491 VFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYgvavPGVEGKAG--MAAIA 568
Cdd:PRK08308  285 VVKMGDKEIFTKDLGYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVY----RGKDPVAGerVKAKV 360
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1907189407 569 DPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKI 610
Cdd:PRK08308  361 ISHEEIDPVQLREWCIQHLAPYQVPHEIESVTEIPKNANGKV 402
PRK07008 PRK07008
long-chain-fatty-acid--CoA ligase; Validated
501-620 2.42e-04

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 235908 [Multi-domain]  Cd Length: 539  Bit Score: 44.31  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 501 SGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMY 580
Cdd:PRK07008  413 TGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDERPLLVVVKRPGAEVTREELL 492
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1907189407 581 QELQKVLASYARP---IFLRLLPQvdtTGTFKIQKTRLqREGF 620
Cdd:PRK07008  493 AFYEGKVAKWWIPddvVFVDAIPH---TATGKLQKLKL-REQF 531
PRK07787 PRK07787
acyl-CoA synthetase; Validated
258-619 2.92e-04

acyl-CoA synthetase; Validated


Pssm-ID: 236096 [Multi-domain]  Cd Length: 471  Bit Score: 43.83  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 258 IYTSGTTGLPKAaiVVHSRyyRIAAFG----HHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRF 333
Cdd:PRK07787  134 VYTSGTTGPPKG--VVLSR--RAIAADldalAEAWQWTADDVLVHGLPLFHVHGLVLGVLGPLRIGNRFVHTGRPTPEAY 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 334 WDDCvKYNCTVvqYIGEICRYllRQPVRDVEQRH---RVRLAV-GNGLRPA-IWEEFTQRFGVPQIgEFYGATEC--NCS 406
Cdd:PRK07787  210 AQAL-SEGGTL--YFGVPTVW--SRIAADPEAARalrGARLLVsGSAALPVpVFDRLAALTGHRPV-ERYGMTETliTLS 283
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 407 I-ANMDGKVGSCGFnsrilthvyPIRLVKVNedtmepLRDSEGLCIPCQpGEPgllVGQINQQDPLrRFDGYVsdsatNK 485
Cdd:PRK07787  284 TrADGERRPGWVGL---------PLAGVETR------LVDEDGGPVPHD-GET---VGELQVRGPT-LFDGYL-----NR 338
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 486 KIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDR-SGDTFRWRGENVSTTEVEAVlsrLLGQTDVAvyGVAVPGVE----G 560
Cdd:PRK07787  339 PDATAAAFTADGWFRTGDVAVVDPDGMHRIVGReSTDLIKSGGYRIGAGEIETA---LLGHPGVR--EAAVVGVPdddlG 413
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 561 KAGMAAIAdPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREG 619
Cdd:PRK07787  414 QRIVAYVV-GADDVAADELIDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLLSEG 471
ACSBG_like cd05933
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ...
258-322 4.47e-04

Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.


Pssm-ID: 341256 [Multi-domain]  Cd Length: 596  Bit Score: 43.50  E-value: 4.47e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907189407 258 IYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDC----LPLYHSAGNIMGVGQCVIYGLTV 322
Cdd:cd05933   156 IYTSGTTGMPKGVMLSHDNITWTAKAASQHMDLRPATVGQESvvsyLPLSHIAAQILDIWLPIKVGGQV 224
LC-FACS_euk cd05927
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ...
116-304 9.56e-04

Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.


Pssm-ID: 341250 [Multi-domain]  Cd Length: 545  Bit Score: 42.20  E-value: 9.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 116 TFAQLDTYSNAVANLFRQLGF--APGDVVAVFLEGRPEfvglWLGLAKAGVVAALLNVnlrrePLAFCLGTSAAKALIYG 193
Cdd:cd05927     7 SYKEVAERADNIGSALRSLGGkpAPASFVGIYSINRPE----WIISELACYAYSLVTV-----PLYDTLGPEAIEYILNH 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 194 GEMaaavaevseqlgkSLLkFCSGDLGPESIlpdTQLLDpMLAEAPTTPLAQAPgkgmdDRLFYI-YTSGTTGLPKAAIV 272
Cdd:cd05927    78 AEI-------------SIV-FCDAGVKVYSL---EEFEK-LGKKNKVPPPPPKP-----EDLATIcYTSGTTGNPKGVML 134
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1907189407 273 VH----SRYYRIAAFGHHSYSMRAADVLYDCLPLYH 304
Cdd:cd05927   135 THgnivSNVAGVFKILEILNKINPTDVYISYLPLAH 170
PRK08043 PRK08043
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
230-424 1.24e-03

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;


Pssm-ID: 181207 [Multi-domain]  Cd Length: 718  Bit Score: 42.00  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 230 LLDPMLAEAPTTPlaqapgkgmDDRLFYIYTSGTTGLPKAaiVVHS---------RYYRIAAFGHHSYSMRAadvlydcL 300
Cdd:PRK08043  352 LLMPRLAQVKQQP---------EDAALILFTSGSEGHPKG--VVHShksllanveQIKTIADFTPNDRFMSA-------L 413
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 301 PLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCV-KYNCTVV----QYIGEICRYllRQPVrdveQRHRVRLAVGN 375
Cdd:PRK08043  414 PLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVyDRNCTVLfgtsTFLGNYARF--ANPY----DFARLRYVVAG 487
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907189407 376 GLRPA-----IWEEftqRFGVpQIGEFYGATECNCSIA---NMDGKVGSCGfnsRIL 424
Cdd:PRK08043  488 AEKLQestkqLWQD---KFGL-RILEGYGVTECAPVVSinvPMAAKPGTVG---RIL 537
PRK07768 PRK07768
long-chain-fatty-acid--CoA ligase; Validated
127-309 1.35e-03

long-chain-fatty-acid--CoA ligase; Validated


Pssm-ID: 236091 [Multi-domain]  Cd Length: 545  Bit Score: 41.91  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 127 VANLFRQLGFAPGDVVAVfLEGRPEFV-----GLWLglakAGVVAALLNVNLRREPLAF-------CLGTSAAKALIYGG 194
Cdd:PRK07768   42 IAGGLAAAGVGPGDAVAV-LAGAPVEIaptaqGLWM----RGASLTMLHQPTPRTDLAVwaedtlrVIGMIGAKAVVVGE 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907189407 195 EMAAAvAEVSEQLGKSLLkfcsgdlgpesilpdtqLLDPMLAEAPTTPlaqaPGKGMDDRLFYIYTSGTTGLPKAAIVVH 274
Cdd:PRK07768  117 PFLAA-APVLEEKGIRVL-----------------TVADLLAADPIDP----VETGEDDLALMQLTSGSTGSPKAVQITH 174
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907189407 275 SR-YYRIAAfghhsysMRAA-------DVLYDCLPLYHSAGNI 309
Cdd:PRK07768  175 GNlYANAEA-------MFVAaefdvetDVMVSWLPLFHDMGMV 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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