|
Name |
Accession |
Description |
Interval |
E-value |
| P_proprotein |
pfam01483 |
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein ... |
68-158 |
7.50e-39 |
|
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain.
:
Pssm-ID: 460225 [Multi-domain] Cd Length: 86 Bit Score: 139.33 E-value: 7.50e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 68 LEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTpsqlrNFKT 147
Cdd:pfam01483 1 LEHVQVSVNITHTRRGDLRITLTSPSGTRSVLLNRRGGDTSSAGFLDWTFMSVHHWGERAEGTWTLEVTDT-----APGD 75
|
90
....*....|.
gi 1907131883 148 PGKLKEWSLVL 158
Cdd:pfam01483 76 TGTLNSWQLTL 86
|
|
| GF_recep_IV super family |
cl37890 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
198-307 |
3.30e-08 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
The actual alignment was detected with superfamily member pfam14843:
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 53.53 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 198 PCDPECSEVGCDGPGPDHCSDCLHYyyklkNNTRICVSSCPPGHY----HADKKRCRKCAPNCE------SCFGSHGNQC 267
Cdd:pfam14843 1 VCDPLCSSEGCWGPGPDQCLSCRNF-----SRGGTCVESCNILQGepreYVVNSTCVPCHPECLpqngtaTCSGPGADNC 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1907131883 268 LSCKYgyflNEETSSCVTQCPDGSYEDI--------KKNVCGKCSENC 307
Cdd:pfam14843 76 TKCAH----FRDGPHCVSSCPSGVLGENdliwkyadANGVCQPCHPNC 119
|
|
| GF_recep_IV super family |
cl37890 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
458-556 |
7.31e-07 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
The actual alignment was detected with superfamily member pfam14843:
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 49.68 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 458 CWGPTQEDCISCpvTRVLDDGRCVMNCPSWKFEFK-----KQCHPCHYTCQG------CQGSGPSNCTSCRADKHGQE-- 524
Cdd:pfam14843 11 CWGPGPDQCLSC--RNFSRGGTCVESCNILQGEPReyvvnSTCVPCHPECLPqngtatCSGPGADNCTKCAHFRDGPHcv 88
|
90 100 110
....*....|....*....|....*....|..
gi 1907131883 525 RFLYHGECLENCPVGHYPAKGHACLPCPDNCE 556
Cdd:pfam14843 89 SSCPSGVLGENDLIWKYADANGVCQPCHPNCT 120
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1107-1154 |
1.12e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
:
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 46.74 E-value: 1.12e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1907131883 1107 CHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCE 1154
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
342-386 |
1.59e-06 |
|
Furin-like repeats;
:
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 46.35 E-value: 1.59e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 342 GHDCQPCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYY 386
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
1052-1096 |
2.19e-06 |
|
Furin-like repeats;
:
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 45.96 E-value: 2.19e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 1052 SHRCQPCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYH 1096
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
958-1007 |
3.42e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
:
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 45.20 E-value: 3.42e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1907131883 958 PCHKNCLECNGPKEDDCKVCADTSKaLHNGLCLDECPEGTYKEEENDECR 1007
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFY-LDGGTCVSECPEGTYADTEGGVCL 49
|
|
| VSP super family |
cl31427 |
Giardia variant-specific surface protein; |
305-624 |
1.26e-05 |
|
Giardia variant-specific surface protein;
The actual alignment was detected with superfamily member pfam03302:
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 49.20 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 305 ENCKACI--GFHNCTECKGGLSL-QGSRCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCinctegyvmEEGRCVQSC 381
Cdd:pfam03302 26 ENCKACSndKREVCEECNSNNYLtPTSQCIDDCAKIGNYYYTTNANNKKICKECTVANCKTC---------EDQGQCQAC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 382 SVSYYLDHsseggyKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGT--------------CQMGAICKDGEYIDDQGH 447
Cdd:pfam03302 97 NDGFYKSG------DACSPCHESCKTCSGGTASDCTECLTGKALRYGNdgtkgtcgegcttgTGAGACKTCGLTIDGTSY 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 448 CQTCEAS--------CAKCWGPTQEDCISCPVTrvldDGRCvMNCPSWKFEFKKQCHpchytcQGCQGSGPSNCTSCRAD 519
Cdd:pfam03302 171 CSECATEteypqngvCTSTAARATATCKASSVA----NGMC-SSCANGYFRMNGGCY------ETTKFPGKSVCEEANSG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 520 KHGQErflyhgeclencPVGHYPAKGHACLPCPDNCELCYNPHVCSRCMSGYViiPPNHTCQKlecrqgefqdseyeecm 599
Cdd:pfam03302 240 GTCQK------------EAPGYKLNNGDLVTCSPGCKTCTSNTVCTTCMDGYV--KTSDSCTK----------------- 288
|
330 340
....*....|....*....|....*
gi 1907131883 600 pCEEGCLGCTeDDPGACTSCATGYY 624
Cdd:pfam03302 289 -CDSSCETCT-GATTTCKTCATGYY 311
|
|
