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Conserved domains on  [gi|1907113750|ref|XP_036015426|]
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regulator of G-protein signaling 22 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 846-975 2.60e-66

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188681  Cd Length: 130  Bit Score: 219.28  E-value: 2.60e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 925
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907113750  926 LLSGGWGRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 975
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 664-779 1.29e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


:

Pssm-ID: 188682  Cd Length: 116  Bit Score: 196.89  E-value: 1.29e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  664 VENRAGFFFTKFCENSGNKLWKHSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYM 743
Cdd:cd08727      1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907113750  744 KIQPPFEDLFDTAEEFILLSLLEPWTQMVMSDKMAY 779
Cdd:cd08727     81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 1019-1116 2.51e-47

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08725:

Pssm-ID: 470619  Cd Length: 123  Bit Score: 164.87  E-value: 2.51e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750 1019 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCDESIIHKKITTIINCFINSYIPPALQIDIPVEQAQKIL 1098
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90
                   ....*....|....*...
gi 1907113750 1099 EHRKELGPYVFREAQSGV 1116
Cdd:cd08725     81 EHRRELGPYIFREAQLTV 98
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 408-530 5.16e-03

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08730:

Pssm-ID: 470619  Cd Length: 165  Bit Score: 39.25  E-value: 5.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  408 REFERFKKFLKGTLGERYWWLWMDIE--RLKVLKDPERHQRHLEKMKKCYLVSsgeryLSAEILSKFKLLHGSRWTAdhl 485
Cdd:cd08730      6 RGMRRFRQFLAGTLGEDYLKFWLDVEmyRRDYKFGEIKRLDFFRSVVTKYLLK-----NSPYCLPVFKRIESNIGLD--- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1907113750  486 KNIQAEVLKPlLLYWAPRFCVTHSASAKNASTELKFWRLRQEKPR 530
Cdd:cd08730     78 ESAIMEVMSP-MTEMPWQLLVYQMEVLSSTDTETTDGSTLEDLKR 121
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 846-975 2.60e-66

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 219.28  E-value: 2.60e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 925
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907113750  926 LLSGGWGRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 975
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 664-779 1.29e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 196.89  E-value: 1.29e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  664 VENRAGFFFTKFCENSGNKLWKHSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYM 743
Cdd:cd08727      1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907113750  744 KIQPPFEDLFDTAEEFILLSLLEPWTQMVMSDKMAY 779
Cdd:cd08727     81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1019-1116 2.51e-47

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 164.87  E-value: 2.51e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750 1019 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCDESIIHKKITTIINCFINSYIPPALQIDIPVEQAQKIL 1098
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90
                   ....*....|....*...
gi 1907113750 1099 EHRKELGPYVFREAQSGV 1116
Cdd:cd08725     81 EHRRELGPYIFREAQLTV 98
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 846-969 2.68e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 50.31  E-value: 2.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYikNKYLNKKyffgprSPASLHQQNQIM 925
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLAPG------SPKEINLDSDLR 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1907113750  926 -LLSGGwgriLHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:pfam00615   74 eEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 845-969 9.49e-07

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 48.80  E-value: 9.49e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750   845 TFTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIifKDQKQREEKSIYIKNKYLNKKyffGPRSPASLHQ-QNQ 923
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKA--EDDEERIAKAREIYDKFLSPN---APKEVNLDSDlREK 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 1907113750   924 IMLlsggwgRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:smart00315   76 IEE------NLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1015-1119 2.53e-06

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 47.65  E-value: 2.53e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  1015 FRKALLNPVIARQFQRFvaLKGDLLENGVLFWQEVQKFKDLchshCDESIIHKKITTIINCFINSYIPPALQIDI-PVEQ 1093
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100
                    ....*....|....*....|....*.
gi 1907113750  1094 AQKILEHRkELGPYVFREAQSGVKQY 1119
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYEL 100
RGS-like_3 cd08730
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These ...
 408-530 5.16e-03

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188685  Cd Length: 165  Bit Score: 39.25  E-value: 5.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  408 REFERFKKFLKGTLGERYWWLWMDIE--RLKVLKDPERHQRHLEKMKKCYLVSsgeryLSAEILSKFKLLHGSRWTAdhl 485
Cdd:cd08730      6 RGMRRFRQFLAGTLGEDYLKFWLDVEmyRRDYKFGEIKRLDFFRSVVTKYLLK-----NSPYCLPVFKRIESNIGLD--- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1907113750  486 KNIQAEVLKPlLLYWAPRFCVTHSASAKNASTELKFWRLRQEKPR 530
Cdd:cd08730     78 ESAIMEVMSP-MTEMPWQLLVYQMEVLSSTDTETTDGSTLEDLKR 121
 
Name Accession Description Interval E-value
RGS_RGS22_3 cd08726
Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) ...
 846-975 2.60e-66

Regulator of G protein signaling domain RGS_RGS22_3; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188681  Cd Length: 130  Bit Score: 219.28  E-value: 2.60e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLHQQNQIM 925
Cdd:cd08726      1 FQDLLHNRLELEFFRKFLEENSASMDLLCWLDIEQFRRIPHTDNAKRDEKAKEIKNKYLNKKYFFGPNSPATKEQQNKVM 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907113750  926 LLSGGWGRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASRQKI 975
Cdd:cd08726     81 HAGGGWGKILHDRPPSSVLIEIQKIVRARLEKHWLPLFLATEQFRRRQAQ 130
RGS_RGS22_2 cd08727
Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) ...
 664-779 1.29e-58

