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Conserved domains on  [gi|1907114323|ref|XP_036015506|]
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rho GTPase-activating protein 8 isoform X1 [Mus musculus]

Protein Classification

SEC14 and RhoGAP domain-containing protein( domain architecture ID 10074405)

SEC14 and RhoGAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 204-392 1.04e-95

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04404:

Pssm-ID: 470621 [Multi-domain]  Cd Length: 195  Bit Score: 285.77  E-value: 1.04e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQG-ELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTF 282
Cdd:cd04404     6 FGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 283 LRELPQPLLTFQAYEQILGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLI 362
Cdd:cd04404    86 LRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLL 165

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907114323 363 WPSQGVASLSALVPLNLFTELLIEYYDKVF 392
Cdd:cd04404   166 WAKDASMSLSAINPINTFTKFLLDHQDEIF 195
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 112-168 1.49e-12

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 65.05  E-value: 1.49e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907114323 112 YKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYC-SNLRELREHLQCDQLLIP 168
Cdd:cd00170    95 YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLgSDLEELLEYIDPDQLPKE 152
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-392 1.04e-95

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 285.77  E-value: 1.04e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQG-ELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTF 282
Cdd:cd04404     6 FGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 283 LRELPQPLLTFQAYEQILGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLI 362
Cdd:cd04404    86 LRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLL 165

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907114323 363 WPSQGVASLSALVPLNLFTELLIEYYDKVF 392
Cdd:cd04404   166 WAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 221-366 3.97e-52

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 171.96  E-value: 3.97e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 221 PPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGK-PVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQI 299
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPdVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907114323 300 LGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ 366
Cdd:pfam00620  81 IEAAKLPDeEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 220-388 2.24e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 155.12  E-value: 2.24e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323  220 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG-DMHLPAVILKTFLRELPQPLLTFQAYEQ 298
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELYEE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323  299 ILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQG-VASLSALVP 376
Cdd:smart00324  83 FIEAAKLEDETeRLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGeVASLKDIRH 162

                          170
                   ....*....|..
gi 1907114323  377 LNLFTELLIEYY 388
Cdd:smart00324 163 QNTVIEFLIENA 174
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 112-168 1.49e-12

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 65.05  E-value: 1.49e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907114323 112 YKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYC-SNLRELREHLQCDQLLIP 168
Cdd:cd00170    95 YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLgSDLEELLEYIDPDQLPKE 152
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 112-176 1.85e-11

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 61.57  E-value: 1.85e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114323 112 YKKNLKALYVVHPTSLIK-ALWNIFKPLISHKFGKKVTYCSNLRELREHLQCDQLLIP-PEVVRYDE 176
Cdd:pfam13716  73 FKKNLKAVYVVHPSTFLRtFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPTElPGVLSYDE 139
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 71-176 3.72e-11

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 61.16  E-value: 3.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323   71 DVARHGILQVAGDDRQGRRIFTFsCCRLPPLHQLNHQRLLE--------------------------------------- 111
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIE-RAGRFDLKSVTLEELLRylvyvlekilqeekktggiegftvifdlkglsmsnpdls 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907114323  112 ------------YKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYCSNL--RELREHLQCDQLliPPEVVRYDE 176
Cdd:smart00516  82 vlrkilkilqdhYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDskEELLEYIDKEQL--PEELGGTLD 158
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-392 1.04e-95

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 285.77  E-value: 1.04e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQG-ELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTF 282
Cdd:cd04404     6 FGVSLQFLKEKNPEqEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 283 LRELPQPLLTFQAYEQILGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLI 362
Cdd:cd04404    86 LRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLL 165

                         170       180       190
                  ....*....|....*....|....*....|
gi 1907114323 363 WPSQGVASLSALVPLNLFTELLIEYYDKVF 392
Cdd:cd04404   166 WAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 221-366 3.97e-52

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 171.96  E-value: 3.97e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 221 PPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGK-PVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQI 299
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPdVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907114323 300 LGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ 366
Cdd:pfam00620  81 IEAAKLPDeEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 221-387 2.23e-48

