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Conserved domains on  [gi|1907197284|ref|XP_036010798|]
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probable E3 ubiquitin-protein ligase HERC1 isoform X12 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 3136-3504 2.79e-124

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 396.55  E-value: 2.79e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3136 QITVKRIStrgrkckpIFVQIARQVVKLNASDLRLPsraWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPN 3215
Cdd:cd00078      2 KITVRRDR--------ILEDALRQLSKVSSSDLKKV---LEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPD 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3216 ataevgyNRDRFLFNPSACLDE-HLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNS 3294
Cdd:cd00078     71 -------DSGLLYPNPSSFADEdHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKE 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3295 ILHIEDSgITEESFHEMIPLDSFVGQsadGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLH-EMDRQVAAVREGMSWIV 3373
Cdd:cd00078    144 LLDNDGD-EDDLELTFTIELDSSFGG---AVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNkGIEEQVEAFRDGFSEVI 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3374 PVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYREVDEQ-HQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANT-AD 3451
Cdd:cd00078    220 PEELLSLFTPEELELLICGSEDIDLEDLKKNTEYKGGYSSdSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGfAD 299

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907197284 3452 ISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSID 3504
Cdd:cd00078    300 LNPKFTIRRVGSPDDRLPTAHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
SPRY_HERC1 cd12881
SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to ...
 678-835 9.98e-87

SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to chromosome condensation regulator RCC1. It is widely expressed in many tissues, playing an important role in intracellular membrane trafficking in the cytoplasm as well as Golgi apparatus. HERC1 also interacts with tuberous sclerosis 2 (TSC2, tuberin), which suppresses cell growth, and results in the destabilization of TSC2. However, the biological function of HERC1 has yet to be defined.


:

Pssm-ID: 293939  Cd Length: 162  Bit Score: 280.77  E-value: 9.98e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  678 EVSFDPEK-AQCCIVENGQILTHGSGGKGYGLAST--GVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDM 754
Cdd:cd12881      1 EASFDPEKsTNCVVVENGGTLVHSSGGRGYGLAATwiGISSGCYQWKFYLVKENRGNEGTCVGVSRKPVTDFNYRTSSDM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  755 WLYRAYSGNLYHNGEQTLTL-SSFTQGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKIC 833
Cdd:cd12881     81 WLYRAYNGNLYHNGEQLLRLsSKFHQGDYITVVLDMEEGTLSFGKNGEEPGVAFEDVDATELYPCVMFYSSGPGEKVKIT 160


                   ..
gi 1907197284  834 DM 835
Cdd:cd12881    161 DM 162
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2662-2998 1.66e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 267.61  E-value: 1.66e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2662 VYLWGAGRHGQL-AEAGRNVMVPATAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQ 2740
Cdd:COG5184     19 VWCWGDNSYGQLgDGTTTDRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLT 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2741 GfvVTQLvtSCGsDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIeALQGEEVVQMSCGFKHSAVVTSDGKLFT 2820
Cdd:COG5184     99 G--VVAV--AAG-YYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2821 FGNGDYGRLGLGNTSNKKLPERVTALEGyqIGQVACGLNHTLAVSADGSmVWAFGDGDYGKLGLGNSTAKSSPQKVDVLC 2900
Cdd:COG5184    173 WGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGT-VWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2901 GIgiKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVieDVAVGAEHTLALASTGDVYAWGS 2980
Cdd:COG5184    250 GV--VAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSGVV--AVAAGSSHTCALLTDGTVWCWGD 325

                          330
                   ....*....|....*...
gi 1907197284 2981 NSEGQLGLGHTNHVREPT 2998
Cdd:COG5184    326 NAYGQLGDGTTTDRSTPV 343
WD40 COG2319
WD40 repeat [General function prediction only];
2087-2441 1.31e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 1.31e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2087 LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQysLQQTcvfnrLEGDAeeslGSPSDPSFSPvswsiSGKYLA- 2165
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRT-----LTGHS----GAVTSVAFSP-----DGKLLAs 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2166 GALEKMVNIWQVNGGKGLVDIQPH--WVSALAWpeegpattwsgeSP--ELLLVGRMDGSlglIEVVDVST-MHRRELEH 2240
Cdd:COG2319    180 GSDDGTVRLWDLATGKLLRTLTGHtgAVRSVAF------------SPdgKLLASGSADGT---VRLWDLATgKLLRTLTG 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2241 cyrKDVSVTCIAWFSEDRPFAVGYFDGKLLM---GTKEPLEkggivLIDAHKETLVSMKWDPTGHILMTCAKEENVKLWG 2317
Cdd:COG2319    245 ---HSGSVRSVAFSPDGRLLASGSADGTVRLwdlATGELLR-----TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2318 PVSGcwRCLHSLC-HPSTVNGIAWcSLPGKgskmqlLMATGCQNGLVCVWRIpqdttqtsmtssegwwdqesncqdgyrk 2396
Cdd:COG2319    317 LATG--KLLRTLTgHTGAVRSVAF-SPDGK------TLASGSDDGTVRLWDL---------------------------- 359

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1907197284 2397 sAGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRD 2441
Cdd:COG2319    360 -ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
UBA_HERC1 cd14401
UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, ...
 1399-1442 2.34e-22

UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, also called HECT domain and RCC1-like domain-containing protein 1, or p532, or p619, is an ubiquitously expressed multi-domain protein involved in ubiquitin-dependent intracellular membrane trafficking through its interaction with vesicle coat proteins such as clathrin and ARF. Moreover, it has been identified as a tuberous sclerosis complex TSC2-interacting protein that may play a role in TSC-mTOR (mammalian target of rapamycin) pathway. In addition to a ubiquitin-association (UBA) domain, HERC1 contains more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain. At this point, it may function as both E3 ubiquitin ligases and guanine nucleotide exchange factors (GEFs).


