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Conserved domains on  [gi|1907093310|ref|XP_036013854|]
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uncharacterized protein LOC212281 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-60 4.26e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 4.26e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310    2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLGLASCKPHLITCLEQIQEP 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-657 9.73e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 9.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 216 KPYKCEICDKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 292
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 293 KKIHSGEKPFKCEVCGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCQKAFRSLS 371
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 372 SLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRiCAGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 451
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 452 YYPSRLSNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKR 518
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 519 IHTGEKPYKCEECgkafhypSLLSKHKIIHTEEKPykcdvcgqAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLS 598
Cdd:COG5048   345 LHTSISPAKEKLL-------NSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHII 409

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310 599 KHKRVHTGENPYNsqVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHK 657
Cdd:COG5048   410 THLSFRPYNCKNP--PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-938 2.88e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 496 KPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKC--EECGKAFHYPSLLSKHKIIHTEEKPYKCDvcGQAFHVPSKLSHHK 573
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 574 IIHtgekpykcevCGKAFCIPLLLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKC--------EVCGK 645
Cdd:COG5048   110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 646 AFRFPSLLLIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHKRihtgekpyqcevcgkdFHVSSSLSKHRIIHTGEKPYKCE 725
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 726 icgktfRFSSSLSKHKRNHTGKKPYKC---EECGKAFHFPSILAKHKISHTgekPYNCDLCGKAFHYASLLSKHK--MIH 800
Cdd:COG5048   244 ------SPSSLSSSDSSSSASESPRSSlptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 801 TGE--KPHKCDI--CGKAFHYPSKLSNHKKIHTGEKPYKC--EVCGNVF------CFASSLSKHKRIHTG---ENPYKCE 865
Cdd:COG5048   315 SGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDkksETLSNSC 394

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093310 866 VCGKAFYYPSLLSKHKIIHTGEKPYKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKaFHYPSRLSKHKK 938
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 130-199 3.10e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 3.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093310 130 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 199
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-60 4.26e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 4.26e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310    2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLGLASCKPHLITCLEQIQEP 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-42 3.48e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.84  E-value: 3.48e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907093310   1 MLSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLG 42
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-41 6.60e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.67  E-value: 6.60e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907093310   2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFL 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-657 9.73e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 9.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 216 KPYKCEICDKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 292
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 293 KKIHSGEKPFKCEVCGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCQKAFRSLS 371
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 372 SLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRiCAGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 451
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 452 YYPSRLSNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKR 518
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 519 IHTGEKPYKCEECgkafhypSLLSKHKIIHTEEKPykcdvcgqAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLS 598
Cdd:COG5048   345 LHTSISPAKEKLL-------NSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHII 409

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310 599 KHKRVHTGENPYNsqVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHK 657
Cdd:COG5048   410 THLSFRPYNCKNP--PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-938 2.88e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 496 KPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKC--EECGKAFHYPSLLSKHKIIHTEEKPYKCDvcGQAFHVPSKLSHHK 573
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 574 IIHtgekpykcevCGKAFCIPLLLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKC--------EVCGK 645
Cdd:COG5048   110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 646 AFRFPSLLLIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHKRihtgekpyqcevcgkdFHVSSSLSKHRIIHTGEKPYKCE 725
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 726 icgktfRFSSSLSKHKRNHTGKKPYKC---EECGKAFHFPSILAKHKISHTgekPYNCDLCGKAFHYASLLSKHK--MIH 800
Cdd:COG5048   244 ------SPSSLSSSDSSSSASESPRSSlptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 801 TGE--KPHKCDI--CGKAFHYPSKLSNHKKIHTGEKPYKC--EVCGNVF------CFASSLSKHKRIHTG---ENPYKCE 865
Cdd:COG5048   315 SGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDkksETLSNSC 394

