cyclin-Y isoform X3 [Mus musculus]
Protein Classification
cyclin family protein( domain architecture ID 1750054)
cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_SF super family | cl40454 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
166-193 | 3.35e-09 | ||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. The actual alignment was detected with superfamily member cd20540: Pssm-ID: 477360 Cd Length: 97 Bit Score: 52.23 E-value: 3.35e-09
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| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_CCNY_like | cd20540 | cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and ... |
166-193 | 3.35e-09 | ||
cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and CCNY-like protein 1 (CCNYL1). They can enhance Wnt/beta-catenin signaling in mitosis. CCNY, also called Cyc-Y, cyclin box protein 1 (CBCP1), cyclin fold protein 1 (CFP1), or cyclin-X (CCNX), is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. It is a positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. It acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410243 Cd Length: 97 Bit Score: 52.23 E-value: 3.35e-09
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| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_CCNY_like | cd20540 | cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and ... |
166-193 | 3.35e-09 | ||
cyclin box found in cyclin-Y (CCNY) family; The CCNY family includes two cyclins, CCNY and CCNY-like protein 1 (CCNYL1). They can enhance Wnt/beta-catenin signaling in mitosis. CCNY, also called Cyc-Y, cyclin box protein 1 (CBCP1), cyclin fold protein 1 (CFP1), or cyclin-X (CCNX), is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. It is a positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. It acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Members of this family contain one cyclin box. The cyclin box is a protein binding domain. Pssm-ID: 410243 Cd Length: 97 Bit Score: 52.23 E-value: 3.35e-09
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