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 162.86  E-value: 2.23e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 221 PPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQIL 300
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 301 GI-TSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQGVASLSALVP-LN 378
Cdd:cd00159    81 ELaKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEDIKkLN 160


                  ....*....
gi 1907114323 379 LFTELLIEY 387
Cdd:cd00159   161 EIVEFLIEN 169
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 220-388 2.24e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 155.12  E-value: 2.24e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323  220 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG-DMHLPAVILKTFLRELPQPLLTFQAYEQ 298
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEyDVHDVAGLLKLFLRELPEPLITYELYEE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323  299 ILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQG-VASLSALVP 376
Cdd:smart00324  83 FIEAAKLEDETeRLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGeVASLKDIRH 162

                          170
                   ....*....|..
gi 1907114323  377 LNLFTELLIEYY 388
Cdd:smart00324 163 QNTVIEFLIENA 174
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-392 5.01e-39

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 139.51  E-value: 5.01e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQ-YLrdKNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQG--KPVNFDDYGDMHLPAVILK 280
Cdd:cd04386     5 FGTPLEeHL--KRTGREIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtfSLPLDEFYSDPHAVASALK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 281 TFLRELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGL 359
Cdd:cd04386    83 SYLRELPDPLLTYNLYEDWVQAANKPDEDeRLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAP 162

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907114323 360 NLIWP------SQGVASLSALVplNLFTELLIEYYDKVF 392
Cdd:cd04386   163 NLLWAknegslAEMAAGTSVHV--VAIVELIISHADWFF 199
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-402 8.90e-32

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 119.71  E-value: 8.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQylRDKNQGELIPPVLRwTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYgDMHLPAVILKTFL 283
Cdd:cd04402     2 FGQPLS--NICEDDNLPKPILD-MLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAE-PVLLLASVLKDFL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 284 RELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLI 362
Cdd:cd04402    78 RNIPGSLLSSDLYEEWMSALDQENEEeKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLL 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907114323 363 WPSQG----VASLSALVPLnlfTELLIEYydkvfsCQEAPGEHT 402
Cdd:cd04402   158 WPPASselqNEDLKKVTSL---VQFLIEN------CQEIFGEDI 192
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-386 3.09e-31

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 118.33  E-value: 3.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQ-GELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTF 282
Cdd:cd04393     3 FGVPLQELQQAGQpENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 283 LRELPQPLLT-------FQAYEQILGITSVESSLrvthcRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLAC 355
Cdd:cd04393    83 LQELPEGLIPaslqirlMQLYQDYNGEDEFGRKL-----RDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAA 157

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907114323 356 VFGLNLIWPSQGVASLSALVPLNLFTELLIE 386
Cdd:cd04393   158 VFGPDVFHVYTDVEDMKEQEICSRIMAKLLE 188
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 219-364 3.22e-28

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 110.23  E-value: 3.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 219 LIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQ 298
Cdd:cd04390    21 LVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYED 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907114323 299 ILGITSVESSLRVT-HCRLI--LRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWP 364
Cdd:cd04390   101 FLSCAQLLSKDEEKgLGELMkqVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRP 169
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 204-358 4.86e-26

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 104.06  E-value: 4.86e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQGelIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQG-KPVNFDDYGdMHLPAVILKTF 282
Cdd:cd04377     1 FGVSLSSLTSEDRS--VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDpDSVNLEDYP-IHVITSVLKQW 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114323 283 LRELPQPLLTFQAYEQILGITSV-ESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFG 358
Cdd:cd04377    78 LRELPEPLMTFELYENFLRAMELeEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFA 154
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-372 7.39e-26

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 104.09  E-value: 7.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKN--QGELIPPVLRWTVTYLrEKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNfddygDMHLP---AVI 278
Cdd:cd04394     2 FGVPLHSLPHSTvpEYGNVPKFLVDACTFL-LDHLSTEGLFRKSGSVVRQKELKAKLEGGEACL-----SSALPcdvAGL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 279 LKTFLRELPQPLLTFQAYEQILGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVF 357
Cdd:cd04394    76 LKQFFRELPEPLLPYDLHEALLKAQELPTdEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIF 155

                         170
                  ....*....|....*
gi 1907114323 358 GLNLIWPSQGVASLS 372
Cdd:cd04394   156 APNLFQSEEGGEKMS 170
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 220-392 3.11e-24

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 99.13  E-value: 3.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 220 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQ-GKPVNFDD--YGDMHLPAVILKTFLRELPQPLLTFQAY 296
Cdd:cd04372    16 RPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISAtvYPDINVITGALKLYFRDLPIPVITYDTY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 297 EQILGITSV-ESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ--GVASLSA 373
Cdd:cd04372    96 PKFIDAAKIsNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPPEdsALTTLND 175

                         170
                  ....*....|....*....
gi 1907114323 374 LVPLNLFTELLIEYYDKVF 392
Cdd:cd04372   176 MRYQILIVQLLITNEDVLF 194
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-392 2.19e-23

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 96.70  E-value: 2.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSL--QYLRDknqGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQgKPVNFD-----DY-GDMHLP 275
Cdd:cd04398     1 FGVPLedLILRE---GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDK-DPLNVLlispeDYeSDIHSV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 276 AVILKTFLRELPQPLLTFQAYEQILGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLA 354
Cdd:cd04398    77 ASLLKLFFRELPEPLLTKALSREFIEAAKIEDeSRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLA 156

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907114323 355 CVFGLNLI-WPSQGVASLSALVPLnlfTELLIEYYDKVF 392
Cdd:cd04398   157 IIWGPTLMnAAPDNAADMSFQSRV---IETLLDNAYQIF 192
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 220-362 6.34e-23

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 95.97  E-value: 6.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 220 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQI 299
Cdd:cd04376     9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907114323 300 LGITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESIS-----------NKMNSSNLACVFGLNLI 362
Cdd:cd04376    89 IGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLL 162
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 204-356 4.45e-22

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 92.88  E-value: 4.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQ---GELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYgDMHLPAVILK 280
Cdd:cd04381     1 FGASLSLAVERSRchdGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEY-EPPTVASLLK 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907114323 281 TFLRELPQPLLT---FQAYEQILGITSVESslRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACV 356
Cdd:cd04381    80 QYLRELPEPLLTkelMPRFEEACGRPTEAE--REQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIV 156
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 205-362 1.81e-21

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 91.33  E-value: 1.81e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 205 GVSLQYLRDKNQgeLIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGK-PVNFDDYG-DMHLPAVILKTF 282
Cdd:cd04383     5 GSLEEYIQDSGQ--AIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEdPLADDQNDhDINSVAGVLKLY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 283 LRELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNL 361
Cdd:cd04383    83 FRGLENPLFPKERFEDLMSCVKLENPTeRVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTL 162


                  .
gi 1907114323 362 I 362
Cdd:cd04383   163 M 163
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 204-386 2.12e-21

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 91.30  E-value: 2.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKnQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG--DMHLPAVILKT 281
Cdd:cd04403     1 FGCHLEALCQR-ENSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDSKweDIHVITGALKL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 282 FLRELPQPLLTFQAYEQIL-GITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLN 360
Cdd:cd04403    80 FFRELPEPLFPYSLFNDFVaAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPT 159

                         170       180
                  ....*....|....*....|....*..
gi 1907114323 361 LIWPSQGVASLSA-LVPLNLFTELLIE 386
Cdd:cd04403   160 LLRPEQETGNIAVhMVYQNQIVELILL 186
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 204-387 2.15e-21

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 91.72  E-value: 2.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVS-LQYLRDKNQGelIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKP-VNFDDYGDMHLPAViLKT 281
Cdd:cd04378     1 FGVDfSQVPRDFPDE--VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDlVELSELSPHDISSV-LKL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 282 FLRELPQPLLTFQAYEQILGI---------------TSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISN 346
Cdd:cd04378    78 FLRQLPEPLILFRLYNDFIALakeiqrdteedkapnTPIEVNRIIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEEN 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1907114323 347 KMNSSNLACVFGLNLIWPSQGVA--SLSALVPLN---LFTELLIEY 387
Cdd:cd04378   158 KMSPNNLGIVFGPTLIRPRPGDAdvSLSSLVDYGyqaRLVEFLITN 203
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 204-392 6.97e-21

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 89.73  E-value: 6.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSL----QYLRDKNQGELIPPVLRWTVTYL-REKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNF---DDYGDMHLP 275
Cdd:cd04400     2 FGSPLeeavELSSHKYNGRDLPSVVYRCIEYLdKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfssSLYPDVHTV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 276 AVILKTFLRELPQPLLTFQAYEQILGITSVESSL--RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNL 353
Cdd:cd04400    82 AGLLKLYLRELPTLILGGELHNDFKRLVEENHDRsqRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907114323 354 ACVFG--LNliwpsqgvaslsalVPLNLFTELLIEyYDKVF 392
Cdd:cd04400   162 CIVFSptLN--------------IPAGIFVLFLTD-FDCIF 187
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-392 8.25e-21

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 89.77  E-value: 8.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQGELIPPVLRWTVTYLREKGLRTEGLFR----RSASAQTVRQVQRLYDQgkpVNFDD--YGDMHLPAV 277
Cdd:cd04395     2 FGVPLDDCPPSSENPYVPLIVEVCCNIVEARGLETVGIYRvpgnNAAISALQEELNRGGFD---IDLQDprWRDVNVVSS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 278 ILKTFLRELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACV 356
Cdd:cd04395    79 LLKSFFRKLPEPLFTNELYPDFIEANRIEDPVeRLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIV 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1907114323 357 FGLNLIWPSQGvaSLSALVPlNL-----FTELLIEYYDKVF 392
Cdd:cd04395   159 FGPTLVRTSDD--NMETMVT-HMpdqckIVETLIQHYDWFF 196
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-392 6.35e-20

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 87.79  E-value: 6.35e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQ----GELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQR-----------LYDQGKPvnfdd 268
Cdd:cd04391     2 FGVPLSTLLERDQkkvpGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQeleakfyegtfLWDQVKQ----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 269 ygdmHLPAVILKTFLRELPQPLLT---FQAYEQILGITSVESSLRVTHCRLILrsLPEHNYAVLRYLMGFLHEVSLESIS 345
Cdd:cd04391    77 ----HDAASLLKLFIRELPQPLLTveyLPAFYSVQGLPSKKDQLQALNLLVLL--LPEANRDTLKALLEFLQKVVDHEEK 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114323 346 NKMNSSNLACVFGLNLiWPSQGVAS----------LSALVPLNLfTELLIEYYDKVF 392
Cdd:cd04391   151 NKMNLWNVAMIMAPNL-FPPRGKHSkdneslqeevNMAAGCANI-MRLLIRYQDLLW 205
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 204-362 1.88e-19

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 85.52  E-value: 1.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKnQGELIPPV-LRWTVTYLREK-----GLRTEGLFRRSASAQTVRQVQRLYDQGKpVNFDDYGDMHLPAV 277
Cdd:cd04389     1 FGSSLEEIMDR-QKEKYPELkLPWILTFLSEKvlalgGFQTEGIFRVPGDIDEVNELKLRVDQWD-YPLSGLEDPHVPAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 278 ILKTFLRELPQPLLTFQAYEQilgitSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESI--SNKMNSSNLAC 355
Cdd:cd04389    79 LLKLWLRELEEPLIPDALYQQ-----CISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENvaHTKMDVSNLAM 153


                  ....*..
gi 1907114323 356 VFGLNLI 362
Cdd:cd04389   154 VFAPNIL 160
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 204-357 2.87e-19

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 85.04  E-value: 2.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYL-RDKNQgelIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQG-KPVNFDDYgDMHLPAVILKT 281
Cdd:cd04407     1 FGVRVGSLtSNKTS---VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADpENVKLENY-PIHAITGLLKQ 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114323 282 FLRELPQPLLTFQAYEQIL-GITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVF 357
Cdd:cd04407    77 WLRELPEPLMTFAQYNDFLrAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVF 153
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-365 6.26e-18

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 81.35  E-value: 6.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLrDKNQGElIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG-DMHLPAVILKTF 282
Cdd:cd04373     1 FGVPLANV-VTSEKP-IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDfTVNAVAGALKSF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 283 LRELPQPLLTF---QAYEQILGITSVESslRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFgl 359
Cdd:cd04373    79 FSELPDPLIPYsmhLELVEAAKINDREQ--RLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICF-- 154


                  ....*.
gi 1907114323 360 nliWPS 365
Cdd:cd04373   155 ---WPT 157
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 233-366 8.98e-18

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 81.35  E-value: 8.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 233 EKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYG-DMHLPAVILKTFLRELPQPLLT---FQAYEQILGITSVESS 308
Cdd:cd04392    21 EKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLThahYPAHLQIADLCQFDEK 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907114323 309 LRVTHCR----------LILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ 366
Cdd:cd04392   101 GNKTSAPdkerllealqLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRN 168
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 231-386 2.11e-17

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 80.13  E-value: 2.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 231 LREKGLRTEGLFRRSASAQtvrQVQRLYDQGKPVNFDDYGDMHLP---------AVILKTFLRELPQPLLTFQAYEQ-IL 300
Cdd:cd04374    39 VETRGINEQGLYRVVGVNS---KVQKLLSLGLDPKTSTPGDVDLDnseweiktiTSALKTYLRNLPEPLMTYELHNDfIN 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 301 GITSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ-GVASLSALVPLNL 379
Cdd:cd04374   116 AAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEeTVAAIMDIKFQNI 195


                  ....*..
gi 1907114323 380 FTELLIE 386
Cdd:cd04374   196 VVEILIE 202
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 214-387 2.70e-17

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 80.24  E-value: 2.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 214 KNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKP-VNFDDYGDMHLPAViLKTFLRELPQPLLT 292
Cdd:cd04409    10 KKSPDGIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDlVELSELSPHDISNV-LKLYLRQLPEPLIL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 293 FQAYEQILGI-----------------------TSVESSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMN 349
Cdd:cd04409    89 FRLYNEFIGLakesqhvnetqeakknsdkkwpnMCTELNRILLKSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEENKMS 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1907114323 350 SSNLACVFGLNLIWPSQGVA--SLSALVPLN---LFTELLIEY 387
Cdd:cd04409   169 ASNLGIIFGPTLIRPRPTDAtvSLSSLVDYPhqaRLVELLITY 211
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 204-366 5.64e-17

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 79.05  E-value: 5.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQGE-LIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQ---GKPVNFDDYGDMHLPAVIL 279
Cdd:cd04379     1 FGVPLSRLVEREGESrDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERnsaAVELSEELYPDINVITGVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 280 KTFLRELPQPLLTFQAYEQILGITSVESSLRVT----HCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLAC 355
Cdd:cd04379    81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQtnthLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                         170
                  ....*....|.
gi 1907114323 356 VFGLNLIWPSQ 366
Cdd:cd04379   161 CFGPVLMFCSQ 171
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 204-358 8.87e-17

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 78.12  E-value: 8.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQGelIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYD-QGKPVNFDDYgDMHLPAVILKTF 282
Cdd:cd04406     1 FGVELSRLTSEDRS--VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDtDANSVNLDDY-NIHVIASVFKQW 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114323 283 LRELPQPLLTFQAYEQILGITSVESSLRVTH-CRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFG 358
Cdd:cd04406    78 LRDLPNPLMTFELYEEFLRAMGLQERRETVRgVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFA 154
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-365 7.08e-16

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 76.25  E-value: 7.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQGEL----------IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQgKPVNFDDYGD-- 271
Cdd:cd04397     1 FGVPLEILVEKFGADStlgvgpgklrIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDK-NPTEVPDLSKen 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 272 -MHLpAVILKTFLRELPQPLLTFQAYEQILGITSVESSL---RVTHcrLILRSLPEHNYAVLRYLMGFLHEVSL-----E 342
Cdd:cd04397    80 pVQL-AALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEerkRVLH--LVYCLLPKYHRDTMEVLFSFLKWVSSfshidE 156

