NCBI Conserved Domain Search

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

564-599

3.51e-14

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 67.27 E-value: 3.51e-14

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907138659  564 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDRKTC 599
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

59-101

1.71e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 62.62 E-value: 1.71e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659    59 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 101
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

257-294

1.76e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 62.65 E-value: 1.76e-12

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907138659  257 CAVENGGCSHLCLrsPNPSGFSCTCPTGINLLRDGKTC 294
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

430-470

1.11e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

Pssm-ID: 459654 Cd Length: 42 Bit Score: 60.25 E-value: 1.11e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907138659  430 GFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVD 470
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

734-775

1.45e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 59.87 E-value: 1.45e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  734 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 775
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

758-798

1.73e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.92 E-value: 1.73e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659   758 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 798
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

146-188

1.78e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.92 E-value: 1.78e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659   146 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 188
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

122-163

4.16e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 58.71 E-value: 4.16e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  122 GYMYWTDWGASPKIERAGMDASSRQVIISSNLTWPNGLAIDY 163
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL super family

cl18310

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

336-528

5.83e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain] Cd Length: 269 Bit Score: 64.65 E-value: 5.83e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  336 AIGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 410
Cdd:cd05819     59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  411 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRTVLINNNLGWPNGLTVDktSSQLLW-AD 480
Cdd:cd05819    137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907138659  481 AHTERIEVADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 528
Cdd:cd05819    214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

671-711

1.87e-09

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 54.14 E-value: 1.87e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659   671 ETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGS 711
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Vgb super family

cl26743

Streptogramin lyase [Defense mechanisms];

610-834

3.39e-09

Streptogramin lyase [Defense mechanisms];

The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.26 E-value: 3.39e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  610 SSRGSIRRisLDTDDHTDVHVPVPGLNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-GLAVDw 688
Cdd:COG4257     35 QGGGRIGR--LDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSNPhGIAFD- 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  689 VARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFWTDWG--HIAKIERAnlDGSERKVLINT 763
Cdd:COG4257    111 PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWVTDFGanAIGRIDPD--TGTLTEYALPT 185

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907138659  764 DLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFALT-QQDRWIYWTDWQTKSIQRVD 834
Cdd:COG4257    186 PGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYGVAvDGDGRVWFAESGANRIVRFD 258

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

1-233

1.43e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 57.01 E-value: 1.43e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659    1 MDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNK 80
Cdd:COG3391      2 LVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   81 LYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASSRQVIISSNL-TWPNGL 159
Cdd:COG3391     82 LYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHGI 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  160 AIDYGSQRLYWADAGMKTI-----EFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQT-KSIQSADRLTGLDRETL 233
Cdd:COG3391    158 AVDPDGKRLYVANSGSNTVsvivsVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLATL 237

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

868-899

1.10e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 48.78 E-value: 1.10e-07

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907138659  868 CGVNNGGCTHLCFARASDFVCACPD----EPDGHPC 899
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36

Name

Accession

Description

Interval

E-value

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

564-599

3.51e-14

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 67.27 E-value: 3.51e-14

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907138659  564 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDRKTC 599
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

59-101

1.71e-12

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 62.62 E-value: 1.71e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659    59 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 101
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

257-294

1.76e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 62.65 E-value: 1.76e-12

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907138659  257 CAVENGGCSHLCLrsPNPSGFSCTCPTGINLLRDGKTC 294
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

430-470

1.11e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 60.25 E-value: 1.11e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907138659  430 GFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVD 470
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

734-775

1.45e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 59.87 E-value: 1.45e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  734 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 775
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

758-798

1.73e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.92 E-value: 1.73e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659   758 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 798
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

146-188

1.78e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.92 E-value: 1.78e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659   146 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 188
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

122-163

4.16e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 58.71 E-value: 4.16e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  122 GYMYWTDWGASPKIERAGMDASSRQVIISSNLTWPNGLAIDY 163
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

336-528

5.83e-11

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 64.65 E-value: 5.83e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  336 AIGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 410
Cdd:cd05819     59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  411 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRTVLINNNLGWPNGLTVDktSSQLLW-AD 480
Cdd:cd05819    137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907138659  481 AHTERIEVADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 528
Cdd:cd05819    214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

714-757

1.19e-09

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 54.53 E-value: 1.19e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907138659   714 KVLINNSLDEPRAIAVFPRKGYLFWTDWGHiAKIERANLDGSER 757
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

