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Conserved domains on  [gi|1907132396|ref|XP_036017478|]
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coronin-1B isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-347 6.86e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 223.62  E-value: 6.86e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  18 SGCDNVVLIWNV--GTAEELYrldSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIF 95
Cdd:PTZ00421  144 AGADMVVNVWDVerGKAVEVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLW 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  96 LADGK-VFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPpyIHFL 174
Cdd:PTZ00421  220 AKRKDlIITLGCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFC 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396 175 NTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPEAALEAEDWVSGQDA 252
Cdd:PTZ00421  298 SSYSSVEPHKGLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNA 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396 253 NPILISL--------REAYVPSKQRDLKVSRRNVLSDSRPASYSRSGASTATAVTDVPSGNLAGAGEAGKLEEVMQELRA 324
Cdd:PTZ00421  378 EPLVYDMsavfdgtsPELMGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQA 457

                         330       340
                  ....*....|....*....|...
gi 1907132396 325 LRMLVKEQGERISRLEEQLGRME 347
Cdd:PTZ00421  458 LSEKLRTQHEEIKRCREALQKKE 480
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 18-347 6.86e-69

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 223.62  E-value: 6.86e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  18 SGCDNVVLIWNV--GTAEELYrldSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIF 95
Cdd:PTZ00421  144 AGADMVVNVWDVerGKAVEVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLW 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  96 LADGK-VFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPpyIHFL 174
Cdd:PTZ00421  220 AKRKDlIITLGCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFC 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396 175 NTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPEAALEAEDWVSGQDA 252
Cdd:PTZ00421  298 SSYSSVEPHKGLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNA 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396 253 NPILISL--------REAYVPSKQRDLKVSRRNVLSDSRPASYSRSGASTATAVTDVPSGNLAGAGEAGKLEEVMQELRA 324
Cdd:PTZ00421  378 EPLVYDMsavfdgtsPELMGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQA 457

                         330       340
                  ....*....|....*....|...
gi 1907132396 325 LRMLVKEQGERISRLEEQLGRME 347
Cdd:PTZ00421  458 LSEKLRTQHEEIKRCREALQKKE 480
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 212-254 2.92e-19

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 79.86  E-value: 2.92e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907132396 212 CEPIVMTVPRKS-DLFQDDLYPDTAGPEAALEAEDWVSGQDANP 254
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-164 1.30e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396   7 AWLPELMTACPSGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHE 86
Cdd:cd00200   100 AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHT 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  87 GarPMRAI-FLADGKVFTTGFsrmSERQLALWDpenLEEPMALQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEI 164
Cdd:cd00200   178 G--EVNSVaFSPDGEKLLSSS---SDGTIKLWD---LSTGKCLGTLRGHENGVNsVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
18-166 4.13e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 4.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  18 SGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkaHEGARPMRAIFLA 97
Cdd:COG2319   180 GSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSP 256

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  98 DGKVFTTGfsrMSERQLALWDPENLEEpmaLQELDSSNGALLPF-YDPDTSVVyVCGKGDSSIRYFEITD 166
Cdd:COG2319   257 DGRLLASG---SADGTVRLWDLATGEL---LRTLTGHSGGVNSVaFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-71 1.27e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.27e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907132396   42 HPDLIYNVSWNHNGSLFCSACKDKSVRIID 71
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 18-347 6.86e-69

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 223.62  E-value: 6.86e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  18 SGCDNVVLIWNV--GTAEELYrldSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHEGARPMRAIF 95
Cdd:PTZ00421  144 AGADMVVNVWDVerGKAVEVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLW 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  96 LADGK-VFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPpyIHFL 174
Cdd:PTZ00421  220 AKRKDlIITLGCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFC 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396 175 NTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRK-SDL-FQDDLYPDTAGPEAALEAEDWVSGQDA 252
Cdd:PTZ00421  298 SSYSSVEPHKGLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNA 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396 253 NPILISL--------REAYVPSKQRDLKVSRRNVLSDSRPASYSRSGASTATAVTDVPSGNLAGAGEAGKLEEVMQELRA 324
Cdd:PTZ00421  378 EPLVYDMsavfdgtsPELMGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQA 457

                         330       340
                  ....*....|....*....|...
gi 1907132396 325 LRMLVKEQGERISRLEEQLGRME 347
Cdd:PTZ00421  458 LSEKLRTQHEEIKRCREALQKKE 480
PTZ00420 PTZ00420
coronin; Provisional
 16-276 2.77e-40

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 149.33  E-value: 2.77e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  16 CPSGCDNVVLIWNVGTAEELYRLdsLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTlVAEREKAHEGARPMRAIF 95
Cdd:PTZ00420  142 CSSGFDSFVNIWDIENEKRAFQI--NMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQE-IASSFHIHDGGKNTKNIW 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  96 L-----ADGKVFTTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPpy 170
Cdd:PTZ00420  219 IdglggDDNYILSTGFSKNNMREMKLWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS-- 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396 171 IHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYK-LHERKCEPIVMTVPRK-SDLFQDDLYPDTAGPEAALEAEDWVS 248
Cdd:PTZ00420  297 IRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWID 376