                         170       180
                  ....*....|....*....|...
gi 1907114323 343 SISNKMNSSNLACVFGLNLIWPS 365
Cdd:cd04397   157 ETGSKMDIHNLATVITPNILYSK 179
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 204-366 1.55e-15

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 74.96  E-value: 1.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRdKNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDqgkpVNFDD----YGDMHLPAV-- 277
Cdd:cd04387     1 FGVKISTVT-KRERSKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFD----TNNKDvsvmLSEMDVNAIag 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 278 ILKTFLRELPQPLLTFQAYEQILGITSVESSLRVTHCRL-ILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACV 356
Cdd:cd04387    76 TLKLYFRELPEPLFTDELYPNFAEGIALSDPVAKESCMLnLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATV 155

                         170
                  ....*....|
gi 1907114323 357 FGLNLIWPSQ 366
Cdd:cd04387   156 FGPTLLRPSE 165
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 215-366 1.83e-15

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 74.46  E-value: 1.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 215 NQGELIPPVLRWTVTYLREKGLrTEGLFRRSASAQTVRQVQRLYDQGKP---VNFDDYGDMHLPAVILKTFLRELPQPLL 291
Cdd:cd04384    13 NSGQDVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEFDSEQIpdlTKDVYIQDIHSVSSLCKLYFRELPNPLL 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907114323 292 TFQAYEQILGITSVES-SLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQ 366
Cdd:cd04384    92 TYQLYEKFSEAVSAASdEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQ 167
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 220-390 2.34e-15

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 74.75  E-value: 2.34e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 220 IPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQ----GKPVNFDDYgDMHLPAVILKTFLRELPQPLLTFQA 295
Cdd:cd04396    32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTppdyGKSFDWDGY-TVHDAASVLRRYLNNLPEPLVPLDL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 296 YEQ----ILGITSVESSLRVTHC--------------RLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVF 357
Cdd:cd04396   111 YEEfrnpLRKRPRILQYMKGRINeplntdidqaikeyRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIF 190

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1907114323 358 GLNLIW-PSQGVAS----LSALVplnlfTELLIEYYDK 390
Cdd:cd04396   191 QPGILShPDHEMDPkeykLSRLV-----VEFLIEHQDK 223
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 204-357 9.38e-15

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 73.22  E-value: 9.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNqGELIPPVLRWTVTYLREKGLRTEGLFRRS---ASAQTVRQVQRLYDqgKPVNFDDYgDMHLPAVILK 280
Cdd:cd04375     5 FGVPLLVNLQRT-GQPLPRSIQQAMRWLRNNALDQVGLFRKSgvkSRIQKLRSMIESST--DNVNYDGQ-QAYDVADMLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 281 TFLRELPQPLLTFQAYEQILGITSV---ESSLRVTHCRLILrsLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVF 357
Cdd:cd04375    81 QYFRDLPEPLLTNKLSETFIAIFQYvpkEQRLEAVQCAILL--LPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCL 158
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 204-375 2.62e-14

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 71.39  E-value: 2.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQGELIPPVLRWTVTyLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKP-VNFDDYGDMHLPAViLKTF 282
Cdd:cd04408     1 FGVDFSQLPRDFPEEVPFVVVRCTAE-IENRALGVQGIYRISGSKARVEKLCQAFENGRDlVDLSGHSPHDITSV-LKHF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 283 LRELPQPLLTFQAYEQILGI--------------TSVESSLrVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKM 348
Cdd:cd04408    79 LKELPEPVLPFQLYDDFIALakelqrdsekaaesPSIVENI-IRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKM 157

                         170       180
                  ....*....|....*....|....*...
gi 1907114323 349 NSSNLACVFGLNLIWPSQGVA-SLSALV 375
Cdd:cd04408   158 SPNNLGIVFGPTLLRPLVGGDvSMICLL 185
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 209-358 6.17e-14

