Domain of unknown function (DUF5921); This family represents a domain of unknown function ...
120-573
0e+00
Domain of unknown function (DUF5921); This family represents a domain of unknown function located between the Transcription factor IIIC subunit delta N-term (pfam12657) and the Putative zinc-finger of transcription factor IIIC complex (pfam12660) within the transcription Factor IIIC 90 kDa subunit (TFIIIC-delta/TFIIIC90, also known as general transcription factor 3C polypeptide 4). TFIIIC is a multisubunit complex that directly recognizes promoter elements and recruits TFIIIB and RNA polymerase III, being absolutely required for RNA polymerase III transcription. TFIIIC90 has an intrinsic histone acetyltransferase activity with a substrate specificity for histone H3. This domain is likely to be involved in the interaction with other components of the TFIIIC complex.
:
Pssm-ID: 466046 Cd Length: 431 Bit Score: 815.93 E-value: 0e+00
Transcription factor IIIC subunit delta N-term; In humans there are six subunits of ...
1-109
1.52e-34
Transcription factor IIIC subunit delta N-term; In humans there are six subunits of transcription factor IIIC, and this one is the 90 kDa subunit; whereas in fungi the complex resolves into nine different subunits and this is No. 9 in yeasts. The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8.
:
Pssm-ID: 463658 Cd Length: 176 Bit Score: 129.49 E-value: 1.52e-34
Putative zinc-finger of transcription factor IIIC complex; This zinc-finger domain is at the ...
599-671
7.50e-10
Putative zinc-finger of transcription factor IIIC complex; This zinc-finger domain is at the very C-terminus of a number of different TFIIIC subunit proteins. This domain might be involved in protein-DNA and/or protein-protein interactions.
The actual alignment was detected with superfamily member pfam12660:
Pssm-ID: 372246 Cd Length: 87 Bit Score: 55.94 E-value: 7.50e-10
Domain of unknown function (DUF5921); This family represents a domain of unknown function ...
120-573
0e+00
Domain of unknown function (DUF5921); This family represents a domain of unknown function located between the Transcription factor IIIC subunit delta N-term (pfam12657) and the Putative zinc-finger of transcription factor IIIC complex (pfam12660) within the transcription Factor IIIC 90 kDa subunit (TFIIIC-delta/TFIIIC90, also known as general transcription factor 3C polypeptide 4). TFIIIC is a multisubunit complex that directly recognizes promoter elements and recruits TFIIIB and RNA polymerase III, being absolutely required for RNA polymerase III transcription. TFIIIC90 has an intrinsic histone acetyltransferase activity with a substrate specificity for histone H3. This domain is likely to be involved in the interaction with other components of the TFIIIC complex.
Pssm-ID: 466046 Cd Length: 431 Bit Score: 815.93 E-value: 0e+00
Transcription factor IIIC subunit delta N-term; In humans there are six subunits of ...
1-109
1.52e-34
Transcription factor IIIC subunit delta N-term; In humans there are six subunits of transcription factor IIIC, and this one is the 90 kDa subunit; whereas in fungi the complex resolves into nine different subunits and this is No. 9 in yeasts. The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8.
Pssm-ID: 463658 Cd Length: 176 Bit Score: 129.49 E-value: 1.52e-34
Putative zinc-finger of transcription factor IIIC complex; This zinc-finger domain is at the ...
599-671
7.50e-10
Putative zinc-finger of transcription factor IIIC complex; This zinc-finger domain is at the very C-terminus of a number of different TFIIIC subunit proteins. This domain might be involved in protein-DNA and/or protein-protein interactions.
Pssm-ID: 372246 Cd Length: 87 Bit Score: 55.94 E-value: 7.50e-10
Domain of unknown function (DUF5921); This family represents a domain of unknown function ...
120-573
0e+00
Domain of unknown function (DUF5921); This family represents a domain of unknown function located between the Transcription factor IIIC subunit delta N-term (pfam12657) and the Putative zinc-finger of transcription factor IIIC complex (pfam12660) within the transcription Factor IIIC 90 kDa subunit (TFIIIC-delta/TFIIIC90, also known as general transcription factor 3C polypeptide 4). TFIIIC is a multisubunit complex that directly recognizes promoter elements and recruits TFIIIB and RNA polymerase III, being absolutely required for RNA polymerase III transcription. TFIIIC90 has an intrinsic histone acetyltransferase activity with a substrate specificity for histone H3. This domain is likely to be involved in the interaction with other components of the TFIIIC complex.
Pssm-ID: 466046 Cd Length: 431 Bit Score: 815.93 E-value: 0e+00
Transcription factor IIIC subunit delta N-term; In humans there are six subunits of ...
1-109
1.52e-34
Transcription factor IIIC subunit delta N-term; In humans there are six subunits of transcription factor IIIC, and this one is the 90 kDa subunit; whereas in fungi the complex resolves into nine different subunits and this is No. 9 in yeasts. The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8.
Pssm-ID: 463658 Cd Length: 176 Bit Score: 129.49 E-value: 1.52e-34
Putative zinc-finger of transcription factor IIIC complex; This zinc-finger domain is at the ...
599-671
7.50e-10
Putative zinc-finger of transcription factor IIIC complex; This zinc-finger domain is at the very C-terminus of a number of different TFIIIC subunit proteins. This domain might be involved in protein-DNA and/or protein-protein interactions.
Pssm-ID: 372246 Cd Length: 87 Bit Score: 55.94 E-value: 7.50e-10
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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