:

Pssm-ID: 270584  Cd Length: 44  Bit Score: 92.06  E-value: 2.34e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907197284 1399 IAVPLLEMGFSLRQIAKAMEATGARGEADAQSITVLAMWMIEHP 1442
Cdd:cd14401      1 IAVPLLEMGFSLRHITRAMEATGTRGEADARNINVLATWMIEHP 44
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 3136-3504 2.79e-124

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 396.55  E-value: 2.79e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3136 QITVKRIStrgrkckpIFVQIARQVVKLNASDLRLPsraWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPN 3215
Cdd:cd00078      2 KITVRRDR--------ILEDALRQLSKVSSSDLKKV---LEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPD 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3216 ataevgyNRDRFLFNPSACLDE-HLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNS 3294
Cdd:cd00078     71 -------DSGLLYPNPSSFADEdHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKE 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3295 ILHIEDSgITEESFHEMIPLDSFVGQsadGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLH-EMDRQVAAVREGMSWIV 3373
Cdd:cd00078    144 LLDNDGD-EDDLELTFTIELDSSFGG---AVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNkGIEEQVEAFRDGFSEVI 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3374 PVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYREVDEQ-HQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANT-AD 3451
Cdd:cd00078    220 PEELLSLFTPEELELLICGSEDIDLEDLKKNTEYKGGYSSdSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGfAD 299

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907197284 3452 ISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSID 3504
Cdd:cd00078    300 LNPKFTIRRVGSPDDRLPTAHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 3167-3500 2.23e-123

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 393.14  E-value: 2.23e-123
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  3167 DLRlpSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATaevgynrdRFLFNPSACL--DEHLMQFKF 3244
Cdd:smart00119    1 DLK--KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDY--------LLYPNPRSGFanEEHLSYFRF 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  3245 LGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIED-SGITEESFHEmipldSFVGQSAD 3323
Cdd:smart00119   71 IGRVLGKALYDNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLLLNNDtSEELDLTFSI-----VLTSEFGQ 145

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  3324 GKMVPIIPGGNSIPLTFSNRKEYVERAIEYRL-HEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEICVDVLK 3402
Cdd:smart00119  146 VKVVELKPGGSNIPVTEENKKEYVHLVIEYRLnKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLK 225

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  3403 KVVRYR-EVDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPAN-TADISQRFQIMKVDRPYDSLPTSQTCFFQLRL 3480
Cdd:smart00119  226 SNTEYKgGYSANSQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGgFAALSPKFTIRKAGSDDERLPTAHTCFNRLKL 305

                           330       340
                    ....*....|....*....|
gi 1907197284  3481 PPYSSQLVMAERLRYAINNC 3500
Cdd:smart00119  306 PPYSSKEILREKLLLAINEG 325
SPRY_HERC1 cd12881
SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to ...
 678-835 9.98e-87

SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to chromosome condensation regulator RCC1. It is widely expressed in many tissues, playing an important role in intracellular membrane trafficking in the cytoplasm as well as Golgi apparatus. HERC1 also interacts with tuberous sclerosis 2 (TSC2, tuberin), which suppresses cell growth, and results in the destabilization of TSC2. However, the biological function of HERC1 has yet to be defined.


Pssm-ID: 293939  Cd Length: 162  Bit Score: 280.77  E-value: 9.98e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  678 EVSFDPEK-AQCCIVENGQILTHGSGGKGYGLAST--GVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDM 754
Cdd:cd12881      1 EASFDPEKsTNCVVVENGGTLVHSSGGRGYGLAATwiGISSGCYQWKFYLVKENRGNEGTCVGVSRKPVTDFNYRTSSDM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  755 WLYRAYSGNLYHNGEQTLTL-SSFTQGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKIC 833
Cdd:cd12881     81 WLYRAYNGNLYHNGEQLLRLsSKFHQGDYITVVLDMEEGTLSFGKNGEEPGVAFEDVDATELYPCVMFYSSGPGEKVKIT 160


                   ..
gi 1907197284  834 DM 835
Cdd:cd12881    161 DM 162
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2662-2998 1.66e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 267.61  E-value: 1.66e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2662 VYLWGAGRHGQL-AEAGRNVMVPATAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQ 2740
Cdd:COG5184     19 VWCWGDNSYGQLgDGTTTDRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLT 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2741 GfvVTQLvtSCGsDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIeALQGEEVVQMSCGFKHSAVVTSDGKLFT 2820
Cdd:COG5184     99 G--VVAV--AAG-YYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2821 FGNGDYGRLGLGNTSNKKLPERVTALEGyqIGQVACGLNHTLAVSADGSmVWAFGDGDYGKLGLGNSTAKSSPQKVDVLC 2900
Cdd:COG5184    173 WGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGT-VWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2901 GIgiKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVieDVAVGAEHTLALASTGDVYAWGS 2980
Cdd:COG5184    250 GV--VAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSGVV--AVAAGSSHTCALLTDGTVWCWGD 325

                          330
                   ....*....|....*...
gi 1907197284 2981 NSEGQLGLGHTNHVREPT 2998
Cdd:COG5184    326 NAYGQLGDGTTTDRSTPV 343
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 3219-3502 5.12e-77

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 258.69  E-value: 5.12e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3219 EVGYNRDRFL-FNPSA---CLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNS 3294
Cdd:pfam00632   16 EYETEDDRTYwFNPSSsesPDLELLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPELYKSLKS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3295 ILHIEDSGITEesfhemIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEM-DRQVAAVREGMSWIV 3373
Cdd:pfam00632   96 LLNMDNDDDED------LGLTFTIPVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSiEPQLEAFRKGFYSVI 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3374 PVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYREV-DEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANTADI 3452
Cdd:pfam00632  170 PKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGyTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVGGFKS 249

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907197284 3453 SQRFQIMKVDRPYD-SLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRS 3502
Cdd:pfam00632  250 LPKFTIVRKGGDDDdRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEG 300
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
3158-3500 1.55e-53

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 205.39  E-value: 1.55e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3158 RQVVKLNASDLRlpsRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNataevgynrDRFLFNP---SAC 3234
Cdd:COG5021    530 REIMDESGDDLK---KTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITE---------DLYTLPInplSSI 597

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3235 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILhieDSGITEESFHEMIPL 3314
Cdd:COG5021    598 NPEHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLL---NNDIDETILDLTFTV 674

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3315 DSfvgqSADGKMVPI--IPGGNSIPLTFSNRKEYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVC 3391
Cdd:COG5021    675 ED----DSFGESRTVelIPNGRNISVTNENKKEYVKKVVDYKLNKrVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIG 750