Regulator of G protein signaling domain RGS_RGS22_2; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188682  Cd Length: 116  Bit Score: 196.89  E-value: 1.29e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  664 VENRAGFFFTKFCENSGNKLWKHSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYM 743
Cdd:cd08727      1 LENRAGNFFTQFCEKSGNKLWKNAVYFWFDLQEYHQLFYTETFQPFKVCRKAQRLFSTYIVPGARHNIGCSVRKRKEIIK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907113750  744 KIQPPFEDLFDTAEEFILLSLLEPWTQMVMSDKMAY 779
Cdd:cd08727     81 KLSPPFEDLFDAAEEHILLLLLEPWSKMVKQDEAEY 116
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 1019-1116 2.51e-47

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 164.87  E-value: 2.51e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750 1019 LLNPVIARQFQRFVALKGDLLENGVLFWQEVQKFKDLCHSHCDESIIHKKITTIINCFINSYIPPALQIDIPVEQAQKIL 1098
Cdd:cd08725      1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                           90
                   ....*....|....*...
gi 1907113750 1099 EHRKELGPYVFREAQSGV 1116
Cdd:cd08725     81 EHRRELGPYIFREAQLTV 98
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 850-969 1.05e-16

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 77.05  E-value: 1.05e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  850 LNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIfKDQKQREEKSIYIKNKYLNKKYFFGPRSPASLhqQNQIMLlsg 929
Cdd:cd07440      1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTT-SSDEELKSKAKEIYDKYISKDAPKEINIPESI--REEIEE--- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907113750  930 gwgRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:cd07440     75 ---NLEEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLY 111
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 670-777 4.02e-09

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 55.48  E-value: 4.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  670 FFFTKFCENSGNKlwkHSVYFWFDLQAYHQLFYQETlqpfKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYMKIQPP- 748
Cdd:cd07440      8 EYFRQFLKSEHCE---ENLEFWLAVEKFKKTTSSDE----ELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPy 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1907113750  749 -FEDLFDTAEEFILLSLL-EPWTQMVMSDKM 777
Cdd:cd07440     81 pDPDCFDEAQEHILNLLEkDSYPRFLKSDLY 111
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 846-969 2.68e-07

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 50.31  E-value: 2.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  846 FTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYikNKYLNKKyffgprSPASLHQQNQIM 925
Cdd:pfam00615    2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADPDEERLKKAKEIY--NEFLAPG------SPKEINLDSDLR 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1907113750  926 -LLSGGwgriLHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:pfam00615   74 eEIREN----LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLY 114
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 845-969 9.49e-07

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 48.80  E-value: 9.49e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750   845 TFTDLLNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIifKDQKQREEKSIYIKNKYLNKKyffGPRSPASLHQ-QNQ 923
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKA--EDDEERIAKAREIYDKFLSPN---APKEVNLDSDlREK 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 1907113750   924 IMLlsggwgRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQF 969
Cdd:smart00315   76 IEE------NLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 1015-1119 2.53e-06

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 47.65  E-value: 2.53e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  1015 FRKALLNPVIARQFQRFvaLKGDLLENGVLFWQEVQKFKDLchshCDESIIHKKITTIINCFINSYIPPALQIDI-PVEQ 1093
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100
                    ....*....|....*....|....*.
gi 1907113750  1094 AQKILEHRkELGPYVFREAQSGVKQY 1119
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYEL 100
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 850-1032 8.23e-05

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 44.83  E-value: 8.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  850 LNNKLEFEHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYiknkylnKKYFFGPRSPASLHQQNQIMLLSG 929
Cdd:cd08728      1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIV-------KRYFHGQDPPGVLLQCEAIIIREI 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  930 GWGRILHEqldaSVLVEIQKHVLNRLENVWLPLF---LSSEQFASRQKIKTQMKDIADELLLQR-HDRKIGVWkpveSKW 1005
Cdd:cd08728     74 AMMKVVTT----SMLLSIQHLVSKSLEERWFKKYqdtFPDCPHEVEPDEEIKVPLKPTKLKAPHvISSQKRAW----EIF 145

                          170       180
                   ....*....|....*....|....*..
gi 1907113750 1006 ISSSCEIIAFRKALLNPVIARQFQRFV 1032
Cdd:cd08728    146 ISFIRSFIKFRRFMVNREIRQEFEDYL 172
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 690-760 1.06e-03

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 39.91  E-value: 1.06e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907113750  690 FWFDLQAYHQLFYQetlqpFKVCKQAQYLFATYIAPSASFDIGLHQEGKKDIYMKIQPPFEDLFDTAEEFI 760
Cdd:cd08716     29 FWLACETYKKIASQ-----RKRISMARKLFASYIQPQAPREINIDSPTRKAIIRNIQEPTQSCFDEAQRIV 94
RGS-like_3 cd08730
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These ...
 408-530 5.16e-03

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188685  Cd Length: 165  Bit Score: 39.25  E-value: 5.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113750  408 REFERFKKFLKGTLGERYWWLWMDIE--RLKVLKDPERHQRHLEKMKKCYLVSsgeryLSAEILSKFKLLHGSRWTAdhl 485
Cdd:cd08730      6 RGMRRFRQFLAGTLGEDYLKFWLDVEmyRRDYKFGEIKRLDFFRSVVTKYLLK-----NSPYCLPVFKRIESNIGLD--- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1907113750  486 KNIQAEVLKPlLLYWAPRFCVTHSASAKNASTELKFWRLRQEKPR 530
Cdd:cd08730     78 ESAIMEVMSP-MTEMPWQLLVYQMEVLSSTDTETTDGSTLEDLKR 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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