369-409

1.75e-09

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 54.14 E-value: 1.75e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659   369 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMR 409
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

671-711

1.87e-09

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 54.14 E-value: 1.87e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659   671 ETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGS 711
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

610-834

3.39e-09

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.26 E-value: 3.39e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  610 SSRGSIRRisLDTDDHTDVHVPVPGLNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-GLAVDw 688
Cdd:COG4257     35 QGGGRIGR--LDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSNPhGIAFD- 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  689 VARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFWTDWG--HIAKIERAnlDGSERKVLINT 763
Cdd:COG4257    111 PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWVTDFGanAIGRIDPD--TGTLTEYALPT 185

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907138659  764 DLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFALT-QQDRWIYWTDWQTKSIQRVD 834
Cdd:COG4257    186 PGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYGVAvDGDGRVWFAESGANRIVRFD 258

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

7-174

5.00e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 58.17 E-value: 5.00e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659    7 SFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISraKWD-GTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 85
Cdd:COG3391     51 GGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS--VIDlATGKVVATIPVGGGPRGLAVDPDGGRLYVAD 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   86 AGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIER--AGMDASSRQVI--ISSNLTwPNGLAI 161
Cdd:COG3391    129 SGNGRVSVIDTA-TGKVVATIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSVIDTATGKVVatIPVGGG-PVGVAV 205

                          170
                   ....*....|...
gi 1907138659  162 DYGSQRLYWADAG 174
Cdd:COG3391    206 SPDGRRLYVANRG 218

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

1-233

1.43e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 57.01 E-value: 1.43e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659    1 MDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNK 80
Cdd:COG3391      2 LVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   81 LYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASSRQVIISSNL-TWPNGL 159
Cdd:COG3391     82 LYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHGI 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  160 AIDYGSQRLYWADAGMKTI-----EFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQT-KSIQSADRLTGLDRETL 233
Cdd:COG3391    158 AVDPDGKRLYVANSGSNTVsvivsVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLATL 237

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

868-899

1.10e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 48.78 E-value: 1.10e-07

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907138659  868 CGVNNGGCTHLCFARASDFVCACPD----EPDGHPC 899
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

635-833

2.98e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 53.09 E-value: 2.98e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  635 LNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-----GLAVDwVARNLYWTDTGRNTIEASRLD 709
Cdd:cd05819     54 FNEPAGVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVD-SSGNIYVADTGNHRIQKFDPD 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  710 GSCRKVL-----INNSLDEPRAIAVFPrKGYLFWTDWGHiAKIERANLDGSERKVL-----INTDLGWPNGLTLDYDTrR 779
Cdd:cd05819    132 GEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN-HRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDG-N 208

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907138659  780 IYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQ-------QDRWIYWTDWQTKSIQRV 833
Cdd:cd05819    209 IYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRpsglavdSDGNLYVADTGNNRIQVF 269

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

79-119

7.06e-07

Pssm-ID: 459654 Cd Length: 42 Bit Score: 46.77 E-value: 7.06e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659   79 NKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEP 119
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

387-427

1.36e-06

Pssm-ID: 459654 Cd Length: 42 Bit Score: 46.00 E-value: 1.36e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  387 RKVYWTDTGT-NRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 427
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

691-731

1.64e-06

Pssm-ID: 459654 Cd Length: 42 Bit Score: 45.61 E-value: 1.64e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  691 RNLYWTDTG-RNTIEASRLDGSCRKVLINNSLDEPRAIAVFP 731
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

103-145

1.78e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.67 E-value: 1.78e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659   103 VLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIERAGMDASSR 145
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

282-485

4.77e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 49.31 E-value: 4.77e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  282 PTGINLLRDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVDPLEGK-VYWSDSTLHRISRAS 360
Cdd:COG3391     17 ALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVID 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  361 LDGSQHEDIITTGlQTTDGLAVDAIGRKVYWTDTGTNRIEVgnLDGSMRKVL-VWQNLDSPRAIVLYHEMGFMYWTDWGE 439
Cdd:COG3391     97 LATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGS 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1907138659  440 N--AKLErSGMDGSDRTVLINNNLG-WPNGLTVDKTSSQLLWADAHTER 485
Cdd:COG3391    174 NtvSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT 221

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

630-669

1.70e-05

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 42.97 E-value: 1.70e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907138659   630 VPVPGLNNVISLDYDSVHGKVYYTDVFLDVIRRADLNGSN 669
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

17-57

1.86e-05

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 42.97 E-value: 1.86e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659    17 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 57
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

25-220

3.94e-05

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 46.54 E-value: 3.94e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   25 SAVALDwdsRDDHVYWTDV--------STDTISRAKWDGTGQEvvvDTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANT 96
Cdd:cd05819     58 AGVAVD---SDGNLYVADTgnhriqkfDPDGNFLASFGGSGDG---DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDP 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   97 DGSMRTVL-----IWENLDRPRDIVVEPmGGYMYWTDWGASpKIERagMDASSRQV-------IISSNLTWPNGLAIDyG 164
Cdd:cd05819    131 DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGNH-RIQV--FDPDGNFLttfgstgTGPGQFNYPTGIAVD-S 205

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907138659  165 SQRLYWADAGMK-----TIEFAGLDGSKRKVLIGSQLPHPFGLTL--YGqRIYWTDWQTKSIQ 220
Cdd:cd05819    206 DGNIYVADSGNNrvqvfDPDGAGFGGNGNFLGSDGQFNRPSGLAVdsDG-NLYVADTGNNRIQ 267

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

36-76

4.02e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 41.76 E-value: 4.02e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659   36 DHVYWTDVSTD-TISRAKWDGTGQEVVVDTSLESPAGLAIDW 76
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

166-205

1.00e-04

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.61 E-value: 1.00e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907138659  166 QRLYWADAGMK-TIEFAGLDGSKRKVLIGSQLPHPFGLTLY 205
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

410-453

1.07e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 40.66 E-value: 1.07e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907138659   410 KVLVWQNLDSPRAIVLYHEMGFMYWTDWGeNAKLERSGMDGSDR 453
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

648-688

2.96e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.37 E-value: 2.96e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  648 GKVYYTDVFLD-VIRRADLNGSNMETVIGHGLKTTDGLAVDW 688
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

778-814

7.94e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.21 E-value: 7.94e-03

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907138659  778 RRIYWVDAHLD-RIESADLNGKLRQVLVSH-VSHPFALT 814
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDdLQHPNAIA 39

Name

Accession

Description

Interval

E-value

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

564-599

3.51e-14

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 67.27 E-value: 3.51e-14

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907138659  564 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDRKTC 599
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

59-101

1.71e-12

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 62.62 E-value: 1.71e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659    59 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 101
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

257-294

1.76e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 62.65 E-value: 1.76e-12

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907138659  257 CAVENGGCSHLCLrsPNPSGFSCTCPTGINLLRDGKTC 294
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

430-470

1.11e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 60.25 E-value: 1.11e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907138659  430 GFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVD 470
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

734-775

1.45e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 59.87 E-value: 1.45e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  734 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 775
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

758-798

1.73e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.92 E-value: 1.73e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659   758 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 798
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

146-188

1.78e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.92 E-value: 1.78e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659   146 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 188
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

122-163

4.16e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 58.71 E-value: 4.16e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  122 GYMYWTDWGASPKIERAGMDASSRQVIISSNLTWPNGLAIDY 163
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

336-528

5.83e-11

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 64.65 E-value: 5.83e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  336 AIGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 410
Cdd:cd05819     59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  411 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRTVLINNNLGWPNGLTVDktSSQLLW-AD 480
Cdd:cd05819    137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907138659  481 AHTERIEVADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 528
Cdd:cd05819    214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

714-757

1.19e-09

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 54.53 E-value: 1.19e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907138659   714 KVLINNSLDEPRAIAVFPRKGYLFWTDWGHiAKIERANLDGSER 757
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

369-409

1.75e-09

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 54.14 E-value: 1.75e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659   369 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMR 409
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

671-711

1.87e-09

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 54.14 E-value: 1.87e-09

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659   671 ETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGS 711
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

610-834

3.39e-09

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 59.26 E-value: 3.39e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  610 SSRGSIRRisLDTDDHTDVHVPVPGLNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-GLAVDw 688
Cdd:COG4257     35 QGGGRIGR--LDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSNPhGIAFD- 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  689 VARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFWTDWG--HIAKIERAnlDGSERKVLINT 763
Cdd:COG4257    111 PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWVTDFGanAIGRIDPD--TGTLTEYALPT 185