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3392 GMPE-ICVDVLKKVVRYREVDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANTA------DISQRFQIMKVDRP 3464
Cdd:COG5021    751 GIPEdIDIDDWKSNTAYHGYTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFkdlqgsDGVRKFTIEKGGTD 830

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1907197284 3465 YDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNC 3500
Cdd:COG5021    831 DDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEG 866
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 720-833 7.76e-26

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 104.73  E-value: 7.76e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  720 WKFYIVKENRGNEGTCVGVSRWPVHDFNHR---TTSDMWLYRAYSGNLYHNGEQTLT-LSSFTQGDFITCVLDMEARTIS 795
Cdd:pfam00622    2 HYFEVEIFGQDGGGWRVGWATKSVPRKGERflgDESGSWGYDGWTGKKYWASTSPLTgLPLFEPGDVIGCFLDYEAGTIS 81

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907197284  796 FGKNGEEPKLAFEDVDAA-ELYPCVmfySSNPGEKVKIC 833
Cdd:pfam00622   82 FTKNGKSLGYAFRDVPFAgPLFPAV---SLGAGEGLKFN 117
WD40 COG2319
WD40 repeat [General function prediction only];
2087-2441 1.31e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 1.31e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2087 LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQysLQQTcvfnrLEGDAeeslGSPSDPSFSPvswsiSGKYLA- 2165
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRT-----LTGHS----GAVTSVAFSP-----DGKLLAs 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2166 GALEKMVNIWQVNGGKGLVDIQPH--WVSALAWpeegpattwsgeSP--ELLLVGRMDGSlglIEVVDVST-MHRRELEH 2240
Cdd:COG2319    180 GSDDGTVRLWDLATGKLLRTLTGHtgAVRSVAF------------SPdgKLLASGSADGT---VRLWDLATgKLLRTLTG 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2241 cyrKDVSVTCIAWFSEDRPFAVGYFDGKLLM---GTKEPLEkggivLIDAHKETLVSMKWDPTGHILMTCAKEENVKLWG 2317
Cdd:COG2319    245 ---HSGSVRSVAFSPDGRLLASGSADGTVRLwdlATGELLR-----TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2318 PVSGcwRCLHSLC-HPSTVNGIAWcSLPGKgskmqlLMATGCQNGLVCVWRIpqdttqtsmtssegwwdqesncqdgyrk 2396
Cdd:COG2319    317 LATG--KLLRTLTgHTGAVRSVAF-SPDGK------TLASGSDDGTVRLWDL---------------------------- 359

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1907197284 2397 sAGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRD 2441
Cdd:COG2319    360 -ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2087-2438 2.80e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 2.80e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2087 LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTkkqyslqqtcvfnrlEGDAEESLGSPSDPSFSpVSWSISGKYLA- 2165
Cdd:cd00200      5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE---------------TGELLRTLKGHTGPVRD-VAASADGTYLAs 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2166 GALEKMVNIWQVNGGKGLVDIQPH--WVSALAWpeegpatTWSGEspeLLLVGRMDGSLGLIEVVDvstmhrRELEHCYR 2243
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHtsYVSSVAF-------SPDGR---ILSSSSRDKTIKVWDVET------GKCLTTLR 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2244 -KDVSVTCIAwFSEDRPF-AVGYFDGKLL---MGTKEPLEkggivLIDAHKETLVSMKWDPTGHILMTCAKEENVKLWGP 2318
Cdd:cd00200    133 gHTDWVNSVA-FSPDGTFvASSSQDGTIKlwdLRTGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2319 VSGcwRCLHSL-CHPSTVNGIAWcslpgkgSKMQLLMATGCQNGLVCVWRIpqdttqtsmtssegwwdqesncqdgyrks 2397
Cdd:cd00200    207 STG--KCLGTLrGHENGVNSVAF-------SPDGYLLASGSEDGTIRVWDL----------------------------- 248

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1907197284 2398 AGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWS 2438
Cdd:cd00200    249 RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
UBA_HERC1 cd14401
UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, ...
 1399-1442 2.34e-22

UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, also called HECT domain and RCC1-like domain-containing protein 1, or p532, or p619, is an ubiquitously expressed multi-domain protein involved in ubiquitin-dependent intracellular membrane trafficking through its interaction with vesicle coat proteins such as clathrin and ARF. Moreover, it has been identified as a tuberous sclerosis complex TSC2-interacting protein that may play a role in TSC-mTOR (mammalian target of rapamycin) pathway. In addition to a ubiquitin-association (UBA) domain, HERC1 contains more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain. At this point, it may function as both E3 ubiquitin ligases and guanine nucleotide exchange factors (GEFs).


Pssm-ID: 270584  Cd Length: 44  Bit Score: 92.06  E-value: 2.34e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907197284 1399 IAVPLLEMGFSLRQIAKAMEATGARGEADAQSITVLAMWMIEHP 1442
Cdd:cd14401      1 IAVPLLEMGFSLRHITRAMEATGTRGEADARNINVLATWMIEHP 44
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 715-833 7.55e-21

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 90.43  E-value: 7.55e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284   715 SGCYQWKFYIVKenrgNEGTCVGVSRWPVHDFNHRTTSD---MWLYRAYSGNLYHNGEQTLTLSSFTQ-GDFITCVLDME 790
Cdd:smart00449    1 SGRHYFEVEIGD----GGHWRVGVATKSVPRGYFALLGEdkgSWGYDGDGGKKYHNSTGPEYGLPLQEpGDVIGCFLDLE 76

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 1907197284   791 ARTISFGKNGEE-PKLAFEDVDAAE-LYPCVMFYSSNpGEKVKIC 833
Cdd:smart00449   77 AGTISFYKNGKYlHGLAFFDVKFSGpLYPAFSLGSGN-SVRLNFG 120
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2763-2812 8.13e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 71.01  E-value: 8.13e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2763 SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVV 2812
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2087-2119 3.83e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 3.83e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907197284  2087 LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWN 2119
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
2086-2119 2.49e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907197284 2086 KLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWN 2119
Cdd:pfam00400    6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 3136-3504 2.79e-124