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093310 866 VCGKAFYYPSLLSKHKIIHTGEKPYKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKaFHYPSRLSKHKK 938
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-509 8.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907093310 484 SLSKHKRIHTGEKPYKCKECGKAFRS 509
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 130-199 3.10e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 3.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093310 130 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 199
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
736-759 3.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|....
gi 1907093310 736 SLSKHKRNHTGKKPYKCEECGKAF 759
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-60 4.26e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 4.26e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310    2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLGLASCKPHLITCLEQIQEP 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-42 3.48e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.84  E-value: 3.48e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907093310   1 MLSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFLG 42
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-41 6.60e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.67  E-value: 6.60e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907093310   2 LSFRDVAIDFSAEEWECLEPAQWNLYRDVMLENYSNLVFL 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-657 9.73e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 9.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 216 KPYKCEICDKAFHYPSILSKHKRIHTGEKPYKC--EECGKAFHISSFLSKHKIIHRGEKPYKCEV-CGKAFHYPSRLSNH 292
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 293 KKIHSGEKPFKCEVCGKAFRILSLLSKHKIIHTEENPYKCEVC-GKAFDYPSRLSTHAKMHTGEKpykcevCQKAFRSLS 371
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 372 SLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRiCAGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 451
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 452 YYPSRLSNHKKIHTGE-------KPFQCEVCGKAFCFPSSLSKHKR--IHTGE--KPYKCKE--CGKAFRSLSSLSKHKR 518
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 519 IHTGEKPYKCEECgkafhypSLLSKHKIIHTEEKPykcdvcgqAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLS 598
Cdd:COG5048   345 LHTSISPAKEKLL-------NSSSKFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHII 409

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093310 599 KHKRVHTGENPYNsqVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHK 657
Cdd:COG5048   410 THLSFRPYNCKNP--PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
440-843 1.22e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.18  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 440 KLYKCEVCGKAFYYPSRLSNHKKIHTGEKPFQCEV--CGKAFCFPSSLSKHKRIHTGEKPYKC-KECGKAFRSLSSLSKH 516
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 517 KRIHTGEKPYKCEECGKAFHYPSLLSKHKIIHTEEKPYKCDVC-GQAFHVPSKLSHHKIIHTGEKPykcevcgKAFCIPL 595
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 596 LLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIH-KGMHTGEKPYKCEDCGKA 674
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 675 F---------HYPSLLSKHKRIHTgekPYQCEVCGKDFHVSSSLSKHR--IIHTGE--KPYKC--EICGKTFRFSSSLSK 739
Cdd:COG5048   265 LptassqsssPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 740 HKRNHTGKKPYKC--EECGKAFHFPSI------LAKHKISHTgEKPYNCDL--CGKAFHYASLLSKHKMIHTGEKPH--K 807
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncK 420

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1907093310 808 CDICGKAFHYPSKLSNHKKIHTGEKPYKCEVCGNVF 843
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
496-938 2.88e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 496 KPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKC--EECGKAFHYPSLLSKHKIIHTEEKPYKCDvcGQAFHVPSKLSHHK 573
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 574 IIHtgekpykcevCGKAFCIPLLLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKC--------EVCGK 645
Cdd:COG5048   110 LSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 646 AFRFPSLLLIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHKRihtgekpyqcevcgkdFHVSSSLSKHRIIHTGEKPYKCE 725
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------ENSSSSLPLTTNSQLSPKSLLSQ 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 726 icgktfRFSSSLSKHKRNHTGKKPYKC---EECGKAFHFPSILAKHKISHTgekPYNCDLCGKAFHYASLLSKHK--MIH 800
Cdd:COG5048   244 ------SPSSLSSSDSSSSASESPRSSlptASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 801 TGE--KPHKCDI--CGKAFHYPSKLSNHKKIHTGEKPYKC--EVCGNVF------CFASSLSKHKRIHTG---ENPYKCE 865
Cdd:COG5048   315 SGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDkksETLSNSC 394