| FU |
smart00261 |
Furin-like repeats; |
1203-1245 |
3.53e-05 |
|
Furin-like repeats;
:
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 42.50 E-value: 3.53e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907131883 1203 TCERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEY 1245
Cdd:smart00261 3 ECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1155-1205 |
6.03e-05 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
:
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 41.74 E-value: 6.03e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1907131883 1155 KCDKSCKSCRGPRPTDCQSCDTFFFLLrsKGQCHRACPEHYYADQHAQTCE 1205
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLD--GGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
772-817 |
1.09e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
:
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 40.97 E-value: 1.09e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1907131883 772 PCHSSCKTCNGSL---CASCPTGMYLWLQACVPSCPQGTWPSVTSGSCE 817
Cdd:cd00064 1 PCHPSCATCTGPGpdqCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
|
|
| VSP super family |
cl31427 |
Giardia variant-specific surface protein; |
603-885 |
3.30e-04 |
|
Giardia variant-specific surface protein;
The actual alignment was detected with superfamily member pfam03302:
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 44.96 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 603 EGCLGCTEDDPGACTSCATGYYMFE-RHCYKACPEKTFGVKWECRACGTNCGSCDQHECYWCEEGfflsggSCVQDCGPG 681
Cdd:pfam03302 26 ENCKACSNDKREVCEECNSNNYLTPtSQCIDDCAKIGNYYYTTNANNKKICKECTVANCKTCEDQ------GQCQACNDG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 682 FHGDQElgECKPCHRACENCTGSGYNQCSSCQEGLQLWHGT----------CLWSTWP--------QVEGKDWNEAVPTE 743
Cdd:pfam03302 100 FYKSGD--ACSPCHESCKTCSGGTASDCTECLTGKALRYGNdgtkgtcgegCTTGTGAgacktcglTIDGTSYCSECATE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 744 KPSLVRSLLQDRRKWKVQIKRDATSQNQPChSSCKTCNGSLCASC-PTGMYLWLQACVPSCPQGTWPS------VTSGSC 816
Cdd:pfam03302 178 TEYPQNGVCTSTAARATATCKASSVANGMC-SSCANGYFRMNGGCyETTKFPGKSVCEEANSGGTCQKeapgykLNNGDL 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907131883 817 EKCSEDCVSCSGADLCQQCLsqpdntlllhegrcyhscpEGFYAKDGVCEHCSSPCKTCEGNATSCNSC 885
Cdd:pfam03302 257 VTCSPGCKTCTSNTVCTTCM-------------------DGYVKTSDSCTKCDSSCETCTGATTTCKTC 306
|
|
| FU |
smart00261 |
Furin-like repeats; |
1255-1297 |
1.96e-03 |
|
Furin-like repeats;
:
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 37.49 E-value: 1.96e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907131883 1255 CKKCHESCMECKGPGSKNCTGCSAGLLLdmDDNRCLHCCNASH 1297
Cdd:smart00261 4 CKPCHPECATCTGPGPDDCTSCKHGFFL--DGGKCVSECPPGT 44
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| P_proprotein |
pfam01483 |
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein ... |
68-158 |
7.50e-39 |
|
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain.
Pssm-ID: 460225 [Multi-domain] Cd Length: 86 Bit Score: 139.33 E-value: 7.50e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 68 LEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTpsqlrNFKT 147
Cdd:pfam01483 1 LEHVQVSVNITHTRRGDLRITLTSPSGTRSVLLNRRGGDTSSAGFLDWTFMSVHHWGERAEGTWTLEVTDT-----APGD 75
|
90
....*....|.
gi 1907131883 148 PGKLKEWSLVL 158
Cdd:pfam01483 76 TGTLNSWQLTL 86
|
|
| COG4935 |
COG4935 |
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
69-160 |
4.50e-18 |
|
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 90.27 E-value: 4.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 69 EHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLfdHSMEGFkNWEFMTIHCWGERAAGDWVLEVYDTPSQlrnfkTP 148
Cdd:COG4935 558 EDVTVTVDITHTYRGDLVITLISPDGTTVVLKNRSG--GSADNI-NATFDVANFSGESANGTWTLRVVDTAGG-----DT 629
|
90
....*....|..
gi 1907131883 149 GKLKEWSLVLYG 160
Cdd:COG4935 630 GTLNSWSLTFTG 641
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
198-307 |
3.30e-08 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 53.53 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 198 PCDPECSEVGCDGPGPDHCSDCLHYyyklkNNTRICVSSCPPGHY----HADKKRCRKCAPNCE------SCFGSHGNQC 267
Cdd:pfam14843 1 VCDPLCSSEGCWGPGPDQCLSCRNF-----SRGGTCVESCNILQGepreYVVNSTCVPCHPECLpqngtaTCSGPGADNC 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1907131883 268 LSCKYgyflNEETSSCVTQCPDGSYEDI--------KKNVCGKCSENC 307
Cdd:pfam14843 76 TKCAH----FRDGPHCVSSCPSGVLGENdliwkyadANGVCQPCHPNC 119
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
458-556 |
7.31e-07 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 49.68 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 458 CWGPTQEDCISCpvTRVLDDGRCVMNCPSWKFEFK-----KQCHPCHYTCQG------CQGSGPSNCTSCRADKHGQE-- 524
Cdd:pfam14843 11 CWGPGPDQCLSC--RNFSRGGTCVESCNILQGEPReyvvnSTCVPCHPECLPqngtatCSGPGADNCTKCAHFRDGPHcv 88
|
90 100 110
....*....|....*....|....*....|..