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 396.55  E-value: 2.79e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3136 QITVKRIStrgrkckpIFVQIARQVVKLNASDLRLPsraWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPN 3215
Cdd:cd00078      2 KITVRRDR--------ILEDALRQLSKVSSSDLKKV---LEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPD 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3216 ataevgyNRDRFLFNPSACLDE-HLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNS 3294
Cdd:cd00078     71 -------DSGLLYPNPSSFADEdHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKE 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3295 ILHIEDSgITEESFHEMIPLDSFVGQsadGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLH-EMDRQVAAVREGMSWIV 3373
Cdd:cd00078    144 LLDNDGD-EDDLELTFTIELDSSFGG---AVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNkGIEEQVEAFRDGFSEVI 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3374 PVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYREVDEQ-HQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANT-AD 3451
Cdd:cd00078    220 PEELLSLFTPEELELLICGSEDIDLEDLKKNTEYKGGYSSdSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGfAD 299

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907197284 3452 ISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSID 3504
Cdd:cd00078    300 LNPKFTIRRVGSPDDRLPTAHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 3167-3500 2.23e-123

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 393.14  E-value: 2.23e-123
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  3167 DLRlpSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATaevgynrdRFLFNPSACL--DEHLMQFKF 3244
Cdd:smart00119    1 DLK--KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDY--------LLYPNPRSGFanEEHLSYFRF 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  3245 LGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIED-SGITEESFHEmipldSFVGQSAD 3323
Cdd:smart00119   71 IGRVLGKALYDNRLLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLLLNNDtSEELDLTFSI-----VLTSEFGQ 145

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  3324 GKMVPIIPGGNSIPLTFSNRKEYVERAIEYRL-HEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEICVDVLK 3402
Cdd:smart00119  146 VKVVELKPGGSNIPVTEENKKEYVHLVIEYRLnKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLK 225

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  3403 KVVRYR-EVDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPAN-TADISQRFQIMKVDRPYDSLPTSQTCFFQLRL 3480
Cdd:smart00119  226 SNTEYKgGYSANSQTIKWFWEVVESFTNEERRKLLQFVTGSSRLPVGgFAALSPKFTIRKAGSDDERLPTAHTCFNRLKL 305

                           330       340
                    ....*....|....*....|
gi 1907197284  3481 PPYSSQLVMAERLRYAINNC 3500
Cdd:smart00119  306 PPYSSKEILREKLLLAINEG 325
SPRY_HERC1 cd12881
SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to ...
 678-835 9.98e-87

SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to chromosome condensation regulator RCC1. It is widely expressed in many tissues, playing an important role in intracellular membrane trafficking in the cytoplasm as well as Golgi apparatus. HERC1 also interacts with tuberous sclerosis 2 (TSC2, tuberin), which suppresses cell growth, and results in the destabilization of TSC2. However, the biological function of HERC1 has yet to be defined.


Pssm-ID: 293939  Cd Length: 162  Bit Score: 280.77  E-value: 9.98e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  678 EVSFDPEK-AQCCIVENGQILTHGSGGKGYGLAST--GVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDM 754
Cdd:cd12881      1 EASFDPEKsTNCVVVENGGTLVHSSGGRGYGLAATwiGISSGCYQWKFYLVKENRGNEGTCVGVSRKPVTDFNYRTSSDM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  755 WLYRAYSGNLYHNGEQTLTL-SSFTQGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKIC 833
Cdd:cd12881     81 WLYRAYNGNLYHNGEQLLRLsSKFHQGDYITVVLDMEEGTLSFGKNGEEPGVAFEDVDATELYPCVMFYSSGPGEKVKIT 160


                   ..
gi 1907197284  834 DM 835
Cdd:cd12881    161 DM 162
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2662-2998 1.66e-79

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 267.61  E-value: 1.66e-79
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2662 VYLWGAGRHGQL-AEAGRNVMVPATAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQ 2740
Cdd:COG5184     19 VWCWGDNSYGQLgDGTTTDRSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLT 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2741 GfvVTQLvtSCGsDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIeALQGEEVVQMSCGFKHSAVVTSDGKLFT 2820
Cdd:COG5184     99 G--VVAV--AAG-YYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2821 FGNGDYGRLGLGNTSNKKLPERVTALEGyqIGQVACGLNHTLAVSADGSmVWAFGDGDYGKLGLGNSTAKSSPQKVDVLC 2900
Cdd:COG5184    173 WGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGT-VWCWGSNSSGQLGDGTTTDRATPVQVAGLT 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2901 GIgiKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVVieDVAVGAEHTLALASTGDVYAWGS 2980
Cdd:COG5184    250 GV--VAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSGVV--AVAAGSSHTCALLTDGTVWCWGD 325

                          330
                   ....*....|....*...
gi 1907197284 2981 NSEGQLGLGHTNHVREPT 2998
Cdd:COG5184    326 NAYGQLGDGTTTDRSTPV 343
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 3219-3502 5.12e-77

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 258.69  E-value: 5.12e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3219 EVGYNRDRFL-FNPSA---CLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNS 3294
Cdd:pfam00632   16 EYETEDDRTYwFNPSSsesPDLELLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLESIDPELYKSLKS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3295 ILHIEDSGITEesfhemIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEM-DRQVAAVREGMSWIV 3373
Cdd:pfam00632   96 LLNMDNDDDED------LGLTFTIPVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSiEPQLEAFRKGFYSVI 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3374 PVPLLSLLTAKQLEQMVCGMPEICVDVLKKVVRYREV-DEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANTADI 3452
Cdd:pfam00632  170 PKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGyTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLPVGGFKS 249

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907197284 3453 SQRFQIMKVDRPYD-SLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRS 3502
Cdd:pfam00632  250 LPKFTIVRKGGDDDdRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEG 300
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2693-3023 1.15e-76

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 259.52  E-value: 1.15e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2693 QQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGfvVTQLvtSCGSDgHSMALTESGEVFSWGDG 2772
Cdd:COG5184      1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAV--AAGGD-HTCALKADGTVWCWGNN 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2773 DYGKLGHGNSDRQRRPRQIEALQGeeVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA-LEGYQi 2851
Cdd:COG5184     76 SYGQLGDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAgLSGVV- 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2852 gQVACGLNHTLAVSADGSmVWAFGDGDYGKLGLGNSTAKSSPQKVDVLcgIGIKKVACGTQFSVALTKDGHVYTFGQDRL 2931
Cdd:COG5184    153 -AIAAGGYHTCALKSDGT-VWCWGANSYGQLGDGTTTDRPTPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSS 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2932 IGLPEGRARNHNRPQQIPVLAGVVieDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLqgKNIRQI 3011
Cdd:COG5184    229 GQLGDGTTTDRATPVQVAGLTGVV--AIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGL--SGVVAV 304

