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Conserved domains on  [gi|1907131823|ref|XP_036017341|]
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interferon-induced protein with tetratricopeptide repeats 3 isoform X3 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12138577)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
104-345 1.52e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 104 TWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMEcpeleceeGWTRLKCGRNERAKMCFEKALEEKPKDPECSSG 183
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL--------GLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 184 MAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKG 263
Cdd:COG0457    82 LGLALQALGRYEE---ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 264 NLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSDL 343
Cdd:COG0457   159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAAL 238


                  ..
gi 1907131823 344 ID 345
Cdd:COG0457   239 AL 240
TPR_12 pfam13424
Tetratricopeptide repeat;
59-134 1.89e-04

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 1.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131823  59 ATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHNDQSEiRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQK 134
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHP-LTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
104-345 1.52e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 104 TWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMEcpeleceeGWTRLKCGRNERAKMCFEKALEEKPKDPECSSG 183
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL--------GLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 184 MAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKG 263
Cdd:COG0457    82 LGLALQALGRYEE---ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 264 NLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSDL 343
Cdd:COG0457   159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAAL 238


                  ..
gi 1907131823 344 ID 345
Cdd:COG0457   239 AL 240
TPR_12 pfam13424
Tetratricopeptide repeat;
59-134 1.89e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 1.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131823  59 ATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHNDQSEiRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQK 134
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHP-LTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 64-308 3.30e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  64 LLAYIKHLDGESKAALECLGQAEDLRKSehNDQSEIRRlvtwgnyAWIYYHMGRLSEAQAYVDKVRQvcqKFANPysmec 143
Cdd:TIGR02917 198 LKGDLLLSLGNIELALAAYRKAIALRPN--NIAVLLAL-------ATILIEAGEFEEAEKHADALLK---KAPNS----- 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 144 PELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLE--EKPEKQFSvDALKQAmelnPQNQYLKVLL 221
Cdd:TIGR02917 261 PLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGnlEQAYQYLN-QILKYA----PNSHQARRLL 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 222 ALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYS------LVMCRYRE 295
Cdd:TIGR02917 336 ASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTqlgiskLSQGDPSE 415

                         250
                  ....*....|...
gi 1907131823 296 ILEQLQNKGDADS 308
Cdd:TIGR02917 416 AIADLETAAQLDP 428
TPR_12 pfam13424
Tetratricopeptide repeat;
101-172 2.68e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.60  E-value: 2.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907131823 101 RLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMECPELECEEGWTRLKCGRNERAKMCFEKALE 172
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
104-345 1.52e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 1.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 104 TWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMEcpeleceeGWTRLKCGRNERAKMCFEKALEEKPKDPECSSG 183
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL--------GLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 184 MAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKG 263
Cdd:COG0457    82 LGLALQALGRYEE---ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 264 NLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQLQNKGDADSSERRQRMAELRRLTMEFMQKTLQRRRSPLNSYSDL 343
Cdd:COG0457   159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAAL 238


                  ..
gi 1907131823 344 ID 345
Cdd:COG0457   239 AL 240
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 145-294 1.40e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.09  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 145 ELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALK 224
Cdd:COG3914    79 ALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE---ALAALRRALALNPDFAEAYLNLGEA 155

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907131823 225 LLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYS-LVMCRYR 294
Cdd:COG3914   156 LRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSnLLFALRQ 226
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 162-300 8.93e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.55  E-value: 8.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 162 RAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKDA 241
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDE---ALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907131823 242 LGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYSLvmcryREILEQL 300
Cdd:COG4235    78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLL-----EASIAEA 131
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 142-277 2.51e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 142 ECPELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLL 221
Cdd:COG4783     2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDE---AIVLLHEALELDPDEPEARLNL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131823 222 ALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALR 277
Cdd:COG4783    79 GLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 155-306 3.45e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 3.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 155 LKCGRNERAKMCFEKALEEKPKDPECSSGMAiAMFRLEEKPEKqfSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEG 234
Cdd:COG2956    19 LLNGQPDKAIDLLEEALELDPETVEAHLALG-NLYRRRGEYDR--AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRA 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907131823 235 ERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYslvmCRYREILEQLQNKGDA 306
Cdd:COG2956    96 EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAY----CELAELYLEQGDYDEA 163
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 158-313 4.66e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.96  E-value: 4.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 158 GRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERL 237
Cdd:COG2956   124 GDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE---AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAA 200