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907138659  764 DLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFALT-QQDRWIYWTDWQTKSIQRVD 834
Cdd:COG4257    186 PGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYGVAvDGDGRVWFAESGANRIVRFD 258

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

7-174

5.00e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 58.17 E-value: 5.00e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659    7 SFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISraKWD-GTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 85
Cdd:COG3391     51 GGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS--VIDlATGKVVATIPVGGGPRGLAVDPDGGRLYVAD 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   86 AGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIER--AGMDASSRQVI--ISSNLTwPNGLAI 161
Cdd:COG3391    129 SGNGRVSVIDTA-TGKVVATIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSVIDTATGKVVatIPVGGG-PVGVAV 205

                          170
                   ....*....|...
gi 1907138659  162 DYGSQRLYWADAG 174
Cdd:COG3391    206 SPDGRRLYVANRG 218

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

1-233

1.43e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 57.01 E-value: 1.43e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659    1 MDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNK 80
Cdd:COG3391      2 LVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   81 LYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASSRQVIISSNL-TWPNGL 159
Cdd:COG3391     82 LYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHGI 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  160 AIDYGSQRLYWADAGMKTI-----EFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQT-KSIQSADRLTGLDRETL 233
Cdd:COG3391    158 AVDPDGKRLYVANSGSNTVsvivsVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLATL 237

YvrE

COG3386

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

31-178

2.54e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 56.44 E-value: 2.54e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   31 WDsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSlESPAGLAID-----WVTN---KLYWTDAGTDRIEVANTDGSMRt 102
Cdd:COG3386     15 WD-PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADhgrGLVRFDPADGEVTVLADEYGKP- 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  103 vliwenLDRPRDIVVEPMGGYmYWTDwgaSPKIERAG----MDASSRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTI 178
Cdd:COG3386     92 ------LNRPNDGVVDPDGRL-YFTD---MGEYLPTGalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

455-496

2.76e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 50.68 E-value: 2.76e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1907138659   455 VLINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANR 496
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

868-899

1.10e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 48.78 E-value: 1.10e-07

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907138659  868 CGVNNGGCTHLCFARASDFVCACPD----EPDGHPC 899
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

635-833

2.98e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 53.09 E-value: 2.98e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  635 LNNVISLDYDSvHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTD-----GLAVDwVARNLYWTDTGRNTIEASRLD 709
Cdd:cd05819     54 FNEPAGVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVD-SSGNIYVADTGNHRIQKFDPD 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  710 GSCRKVL-----INNSLDEPRAIAVFPrKGYLFWTDWGHiAKIERANLDGSERKVL-----INTDLGWPNGLTLDYDTrR 779
Cdd:cd05819    132 GEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN-HRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDG-N 208

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907138659  780 IYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQ-------QDRWIYWTDWQTKSIQRV 833
Cdd:cd05819    209 IYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRpsglavdSDGNLYVADTGNNRIQVF 269

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

79-119

7.06e-07

Pssm-ID: 459654 Cd Length: 42 Bit Score: 46.77 E-value: 7.06e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659   79 NKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEP 119
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_like_5

cd14963

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

338-493

1.15e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 51.52 E-value: 1.15e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  338 GVDPLEGKVYWSDSTLHRISRASLDGSQ-----HEDIITTGLQTTDGLAVDAiGRKVYWTDTGTNRIEVGNLDGSMRKVL 412
Cdd:cd14963     14 GVAVSDGRIYVADTNNHRVQVFDYEGKFkksfgGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYF 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  413 VWQ----NLDSPRAIVLYHemGFMYWTDWGENA--------KLERS-GMDGSDRtvlinNNLGWPNGLTVDKtSSQLLWA 479
Cdd:cd14963     93 PEKkdrvKLISPAGLAIDD--GKLYVSDVKKHKvivfdlegKLLLEfGKPGSEP-----GELSYPNGIAVDE-DGNIYVA 164

                          170
                   ....*....|....
gi 1907138659  480 DAHTERIEVADLNG 493
Cdd:cd14963    165 DSGNGRIQVFDKNG 178

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

387-427

1.36e-06

Pssm-ID: 459654 Cd Length: 42 Bit Score: 46.00 E-value: 1.36e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  387 RKVYWTDTGT-NRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 427
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