                          330
                   ....*....|..
gi 1907197284 3012 SAGRCHSAAWTA 3023
Cdd:COG5184    305 AAGSSHTCALLT 316
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
3158-3500 1.55e-53

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 205.39  E-value: 1.55e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3158 RQVVKLNASDLRlpsRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNataevgynrDRFLFNP---SAC 3234
Cdd:COG5021    530 REIMDESGDDLK---KTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITE---------DLYTLPInplSSI 597

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3235 LDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILhieDSGITEESFHEMIPL 3314
Cdd:COG5021    598 NPEHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLL---NNDIDETILDLTFTV 674

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3315 DSfvgqSADGKMVPI--IPGGNSIPLTFSNRKEYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVC 3391
Cdd:COG5021    675 ED----DSFGESRTVelIPNGRNISVTNENKKEYVKKVVDYKLNKrVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIG 750

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 3392 GMPE-ICVDVLKKVVRYREVDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLPANTA------DISQRFQIMKVDRP 3464
Cdd:COG5021    751 GIPEdIDIDDWKSNTAYHGYTEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFkdlqgsDGVRKFTIEKGGTD 830

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1907197284 3465 YDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNC 3500
Cdd:COG5021    831 DDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEG 866
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 2661-2894 1.62e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 184.02  E-value: 1.62e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2661 DVYLWGAGRHGQLAEAGR-NVMVPAT-APSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISA 2738
Cdd:COG5184    118 TVWCWGDNSSGQLGDGTTtNRLTPVQvDAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2739 LQGfvVTQLvtSCGSDgHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGeeVVQMSCGFKHSAVVTSDGKL 2818
Cdd:COG5184    198 LSG--VVAV--AAGGD-HSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCALKSDGTV 270

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907197284 2819 FTFGNGDYGRLGLGNTSNKKLPERVTALEGYQigQVACGLNHTLAVSADGSmVWAFGDGDYGKLGLGNSTAKSSPQ 2894
Cdd:COG5184    271 WCWGDNSYGQLGDGTTTDRSTPVKVPGLSGVV--AVAAGSSHTCALLTDGT-VWCWGDNAYGQLGDGTTTDRSTPV 343
SPRY pfam00622
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ...
 720-833 7.76e-26

SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin.


Pssm-ID: 459877  Cd Length: 121  Bit Score: 104.73  E-value: 7.76e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  720 WKFYIVKENRGNEGTCVGVSRWPVHDFNHR---TTSDMWLYRAYSGNLYHNGEQTLT-LSSFTQGDFITCVLDMEARTIS 795
Cdd:pfam00622    2 HYFEVEIFGQDGGGWRVGWATKSVPRKGERflgDESGSWGYDGWTGKKYWASTSPLTgLPLFEPGDVIGCFLDYEAGTIS 81

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1907197284  796 FGKNGEEPKLAFEDVDAA-ELYPCVmfySSNPGEKVKIC 833
Cdd:pfam00622   82 FTKNGKSLGYAFRDVPFAgPLFPAV---SLGAGEGLKFN 117
WD40 COG2319
WD40 repeat [General function prediction only];
2087-2441 1.31e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 1.31e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2087 LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQysLQQTcvfnrLEGDAeeslGSPSDPSFSPvswsiSGKYLA- 2165
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--LLRT-----LTGHS----GAVTSVAFSP-----DGKLLAs 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2166 GALEKMVNIWQVNGGKGLVDIQPH--WVSALAWpeegpattwsgeSP--ELLLVGRMDGSlglIEVVDVST-MHRRELEH 2240
Cdd:COG2319    180 GSDDGTVRLWDLATGKLLRTLTGHtgAVRSVAF------------SPdgKLLASGSADGT---VRLWDLATgKLLRTLTG 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2241 cyrKDVSVTCIAWFSEDRPFAVGYFDGKLLM---GTKEPLEkggivLIDAHKETLVSMKWDPTGHILMTCAKEENVKLWG 2317
Cdd:COG2319    245 ---HSGSVRSVAFSPDGRLLASGSADGTVRLwdlATGELLR-----TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2318 PVSGcwRCLHSLC-HPSTVNGIAWcSLPGKgskmqlLMATGCQNGLVCVWRIpqdttqtsmtssegwwdqesncqdgyrk 2396
Cdd:COG2319    317 LATG--KLLRTLTgHTGAVRSVAF-SPDGK------TLASGSDDGTVRLWDL---------------------------- 359

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1907197284 2397 sAGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRD 2441
Cdd:COG2319    360 -ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2087-2438 2.80e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 2.80e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2087 LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTkkqyslqqtcvfnrlEGDAEESLGSPSDPSFSpVSWSISGKYLA- 2165
Cdd:cd00200      5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE---------------TGELLRTLKGHTGPVRD-VAASADGTYLAs 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2166 GALEKMVNIWQVNGGKGLVDIQPH--WVSALAWpeegpatTWSGEspeLLLVGRMDGSLGLIEVVDvstmhrRELEHCYR 2243
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHtsYVSSVAF-------SPDGR---ILSSSSRDKTIKVWDVET------GKCLTTLR 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2244 -KDVSVTCIAwFSEDRPF-AVGYFDGKLL---MGTKEPLEkggivLIDAHKETLVSMKWDPTGHILMTCAKEENVKLWGP 2318
Cdd:cd00200    133 gHTDWVNSVA-FSPDGTFvASSSQDGTIKlwdLRTGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2319 VSGcwRCLHSL-CHPSTVNGIAWcslpgkgSKMQLLMATGCQNGLVCVWRIpqdttqtsmtssegwwdqesncqdgyrks 2397
Cdd:cd00200    207 STG--KCLGTLrGHENGVNSVAF-------SPDGYLLASGSEDGTIRVWDL----------------------------- 248

