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Conserved domains on  [gi|1907099439|ref|XP_036014356|]
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bis(5'-adenosyl)-triphosphatase isoform X3 [Mus musculus]

Protein Classification

HIT family protein( domain architecture ID 10101080)

HIT (Histidine triad) family protein, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), is part of a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides; similar to Homo sapiens Bis(5'-adenosyl)-triphosphatase (also called fragile histidine triad protein) that cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP

CATH:  3.30.428.10
Gene Ontology:  GO:0003824
PubMed:  1472710
SCOP:  4000950

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHIT cd01275
FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH ...
 5-124 3.88e-47

FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.


:

Pssm-ID: 238606 [Multi-domain]  Cd Length: 126  Bit Score: 148.98  E-value: 3.88e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439   5 FGQHLIKPS---VVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFS 81
Cdd:cd01275     3 FCDIPIKPDednLVFYRTKHSFAVVNLYPYNPGHVLVVPYRHVPRLEDLTPEEIADLFKLVQLAMKALKVVYKPDGFNIG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907099439  82 MQDGPEAGQTVKHVHVHVLPRKAGDFPRND-NIYDELQKHDREE 124
Cdd:cd01275    83 INDGKAGGGIVPHVHIHIVPRWNGDTNFMPvIIYTKVLPEDLED 126
 
Name Accession Description Interval E-value
FHIT cd01275
FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH ...
 5-124 3.88e-47

FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.


Pssm-ID: 238606 [Multi-domain]  Cd Length: 126  Bit Score: 148.98  E-value: 3.88e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439   5 FGQHLIKPS---VVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFS 81
Cdd:cd01275     3 FCDIPIKPDednLVFYRTKHSFAVVNLYPYNPGHVLVVPYRHVPRLEDLTPEEIADLFKLVQLAMKALKVVYKPDGFNIG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907099439  82 MQDGPEAGQTVKHVHVHVLPRKAGDFPRND-NIYDELQKHDREE 124
Cdd:cd01275    83 INDGKAGGGIVPHVHIHIVPRWNGDTNFMPvIIYTKVLPEDLED 126
HIT pfam01230
HIT domain;
12-105 1.94e-30

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 1.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439  12 PSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQT 91
Cdd:pfam01230   5 PSTVVYEDDLVLAFLDIDPQAPGHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADGYRIVINNGAHAGQS 84

                          90
                  ....*....|....
gi 1907099439  92 VKHVHVHVLPRKAG 105
Cdd:pfam01230  85 VPHLHIHVIPRRKH 98
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 12-124 4.64e-27

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 98.10  E-value: 4.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439  12 PSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQT 91
Cdd:COG0537    14 PALIVYEDEHVLAFLDINPYAPGHTLVIPKRHVASLFDLTPEELAELMRLAQKVAKALRKALGPDGFNLGINNGEAAGQT 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907099439  92 VKHVHVHVLPRKAGDFPRNDNIYDELQKHDREE 124
Cdd:COG0537    94 VPHLHVHVIPRYEGDDNFMPVIGTKVDPEELEE 126
 
Name Accession Description Interval E-value
FHIT cd01275
FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH ...
 5-124 3.88e-47

FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Fhit plays a very important role in the development of tumours. Infact, Fhit deletions are among the earliest and most frequent genetic alterations in the development of tumours.


Pssm-ID: 238606 [Multi-domain]  Cd Length: 126  Bit Score: 148.98  E-value: 3.88e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439   5 FGQHLIKPS---VVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFS 81
Cdd:cd01275     3 FCDIPIKPDednLVFYRTKHSFAVVNLYPYNPGHVLVVPYRHVPRLEDLTPEEIADLFKLVQLAMKALKVVYKPDGFNIG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907099439  82 MQDGPEAGQTVKHVHVHVLPRKAGDFPRND-NIYDELQKHDREE 124
Cdd:cd01275    83 INDGKAGGGIVPHVHIHIVPRWNGDTNFMPvIIYTKVLPEDLED 126
HIT_like cd00468
HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH ...
 16-101 9.59e-33

HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified in the literacture into three major branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Further sequence analysis reveals several new closely related, yet uncharacterized subgroups.


Pssm-ID: 238263 [Multi-domain]  Cd Length: 86  Bit Score: 111.02  E-value: 9.59e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439  16 FLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQTVKHV 95
Cdd:cd00468     1 VPDDEHSFAFVNLKPAAPGHVLVCPKRHVETLPDLDEALLADLVITAQRVAAELEKHGNVPSLTVFVNDGAAAGQSVPHV 80


                  ....*.
gi 1907099439  96 HVHVLP 101
Cdd:cd00468    81 HLHVLP 86
HIT pfam01230
HIT domain;
12-105 1.94e-30

HIT domain;


Pssm-ID: 395984 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 1.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439  12 PSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQT 91
Cdd:pfam01230   5 PSTVVYEDDLVLAFLDIDPQAPGHILVIPKKHIRELHDLTPEELGDLMSVAQKVARALGKVFKADGYRIVINNGAHAGQS 84

                          90
                  ....*....|....
gi 1907099439  92 VKHVHVHVLPRKAG 105
Cdd:pfam01230  85 VPHLHIHVIPRRKH 98
HinT COG0537
Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide ...
 12-124 4.64e-27

Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 440303 [Multi-domain]  Cd Length: 133  Bit Score: 98.10  E-value: 4.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439  12 PSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQT 91
Cdd:COG0537    14 PALIVYEDEHVLAFLDINPYAPGHTLVIPKRHVASLFDLTPEELAELMRLAQKVAKALRKALGPDGFNLGINNGEAAGQT 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907099439  92 VKHVHVHVLPRKAGDFPRNDNIYDELQKHDREE 124
Cdd:COG0537    94 VPHLHVHVIPRYEGDDNFMPVIGTKVDPEELEE 126
HINT_subgroup cd01277
HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the ...
 12-102 2.28e-19

HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life. Although the biochemical function has not been characterised for many of the members of this subgroup, the proteins from Yeast have been shown to be involved in secretion, peroxisome formation and gene expression.


Pssm-ID: 238608 [Multi-domain]  Cd Length: 103  Bit Score: 77.26  E-value: 2.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439  12 PSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQT 91
Cdd:cd01277    13 PSYKVYEDDHVLAFLDINPASKGHTLVIPKKHYENLLDLDPEELAELILAAKKVARALKKALKADGLNILQNNGRAAGQV 92

                          90
                  ....*....|.
gi 1907099439  92 VKHVHVHVLPR 102
Cdd:cd01277    93 VFHVHVHVIPR 103
PKCI_related cd01276
Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ...
 12-100 8.55e-10

Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a hydrophobic residue) that is a signature for this family. No enzymatic activity has been reported however, for PKCI and its related members.


Pssm-ID: 238607 [Multi-domain]  Cd Length: 104  Bit Score: 52.56  E-value: 8.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907099439  12 PSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDL---HPDEVADLFQVTQRVgtVVEKHFQGTSITFSMQDGPEA 88
Cdd:cd01276    13 PAKKVYEDDEVLAFHDINPQAPVHILVIPKKHIASLSDAteeDEELLGHLLSAAAKV--AKDLGIAEDGYRLVINCGKDG 90

                          90
                  ....*....|..
gi 1907099439  89 GQTVKHVHVHVL 100
Cdd:cd01276    91 GQEVFHLHLHLL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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