RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  19 KIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLL 98
Cdd:cd04393     1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHG-LEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  99 RFFLQELPEPVIPGSLHIHLLQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVF 177
Cdd:cd04393    80 RLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHhENRMTAENLAAVF 159

                         170       180
                  ....*....|....*....|....*...
gi 1907129615 178 GPDVFHIYTDVEDMKEQEIVSRIMAGLL 205
Cdd:cd04393   160 GPDVFHVYTDVEDMKEQEICSRIMAKLL 187

DNA replication and checkpoint protein; Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent re-licensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615 512 LQKKIRQFEEQFERERNSKPSYSDIAANPKVLKWMTELTKLRKQ--IKDAKHKNSdgeFAPQTRPRSNTLPKSFGSSLDH 589
Cdd:pfam11719   4 LKAEIKEWERAFAAKNGRKPSKDDIKKNPEIAKKYKLYSKLKKGesIKTKTPSKP---VKLEARPKKRKHESTNKSPEKN 80

                  ..
gi 1907129615 590 ED 591
Cdd:pfam11719  81 SQ 82

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  19 KIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLL 98
Cdd:cd04393     1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHG-LEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  99 RFFLQELPEPVIPGSLHIHLLQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVF 177
Cdd:cd04393    80 RLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHhENRMTAENLAAVF 159

                         170       180
                  ....*....|....*....|....*...
gi 1907129615 178 GPDVFHIYTDVEDMKEQEIVSRIMAGLL 205
Cdd:cd04393   160 GPDVFHVYTDVEDMKEQEICSRIMAKLL 187

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615   37 EVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLV-KEADVPSAISLLRFFLQELPEPVIPGSLH 115
Cdd:smart00324   2 PIPIIVEKCIEYLEKRG-LDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  116 IHLLQLSQDyNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFH-IYTDVEDMKE 193
Cdd:smart00324  81 EEFIEAAKL-EDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEEnKMTARNLAIVFGPTLLRpPDGEVASLKD 159

                   ....*...
gi 1907129615  194 QEIVSRIM 201
Cdd:smart00324 160 IRHQNTVI 167

DNA replication and checkpoint protein; Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent re-licensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615 512 LQKKIRQFEEQFERERNSKPSYSDIAANPKVLKWMTELTKLRKQ--IKDAKHKNSdgeFAPQTRPRSNTLPKSFGSSLDH 589
Cdd:pfam11719   4 LKAEIKEWERAFAAKNGRKPSKDDIKKNPEIAKKYKLYSKLKKGesIKTKTPSKP---VKLEARPKKRKHESTNKSPEKN 80

                  ..
gi 1907129615 590 ED 591
Cdd:pfam11719  81 SQ 82

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  19 KIFGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLL 98
Cdd:cd04393     1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHG-LEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  99 RFFLQELPEPVIPGSLHIHLLQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHH-EEIWSANSLAAVF 177
Cdd:cd04393    80 RLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHhENRMTAENLAAVF 159

                         170       180
                  ....*....|....*....|....*...
gi 1907129615 178 GPDVFHIYTDVEDMKEQEIVSRIMAGLL 205
Cdd:cd04393   160 GPDVFHVYTDVEDMKEQEICSRIMAKLL 187

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615   37 EVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLV-KEADVPSAISLLRFFLQELPEPVIPGSLH 115
Cdd:smart00324   2 PIPIIVEKCIEYLEKRG-LDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  116 IHLLQLSQDyNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGPDVFH-IYTDVEDMKE 193
Cdd:smart00324  81 EEFIEAAKL-EDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEEnKMTARNLAIVFGPTLLRpPDGEVASLKD 159

                   ....*...
gi 1907129615  194 QEIVSRIM 201
Cdd:smart00324 160 IRHQNTVI 167

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  21 FGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRF 100
Cdd:cd04404     6 FGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHA-LTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615 101 FLQELPEPVIPGSLHIHLLQLSQdyNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGP 179
Cdd:cd04404    85 FLRELPEPLLTFDLYDDIVGFLN--VDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQnKMTNSNLAVVFGP 162

                  .
gi 1907129615 180 D 180
Cdd:cd04404   163 N 163

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  21 FGIPLDELQQggHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDL--VKEADVPSAISLL 98
Cdd:cd04403     1 FGCHLEALCQ--RENSTVPKFVRLCIEAVEKRG-LDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLddSKWEDIHVITGAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  99 RFFLQELPEPVIPGSLHIHLLQLSQDYNNEDEFgRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVF 177
Cdd:cd04403    78 KLFFRELPEPLFPYSLFNDFVAAIKLSDYEQRV-SAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKnRMTTQNLAIVF 156

                  ....*.
gi 1907129615 178 GPDVFH 183
Cdd:cd04403   157 GPTLLR 162

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  21 FGIPLDELQQgghPDNEVPFIVRHVVDYIEEhGGLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLV-KEADVPSAISLLR 99
Cdd:cd04373     1 FGVPLANVVT---SEKPIPIFLEKCVEFIEA-TGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVsKDFTVNAVAGALK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615 100 FFLQELPEPVIPGSLHIHLLQLSQdYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVFG 178
Cdd:cd04373    77 SFFSELPDPLIPYSMHLELVEAAK-INDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKvNLMTSENLSICFW 155

                         170
                  ....*....|....*
gi 1907129615 179 PDVFHIytDVEDMKE 193
Cdd:cd04373   156 PTLMRP--DFTSMEA 168

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  21 FGIPLDELQQGgHPDNEVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSG-EEVDLVKEA--DVPSAISL 97
Cdd:cd04395     2 FGVPLDDCPPS-SENPYVPLIVEVCCNIVEARG-LETVGIYRVPGNNAAISALQEELNRGgFDIDLQDPRwrDVNVVSSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  98 LRFFLQELPEPVIPGSLHIHLLQLSQDYNNEDEFgRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAV 176
Cdd:cd04395    80 LKSFFRKLPEPLFTNELYPDFIEANRIEDPVERL-KELRRLIHSLPDHHYETLKHLIRHLKTVADNSEvNKMEPRNLAIV 158

                         170       180
                  ....*....|....*....|....*..
gi 1907129615 177 FGPDVFHIYTD-----VEDMKEQ-EIV 197
Cdd:cd04395   159 FGPTLVRTSDDnmetmVTHMPDQcKIV 185

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  20 IFGIPLDE-LQQGGHPDN--EVPFIVRHVVDYIEEHGGLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEA---DVPS 93
Cdd:cd04400     1 IFGSPLEEaVELSSHKYNgrDLPSVVYRCIEYLDKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSlypDVHT 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  94 AISLLRFFLQELPEPVIPGSLHIHLLQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASH 163
Cdd:cd04400    81 VAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEH 150

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  20 IFGIPLDELQQGGHPDNE-VPFIVRHVVDYIEEHGGLEqqGLFQVNGNAETVEWLRQRYDSGEEVDlvkEADVPSAIS-L 97
Cdd:cd04394     1 VFGVPLHSLPHSTVPEYGnVPKFLVDACTFLLDHLSTE--GLFRKSGSVVRQKELKAKLEGGEACL---SSALPCDVAgL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  98 LRFFLQELPEPVIPGSLHIHLLQlSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASH-HEEIWSANSLAAV 176
Cdd:cd04394    76 LKQFFRELPEPLLPYDLHEALLK-AQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRcSENKMDSSNLAVI 154

                         170
                  ....*....|....*
gi 1907129615 177 FGPDVFHIYTDVEDM 191
Cdd:cd04394   155 FAPNLFQSEEGGEKM 169

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  37 EVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHI 116
Cdd:cd04376     8 QVPRLVESCCQHLEKHG-LQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYT 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907129615 117 HLLQlSQDYNNEDEFGrKLRFLLQQLPPVNYSLLKFLCRFLANVASHHEEI------------WSANSLAAVFGPDVFH 183
Cdd:cd04376    87 AFIG-TALLEPDEQLE-ALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSidedgqevsgnkMTSLNLATIFGPNLLH 163

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  38 VPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISLLRFFLQELPEPVIPGSLHIH 117
Cdd:cd04382    17 IPALIVHCVNEIEARG-LTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615 118 LLQLSQDYNNEDefGRK-LRFLLQQLPPVNYSLLKFLCRFLANVASHHEEIWSANSLAAVFGPDVF-HIYTDVEDMKE-Q 194
Cdd:cd04382    96 FMEAAEILDEDN--SRAaLYQAISELPQPNRDTLAFLILHLQRVAQSPECKMDINNLARVFGPTIVgYSVPNPDPMTIlQ 173

                         170
                  ....*....|...
gi 1907129615 195 EIVS--RIMAGLL 205
Cdd:cd04382   174 DTVRqpRVVERLL 186

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  21 FGIPLDEL---QQGGHPDNEVPFIVRHVVDYIEEHGGLEQQGLFQVNGNAETVEWLRQRYDSGeEVDLVKEADVPSAISL 97
Cdd:cd04389     1 FGSSLEEImdrQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQW-DYPLSGLEDPHVPASL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  98 LRFFLQELPEPVIPGSLHIHLLQLSQDYNNEDEfgrklrfLLQQLPPVNYSLLKFLCRFL------ANVAshHEEIWSAN 171
Cdd:cd04389    80 LKLWLRELEEPLIPDALYQQCISASEDPDKAVE-------IVQKLPIINRLVLCYLINFLqvfaqpENVA--HTKMDVSN 150