                         250       260
                  ....*....|....*....|....*...
gi 1907132396 249 GQDANPILISLREAyvpsKQRDLKVSRR 276
Cdd:PTZ00420  377 GKDNKMKRINIKDL----TEDDLRITKK 400
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 212-254 2.92e-19

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 79.86  E-value: 2.92e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907132396 212 CEPIVMTVPRKS-DLFQDDLYPDTAGPEAALEAEDWVSGQDANP 254
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-164 1.30e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396   7 AWLPELMTACPSGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkAHE 86
Cdd:cd00200   100 AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHT 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  87 GarPMRAI-FLADGKVFTTGFsrmSERQLALWDpenLEEPMALQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEI 164
Cdd:cd00200   178 G--EVNSVaFSPDGEKLLSSS---SDGTIKLWD---LSTGKCLGTLRGHENGVNsVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
18-166 4.13e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 4.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  18 SGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREkaHEGARPMRAIFLA 97
Cdd:COG2319   180 GSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSP 256

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  98 DGKVFTTGfsrMSERQLALWDPENLEEpmaLQELDSSNGALLPF-YDPDTSVVyVCGKGDSSIRYFEITD 166
Cdd:COG2319   257 DGRLLASG---SADGTVRLWDLATGEL---LRTLTGHSGGVNSVaFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
18-129 5.58e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 5.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  18 SGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEReKAHEGARpmRAI-FL 96
Cdd:COG2319   264 GSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAV--RSVaFS 339

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1907132396  97 ADGKVFTTGFsrmSERQLALWDPENLEEPMALQ 129
Cdd:COG2319   340 PDGKTLASGS---DDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-105 1.11e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396   7 AWLPELMTACPSGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEReKAHE 86
Cdd:cd00200   184 AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHT 261

                          90       100
                  ....*....|....*....|
gi 1907132396  87 GarPMRAI-FLADGKVFTTG 105
Cdd:cd00200   262 N--SVTSLaWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-160 2.58e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396   7 AWLPELMTACPSGCDNVVLIWNVGTAEELYRLdSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVaeRE-KAH 85
Cdd:cd00200    16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV--RTlTGH 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907132396  86 EGarPMRAI-FLADGKVFTTGfsrMSERQLALWDpenLEEPMALQELDS-SNGALLPFYDPDTSVVyVCGKGDSSIR 160
Cdd:cd00200    93 TS--YVSSVaFSPDGRILSSS---SRDKTIKVWD---VETGKCLTTLRGhTDWVNSVAFSPDGTFV-ASSSQDGTIK 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-181 1.02e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  18 SGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEReKAHEGarPMRAIFLA 97
Cdd:cd00200    69 GSSDKTIRLWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTD--WVNSVAFS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  98 DGKVFTTGFSrmSERQLALWDPENLEEpmaLQELDSSNGAL--LPFyDPDTSVVYVCGkGDSSIRYFEITDEppyiHFLN 175
Cdd:cd00200   145 PDGTFVASSS--QDGTIKLWDLRTGKC---VATLTGHTGEVnsVAF-SPDGEKLLSSS-SDGTIKLWDLSTG----KCLG 213


                  ....*.
gi 1907132396 176 TFTSKE 181
Cdd:cd00200   214 TLRGHE 219
WD40 COG2319
WD40 repeat [General function prediction only];
21-129 1.64e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  21 DNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEReKAHEGArpMRAI-FLADG 99
Cdd:COG2319    99 DGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGA--VTSVaFSPDG 174

                          90       100       110
                  ....*....|....*....|....*....|
gi 1907132396 100 KVFTTGFsrmSERQLALWDPENLEEPMALQ 129
Cdd:COG2319   175 KLLASGS---DDGTVRLWDLATGKLLRTLT 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-166 1.61e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132396  42 HPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAeREKAHEGarPMRAI-FLADGK-VFTTGfsrmSERQLALWDP 119
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTG--PVRDVaASADGTyLASGS----SDKTIRLWDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1907132396 120 ENLEEpmaLQELDSSNGALL-PFYDPDTSVVyVCGKGDSSIRYFEITD 166
Cdd:cd00200    81 ETGEC---VRTLTGHTSYVSsVAFSPDGRIL-SSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
18-73 3.25e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 3.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907132396  18 SGCDNVVLIWNVGTAEELYRLDSlHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPR 73
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-69 4.54e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.63  E-value: 4.54e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907132396   7 AWLPELMTACPSGCDNVVLIWNVGTAEELYRLdSLHPDLIYNVSWNHNGSLFCSACKDKSVRI 69
Cdd:cd00200   226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-71 1.27e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.27e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1907132396   42 HPDLIYNVSWNHNGSLFCSACKDKSVRIID 71
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-71 8.09e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 8.09e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907132396  42 HPDLIYNVSWNHNGSLFCSACKDKSVRIID 71
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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