NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907113887|ref|XP_036015441|]
View 

protein LYRIC isoform X9 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LYRIC super family cl25675
Lysine-rich CEACAM1 co-isolated protein family; LYRIC is a family of proteins found in ...
 15-179 1.07e-61

Lysine-rich CEACAM1 co-isolated protein family; LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localizes to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalized with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumour cell migration and invasion by activating the transcription factor NF-kappaB.


The actual alignment was detected with superfamily member pfam15686:

Pssm-ID: 434858  Cd Length: 423  Bit Score: 202.84  E-value: 1.07e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113887  15 VSNFKSGKGDSTLQ------VSSRLNENLTVNGGGWSEKSVKLSSQLS---EEKWNSVPPASAGKRKTEPSAWTQDTGDT 85
Cdd:pfam15686 246 VLNSKSGKGDSTLQelvapqVSPGLNEVPTVNGGGWTEKSVKIPSQISageEEKWTSVPAPSAGRRKQEPSAWGQDTGDT 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113887  86 NA--NGKDWGRNWSDRSI--FSGIGSTAEPVSqSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPSSDWNAPAEEWGNWV 161
Cdd:pfam15686 326 AAswTVIDRGRTTTERNLvsFSGLGSNAEEVP-STVSDLQWDSPPAVPPIDDEWSGLNGLSSADPSSDWNAPAEEWGNYV 404

                         170
                  ....*....|....*....
gi 1907113887 162 DEDR-ASLLKSQEPISNDQ 179
Cdd:pfam15686 405 EEEKvAAPPLKEEPVPEPQ 423
 
Name Accession Description Interval E-value
LYRIC pfam15686
Lysine-rich CEACAM1 co-isolated protein family; LYRIC is a family of proteins found in ...
 15-179 1.07e-61

Lysine-rich CEACAM1 co-isolated protein family; LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localizes to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalized with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumour cell migration and invasion by activating the transcription factor NF-kappaB.


Pssm-ID: 434858  Cd Length: 423  Bit Score: 202.84  E-value: 1.07e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113887  15 VSNFKSGKGDSTLQ------VSSRLNENLTVNGGGWSEKSVKLSSQLS---EEKWNSVPPASAGKRKTEPSAWTQDTGDT 85
Cdd:pfam15686 246 VLNSKSGKGDSTLQelvapqVSPGLNEVPTVNGGGWTEKSVKIPSQISageEEKWTSVPAPSAGRRKQEPSAWGQDTGDT 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113887  86 NA--NGKDWGRNWSDRSI--FSGIGSTAEPVSqSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPSSDWNAPAEEWGNWV 161
Cdd:pfam15686 326 AAswTVIDRGRTTTERNLvsFSGLGSNAEEVP-STVSDLQWDSPPAVPPIDDEWSGLNGLSSADPSSDWNAPAEEWGNYV 404

                         170
                  ....*....|....*....
gi 1907113887 162 DEDR-ASLLKSQEPISNDQ 179
Cdd:pfam15686 405 EEEKvAAPPLKEEPVPEPQ 423
 
Name Accession Description Interval E-value
LYRIC pfam15686
Lysine-rich CEACAM1 co-isolated protein family; LYRIC is a family of proteins found in ...
 15-179 1.07e-61

Lysine-rich CEACAM1 co-isolated protein family; LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localizes to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalized with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumour cell migration and invasion by activating the transcription factor NF-kappaB.


Pssm-ID: 434858  Cd Length: 423  Bit Score: 202.84  E-value: 1.07e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113887  15 VSNFKSGKGDSTLQ------VSSRLNENLTVNGGGWSEKSVKLSSQLS---EEKWNSVPPASAGKRKTEPSAWTQDTGDT 85
Cdd:pfam15686 246 VLNSKSGKGDSTLQelvapqVSPGLNEVPTVNGGGWTEKSVKIPSQISageEEKWTSVPAPSAGRRKQEPSAWGQDTGDT 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907113887  86 NA--NGKDWGRNWSDRSI--FSGIGSTAEPVSqSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPSSDWNAPAEEWGNWV 161
Cdd:pfam15686 326 AAswTVIDRGRTTTERNLvsFSGLGSNAEEVP-STVSDLQWDSPPAVPPIDDEWSGLNGLSSADPSSDWNAPAEEWGNYV 404

                         170
                  ....*....|....*....
gi 1907113887 162 DEDR-ASLLKSQEPISNDQ 179
Cdd:pfam15686 405 EEEKvAAPPLKEEPVPEPQ 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH