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Conserved domains on  [gi|1907123329|ref|XP_036016322|]
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zinc finger protein 871 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-411 3.57e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329  75 AKKCYICKQCGKAFAFPTYLQTHERIHTGEKPYVCLQCGKTFAHSR--SLKTHKRTHSVRDLFVCNYCGKTLRHYSSLQI 152
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 153 HTRIHTGE-KPYVCKPCGKAFITYRSFRIHERIHTGETPYECKQCGNTFMRWIQ-LRKHEIIHSGVKPyacklcgKSFTC 230
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANSLS-------KDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 231 SGSLRTHERIHTGERPYVCDQCGYSFTRLNSLLRHKITHTGEKPYVCNHCGKTFPRSASLQRHVKIHTEEKPYVCKQCGV 310
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 311 AFPSSADLLEHEQTHIDekpyiceqcgnafvlwsqFQKHKALHAvpvSYVCKQCGKSFTSSRSLKTHER--IHTGE--KP 386
Cdd:COG5048   263 SSLPTASSQSSSPNESD------------------SSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321

                         330       340
                  ....*....|....*....|....*..
gi 1907123329 387 YEC--KQCGKTFLWSYSLQRHEKTHTD 411
Cdd:COG5048   322 FSCpySLCGKLFSRNDALKRHILLHTS 348
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 369-461 1.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 369 TSSRSLKTherihTGEKPYECK--QCGKTFLWSYSLQRHEKT-HTDGKVHvckqcgETFPYDSHlqvhEKLHFDDEPFNC 445
Cdd:COG5189   337 TPSRMLKV-----KDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLH------ENPSPEKM----NIFSAKDKPYRC 401

                          90
                  ....*....|....*.
gi 1907123329 446 KYCGKPFFTLNHLHRH 461
Cdd:COG5189   402 EVCDKRYKNLNGLKYH 417
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-411 3.57e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329  75 AKKCYICKQCGKAFAFPTYLQTHERIHTGEKPYVCLQCGKTFAHSR--SLKTHKRTHSVRDLFVCNYCGKTLRHYSSLQI 152
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 153 HTRIHTGE-KPYVCKPCGKAFITYRSFRIHERIHTGETPYECKQCGNTFMRWIQ-LRKHEIIHSGVKPyacklcgKSFTC 230
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANSLS-------KDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 231 SGSLRTHERIHTGERPYVCDQCGYSFTRLNSLLRHKITHTGEKPYVCNHCGKTFPRSASLQRHVKIHTEEKPYVCKQCGV 310
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 311 AFPSSADLLEHEQTHIDekpyiceqcgnafvlwsqFQKHKALHAvpvSYVCKQCGKSFTSSRSLKTHER--IHTGE--KP 386
Cdd:COG5048   263 SSLPTASSQSSSPNESD------------------SSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321

                         330       340
                  ....*....|....*....|....*..
gi 1907123329 387 YEC--KQCGKTFLWSYSLQRHEKTHTD 411
Cdd:COG5048   322 FSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-258 6.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.13e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907123329 233 SLRTHERIHTGERPYVCDQCGYSFTR 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 369-461 1.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 369 TSSRSLKTherihTGEKPYECK--QCGKTFLWSYSLQRHEKT-HTDGKVHvckqcgETFPYDSHlqvhEKLHFDDEPFNC 445
Cdd:COG5189   337 TPSRMLKV-----KDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLH------ENPSPEKM----NIFSAKDKPYRC 401

                          90
                  ....*....|....*.
gi 1907123329 446 KYCGKPFFTLNHLHRH 461
Cdd:COG5189   402 EVCDKRYKNLNGLKYH 417
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
75-411 3.57e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329  75 AKKCYICKQCGKAFAFPTYLQTHERIHTGEKPYVCLQCGKTFAHSR--SLKTHKRTHSVRDLFVCNYCGKTLRHYSSLQI 152
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 153 HTRIHTGE-KPYVCKPCGKAFITYRSFRIHERIHTGETPYECKQCGNTFMRWIQ-LRKHEIIHSGVKPyacklcgKSFTC 230
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANSLS-------KDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 231 SGSLRTHERIHTGERPYVCDQCGYSFTRLNSLLRHKITHTGEKPYVCNHCGKTFPRSASLQRHVKIHTEEKPYVCKQCGV 310
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 311 AFPSSADLLEHEQTHIDekpyiceqcgnafvlwsqFQKHKALHAvpvSYVCKQCGKSFTSSRSLKTHER--IHTGE--KP 386
Cdd:COG5048   263 SSLPTASSQSSSPNESD------------------SSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKP 321

                         330       340
                  ....*....|....*....|....*..
gi 1907123329 387 YEC--KQCGKTFLWSYSLQRHEKTHTD 411
Cdd:COG5048   322 FSCpySLCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-315 4.28e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 161 KPYVCKPCGKAFITYRSFRIHER--IHTGE--TPYEC--KQCGNTFMRWIQLRKHEIIHSGVKPYACKLC-------GKS 227
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 228 FTCSGSLRTHERIHTGERPYVCD--QCGYSFTRLNSLLRHKITHTGEKPYVCN--HCGKTFPRSASLQRHVKIHTEEKPY 303
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|..
gi 1907123329 304 VCKQCGVAFPSS 315
Cdd:COG5048   448 LCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-258 6.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.13e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907123329 233 SLRTHERIHTGERPYVCDQCGYSFTR 258
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-396 9.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.44e-04
                          10        20
                  ....*....|....*....|....
gi 1907123329 373 SLKTHERIHTGEKPYECKQCGKTF 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
105-266 1.31e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 105 KPYVCLQCGKTFAHSRSLKTHKRT--HSVRDL--FVC--NYCGKTLRHYSSLQIHTRIHTGEKPYVCKPC------GKAF 172
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 173 ITYR--SFRIHERIHTGETPYECKQCGN-TFMRWIQLRKHEIIHSGVKPYACK--LCGKSFTCSGSLRTHERIHTGERPY 247
Cdd:COG5048   368 NNEPpqSLQQYKDLKNDKKSETLSNSCIrNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 1907123329 248 VCDQCGYSFTRLNSLLRHK 266
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 369-461 1.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 369 TSSRSLKTherihTGEKPYECK--QCGKTFLWSYSLQRHEKT-HTDGKVHvckqcgETFPYDSHlqvhEKLHFDDEPFNC 445
Cdd:COG5189   337 TPSRMLKV-----KDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLH------ENPSPEKM----NIFSAKDKPYRC 401

                          90
                  ....*....|....*.
gi 1907123329 446 KYCGKPFFTLNHLHRH 461
Cdd:COG5189   402 EVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 215-295 1.67e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123329 215 GVKPYACKL--CGKSFTCSGSLRTHeRIHtgerpyvcDQCGYSFTRLNSLLRHKITHTGEKPYVCNHCGKTFPRSASLQR 292
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1907123329 293 HVK 295
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
93-118 1.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907123329  93 YLQTHERIHTGEKPYVCLQCGKTFAH 118
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
149-174 4.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907123329 149 SLQIHTRIHTGEKPYVCKPCGKAFIT 174
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
261-284 8.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.04e-03
                          10        20
                  ....*....|....*....|....
gi 1907123329 261 SLLRHKITHTGEKPYVCNHCGKTF 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
289-312 9.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.78e-03
                          10        20
                  ....*....|....*....|....
gi 1907123329 289 SLQRHVKIHTEEKPYVCKQCGVAF 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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