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1907197284 2398 AGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWS 2438
Cdd:cd00200    249 RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2008-2462 7.84e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 7.84e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2008 GFIAQLYAHPSYDPSAVGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTAPQTLADMGGDLRkcsfikL 2087
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT------L 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2088 EAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTkkqyslqqtcvfnrlEGDAEESLGSPSDPSFSpVSWSISGKYLA-G 2166
Cdd:COG2319     75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---------------TGLLLRTLTGHTGAVRS-VAFSPDGKTLAsG 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2167 ALEKMVNIWQVNGGKGLVDIQPH--WVSALAWpeegpattwsgeSP--ELLLVGRMDGSlglIEVVDVSTmhRRELEHCY 2242
Cdd:COG2319    139 SADGTVRLWDLATGKLLRTLTGHsgAVTSVAF------------SPdgKLLASGSDDGT---VRLWDLAT--GKLLRTLT 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2243 RKDVSVTCIAwFSED-RPFAVGYFDGKLL---MGTKEPlekggIVLIDAHKETLVSMKWDPTGHILMTCAKEENVKLWGP 2318
Cdd:COG2319    202 GHTGAVRSVA-FSPDgKLLASGSADGTVRlwdLATGKL-----LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2319 VSGcwRCLHSL-CHPSTVNGIAWcSLPGKgskmqlLMATGCQNGLVCVWRIpqdttqtsmtssegwwdqesncqdgyrks 2397
Cdd:COG2319    276 ATG--ELLRTLtGHSGGVNSVAF-SPDGK------LLASGSDDGTVRLWDL----------------------------- 317

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907197284 2398 AGAKCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIP 2462
Cdd:COG2319    318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
UBA_HERC1 cd14401
UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, ...
 1399-1442 2.34e-22

UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, also called HECT domain and RCC1-like domain-containing protein 1, or p532, or p619, is an ubiquitously expressed multi-domain protein involved in ubiquitin-dependent intracellular membrane trafficking through its interaction with vesicle coat proteins such as clathrin and ARF. Moreover, it has been identified as a tuberous sclerosis complex TSC2-interacting protein that may play a role in TSC-mTOR (mammalian target of rapamycin) pathway. In addition to a ubiquitin-association (UBA) domain, HERC1 contains more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain. At this point, it may function as both E3 ubiquitin ligases and guanine nucleotide exchange factors (GEFs).


Pssm-ID: 270584  Cd Length: 44  Bit Score: 92.06  E-value: 2.34e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907197284 1399 IAVPLLEMGFSLRQIAKAMEATGARGEADAQSITVLAMWMIEHP 1442
Cdd:cd14401      1 IAVPLLEMGFSLRHITRAMEATGTRGEADARNINVLATWMIEHP 44
SPRY smart00449
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ...
 715-833 7.55e-21

Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.


Pssm-ID: 214669  Cd Length: 122  Bit Score: 90.43  E-value: 7.55e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284   715 SGCYQWKFYIVKenrgNEGTCVGVSRWPVHDFNHRTTSD---MWLYRAYSGNLYHNGEQTLTLSSFTQ-GDFITCVLDME 790
Cdd:smart00449    1 SGRHYFEVEIGD----GGHWRVGVATKSVPRGYFALLGEdkgSWGYDGDGGKKYHNSTGPEYGLPLQEpGDVIGCFLDLE 76

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 1907197284   791 ARTISFGKNGEE-PKLAFEDVDAAE-LYPCVMFYSSNpGEKVKIC 833
Cdd:smart00449   77 AGTISFYKNGKYlHGLAFFDVKFSGpLYPAFSLGSGN-SVRLNFG 120
SPRY cd11709
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ...
 716-833 1.67e-18

SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome.


Pssm-ID: 293931  Cd Length: 118  Bit Score: 83.63  E-value: 1.67e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  716 GCYQWKFYIVKENRGNegTCVGVSRWPVHDFNHRTTSD---MWLYRAYSGNLYHNGEQTLTLSSFTQGDFITCVLDMEAR 792
Cdd:cd11709      1 GKWYWEVRVDSGNGGL--IQVGWATKSFSLDGEGGVGDdeeSWGYDGSRLRKGHGGSSGPGGRPWKSGDVVGCLLDLDEG 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1907197284  793 TISFGKNGEEPKLAFEDVDAA--ELYPCVMFYSsnpGEKVKIC 833
Cdd:cd11709     79 TLSFSLNGKDLGVAFTNLFLKggGLYPAVSLGS---GQGVTIN 118
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2763-2812 8.13e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 71.01  E-value: 8.13e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2763 SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVV 2812
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2815-2864 3.58e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 69.08  E-value: 3.58e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2815 DGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAV 2864
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2973-3021 5.67e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 68.31  E-value: 5.67e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1907197284 2973 GDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGKNIRQISAGRCHSAAW 3021
Cdd:pfam00415    2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
SPRY_RanBP_like cd12885
SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY ...
 727-832 5.30e-12

SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY domains found in Ran binding proteins (RBP or RanBPM) 9 and 10, SSH4 (suppressor of SHR3 null mutation protein 4), SPRY domain-containing protein 3 (SPRYD3) as well as HECT, a C-terminal catalytic domain of a subclass of ubiquitin-protein ligase (E3). RanBP9 and RanBP10 act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. The SPRY domain in SSH4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. SPRYD3 is highly expressed in most tissues in humans, possibly involved in important cellular processes. HECT E3 mediates the direct transfer of ubiquitin from E2 to substrate.