gi 1907131883 525 RFLYHGECLENCPVGHYPAKGHACLPCPDNCE 556
Cdd:pfam14843 89 SSCPSGVLGENDLIWKYADANGVCQPCHPNCT 120
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1107-1154 |
1.12e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 46.74 E-value: 1.12e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1907131883 1107 CHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCE 1154
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
342-386 |
1.59e-06 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 46.35 E-value: 1.59e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 342 GHDCQPCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYY 386
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
1052-1096 |
2.19e-06 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 45.96 E-value: 2.19e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 1052 SHRCQPCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYH 1096
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
958-1007 |
3.42e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 45.20 E-value: 3.42e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1907131883 958 PCHKNCLECNGPKEDDCKVCADTSKaLHNGLCLDECPEGTYKEEENDECR 1007
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFY-LDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1057-1105 |
3.56e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 45.20 E-value: 3.56e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1907131883 1057 PCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYHTDKDSQQCV 1105
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
1101-1145 |
4.54e-06 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 44.81 E-value: 4.54e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 1101 SQQCVLCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYY 1145
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
347-388 |
9.88e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 44.05 E-value: 9.88e-06
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1907131883 347 PCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYYLD 388
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYAD 42
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
251-300 |
1.07e-05 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 44.05 E-value: 1.07e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1907131883 251 KCAPNCESCFGSHGNQCLSCKYGYFLNEETssCVTQCPDGSYEDIKKNVC 300
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGT--CVSECPEGTYADTEGGVC 48
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
305-624 |
1.26e-05 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 49.20 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 305 ENCKACI--GFHNCTECKGGLSL-QGSRCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCinctegyvmEEGRCVQSC 381
Cdd:pfam03302 26 ENCKACSndKREVCEECNSNNYLtPTSQCIDDCAKIGNYYYTTNANNKKICKECTVANCKTC---------EDQGQCQAC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 382 SVSYYLDHsseggyKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGT--------------CQMGAICKDGEYIDDQGH 447
Cdd:pfam03302 97 NDGFYKSG------DACSPCHESCKTCSGGTASDCTECLTGKALRYGNdgtkgtcgegcttgTGAGACKTCGLTIDGTSY 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 448 CQTCEAS--------CAKCWGPTQEDCISCPVTrvldDGRCvMNCPSWKFEFKKQCHpchytcQGCQGSGPSNCTSCRAD 519
Cdd:pfam03302 171 CSECATEteypqngvCTSTAARATATCKASSVA----NGMC-SSCANGYFRMNGGCY------ETTKFPGKSVCEEANSG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 520 KHGQErflyhgeclencPVGHYPAKGHACLPCPDNCELCYNPHVCSRCMSGYViiPPNHTCQKlecrqgefqdseyeecm 599
Cdd:pfam03302 240 GTCQK------------EAPGYKLNNGDLVTCSPGCKTCTSNTVCTTCMDGYV--KTSDSCTK----------------- 288
|
330 340
....*....|....*....|....*
gi 1907131883 600 pCEEGCLGCTeDDPGACTSCATGYY 624
Cdd:pfam03302 289 -CDSSCETCT-GATTTCKTCATGYY 311
|
|
| FU |
smart00261 |
Furin-like repeats; |
1203-1245 |
3.53e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 42.50 E-value: 3.53e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907131883 1203 TCERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEY 1245
Cdd:smart00261 3 ECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
446-489 |
4.84e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 42.11 E-value: 4.84e-05
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1907131883 446 GHCQTCEASCAKCWGPTQEDCISCPVTRVLDDGRCVMNCPSWKF 489
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1155-1205 |
6.03e-05 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 41.74 E-value: 6.03e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1907131883 1155 KCDKSCKSCRGPRPTDCQSCDTFFFLLrsKGQCHRACPEHYYADQHAQTCE 1205
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLD--GGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
954-998 |
7.03e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 41.34 E-value: 7.03e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 954 RQCVPCHKNCLECNGPKEDDCKVCADTSKaLHNGLCLDECPEGTY 998
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFF-LDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
597-639 |
7.38e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 41.34 E-value: 7.38e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907131883 597 ECMPCEEGCLGCTEDDPGACTSCATGYYMFERHCYKACPEKTF 639
Cdd:smart00261 3 ECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
246-292 |
1.05e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 40.96 E-value: 1.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907131883 246 KKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETssCVTQCPDGSY 292
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGK--CVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
772-817 |
1.09e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 40.97 E-value: 1.09e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1907131883 772 PCHSSCKTCNGSL---CASCPTGMYLWLQACVPSCPQGTWPSVTSGSCE 817
Cdd:cd00064 1 PCHPSCATCTGPGpdqCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
1150-1196 |
1.61e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 40.57 E-value: 1.61e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907131883 1150 SGRCEKCDKSCKSCRGPRPTDCQSCDTFFFLLrsKGQCHRACPEHYY 1196
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLD--GGKCVSECPPGTY 45
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
603-885 |
3.30e-04 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 44.96 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 603 EGCLGCTEDDPGACTSCATGYYMFE-RHCYKACPEKTFGVKWECRACGTNCGSCDQHECYWCEEGfflsggSCVQDCGPG 681
Cdd:pfam03302 26 ENCKACSNDKREVCEECNSNNYLTPtSQCIDDCAKIGNYYYTTNANNKKICKECTVANCKTCEDQ------GQCQACNDG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 682 FHGDQElgECKPCHRACENCTGSGYNQCSSCQEGLQLWHGT----------CLWSTWP--------QVEGKDWNEAVPTE 743
Cdd:pfam03302 100 FYKSGD--ACSPCHESCKTCSGGTASDCTECLTGKALRYGNdgtkgtcgegCTTGTGAgacktcglTIDGTSYCSECATE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 744 KPSLVRSLLQDRRKWKVQIKRDATSQNQPChSSCKTCNGSLCASC-PTGMYLWLQACVPSCPQGTWPS------VTSGSC 816
Cdd:pfam03302 178 TEYPQNGVCTSTAARATATCKASSVANGMC-SSCANGYFRMNGGCyETTKFPGKSVCEEANSGGTCQKeapgykLNNGDL 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907131883 817 EKCSEDCVSCSGADLCQQCLsqpdntlllhegrcyhscpEGFYAKDGVCEHCSSPCKTCEGNATSCNSC 885
Cdd:pfam03302 257 VTCSPGCKTCTSNTVCTTCM-------------------DGYVKTSDSCTKCDSSCETCTGATTTCKTC 306
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
273-567 |
4.39e-04 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 44.91 E-value: 4.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 273 GYFLNEETSSCVTQCPDGSYEDiKKNVCGKCSENC---------KACIGFHN--CTECKGGLSLQGSRCSVTCEDGQFFN 341
Cdd:PTZ00214 350 GYLCGDATNGGVSGCATCGYNS-GAVTCTRCSAGYlgvdgkscsESCSGDTRgvCTKVAEGSESTEVSCRCVCKPTFYNS 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 342 GHDCQPCHRFCATCSGAGADGCINCTEGYVM-------EEGRCVQSCSVSyylDHSSE-----GGYKSCKRC-DNSCLTC 408
Cdd:PTZ00214 429 SGTCTPCTDSCAVCKDGTPTGCQQCSPGKILefsivssESADCVDQCSVG---SECAEcgitiDGSRYCTRCkDASTYPF 505
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 409 NGPGFKNcsscpsgylldlgtCQMGAICKDGEyiddQGHCQTCEASCAKCWGP--TQEDCISCPVTRVLDDGRCVMNCPS 486
Cdd:PTZ00214 506 NGVCIPN--------------TQRDAYCTSTA----NGACTTCSGAAFLMNGGcyTTEHYPGSTICDKQSNGKCTTTKKG 567
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 487 WKFEFKKQCHPCHYTCQGCQGSGPSNCTSCRADK-HGQERFLYHGECLE-NCPVGHYPAKGHACLPCPD-NCELCYNPHV 563
Cdd:PTZ00214 568 YGISPDGKLLECDPTCLACTAPGPGRCTRCPSDKlLKRASGAATGSCVDpGACVDGYYADGDACLPCATpGCKTCGHASF 647
|
....