691-731

1.64e-06

Pssm-ID: 459654 Cd Length: 42 Bit Score: 45.61 E-value: 1.64e-06

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  691 RNLYWTDTG-RNTIEASRLDGSCRKVLINNSLDEPRAIAVFP 731
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

103-145

1.78e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.67 E-value: 1.78e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659   103 VLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIERAGMDASSR 145
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

336-366

2.32e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.29 E-value: 2.32e-06

                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907138659   336 AIGVDPLEGKVYWSDSTLHRISRASLDGSQH 366
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

330-406

3.42e-06

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 49.89 E-value: 3.42e-06

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907138659  330 TMKNTIAIGVDPlEGKVYWSDSTLHRISRASLDGsQHEDIITTGLQTTD--GLAVDAIGRKVYWTDTGTNRIEVGNLDG 406
Cdd:cd14962     55 RFVSPIGVAIDA-NGNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVKVFDLDG 131

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

282-485

4.77e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 49.31 E-value: 4.77e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  282 PTGINLLRDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVDPLEGK-VYWSDSTLHRISRAS 360
Cdd:COG3391     17 ALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVID 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  361 LDGSQHEDIITTGlQTTDGLAVDAIGRKVYWTDTGTNRIEVgnLDGSMRKVL-VWQNLDSPRAIVLYHEMGFMYWTDWGE 439
Cdd:COG3391     97 LATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGS 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1907138659  440 N--AKLErSGMDGSDRTVLINNNLG-WPNGLTVDKTSSQLLWADAHTER 485
Cdd:COG3391    174 NtvSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT 221

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

630-669

1.70e-05

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 42.97 E-value: 1.70e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907138659   630 VPVPGLNNVISLDYDSVHGKVYYTDVFLDVIRRADLNGSN 669
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

17-57

1.86e-05

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 42.97 E-value: 1.86e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1907138659    17 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 57
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

25-220

3.94e-05

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 46.54 E-value: 3.94e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   25 SAVALDwdsRDDHVYWTDV--------STDTISRAKWDGTGQEvvvDTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANT 96
Cdd:cd05819     58 AGVAVD---SDGNLYVADTgnhriqkfDPDGNFLASFGGSGDG---DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDP 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   97 DGSMRTVL-----IWENLDRPRDIVVEPmGGYMYWTDWGASpKIERagMDASSRQV-------IISSNLTWPNGLAIDyG 164
Cdd:cd05819    131 DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGNH-RIQV--FDPDGNFLttfgstgTGPGQFNYPTGIAVD-S 205

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907138659  165 SQRLYWADAGMK-----TIEFAGLDGSKRKVLIGSQLPHPFGLTL--YGqRIYWTDWQTKSIQ 220
Cdd:cd05819    206 DGNIYVADSGNNrvqvfDPDGAGFGGNGNFLGSDGQFNRPSGLAVdsDG-NLYVADTGNNRIQ 267

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

36-76

4.02e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 41.76 E-value: 4.02e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659   36 DHVYWTDVSTD-TISRAKWDGTGQEVVVDTSLESPAGLAIDW 76
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_like_3

cd14956

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

26-173

4.86e-05

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 46.51 E-value: 4.86e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   26 AVALDwdsRDDHVYWTDVSTDTIS--------RAKWDGTGQEvvvDTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 97
Cdd:cd14956     17 GIAVD---ADDNVYVADARNGRIQvfdkdgtfLRRFGTTGDG---PGQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLT 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   98 GSMRTvlIWEN-------LDRPRDIVVEPMGGYmYWTDWGaSPKIERAGMDASsrqvIISS---------NLTWPNGLAI 161
Cdd:cd14956     90 GELQT--IGGSsgsgpgqFNAPRGVAVDADGNL-YVADFG-NQRIQKFDPDGS----FLRQwggtgiepgSFNYPRGVAV 161

                          170
                   ....*....|..
gi 1907138659  162 DyGSQRLYWADA 173
Cdd:cd14956    162 D-PDGTLYVADT 172