Pssm-ID: 293943  Cd Length: 132  Bit Score: 65.76  E-value: 5.30e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  727 ENRGNEGTC-VGVSRWPVHDFNH-RTTSDMWLYRAYSGNLYHNGEQ-TLTLSSFTQGDFITCVLDMEARTISFGKNGEEP 803
Cdd:cd12885     23 LDLGEKGIVsIGFCTSGFPLNRMpGWEDGSYGYHGDDGRVYLGGGEgENYGPPFGTGDVVGCGINFKTGEVFFTKNGELL 102

                           90       100
                   ....*....|....*....|....*....
gi 1907197284  804 KLAFEDVDAAELYPCVMFYSsnPGEKVKI 832
Cdd:cd12885    103 GTAFENVVKGRLYPTVGLGS--PGVKVRV 129
UBA_HERC1_2 cd14331
UBA domain found in probable E3 ubiquitin-protein ligase HERC1, HERC2 and similar proteins; ...
 1400-1441 1.30e-11

UBA domain found in probable E3 ubiquitin-protein ligase HERC1, HERC2 and similar proteins; HERC1, also called HECT domain and RCC1-like domain-containing protein 1, p532, or p619, is an ubiquitously expressed giant protein involved in ubiquitin-dependent intracellular membrane trafficking through its interaction with vesicle coat proteins such as clathrin and ARF. Moreover, it has been identified as a tuberous sclerosis complex TSC2-interacting protein that may play a role in TSC-mTOR (mammalian target of rapamycin) pathway. HERC2, also called HECT domain and RCC1-like domain-containing protein 2, is a SUMO-regulated E3 ubiquitin ligase that plays an important role in the SUMO-dependent pathway which orchestrates the DNA double-strand break (DSB) response. Moreover, HERC2 functions as a RNF8 auxiliary factor that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. HERC1 and HERC2 are multi-domain proteins with different domain organizations. Both of them contain a ubiquitin-association (UBA) domain, more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain.


Pssm-ID: 270516  Cd Length: 40  Bit Score: 61.67  E-value: 1.30e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907197284 1400 AVPLLEMGFSLRQIAKAMEATGARGeaDAQSITVLAMWMIEH 1441
Cdd:cd14331      1 IVQLMEMGFSRRQIEMAMQALGSES--DAPNIENLVNWLLEH 40
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2867-2917 3.37e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 3.37e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907197284 2867 DGSmVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVAL 2917
Cdd:pfam00415    1 DGR-VYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
2956-2985 1.29e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 52.81  E-value: 1.29e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907197284 2956 IEDVAVGAEHTLALASTGDVYAWGSNSEGQ 2985
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
SPRY_RanBP9_10 cd12909
SPRY domain in Ran binding proteins 9 and 10; This family includes SPRY domain in Ran binding ...
 777-831 3.58e-07

SPRY domain in Ran binding proteins 9 and 10; This family includes SPRY domain in Ran binding protein (RBP or RanBPM) 9 and 10, and similar proteins. RanBP9 (also known as RanBPM), a binding partner of Ran, is a small Ras-like GTPase that exerts multiple functions via interactions with various proteins. RanBP9 and RanBP10 also act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. SPRY domain of RanBPM forms a complex with CD39, a prototypic member of the NTPDase family, thus down-regulating activity substantially. RanBP10 enhances the transcriptional activity of AR in a ligand-dependent manner and exhibits a protein expression pattern different from RanBPM in various cell lines. RanBP10 is highly expressed in AR-positive prostate cancer LNCaP cells, while RanBPM is abundant in WI-38 and MCF-7 cells.


Pssm-ID: 293966  Cd Length: 144  Bit Score: 52.14  E-value: 3.58e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907197284  777 FTQGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSsnPGEKVK 831
Cdd:cd12909     87 FTTGDVIGCGINFRDNTAFYTKNGVNLGIAFRDIKKGNLYPTVGLRT--PGEHVE 139
SPRY_Ash2 cd12872
SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or ...
 701-822 6.21e-07

SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or homeotic discs 2) -like proteins, core components of all mixed-lineage leukemia (MLL) family histone methyltransferases. Ash2 is a member of the trithorax group of transcriptional regulators of the Hox genes. Recent studies show that the SPRY domain of Ash2 mediates the interaction with RbBP5 and has an important role in regulating the methyltransferase activity of MLL complexes. In yeast, Ash2 is involved in histone methylation and is required for the earliest stages of embryogenesis.


Pssm-ID: 293932  Cd Length: 150  Bit Score: 51.75  E-value: 6.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  701 SGGKGY--GLASTGVTSGCYQWKFYIVKENRGNEGTC-VGVSRW------PVHdfnhrttsdmwlYRAYS-------GNL 764
Cdd:cd12872     11 TGEKGYrmARANHGVREGKWYFEVKILEGGGTETGHVrVGWSRReaslqaPVG------------YDKYSyairdkdGSK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  765 YHNGE-QTLTLSSFTQGDFITCVLDMEarTISFGKNGEEPKLAFEDVDAA-ELYPCVMFY 822
Cdd:cd12872     79 FHQSRgKPYGEPGFKEGDVIGFLITLP--KIEFFKNGKSQGVAFEDIYGTgGYYPAVSLY 136
SPRY_SOCS_Fbox cd12875
SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family ...
 711-819 7.65e-07

SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family consists of the SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) as well as F-box protein 45 (Fbxo45), a novel synaptic E3 and ubiquitin ligase. The SPSB protein is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4) and are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation. Fbxo45 is related to this family; it is located N-terminal to the SPRY domain, and known to induce the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis.


Pssm-ID: 293935  Cd Length: 169  Bit Score: 51.69  E-value: 7.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  711 TGVTSGCYQWKFYIVKENRGNEGTcVGVS--RWPVHDFNHRT----TSDMWLYRAYSGNLYHNGEQTLT-----LSSFTQ 779
Cdd:cd12875     37 KGYTRGLHAWEVKWISRPRGSHAV-VGVAtkDAPLQCDGYVTllgsNSESWGWDLGDNKLYHNGKKVIGsypakSENYQV 115

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907197284  780 GDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCV 819
Cdd:cd12875    116 PDRILVILDMEDGTLAFEANGEYLGVAFRGLPGKLLYPAV 155
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2708-2760 1.11e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.90  E-value: 1.11e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907197284 2708 NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLvtSCGSDgHSMAL 2760
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQV--ACGGD-HTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
2799-2828 3.67e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.88  E-value: 3.67e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907197284 2799 VVQMSCGFKHSAVVTSDGKLFTFGNGDYGR 2828
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2920-2969 6.01e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 6.01e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907197284 2920 DGHVYTFG--QDRLIGLpeGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLAL 2969
Cdd:pfam00415    1 DGRVYTWGrnDYGQLGL--GTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2078-2176 6.21e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 6.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284 2078 DLRKCSFIK-LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQyslqqtCVFnRLEGdAEESLGSpsdpsfspVS 2156
Cdd:cd00200    205 DLSTGKCLGtLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE------CVQ-TLSG-HTNSVTS--------LA 268

                           90       100
                   ....*....|....*....|.
gi 1907197284 2157 WSISGKYLA-GALEKMVNIWQ 2176
Cdd:cd00200    269 WSPDGKRLAsGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2087-2119 3.83e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 3.83e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1907197284  2087 LEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWN 2119
Cdd:smart00320    8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
2750-2775 4.13e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.80  E-value: 4.13e-05
                           10        20
                   ....*....|....*....|....*.
gi 1907197284 2750 SCGSDgHSMALTESGEVFSWGDGDYG 2775
Cdd:pfam13540    5 AAGDN-HTLALTSDGRVYCWGDNSYG 29
SPRY_hnRNP cd12884
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ...
 759-821 6.97e-05

SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation.