gi 1907131883 564 CSRC 567
Cdd:PTZ00214 648 CTEC 651
|
|
| Nar1 |
COG4624 |
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
248-383 |
5.32e-04 |
|
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 44.25 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 248 RCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETSSCVTQCPDGSYEDIKKNVCGKCSENCKACIGFHNCTECKGGLSLQG 327
Cdd:COG4624 2 LLLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDK 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907131883 328 SRCSVTCEDGqffNGHDCQPCHRFCATCSGAGADG--------CINCtegyvmeeGRCVQSCSV 383
Cdd:COG4624 82 RGPSIIRDKE---KCKNCYPCVRACPVKAIKVDDGkaeideekCISC--------GQCVAVCPF 134
|
|
| FU |
smart00261 |
Furin-like repeats; |
689-726 |
5.71e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 39.03 E-value: 5.71e-04
10 20 30
....*....|....*....|....*....|....*...
gi 1907131883 689 GECKPCHRACENCTGSGYNQCSSCQEGLQLWHGTCLWS 726
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSE 39
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
497-542 |
5.90e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 39.04 E-value: 5.90e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1907131883 497 PCHYTCQGCQGSGPSNCTSCRADKHgqerfLYHGECLENCPVGHYP 542
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFY-----LDGGTCVSECPEGTYA 41
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
600-640 |
8.67e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 38.65 E-value: 8.67e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1907131883 600 PCEEGCLGCTEDDPGACTSCATGYYMFERHCYKACPEKTFG 640
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYA 41
|
|
| FU |
smart00261 |
Furin-like repeats; |
767-808 |
9.16e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 38.26 E-value: 9.16e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 767 TSQNQPCHSSCKTCNGSL---CASCPTGMYLWLQACVPSCPQGTW 808
Cdd:smart00261 1 DGECKPCHPECATCTGPGpddCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1207-1250 |
1.10e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 38.27 E-value: 1.10e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1907131883 1207 CHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEYREGKG 1250
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEG 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
1255-1297 |
1.96e-03 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 37.49 E-value: 1.96e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907131883 1255 CKKCHESCMECKGPGSKNCTGCSAGLLLdmDDNRCLHCCNASH 1297
Cdd:smart00261 4 CKPCHPECATCTGPGPDDCTSCKHGFFL--DGGKCVSECPPGT 44
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
693-724 |
5.69e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 36.34 E-value: 5.69e-03
10 20 30
....*....|....*....|....*....|..
gi 1907131883 693 PCHRACENCTGSGYNQCSSCQEGLQLWHGTCL 724
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCV 32
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| P_proprotein |
pfam01483 |
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein ... |
68-158 |
7.50e-39 |
|
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain.
Pssm-ID: 460225 [Multi-domain] Cd Length: 86 Bit Score: 139.33 E-value: 7.50e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 68 LEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTpsqlrNFKT 147
Cdd:pfam01483 1 LEHVQVSVNITHTRRGDLRITLTSPSGTRSVLLNRRGGDTSSAGFLDWTFMSVHHWGERAEGTWTLEVTDT-----APGD 75
|
90
....*....|.
gi 1907131883 148 PGKLKEWSLVL 158
Cdd:pfam01483 76 TGTLNSWQLTL 86
|
|
| COG4935 |
COG4935 |
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
69-160 |
4.50e-18 |
|
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 90.27 E-value: 4.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 69 EHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLfdHSMEGFkNWEFMTIHCWGERAAGDWVLEVYDTPSQlrnfkTP 148
Cdd:COG4935 558 EDVTVTVDITHTYRGDLVITLISPDGTTVVLKNRSG--GSADNI-NATFDVANFSGESANGTWTLRVVDTAGG-----DT 629
|
90
....*....|..
gi 1907131883 149 GKLKEWSLVLYG 160
Cdd:COG4935 630 GTLNSWSLTFTG 641
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
198-307 |
3.30e-08 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 53.53 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 198 PCDPECSEVGCDGPGPDHCSDCLHYyyklkNNTRICVSSCPPGHY----HADKKRCRKCAPNCE------SCFGSHGNQC 267
Cdd:pfam14843 1 VCDPLCSSEGCWGPGPDQCLSCRNF-----SRGGTCVESCNILQGepreYVVNSTCVPCHPECLpqngtaTCSGPGADNC 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1907131883 268 LSCKYgyflNEETSSCVTQCPDGSYEDI--------KKNVCGKCSENC 307
Cdd:pfam14843 76 TKCAH----FRDGPHCVSSCPSGVLGENdliwkyadANGVCQPCHPNC 119
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
458-556 |
7.31e-07 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 49.68 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 458 CWGPTQEDCISCpvTRVLDDGRCVMNCPSWKFEFK-----KQCHPCHYTCQG------CQGSGPSNCTSCRADKHGQE-- 524
Cdd:pfam14843 11 CWGPGPDQCLSC--RNFSRGGTCVESCNILQGEPReyvvnSTCVPCHPECLPqngtatCSGPGADNCTKCAHFRDGPHcv 88
|
90 100 110
....*....|....*....|....*....|..