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

337-534

5.65e-05

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 46.16 E-value: 5.65e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  337 IGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGsmRKV 411
Cdd:cd05819     13 IAVDS-SGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQfnepaGVAVDSDGN-LYVADTGNHRIQKFDPDG--NFL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  412 LVW-------QNLDSPRAIVLyHEMGFMYWTDWGeNAKLERSGMDGSDRTVLINNNLGW-----PNGLTVDktSSQLLW- 478
Cdd:cd05819     89 ASFggsgdgdGEFNGPRGIAV-DSSGNIYVADTG-NHRIQKFDPDGEFLTTFGSGGSGPgqfngPTGVAVD--SDGNIYv 164

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907138659  479 ADAHTERIEVADLNGA------NRHTLVSPVQHPYGLTlLDS--YIYWTDWQTRSIHRADKSTG 534
Cdd:cd05819    165 ADTGNHRIQVFDPDGNflttfgSTGTGPGQFNYPTGIA-VDSdgNIYVADSGNNRVQVFDPDGA 227

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

189-230

5.81e-05

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 41.43 E-value: 5.81e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907138659   189 KVLIGSQLPHPFGLTL--YGQRIYWTDWQTKSIQSADrLTGLDR 230
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN-LDGTNR 43

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

25-220

9.33e-05

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 45.39 E-value: 9.33e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   25 SAVALDwdsRDDHVYWTDVSTDTISraKWDGTGQEVVV-------DTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 97
Cdd:cd05819     11 QGIAVD---SSGNIYVADTGNNRIQ--VFDPDGNFITSfgsfgsgDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPD 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   98 GSMRTVLI-----WENLDRPRDIVVEPMgGYMYWTDWGAspkieragmdasSRQVIISSN----LTW------------P 156
Cdd:cd05819     85 GNFLASFGgsgdgDGEFNGPRGIAVDSS-GNIYVADTGN------------HRIQKFDPDgeflTTFgsggsgpgqfngP 151

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907138659  157 NGLAIDyGSQRLYWADAGMKTI-------EFAGLDGSkrKVLIGSQLPHPFGLTLYGQ-RIYWTDWQTKSIQ 220
Cdd:cd05819    152 TGVAVD-SDGNIYVADTGNHRIqvfdpdgNFLTTFGS--TGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ 220

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

166-205

1.00e-04

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.61 E-value: 1.00e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907138659  166 QRLYWADAGMK-TIEFAGLDGSKRKVLIGSQLPHPFGLTLY 205
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

625-834

1.03e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 45.07 E-value: 1.03e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  625 HTDVHVPVPGLNNVISLDYDSVHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVDWVA-----RNLYWTDTG 699
Cdd:COG3391      9 VAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADagadgRRLYVANSG 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  700 RNTIeaSRLDGSCRKVLINNSL-DEPRAIAVFPRKGYLFWTDW--GHIAKIeranlDGSERKVLINTDLG-WPNGLTLDY 775
Cdd:COG3391     89 SGRV--SVIDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSgnGRVSVI-----DTATGKVVATIPVGaGPHGIAVDP 161

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907138659  776 DTRRIYWVDAHLDR-------IESADLNgKLRQVLVSHVSHPFALTQQDRWIY-------WTDWQTKSIQRVD 834
Cdd:COG3391    162 DGKRLYVANSGSNTvsvivsvIDTATGK-VVATIPVGGGPVGVAVSPDGRRLYvanrgsnTSNGGSNTVSVID 233

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

410-453

1.07e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 40.66 E-value: 1.07e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907138659   410 KVLVWQNLDSPRAIVLYHEMGFMYWTDWGeNAKLERSGMDGSDR 453
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

NHL_like_5

cd14963

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

282-526

1.27e-04

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.97 E-value: 1.27e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  282 PTGINLLRDGKtcspgmnsflIFA-----RRIDVrmVSLD---IPYFADVVVPINMTMknTIAIGVDplEGKVYWSDSTL 353
Cdd:cd14963     58 PYGIAVDSDGN----------IYVadlynGRIQV--FDPDgkfLKYFPEKKDRVKLIS--PAGLAID--DGKLYVSDVKK 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  354 HRISRASLDGSQHEDIITTG-----LQTTDGLAVDAIGRkVYWTDTGTNRIEVGNLDGSmrkvlvwqnldspraivlyhe 428
Cdd:cd14963    122 HKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVDEDGN-IYVADSGNGRIQVFDKNGK--------------------- 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  429 mgFMYWtdwgenaklersgMDGSDrtvLINNNLGWPNGLTVDKTsSQLLWADAHTERIEVADLNGANRHTLVSPVQ---- 504
Cdd:cd14963    180 --FIKE-------------LNGSP---DGKSGFVNPRGIAVDPD-GNLYVVDNLSHRVYVFDEQGKELFTFGGRGKddgq 240