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093310 866 VCGKAFYYPSLLSKHKIIHTGEKPYKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKaFHYPSRLSKHKK 938
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
103-546 1.93e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 103 MNPNKCEECARSFHSPSLSSEENRIHTGEKPYKCEV--CGKAFCIPLLLSKHKRVHTgenlykcevcgkafQHPSRLSRH 180
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH--------------NNPSDLNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 181 KKIHSEEKPYKCEVCGKAFHFPSLLLVHKRVHTGEKPYK-------CEICDKAFHYPSILSKHKRIHTGEKPYKCE---E 250
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPansL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 251 CGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSNHKKIHSgEKPFKCEVCGKAFRILSLLSKH-KIIHTEENP 329
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 330 YKCEVCGKAFDYPSRLSTHAKMHTGEK------PYKCEVCQKAFRSLSSLSKHKR--IHTEDNYY----NNELCGKAFIY 397
Cdd:COG5048   256 SASESPRSSLPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKpfscPYSLCGKLFSR 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 398 PSRLSKHKRICAGEKPYKC--EVCGKAFHVSSLLSKHRTIHtgeklykcevcgkafyyPSRLSNHKKIHTGEKPFQCEVC 475
Cdd:COG5048   336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSETLSNSCIRNF 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907093310 476 GKAFCFPSSLSKHKRihTGEKPYKCKECGKAFRSLSSLSKHKRIHTGEKPYKCEECGKaFHYPSLLSKHKI 546
Cdd:COG5048   399 KRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
607-920 3.72e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 3.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 607 ENPYNSQVCSKAFVYPSKlSKHKKVRTKEKPYKCEVCGKAFRFPSLLLIHKGMHTGEKPYKCED--CGKAFHYPSLLSKH 684
Cdd:COG5048     4 TSSQSSSSNNSVLSSTPK-STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 685 KRIHTGEKPYQCEVCGKDFHVSSSLSKHRIIHT----GEKPYKCEICGKTFRFSSSLSKHKRNHTGKKPYKC-------- 752
Cdd:COG5048    83 LRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSnsndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntp 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 753 ------------EECGKAFHFPSILAKHKISHTGEKPYNCDLCGKAFHYASLLSKHKMIHTgEKPHKCDICGKAFHYPSK 820
Cdd:COG5048   163 qsnslhpplpanSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 821 LSNH-KKIHTGEKPYKCEVCGNVFCFASS---------LSKHKRIHTgenPYKCEVCGKAFYYPSLLSKHK--IIHTGE- 887
Cdd:COG5048   242 SQSPsSLSSSDSSSSASESPRSSLPTASSqssspnesdSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1907093310 888 -KPYKCD--LCGKAFHYPSLLSKHKVIHTGKKPYKC 920
Cdd:COG5048   319 lKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
369-826 1.29e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 369 SLSSLSKHKRIHTEDNYYNNELCGKAFIYPSRLSKHKRICAGEKPYKCEV--CGKAFHVSSLLSKHRTIHTGEKLYKCEV 446
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 447 -CGKAFYYPSRLSNHKKIHTGEKPFQCEVCGKAFCFPSSLSKHKRIHTGEKPYKCKEC-GKAFRSLSSLSKHKRIHTGEK 524
Cdd:COG5048    97 sLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 525 pykceeCGKAFHYPSLLSKHKIIHTEEKPYKCdvcgQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAFCIPLLLSKHKRvH 604
Cdd:COG5048   177 ------SKDPSSNLSLLISSNVSTSIPSSSEN----SPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQS-P 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 605 TGENPYNSQVCSKAFVYPSKLSKHKKVRTKekpykcevcgkafrFPSLLLIHKGMHTgekPYKCEDCGKAFHYPSLLSKH 684
Cdd:COG5048   246 SSLSSSDSSSSASESPRSSLPTASSQSSSP--------------NESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRH 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 685 KR--IHTGE--KPYQC--EVCGKDFHVSSSLSKHRIIHTGEKPYKC--EICGKTFRFSS------SLSKHKRNHTGKKPY 750
Cdd:COG5048   309 LRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSE 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 751 kCEECGKAFHFP--SILAKHKISHTGEKPYNCD--LCGKAFHYASLLSKHKMIHTGEKPHKCDICGKaFHYPSKLSNHKK 826
Cdd:COG5048   389 -TLSNSCIRNFKrdSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 340-434 1.57e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 51.64  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 340 DYPSRLsthaKMHTGEKPYKCEV--CQKAFRSLSSLsKHKRIHTEDNYYNNElcgkafiYPSRlSKHKRICAGEKPYKCE 417
Cdd:COG5189   336 DTPSRM----LKVKDGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHE-------NPSP-EKMNIFSAKDKPYRCE 402