gi 1907131883 525 RFLYHGECLENCPVGHYPAKGHACLPCPDNCE 556
Cdd:pfam14843 89 SSCPSGVLGENDLIWKYADANGVCQPCHPNCT 120
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1107-1154 |
1.12e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 46.74 E-value: 1.12e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1907131883 1107 CHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCE 1154
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
342-386 |
1.59e-06 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 46.35 E-value: 1.59e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 342 GHDCQPCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYY 386
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
1052-1096 |
2.19e-06 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 45.96 E-value: 2.19e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 1052 SHRCQPCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYH 1096
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
958-1007 |
3.42e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 45.20 E-value: 3.42e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1907131883 958 PCHKNCLECNGPKEDDCKVCADTSKaLHNGLCLDECPEGTYKEEENDECR 1007
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFY-LDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1057-1105 |
3.56e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 45.20 E-value: 3.56e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1907131883 1057 PCHKKCSRCSGPSEDQCYTCPRETFLLNTTCVKECPEGYHTDKDSQQCV 1105
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
1101-1145 |
4.54e-06 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 44.81 E-value: 4.54e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 1101 SQQCVLCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYY 1145
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
1057-1172 |
4.61e-06 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 47.37 E-value: 4.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 1057 PCHKKCSR--CSGPSEDQCYTCprETFLLNTTCVKECPEGYHTDK---DSQQCVLCHSSC------RTCEGPHSMQCLSC 1125
Cdd:pfam14843 1 VCDPLCSSegCWGPGPDQCLSC--RNFSRGGTCVESCNILQGEPReyvVNSTCVPCHPEClpqngtATCSGPGADNCTKC 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131883 1126 RPgwFQLGKECLLQCRDGYYGEST--------SGRCEKCDKSCK-SCRGPRPTDCQ 1172
Cdd:pfam14843 79 AH--FRDGPHCVSSCPSGVLGENDliwkyadaNGVCQPCHPNCTqGCTGPGLTGCP 132
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
347-388 |
9.88e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 44.05 E-value: 9.88e-06
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1907131883 347 PCHRFCATCSGAGADGCINCTEGYVMEEGRCVQSCSVSYYLD 388
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYAD 42
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
251-300 |
1.07e-05 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 44.05 E-value: 1.07e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1907131883 251 KCAPNCESCFGSHGNQCLSCKYGYFLNEETssCVTQCPDGSYEDIKKNVC 300
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGT--CVSECPEGTYADTEGGVC 48
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
305-624 |
1.26e-05 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 49.20 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 305 ENCKACI--GFHNCTECKGGLSL-QGSRCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCinctegyvmEEGRCVQSC 381
Cdd:pfam03302 26 ENCKACSndKREVCEECNSNNYLtPTSQCIDDCAKIGNYYYTTNANNKKICKECTVANCKTC---------EDQGQCQAC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 382 SVSYYLDHsseggyKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGT--------------CQMGAICKDGEYIDDQGH 447
Cdd:pfam03302 97 NDGFYKSG------DACSPCHESCKTCSGGTASDCTECLTGKALRYGNdgtkgtcgegcttgTGAGACKTCGLTIDGTSY 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 448 CQTCEAS--------CAKCWGPTQEDCISCPVTrvldDGRCvMNCPSWKFEFKKQCHpchytcQGCQGSGPSNCTSCRAD 519
Cdd:pfam03302 171 CSECATEteypqngvCTSTAARATATCKASSVA----NGMC-SSCANGYFRMNGGCY------ETTKFPGKSVCEEANSG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 520 KHGQErflyhgeclencPVGHYPAKGHACLPCPDNCELCYNPHVCSRCMSGYViiPPNHTCQKlecrqgefqdseyeecm 599
Cdd:pfam03302 240 GTCQK------------EAPGYKLNNGDLVTCSPGCKTCTSNTVCTTCMDGYV--KTSDSCTK----------------- 288
|
330 340
....*....|....*....|....*
gi 1907131883 600 pCEEGCLGCTeDDPGACTSCATGYY 624
Cdd:pfam03302 289 -CDSSCETCT-GATTTCKTCATGYY 311
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
244-520 |
3.51e-05 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 48.04 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 244 ADKKRCRKCAP----NCESCFGSHGNQCLSCKYGYFLNEeTSSCVTQCpdgsyEDIKKNVCGKCSENCKACIGFH--NCT 317
Cdd:pfam03302 12 ADKTKCTSSAPckteNCKACSNDKREVCEECNSNNYLTP-TSQCIDDC-----AKIGNYYYTTNANNKKICKECTvaNCK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 318 ECKGGLSLQgsrcsvTCEDGQFFNGHDCQPCHRFCATCSGAGADGCINCTEGYVME------EGRCVQSCSVSYYLDHSS 391
Cdd:pfam03302 86 TCEDQGQCQ------ACNDGFYKSGDACSPCHESCKTCSGGTASDCTECLTGKALRygndgtKGTCGEGCTTGTGAGACK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 392 E-----GGYKSCKRCDNS----------------CLTCNGPGFKN--CSSCPSGYLLDLGTC---------------QMG 433
Cdd:pfam03302 160 TcgltiDGTSYCSECATEteypqngvctstaaraTATCKASSVANgmCSSCANGYFRMNGGCyettkfpgksvceeaNSG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 434 AICKDGE--YIDDQGHCQTCEASCAKCWGPTqeDCISCPVTRVLDDGRCVMNCPSWkfefkKQCHPCHYTCQGC------ 505