                          250       260
                   ....*....|....*....|....*
gi 1907138659  505 --HPYGLTLLDS-YIYWTDWQTRSI 526
Cdd:cd14963    241 fnLPNGLFIDDDgRLYVTDRENNRV 265

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

17-174

1.36e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 44.89 E-value: 1.36e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   17 VIPLADVRSAVALDWDSRDDhVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNkLYWTDAGTDRIEVANT 96
Cdd:cd14952      3 VLPFTGLDGPGGVAVDAAGN-VYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAAGT-VYVTDFGNNRVLKLAA 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907138659   97 DGSMRTVLIWENLDRPRDIVVEPmGGYMYWTDWGASPKIERAGmdASSRQVIIS-SNLTWPNGLAIDyGSQRLYWADAG 174
Cdd:cd14952     81 GSTTQTVLPFTGLNDPTGVAVDA-AGNVYVADTGNNRVLKLAA--GSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDTG 155

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

344-383

1.46e-04

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.22 E-value: 1.46e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  344 GKVYWSDSTLH-RISRASLDGSqHEDIITTG-LQTTDGLAVD 383
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGS-DRKTLFTDdLQHPNAIAVD 41

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

207-247

2.08e-04

Pssm-ID: 459654 Cd Length: 42 Bit Score: 39.84 E-value: 2.08e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  207 QRIYWTDWQTKSIQSADRLTGLDRETL-QENLENLMDIHVFH 247
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLfTDDLQHPNAIAVDP 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

344-496

2.18e-04

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 44.12 E-value: 2.18e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  344 GKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAiGRKVYWTDTGTNRieVGNLDG--SMRKVLVWQNLDSPR 421
Cdd:cd14952     63 GTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTGVAVDA-AGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPD 139

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907138659  422 AIVLyHEMGFMYWTDWGENAKLERSGmDGSDRTVLINNNLGWPNGLTVDKTSSqllwadahterIEVADLNGaNR 496
Cdd:cd14952    140 GVAV-DGAGNVYVTDTGNNRVLKLAA-GSTTQTVLPFTGLNSPSGVAVDTAGN-----------VYVTDHGN-NR 200

SGL

pfam08450

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...

31-172

2.38e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.

Pssm-ID: 462480 [Multi-domain] Cd Length: 246 Bit Score: 44.18 E-value: 2.38e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659   31 WDSRDDHVYWTDVSTDTISRAkWDGTGQEVVVDTSleSPAGLAIDWVTNKLYWTDAgtDRIEVANTDGSMRTVLIWENLD 110
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRL-DPATGKETVWDTP--GPVGAIAPRDDGGLIVALK--DGVALLDLATGELTPLADPEDD 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907138659  111 -----RPRDIVVEPMGGYmywtdWGASPKIERAGM---------DASSRQVIISSNLTWPNGLAIDYGSQRLYWAD 172
Cdd:pfam08450   82 dwplnRFNDGKVDPDGRF-----WFGTMGDDEAPGgdpgalyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFAD 152

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

683-799

4.98e-04

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 43.34 E-value: 4.98e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  683 GLAVDWVARnLYWTDTGRNTIeaSRLDGSCRKV-LINNSLDE----PRAIAVFPrKGYLFWTDWGHiAKIERANLDGSER 757
Cdd:cd14962     16 GVAADGRGR-IYVADTGRGAV--FVFDLPNGKVfVIGNAGPNrfvsPIGVAIDA-NGNLYVSDAEL-GKVFVFDRDGKFL 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1907138659  758 KVlINTDLGW--PNGLTLDYDTRRIYWVDAHLDRIESADLNGKL 799
Cdd:cd14962     91 RA-IGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL 133

NHL_like_3

cd14956

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

331-494

1.12e-03

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 42.27 E-value: 1.12e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  331 MKNTIAIGVDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTG-----LQTTDGLAVDAIGRkVYWTDTGTNRIEVGNLD 405
Cdd:cd14956     12 FKDPRGIAVDA-DDNVYVADARNGRIQVFDKDGTFLRRFGTTGdgpgqFGRPRGLAVDKDGW-LYVADYWGDRIQVFTLT 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  406 GSmrkvlvWQNL-----------DSPRAIVLYHEmGFMYWTDWGeNAKLERSGMDGSdrTVLINNNLG-------WPNGL 467
Cdd:cd14956     90 GE------LQTIggssgsgpgqfNAPRGVAVDAD-GNLYVADFG-NQRIQKFDPDGS--FLRQWGGTGiepgsfnYPRGV 159