                          90
                  ....*....|....*..
gi 1907093310 418 VCGKAFHVSSLLSKHRT 434
Cdd:COG5189   403 VCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 214-297 2.15e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 214 GEKPYKCEI--CDKAFHYPSILSKHKrihtgekpyKCEECGKAFHISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSN 291
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1907093310 292 HKKiHS 297
Cdd:COG5189   417 HRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 662-745 8.67e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 8.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 662 GEKPYKCE--DCGKAFHYPSLLsKHKRIHTGekpyqcevCGKDFHVSSSLSKHRIIHTGEKPYKCEICGKTFRFSSSLSK 739
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1907093310 740 HKRNHT 745
Cdd:COG5189   417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 578-661 2.27e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 578 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENPYNSQVCSKafvypsklSKHKKVRTKEKPYKCEVCGKAFRFPSLLLI 655
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1907093310 656 HKGMHT 661
Cdd:COG5189   417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 270-353 2.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 270 GEKPYKCEV--CGKAFHYPSRLSNHKKiHSGEKPFKCEVCGKafrilsllSKHKIIHTEENPYKCEVCGKAFDYPSRLST 347
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1907093310 348 HAKMHT 353
Cdd:COG5189   417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 494-573 4.48e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 4.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 494 GEKPYKCK--ECGKAFRSLSSLSKHKrihtgekpyKCEECGKAFHYPSLLSKHKIIHTEEKPYKCDVCGQAFHVPSKLSH 571
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1907093310 572 HK 573
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-509 8.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907093310 484 SLSKHKRIHTGEKPYKCKECGKAFRS 509
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 718-797 9.92e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 9.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 718 GEKPYKCEI--CGKTFRFSSSLSKHKRNHtgkkpykceECGKAFHFPSILAKHKISHTGEKPYNCDLCGKAFHYASLLSK 795
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1907093310 796 HK 797
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
512-535 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....
gi 1907093310 512 SLSKHKRIHTGEKPYKCEECGKAF 535
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-255 2.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|...
gi 1907093310 233 LSKHKRIHTGEKPYKCEECGKAF 255
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 522-591 3.07e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 3.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093310 522 GEKPYKCE--ECGKAFHYPSLLSKHKIiHTEekpykcdvCGQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAF 591
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 130-199 3.10e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 3.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093310 130 GEKPYKCEV--CGKAFCIPLLLsKHKRVHTGENlykcevcGKAFQHPSRLSrHKKIHSEEKPYKCEVCGKAF 199
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGL-KYHMLHGHQN-------QKLHENPSPEK-MNIFSAKDKPYRCEVCDKRY 408
zf-H2C2_2 pfam13465
Zinc-finger double domain;
736-759 3.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|....
gi 1907093310 736 SLSKHKRNHTGKKPYKCEECGKAF 759
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 858-938 3.95e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093310 858 GENPYKCEV--CGKAFYYPSLLSKHKiihtgekpyKCDLCGKAFHYPSLLSKHKVIHTGKKPYKCEVCGKAFHYPSRLSK 935
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1907093310 936 HKK 938
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
681-703 6.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.21e-03
                          10        20
                  ....*....|....*....|...
gi 1907093310 681 LSKHKRIHTGEKPYQCEVCGKDF 703
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
848-873 7.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907093310 848 SLSKHKRIHTGENPYKCEVCGKAFYY 873
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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