Cdd:pfam03302 240 GTCQKEApgYKLNNGDLVTCSPGCKTCTSNT--VCTTCMDGYVKTSDSCTKCDSSC-----ETCTGATTTCKTCatgyyk 312
|
330
....*....|....*
gi 1907131883 506 QGSGPSNCTSCRADK 520
Cdd:pfam03302 313 SGTGCVSCTSSESDN 327
|
|
| FU |
smart00261 |
Furin-like repeats; |
1203-1245 |
3.53e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 42.50 E-value: 3.53e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907131883 1203 TCERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEY 1245
Cdd:smart00261 3 ECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
446-489 |
4.84e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 42.11 E-value: 4.84e-05
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1907131883 446 GHCQTCEASCAKCWGPTQEDCISCPVTRVLDDGRCVMNCPSWKF 489
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1155-1205 |
6.03e-05 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 41.74 E-value: 6.03e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1907131883 1155 KCDKSCKSCRGPRPTDCQSCDTFFFLLrsKGQCHRACPEHYYADQHAQTCE 1205
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLD--GGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
954-998 |
7.03e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 41.34 E-value: 7.03e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 954 RQCVPCHKNCLECNGPKEDDCKVCADTSKaLHNGLCLDECPEGTY 998
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFF-LDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
597-639 |
7.38e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 41.34 E-value: 7.38e-05
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907131883 597 ECMPCEEGCLGCTEDDPGACTSCATGYYMFERHCYKACPEKTF 639
Cdd:smart00261 3 ECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
246-292 |
1.05e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 40.96 E-value: 1.05e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907131883 246 KKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETssCVTQCPDGSY 292
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGK--CVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
772-817 |
1.09e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 40.97 E-value: 1.09e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1907131883 772 PCHSSCKTCNGSL---CASCPTGMYLWLQACVPSCPQGTWPSVTSGSCE 817
Cdd:cd00064 1 PCHPSCATCTGPGpdqCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
1150-1196 |
1.61e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 40.57 E-value: 1.61e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907131883 1150 SGRCEKCDKSCKSCRGPRPTDCQSCDTFFFLLrsKGQCHRACPEHYY 1196
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLD--GGKCVSECPPGTY 45
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
872-1179 |
1.70e-04 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 45.73 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 872 CKTC-EGNATSCNSCEGDFVLDH-GVCWKTCPEKHVAVEGVCKHCPERCQDCIHEKtCKECMpdfflyNDMCHRSCPKSF 949
Cdd:pfam03302 28 CKACsNDKREVCEECNSNNYLTPtSQCIDDCAKIGNYYYTTNANNKKICKECTVAN-CKTCE------DQGQCQACNDGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 950 YPDMRQCVPCHKNCLECNGPKEDDCKVCAdTSKALHNGL--CLDECPEGTYKEEENDECRDCPescLICSSAWTCLACRE 1027
Cdd:pfam03302 101 YKSGDACSPCHESCKTCSGGTASDCTECL-TGKALRYGNdgTKGTCGEGCTTGTGAGACKTCG---LTIDGTSYCSECAT 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 1028 GFTVVHDVCTAPKECAAVEYWDEGS---HRCQPCHKKCSRCSGpsedQCYTCPR-------ETFLLNTTCVKECPeGYHT 1097
Cdd:pfam03302 177 ETEYPQNGVCTSTAARATATCKASSvanGMCSSCANGYFRMNG----GCYETTKfpgksvcEEANSGGTCQKEAP-GYKL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 1098 dkDSQQCVLCHSSCRTCEGPHSMQclscrpgwfqlgkecllQCRDGYYgeSTSGRCEKCDKSCKSCRGpRPTDCQSCDTF 1177
Cdd:pfam03302 252 --NNGDLVTCSPGCKTCTSNTVCT-----------------TCMDGYV--KTSDSCTKCDSSCETCTG-ATTTCKTCATG 309
|
..
gi 1907131883 1178 FF 1179
Cdd:pfam03302 310 YY 311
|
|
| FU |
smart00261 |
Furin-like repeats; |
492-541 |
1.86e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 40.19 E-value: 1.86e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1907131883 492 KKQCHPCHYTCQGCQGSGPSNCTSCRADkhgqeRFLYHGECLENCPVGHY 541
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHG-----FFLDGGKCVSECPPGTY 45
|
|
| Furin-like_2 |
pfam15913 |
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
232-290 |
2.48e-04 |
|
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 41.65 E-value: 2.48e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907131883 232 ICVSSCPPGHY---HADKKRCRKC-APNCESCFGShgNQCLSCKYGYFLNEetSSCVTQCPDG 290
Cdd:pfam15913 34 VCLHSCPPGYFgirGQEVNRCTKCkAENCESCFSK--DFCTKCKEGFYLHK--GKCLDTCPEG 92
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
603-885 |
3.30e-04 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 44.96 E-value: 3.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 603 EGCLGCTEDDPGACTSCATGYYMFE-RHCYKACPEKTFGVKWECRACGTNCGSCDQHECYWCEEGfflsggSCVQDCGPG 681
Cdd:pfam03302 26 ENCKACSNDKREVCEECNSNNYLTPtSQCIDDCAKIGNYYYTTNANNKKICKECTVANCKTCEDQ------GQCQACNDG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 682 FHGDQElgECKPCHRACENCTGSGYNQCSSCQEGLQLWHGT----------CLWSTWP--------QVEGKDWNEAVPTE 743