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131823 238 IKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYSLVmcryrEILEQLQNKGDADSSERRQ 313
Cdd:COG2956   201 LERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALA-----DLLERKEGLEAALALLERQ 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 55-277 1.13e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  55 SEEKATMYDLLAYIKHLDGESKAALECLgqaEDLRKSEHNDQSEIRRLVTwgnyawIYYHMGRLSEAQAYVDKVRQVCQK 134
Cdd:COG2956    72 DPDRAEALLELAQDYLKAGLLDRAEELL---EKLLELDPDDAEALRLLAE------IYEQEGDWEKAIEVLERLLKLGPE 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 135 FANPYsmecpeleCEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQN 214
Cdd:COG2956   143 NAHAY--------CELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEE---AIAALERALEQDPDY 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907131823 215 QYLKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQkAAQFYKKKGNLDRAIELLGKALR 277
Cdd:COG2956   212 LPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLA-LADLLERKEGLEAALALLERQLR 273
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
59-277 1.61e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  59 ATMYDLLAYIKHLDGESKAALECLGQAEDLrksehndqsEIRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANP 138
Cdd:COG0457    42 AEALYNLGLAYLRLGRYEEALADYEQALEL---------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 139 YsmecpeleCEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQAMELNPQNQYLK 218
Cdd:COG0457   113 L--------YNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALG 184

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907131823 219 VLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALR 277
Cdd:COG0457   185 EAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQY 243
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 108-248 4.32e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 4.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 108 YAWIYYHMGRLSEAQAYVDKVRQvcqkfANPYSmecPELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIA 187
Cdd:COG4783    10 LAQALLLAGDYDEAEALLEKALE-----LDPDN---PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907131823 188 MFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKDALGKAPNQ 248
Cdd:COG4783    82 LLKAGDYDE---ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 152-246 1.02e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 152 WTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALKLLRMGEE 231
Cdd:COG5010    62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDE---AKEYYEKALALSPDNPNAYSNLAALLLSLGQD 138

                          90
                  ....*....|....*
gi 1907131823 232 AEGERLIKDALGKAP 246
Cdd:COG5010   139 DEAKAALQRALGTSP 153
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 77-212 8.63e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 8.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  77 AALECLGQAEDLRKSEHNDQSEIRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSmecpelecEEGWTRLK 156
Cdd:COG5010    29 AALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYY--------NLALLYSR 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131823 157 CGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNP 212
Cdd:COG5010   101 SGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE---AKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
158-247 1.12e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.92  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 158 GRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfsVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERL 237
Cdd:COG3063     6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDE----AIALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                          90
                  ....*....|
gi 1907131823 238 IKDALGKAPN 247
Cdd:COG3063    82 LERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 200-278 1.34e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.25  E-value: 1.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907131823 200 SVDALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRS 278
Cdd:COG5010    73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
TPR_12 pfam13424
Tetratricopeptide repeat;
59-134 1.89e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 39.68  E-value: 1.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131823  59 ATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHNDQSEiRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQK 134
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHP-LTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 64-308 3.30e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  64 LLAYIKHLDGESKAALECLGQAEDLRKSehNDQSEIRRlvtwgnyAWIYYHMGRLSEAQAYVDKVRQvcqKFANPysmec 143
Cdd:TIGR02917 198 LKGDLLLSLGNIELALAAYRKAIALRPN--NIAVLLAL-------ATILIEAGEFEEAEKHADALLK---KAPNS----- 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 144 PELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLE--EKPEKQFSvDALKQAmelnPQNQYLKVLL 221
Cdd:TIGR02917 261 PLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGnlEQAYQYLN-QILKYA----PNSHQARRLL 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 222 ALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYS------LVMCRYRE 295
Cdd:TIGR02917 336 ASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTqlgiskLSQGDPSE 415

                         250
                  ....*....|...
gi 1907131823 296 ILEQLQNKGDADS 308
Cdd:TIGR02917 416 AIADLETAAQLDP 428
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 62-206 9.72e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.52  E-value: 9.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  62 YDLLAYIKHLDGESKAALECLGQAEDLrkseHNDQSEIrrlvtWGNYAWIYYHMGRLSEAQAYVDKVRQVcqkfaNPysm 141
Cdd:COG3914   115 LFNLGNLLLALGRLEEALAALRRALAL----NPDFAEA-----YLNLGEALRRLGRLEEAIAALRRALEL-----DP--- 177