                          170       180
                   ....*....|....*....|....*...
gi 1907138659  468 TVDktSSQLLW-ADAHTERIEVADLNGA 494
Cdd:cd14956    160 AVD--PDGTLYvADTYNDRIQVFDNDGA 185

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

320-399

1.18e-03

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.81 E-value: 1.18e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  320 FADVVVPInmtmkntiAIGVDPlEGKVYWSDSTLHRISRasLDGSQHEDIIT--TGLQTTDGLAVDAIGrKVYWTDTGTN 397
Cdd:cd14952    174 FTGLNSPS--------GVAVDT-AGNVYVTDHGNNRVLK--LAAGSTTPTVLpfTGLNGPLGVAVDAAG-NVYVADRGND 241


                   ..
gi 1907138659  398 RI 399
Cdd:cd14952    242 RV 243

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

496-537

1.25e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 37.58 E-value: 1.25e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1907138659   496 RHTLVSPVQHPYGLTL--LDSYIYWTDWQTRSIHRADKsTGSNV 537
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVANL-DGTNR 43

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

339-472

1.27e-03

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.81 E-value: 1.27e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  339 VDPlEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIGrKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLD 418
Cdd:cd14952    101 VDA-AGNVYVADTGNNRVLKLAAGSNTQTVLPFTGLSNPDGVAVDGAG-NVYVTDTGNNRVLKLAAGSTTQTVLPFTGLN 178

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907138659  419 SPRAIVLYHEmGFMYWTDWGENAKLE-RSGMDGSdrTVLINNNLGWPNGLTVDKT 472
Cdd:cd14952    179 SPSGVAVDTA-GNVYVTDHGNNRVLKlAAGSTTP--TVLPFTGLNGPLGVAVDAA 230

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

800-840

1.39e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 37.58 E-value: 1.39e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1907138659   800 RQVLVSHVSHP--FALTQQDRWIYWTDWQTKSIQRVDkYSGRN 840
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42

YvrE

COG3386

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

648-834

2.64e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.03 E-value: 2.64e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  648 GKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTdGLAVDWvARNLYWTDTGRNTIEASRLDGSCRKVLinNSLDEPRAI 727
Cdd:COG3386     19 GRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPN-GLAFDP-DGRLLVADHGRGLVRFDPADGEVTVLA--DEYGKPLNR 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  728 ---AVFPRKGYLFWTD---WGHIAKIERANLDGSERKVLinTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADL--NGKL 799
Cdd:COG3386     95 pndGVVDPDGRLYFTDmgeYLPTGALYRVDPDGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLdaDGTL 172

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  800 --RQVLVSHVSHP-----FALTQQDRwIYWTDWQTKSIQRVD 834
Cdd:COG3386    173 gnRRVFADLPDGPggpdgLAVDADGN-LWVALWGGGGVVRFD 213

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

648-688

2.96e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.37 E-value: 2.96e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907138659  648 GKVYYTDVFLD-VIRRADLNGSNMETVIGHGLKTTDGLAVDW 688
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

639-810

3.75e-03

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 40.65 E-value: 3.75e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  639 ISLDYDSvHGKVYYTDVFLDVIRRADLNGsNMETVIGHGLKTTD--GLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 716
Cdd:cd14962     60 IGVAIDA-NGNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDI 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907138659  717 -----INNSLDEPRAIAVfPRKGYLFWTDWGHiAKIERANLDGSERKVL--INTDLGW---PNGLTLDYDTRrIYWVDAH 786
Cdd:cd14962    138 gkrgsGPGEFNLPTDLAV-DRDGNLYVTDTMN-FRVQIFDADGKFLRSFgeRGDGPGSfarPKGIAVDSEGN-IYVVDAA 214

                          170       180
                   ....*....|....*....|....
gi 1907138659  787 LDRIESADLNGKLRQVLVSHVSHP 810
Cdd:cd14962    215 FDNVQIFNPEGELLLTVGGPGSGP 238

Ldl_recept_b