Pssm-ID: 293942  Cd Length: 177  Bit Score: 46.43  E-value: 6.97e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907197284  759 AYSGN--LYHNGEQTLTLSSFTQGDFITCVLDMEAR--TISFGKNGEEPKLAFEdVDAAELYPCVMF 821
Cdd:cd12884     93 GYGSTgkKSTNCKFEDYGEPFGENDVIGCYLDFESEpvEISFSKNGKDLGVAFK-ISKEELGGKALF 158
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
2853-2880 7.82e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.03  E-value: 7.82e-05
                           10        20
                   ....*....|....*....|....*...
gi 1907197284 2853 QVACGLNHTLAVSADGSmVWAFGDGDYG 2880
Cdd:pfam13540    3 SVAAGDNHTLALTSDGR-VYCWGDNSYG 29
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
2904-2929 1.28e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 41.26  E-value: 1.28e-04
                           10        20
                   ....*....|....*....|....*.
gi 1907197284 2904 IKKVACGTQFSVALTKDGHVYTFGQD 2929
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDN 26
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 2401-2438 1.71e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.71e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907197284  2401 KCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWS 2438
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
2086-2119 2.49e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907197284 2086 KLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWN 2119
Cdd:pfam00400    6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SPRY_like cd12886
SPRY domain-like in bacteria; This family contains SPRY-like domains that are found only in ...
 721-828 3.35e-04

SPRY domain-like in bacteria; This family contains SPRY-like domains that are found only in bacterial and are mostly uncharacterized. SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 eukaryotic protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L).


Pssm-ID: 293944  Cd Length: 129  Bit Score: 43.26  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  721 KFYI-VKENRGNEGTC--VGVSR--WPVHDFNHRTTSDMWLYRA--YSGNLYHNGEQTLT-LSSFTQGDFITCVLDMEAR 792
Cdd:cd12886      2 KWYWeVTVVSSAASTYagIGVANaaATGNNGLNGIELSSIGYSLgvYSGNKLSNGSSVATyGAGFTAGDVIGVALDLDAG 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1907197284  793 TISFGKNGEepKLAFEDVDAAEL--------YPCVMFYSSNPGE 828
Cdd:cd12886     82 KIWFYKNGV--WQGGGDPAPGTNpafagtamYPAVTGGSSTGGS 123
SPRY_DDX1 cd12873
SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD ...
 776-819 4.05e-04

SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD box gene, DDX1, an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication. It is suggested that DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the Rev response element (RRE). DDX1 RNA is overexpressed in breast cancer, data showing a strong and independent association between poor prognosis and deregulation of the DEAD box protein DDX1, thus potentially serving as an effective prognostic biomarker for early recurrence in primary breast cancer. DDX1 also interacts with RelA and enhances nuclear factor kappaB-mediated transcription. DEAD-box proteins are associated with all levels of RNA metabolism and function, and have been implicated in translation initiation, transcription, RNA splicing, ribosome assembly, RNA transport, and RNA decay.


Pssm-ID: 293933  Cd Length: 155  Bit Score: 43.72  E-value: 4.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907197284  776 SFTQGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAE---LYPCV 819
Cdd:cd12873     94 PFGLGDVIGCYLDLDNGTISFSKNGKDLGKAFDIPPHLRnsaLFPAV 140
WD40 pfam00400
WD domain, G-beta repeat;
2401-2438 4.66e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.66e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907197284 2401 KCVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWS 2438
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2402-2462 4.70e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 4.70e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907197284 2402 CVYQLRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIP 2462
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA 61
SPRY2_RyR cd12878
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of ...
 755-832 6.51e-04

SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1


Pssm-ID: 240458  Cd Length: 133  Bit Score: 42.29  E-value: 6.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907197284  755 WLYRAYSGNLYHNGEQTLTlSSFTQGDFITCVLDMEARTISFGKNGE---EPK---LAFEDVDAAELY-PCVMFYSsnpG 827
Cdd:cd12878     50 YAFDGFLARKWHQGSESFG-KQWQPGDVVGCMLDLVDRTISFTLNGElliDSSgseVAFKDIEIGEGFvPACSLGV---G 125


                   ....*
gi 1907197284  828 EKVKI 832
Cdd:cd12878    126 QKGRL 130
SPRY_Fbox cd12907
SPRY domain in the F-box family Fbxo45; Fbxo45 is a novel synaptic E3 and ubiquitin ligase, ...
 755-819 4.53e-03

SPRY domain in the F-box family Fbxo45; Fbxo45 is a novel synaptic E3 and ubiquitin ligase, related to the suppressor of cytokine signaling (SOCS) proteins and located N-terminal to a SPRY (SPla and the ryanodine receptor) domain. Fbxo45 induces the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. F-box motifs are found in proteins that function as the substrate recognition component of SCF E3 complexes.


Pssm-ID: 293964  Cd Length: 175  Bit Score: 40.84  E-value: 4.53e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907197284  755 WLYRAYSGNLYHNGEQtltLSSFTQ---------GDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCV 819
Cdd:cd12907     85 WGWNLVDNHLLHNGDS---QGNYPQcnnapkyqvGERIRVILDCEDNTLAFERGYEFLGVAFRGLPPTKLYPAV 155
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
2661-2705 7.80e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 37.11  E-value: 7.80e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907197284 2661 DVYLWGAGRHGQLaeaGR----NVMVPATAPSFSQ--AQQVICGQNCTFVI 2705
Cdd:pfam00415    3 RVYTWGRNDYGQL---GLgtteNVLVPQKVEGLSGnkVVQVACGGDHTVAL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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