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907131823 142 ECPELECEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQ 206
Cdd:COG3914   178 DNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAA 242
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
149-277 1.16e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.28  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 149 EEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEkqfSVDALKQAMELNPQNQYLKVLLALKLLRM 228
Cdd:COG4785    78 ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDA---ALEDFDRALELDPDYAYAYLNRGIALYYL 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907131823 229 GEEAEGERLIKDALGKAPN-----------QTDVLQKAAQF---------YKKKGNLDRAIELLGKALR 277
Cdd:COG4785   155 GRYELAIADLEKALELDPNdperalwlylaERKLDPEKALAllledwataYLLQGDTEEARELFKLALA 223
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
202-277 1.89e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 1.89e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131823 202 DALKQAMELNPQNQYLKVLLALKLLRMGEEAEGERLIKdALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALR 277
Cdd:COG3063    13 EYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEK-ALKLDPNNAEALLNLAELLLELGDYDEALAYLERALE 87
TPR_12 pfam13424
Tetratricopeptide repeat;
101-172 2.68e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.60  E-value: 2.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907131823 101 RLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSMECPELECEEGWTRLKCGRNERAKMCFEKALE 172
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
TPR_19 pfam14559
Tetratricopeptide repeat;
229-289 2.80e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.02  E-value: 2.80e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907131823 229 GEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYSLV 289
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALL 62
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 151-284 4.46e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 151 GWTRLKCGRNERAKMCFEKALEEKPKDPecSSGMAIAMFRLEE-KPEKQFSvdALKQAMELNPQNQYLKVLLALKLLRMG 229
Cdd:TIGR02917 370 GEAYLALGDFEKAAEYLAKATELDPENA--AARTQLGISKLSQgDPSEAIA--DLETAAQLDPELGRADLLLILSYLRSG 445

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907131823 230 EEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSP 284
Cdd:TIGR02917 446 QFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFP 500
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
59-245 4.56e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.45  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  59 ATMYDLLAYIKHLDGESKAALECLGQAEDLRKSEHNdqseirrlvTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANP 138
Cdd:COG0457    76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAE---------ALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 139 YsmecpeleCEEGWTRLKCGRNERAKMCFEKALEEKPKDPECSSGMAIAMFRLEEKPEKQFSVDALKQAMELNPQNQYLK 218
Cdd:COG0457   147 L--------YNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAA 218

                         170       180
                  ....*....|....*....|....*..
gi 1907131823 219 VLLALKLLRMGEEAEGERLIKDALGKA 245
Cdd:COG0457   219 LAELLLLALALLLALRLAALALYQYRA 245
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 63-313 5.58e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  63 DLLAYIKHLD-GESKAALEClgqAEDLRKSEHNDQSeirrlvTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFAnPYSM 141
Cdd:TIGR02917 434 DLLLILSYLRsGQFDKALAA---AKKLEKKQPDNAS------LHNLLGAIYLGKGDLAKAREAFEKALSIEPDFF-PAAA 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 142 ECPELEceegwtrLKCGRNERAKMCFEKALEEKPKDPEcssgmAI-AMFRLEEK---PEKqfSVDALKQAMELNPQNQYL 217
Cdd:TIGR02917 504 NLARID-------IQEGNPDDAIQRFEKVLTIDPKNLR-----AIlALAGLYLRtgnEEE--AVAWLEKAAELNPQEIEP 569

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823 218 KVLLALKLLRMGEEAEGERLIKDALGKAPNQTDVLQKAAQFYKKKGNLDRAIELLGKALRSTVNNSPLYSLVMCRY---- 293
Cdd:TIGR02917 570 ALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYavmk 649

                         250       260
                  ....*....|....*....|....*.
gi 1907131823 294 ------REILEQLQNKGDADSSERRQ 313
Cdd:TIGR02917 650 nyakaiTSLKRALELKPDNTEAQIGL 675
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 62-177 6.47e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 36.71  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131823  62 YDLLAYIKHLDGESKAALECLGQAEDLRKSEHNdqseirrlvTWGNYAWIYYHMGRLSEAQAYVDKVRQvcqkfANPysm 141
Cdd:COG4783    41 FALLGEILLQLGDLDEAIVLLHEALELDPDEPE---------ARLNLGLALLKAGDYDEALALLEKALK-----LDP--- 103

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907131823 142 ECPELECEEGWTRLKCGRNERAKMCFEKALEEKPKD 177
Cdd:COG4783   104 EHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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