                  ....*...
gi 1907129615 172 sLAAVFGP 179
Cdd:cd04389   151 -LAMVFAP 157

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  21 FGIPLDELQQGGHPdneVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSG-EEVDLvKEADVPSAISLLR 99
Cdd:cd04377     1 FGVSLSSLTSEDRS---VPLVLEKLLEHIEMHG-LYTEGIYRKSGSANKIKELRQGLDTDpDSVNL-EDYPIHVITSVLK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615 100 FFLQELPEPVIPGSLHIHLLQLSQDYNNEDEFgRKLRFLLQQLPPVNYSLLKFLCRFLANVAShHEEI--WSANSLAAVF 177
Cdd:cd04377    76 QWLRELPEPLMTFELYENFLRAMELEEKQERV-RALYSVLEQLPRANLNTLERLIFHLVRVAL-QEEVnrMSANALAIVF 153

                         170       180
                  ....*....|....*....|...
gi 1907129615 178 GP------DVFHIYTDVEDMKEQ 194
Cdd:cd04377   154 APcilrcpDTADPLQSLQDVSKT 176

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  38 VPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSG--EEVDLVKEADVPSAISLLRFFLQELPEPVIPGSlh 115
Cdd:cd04387    16 VPYIVRQCVEEVERRG-MEEVGIYRISGVATDIQALKAAFDTNnkDVSVMLSEMDVNAIAGTLKLYFRELPEPLFTDE-- 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907129615 116 iHLLQLSQDYNNEDEFGRK--LRFLLQQLPPVNYSLLKFLCRFLANVASHHEE-IWSANSLAAVFGP 179
Cdd:cd04387    93 -LYPNFAEGIALSDPVAKEscMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVnKMSLHNLATVFGP 158

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  21 FGIPLDELQQGGHPDNEVPFIVRHVVDYIEEHgGLEQQGLFQVNGNAETVEWLRQRYDSGEE-VDLVKEA--DVPSAISL 97
Cdd:cd04379     1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERR-GLDVIGLYRLCGSAAKKKELRDAFERNSAaVELSEELypDINVITGV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  98 LRFFLQELPEPVIPGSLHIHLLQ-LSQDYNNEDEFGRKL-RFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLA 174
Cdd:cd04379    80 LKDYLRELPEPLITPQLYEMVLEaLAVALPNDVQTNTHLtLSIIDCLPLSAKATLLLLLDHLSLVLSNSErNKMTPQNLA 159

                  ....*...
gi 1907129615 175 AVFGPDVF 182
Cdd:cd04379   160 VCFGPVLM 167

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  19 KIFGIPLDELQQGGHPD-NEVPF-IVR---HVVDYIEEHGgLEQQGLFQVNGN--------AETVEWLrqryDSGEEVDL 85
Cdd:cd04380    26 PGIRNLIDQLELGDNPDySEVPLsIPKeiwRLVDYLYTRG-LAQEGLFEEPGLpsepgellAEIRDAL----DTGSPFNS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  86 VKEADVPSAISLLrfFLQELPEPVIPGSLHIHLLQlSQDYNNEDefgrKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE 165
Cdd:cd04380   101 PGSAESVAEALLL--FLESLPDPIIPYSLYERLLE-AVANNEED----KRQVIRISLPPVHRNVFVYLCSFLRELLSESA 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907129615 166 EI-WSANSLAAVFGPDVFHIYTDV---EDMKEQEIVSRIMAGLL 205
Cdd:cd04380   174 DRgLDENTLATIFGRVLLRDPPRAggkERRAERDRKRAFIEQFL 217

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  19 KIFGIPLD-ELQQGGHPdneVPFIVRHVVDYIEEHGgLEQQGLFQVNGNAETVEWLRQRYDSGEEVDLVKEADVPSAISL 97
Cdd:cd04375     3 NVFGVPLLvNLQRTGQP---LPRSIQQAMRWLRNNA-LDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129615  98 LRFFLQELPEPVIPGSLHIHLLQLSQdYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASH-HEEIWSANSLAAV 176
Cdd:cd04375    79 LKQYFRDLPEPLLTNKLSETFIAIFQ-YVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANsQENQMTATNLAVC 157

                  ....*..
gi 1907129615 177 FGPDVFH 183
Cdd:cd04375   158 LAPSLFH 164