Cdd:pfam03302 100 FYKSGD--ACSPCHESCKTCSGGTASDCTECLTGKALRYGNdgtkgtcgegCTTGTGAgacktcglTIDGTSYCSECATE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 744 KPSLVRSLLQDRRKWKVQIKRDATSQNQPChSSCKTCNGSLCASC-PTGMYLWLQACVPSCPQGTWPS------VTSGSC 816
Cdd:pfam03302 178 TEYPQNGVCTSTAARATATCKASSVANGMC-SSCANGYFRMNGGCyETTKFPGKSVCEEANSGGTCQKeapgykLNNGDL 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907131883 817 EKCSEDCVSCSGADLCQQCLsqpdntlllhegrcyhscpEGFYAKDGVCEHCSSPCKTCEGNATSCNSC 885
Cdd:pfam03302 257 VTCSPGCKTCTSNTVCTTCM-------------------DGYVKTSDSCTKCDSSCETCTGATTTCKTC 306
|
|
| FU |
smart00261 |
Furin-like repeats; |
396-430 |
3.56e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 39.42 E-value: 3.56e-04
10 20 30
....*....|....*....|....*....|....*
gi 1907131883 396 KSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGTC 430
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKC 36
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
273-567 |
4.39e-04 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 44.91 E-value: 4.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 273 GYFLNEETSSCVTQCPDGSYEDiKKNVCGKCSENC---------KACIGFHN--CTECKGGLSLQGSRCSVTCEDGQFFN 341
Cdd:PTZ00214 350 GYLCGDATNGGVSGCATCGYNS-GAVTCTRCSAGYlgvdgkscsESCSGDTRgvCTKVAEGSESTEVSCRCVCKPTFYNS 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 342 GHDCQPCHRFCATCSGAGADGCINCTEGYVM-------EEGRCVQSCSVSyylDHSSE-----GGYKSCKRC-DNSCLTC 408
Cdd:PTZ00214 429 SGTCTPCTDSCAVCKDGTPTGCQQCSPGKILefsivssESADCVDQCSVG---SECAEcgitiDGSRYCTRCkDASTYPF 505
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 409 NGPGFKNcsscpsgylldlgtCQMGAICKDGEyiddQGHCQTCEASCAKCWGP--TQEDCISCPVTRVLDDGRCVMNCPS 486
Cdd:PTZ00214 506 NGVCIPN--------------TQRDAYCTSTA----NGACTTCSGAAFLMNGGcyTTEHYPGSTICDKQSNGKCTTTKKG 567
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 487 WKFEFKKQCHPCHYTCQGCQGSGPSNCTSCRADK-HGQERFLYHGECLE-NCPVGHYPAKGHACLPCPD-NCELCYNPHV 563
Cdd:PTZ00214 568 YGISPDGKLLECDPTCLACTAPGPGRCTRCPSDKlLKRASGAATGSCVDpGACVDGYYADGDACLPCATpGCKTCGHASF 647
|
....
gi 1907131883 564 CSRC 567
Cdd:PTZ00214 648 CTEC 651
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
1140-1282 |
5.04e-04 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 44.19 E-value: 5.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 1140 CRDGYYGESTSGRCEKCDK----SCKSCRGPRPTDCQSCDTFFFLLRSKgQCHRACPEhyYADQHAQTCERCHPTCDKCs 1215
Cdd:pfam03302 4 CKPGYELSADKTKCTSSAPckteNCKACSNDKREVCEECNSNNYLTPTS-QCIDDCAK--IGNYYYTTNANNKKICKEC- 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907131883 1216 gkEAWSCLSCVwsyhllKGICIPECIVGEYREGKgenfNCKKCHESCMECKGPGSKNCTGCSAGLLL 1282
Cdd:pfam03302 80 --TVANCKTCE------DQGQCQACNDGFYKSGD----ACSPCHESCKTCSGGTASDCTECLTGKAL 134
|
|
| Nar1 |
COG4624 |
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
248-383 |
5.32e-04 |
|
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 44.25 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 248 RCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETSSCVTQCPDGSYEDIKKNVCGKCSENCKACIGFHNCTECKGGLSLQG 327
Cdd:COG4624 2 LLLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDK 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907131883 328 SRCSVTCEDGqffNGHDCQPCHRFCATCSGAGADG--------CINCtegyvmeeGRCVQSCSV 383
Cdd:COG4624 82 RGPSIIRDKE---KCKNCYPCVRACPVKAIKVDDGkaeideekCISC--------GQCVAVCPF 134
|
|
| FU |
smart00261 |
Furin-like repeats; |
689-726 |
5.71e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 39.03 E-value: 5.71e-04
10 20 30
....*....|....*....|....*....|....*...
gi 1907131883 689 GECKPCHRACENCTGSGYNQCSSCQEGLQLWHGTCLWS 726
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSE 39
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
497-542 |
5.90e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 39.04 E-value: 5.90e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1907131883 497 PCHYTCQGCQGSGPSNCTSCRADKHgqerfLYHGECLENCPVGHYP 542
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFY-----LDGGTCVSECPEGTYA 41
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
600-640 |
8.67e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 38.65 E-value: 8.67e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1907131883 600 PCEEGCLGCTEDDPGACTSCATGYYMFERHCYKACPEKTFG 640
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYA 41
|
|
| FU |
smart00261 |
Furin-like repeats; |
767-808 |
9.16e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 38.26 E-value: 9.16e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 767 TSQNQPCHSSCKTCNGSL---CASCPTGMYLWLQACVPSCPQGTW 808
Cdd:smart00261 1 DGECKPCHPECATCTGPGpddCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
198-248 |
9.76e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 38.27 E-value: 9.76e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1907131883 198 PCDPECSevGCDGPGPDHCSDCLHYYYklkNNTRICVSSCPPGHYHADKKR 248
Cdd:cd00064 1 PCHPSCA--TCTGPGPDQCTSCRHGFY---LDGGTCVSECPEGTYADTEGG 46
|
|
| Furin-like |
pfam00757 |
Furin-like cysteine rich region; |
199-307 |
1.06e-03 |
|
Furin-like cysteine rich region;
Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 40.88 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 199 CDPECSEvGCDGPGPDHCSDCLHYYYklknnTRICVSSCPPGHYHADkkrcRKCApNCESCFGSHGNQClsckygYFLNE 278
Cdd:pfam00757 49 CHEQCLG-GCTGPNDSDCLACRHFND-----EGTCVDQCPPGTYQFG----WRCV-TFKECPKSHLPGY------NPLVI 111
|
90 100 110
....*....|....*....|....*....|