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 69.64  E-value: 6.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 209 QYLRDKNqgelIPPVLRWTVTYLREKGLRTEGLFRRSAsaqTVRQVQRLYD--QGKPVNFD-DYGDMHLPAV--ILKTFL 283
Cdd:cd04385     8 QQLTDND----IPVIVDKCIDFITQHGLMSEGIYRKNG---KNSSVKKLLEafRKDARSVQlREGEYTVHDVadVLKRFL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907114323 284 RELPQPLLTFQAYEQILGITSVE-SSLRVTHCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFG 358
Cdd:cd04385    81 RDLPDPLLTSELHAEWIEAAELEnKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFG 156
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 204-362 1.24e-13

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 69.68  E-value: 1.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQGEL---IPPVLRWTVTYLREKGLRTEGLFR----RSASAQTVRQVQRLYDQGKPVNFDdyGDMHLPA 276
Cdd:cd04380    31 LIDQLELGDNPDYSEVplsIPKEIWRLVDYLYTRGLAQEGLFEepglPSEPGELLAEIRDALDTGSPFNSP--GSAESVA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 277 VILKTFLRELPQPLLTFQAYEQILgitsVESSLRVTHCRLILR-SLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLAC 355
Cdd:cd04380   109 EALLLFLESLPDPIIPYSLYERLL----EAVANNEEDKRQVIRiSLPPVHRNVFVYLCSFLRELLSESADRGLDENTLAT 184


                  ....*..
gi 1907114323 356 VFGLNLI 362
Cdd:cd04380   185 IFGRVLL 191
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 204-358 1.46e-12

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 66.16  E-value: 1.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 204 FGVSLQYLRDKNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYGDMHLPAVILKTFL 283
Cdd:cd04382     1 IGTGELADFDPSTSPMIPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114323 284 RELPQPLLTFQAYEQILGITSVESSLRV--THCRLIlRSLPEHNYAVLRYLMGFLHEVSlESISNKMNSSNLACVFG 358
Cdd:cd04382    81 RSLKEPLITFALWKEFMEAAEILDEDNSraALYQAI-SELPQPNRDTLAFLILHLQRVA-QSPECKMDINNLARVFG 155
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 112-168 1.49e-12

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 65.05  E-value: 1.49e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907114323 112 YKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYC-SNLRELREHLQCDQLLIP 168
Cdd:cd00170    95 YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLgSDLEELLEYIDPDQLPKE 152
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 112-176 1.85e-11

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 61.57  E-value: 1.85e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114323 112 YKKNLKALYVVHPTSLIK-ALWNIFKPLISHKFGKKVTYCSNLRELREHLQCDQLLIP-PEVVRYDE 176
Cdd:pfam13716  73 FKKNLKAVYVVHPSTFLRtFLKTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLPTElPGVLSYDE 139
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 71-176 3.72e-11

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 61.16  E-value: 3.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323   71 DVARHGILQVAGDDRQGRRIFTFsCCRLPPLHQLNHQRLLE--------------------------------------- 111
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIE-RAGRFDLKSVTLEELLRylvyvlekilqeekktggiegftvifdlkglsmsnpdls 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907114323  112 ------------YKKNLKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYCSNL--RELREHLQCDQLliPPEVVRYDE 176
Cdd:smart00516  82 vlrkilkilqdhYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDskEELLEYIDKEQL--PEELGGTLD 158
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 218-358 2.30e-10

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 59.89  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114323 218 ELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQGKPVNFDDYgDMHLPAVILKTFLRELPQPLLTFQAYE 297
Cdd:cd04388    13 DVAPPLLIKLVEAIEKKGLESSTLYRTQSSSSLTELRQILDCDAASVDLEQF-DVAALADALKRYLLDLPNPVIPAPVYS 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907114323 298 QILGITSVESSLR--VTHCRLILRS--LPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFG 358
Cdd:cd04388    92 EMISRAQEVQSSDeyAQLLRKLIRSpnLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFS 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
116-165 1.47e-05

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 44.94  E-value: 1.47e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907114323 116 LKALYVVHPTSLIKALWNIFKPLISHKFGKKVTYC--SNLRELREHLQCDQL 165
Cdd:pfam00650  94 LGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLknSNEEELEKYIPPEQL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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