gi 1907131883 279 ETSSCVTQCPDGSYEDIKKNV-CGKCSENC 307
Cdd:pfam00757 112 HNGECVRECPSGYTEVENNSRkCEPCEGLC 141
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1207-1250 |
1.10e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 38.27 E-value: 1.10e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1907131883 1207 CHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEYREGKG 1250
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEG 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
451-490 |
1.29e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 38.27 E-value: 1.29e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1907131883 451 CEASCAKCWGPTQEDCISCPVTRVLDDGRCVMNCPSWKFE 490
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYA 41
|
|
| FU |
smart00261 |
Furin-like repeats; |
198-242 |
1.31e-03 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 37.87 E-value: 1.31e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1907131883 198 PCDPECSevGCDGPGPDHCSDCLHYYYKLKNntrICVSSCPPGHY 242
Cdd:smart00261 6 PCHPECA--TCTGPGPDDCTSCKHGFFLDGG---KCVSECPPGTY 45
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
766-1117 |
1.58e-03 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 42.65 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 766 ATSQNQPCHSSCKTCN--------GSLCASCPTGMYLW-LQACVPSCPQgtWPSVTSGSCEKCSEDCVSCSGADlCQQCL 836
Cdd:pfam03302 12 ADKTKCTSSAPCKTENckacsndkREVCEECNSNNYLTpTSQCIDDCAK--IGNYYYTTNANNKKICKECTVAN-CKTCE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 837 SQPdntlllhegrCYHSCPEGFYAKDGVCEHCSSPCKTCEGNATS-CNSCEGDFVLDHG------VCWKTCPEKhvAVEG 909
Cdd:pfam03302 89 DQG----------QCQACNDGFYKSGDACSPCHESCKTCSGGTASdCTECLTGKALRYGndgtkgTCGEGCTTG--TGAG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 910 VCKHCPERCQDCiheKTCKECMPDF-FLYNDMCH-------RSCPKSFYPDMRqCVPCHKNCLECNGPkeddckvCADTS 981
Cdd:pfam03302 157 ACKTCGLTIDGT---SYCSECATETeYPQNGVCTstaaratATCKASSVANGM-CSSCANGYFRMNGG-------CYETT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 982 KALHNGLCLDECPEGTYKEE------ENDECRDCPESCLICSSAWTCLACREGFTVVHDVCTApkecaaveywdegshrc 1055
Cdd:pfam03302 226 KFPGKSVCEEANSGGTCQKEapgyklNNGDLVTCSPGCKTCTSNTVCTTCMDGYVKTSDSCTK----------------- 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907131883 1056 qpCHKKCSRCSGpSEDQCYTCPRETFLLNTTCVKecpegyHTDKDSQQCVLCHSSCRTCEGP 1117
Cdd:pfam03302 289 --CDSSCETCTG-ATTTCKTCATGYYKSGTGCVS------CTSSESDNGITGVKGCLNCAPP 341
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
1156-1273 |
1.62e-03 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 40.05 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 1156 CDKSCKS--CRGPRPTDCQSCDTFFFllrsKGQCHRACPEHYYAD---QHAQTCERCHPTCDK------CSGKEAWSCLS 1224
Cdd:pfam14843 2 CDPLCSSegCWGPGPDQCLSCRNFSR----GGTCVESCNILQGEPreyVVNSTCVPCHPECLPqngtatCSGPGADNCTK 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1907131883 1225 CVwsyHLLKGI-CIPECIVGEYREGKG------ENFNCKKCHESCME-CKGPGSKNC 1273
Cdd:pfam14843 78 CA---HFRDGPhCVSSCPSGVLGENDLiwkyadANGVCQPCHPNCTQgCTGPGLTGC 131
|
|
| Furin-like_2 |
pfam15913 |
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
798-866 |
1.67e-03 |
|
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 39.34 E-value: 1.67e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907131883 798 ACVPSCPQGTW--PSVTSGSCEKC-SEDCVSCSGADLCQQCLSQpdntLLLHEGRCYHSCPEGFYAKDGVCE 866
Cdd:pfam15913 34 VCLHSCPPGYFgiRGQEVNRCTKCkAENCESCFSKDFCTKCKEG----FYLHKGKCLDTCPEGTAAQNSTME 101
|
|
| FU |
smart00261 |
Furin-like repeats; |
1255-1297 |
1.96e-03 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 37.49 E-value: 1.96e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1907131883 1255 CKKCHESCMECKGPGSKNCTGCSAGLLLdmDDNRCLHCCNASH 1297
Cdd:smart00261 4 CKPCHPECATCTGPGPDDCTSCKHGFFL--DGGKCVSECPPGT 44
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
401-447 |
2.21e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 37.50 E-value: 2.21e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907131883 401 CDNSCLTCNGPGFKNCSSCPSGYLLDLGTCQmgAICKDGEYIDDQGH 447
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCV--SECPEGTYADTEGG 46
|
|
| FU |
smart00261 |
Furin-like repeats; |
862-904 |
2.27e-03 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 37.10 E-value: 2.27e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1907131883 862 DGVCEHCSSPCKTCEG-NATSCNSCEGDFVLDHGVCWKTCPEKH 904
Cdd:smart00261 1 DGECKPCHPECATCTGpGPDDCTSCKHGFFLDGGKCVSECPPGT 44
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
347-467 |
2.43e-03 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 39.66 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131883 347 PCHRFC--ATCSGAGADGCINCTegYVMEEGRCVQSCSVSYYLDHSSEGGyKSCKRCDNSCL------TCNGPGFKNC-- 416
Cdd:pfam14843 1 VCDPLCssEGCWGPGPDQCLSCR--NFSRGGTCVESCNILQGEPREYVVN-STCVPCHPECLpqngtaTCSGPGADNCtk 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907131883 417 -----------SSCPSGYlldlgtcqMGAICKDGEYIDDQGHCQTCEASCAK-CWGPTQEDCI 467
Cdd:pfam14843 78 cahfrdgphcvSSCPSGV--------LGENDLIWKYADANGVCQPCHPNCTQgCTGPGLTGCP 132
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
693-724 |
5.69e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 36.34 E-value: 5.69e-03
10 20 30
....*....|....*....|....*....|..
gi 1907131883 693 PCHRACENCTGSGYNQCSSCQEGLQLWHGTCL 724
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCV 32
|
|
| |
