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Conserved domains on  [gi|1907068596|ref|XP_036020351|]
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angio-associated migratory cell protein isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10078108)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; similar to Homo sapiens angio-associated migratory cell protein that plays a role in angiogenesis and cell migration

Gene Ontology:  GO:0005515
PubMed:  10322433

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-387 2.07e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 2.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:cd00200    83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 244 DLKQGNPIHVLkgtEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:cd00200   163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907068596 324 LGFCSVMP---LAAVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWD 387
Cdd:cd00200   222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-428 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907068596  390 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 428
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-387 2.07e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 2.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:cd00200    83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 244 DLKQGNPIHVLkgtEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:cd00200   163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907068596 324 LGFCSVMP---LAAVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWD 387
Cdd:cd00200   222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
87-427 1.20e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 1.20e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:COG2319   152 GKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 244 DLKQGNPIHVLKGtegHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:COG2319   232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------------------ 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 324 lgfcsVMPLA--------AVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGRLL 394
Cdd:COG2319   291 -----VNSVAfspdgkllASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1907068596 395 TDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 427
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-162 3.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.61e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907068596  124 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
125-162 2.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907068596 125 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 162
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-428 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907068596  390 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 428
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-387 2.07e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 2.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:cd00200    83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 244 DLKQGNPIHVLkgtEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:cd00200   163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907068596 324 LGFCSVMP---LAAVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWD 387
Cdd:cd00200   222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
87-427 1.20e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 1.20e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:COG2319   152 GKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 244 DLKQGNPIHVLKGtegHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:COG2319   232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------------------ 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 324 lgfcsVMPLA--------AVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGRLL 394
Cdd:COG2319   291 -----VNSVAfspdgkllASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1907068596 395 TDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 427
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
87-427 3.98e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 3.98e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596  87 TFALHSASVFCVSLDPkTNTLAVTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:COG2319    31 LLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 167 KEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:COG2319   110 GLLLRTLTGhtGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 244 DLKQGNPIHVLKgteGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETvasqpslgegeesesnsvES 323
Cdd:COG2319   190 DLATGKLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS------------------GS 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 324 LGFCSVMP---LAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVqllweagTAVVY--------TCSLDGVVRLWDARTGR 392
Cdd:COG2319   249 VRSVAFSPdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGV-------NSVAFspdgkllaSGSDDGTVRLWDLATGK 321

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1907068596 393 LLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 427
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
107-428 1.02e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.89  E-value: 1.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 107 LAVTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFE--AGDLEWMEWH 184
Cdd:COG2319     8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLghTAAVLSVAFS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 185 PRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNPIHVLKGtegHQGP 263
Cdd:COG2319    88 PDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG---HSGA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 264 LTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsveslgfcsVMPLA--------AV 335
Cdd:COG2319   165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----------------------VRSVAfspdgkllAS 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 336 GYLDGTLAIYDLSTQTLRHQCQHQSGIVQ-LLWEAGTAVVYTCSLDGVVRLWDARTGRLLTDYRGHTAEILDFALSKDAS 414
Cdd:COG2319   222 GSADGTVRLWDLATGKLLRTLTGHSGSVRsVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301

                         330
                  ....*....|....
gi 1907068596 415 LVVTTSGDHKAKVF 428
Cdd:COG2319   302 LLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 326-431 1.39e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 326 FCSVMPLAAVGYLDGTLAIYDLST-QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGRLLTDYRGHTAEI 404
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                          90       100
                  ....*....|....*....|....*..
gi 1907068596 405 LDFALSKDASLVVTTSGDHKAKVFCVQ 431
Cdd:cd00200    97 SSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
223-431 2.99e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 2.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 223 RVLPDGKRAVVGYEDGTIRIWDLKQGNPIHVLkgtEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPE 302
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLL---LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 303 TVAsqpslgegeesesnsVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDG 381
Cdd:COG2319    78 TAA---------------VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADG 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907068596 382 VVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 431
Cdd:COG2319   143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-162 3.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.61e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907068596  124 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
125-162 2.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907068596 125 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 162
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 181-267 5.38e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907068596 181 MEWHPRAPVLLAGTADGNTWM--------WKVPNGdcktfqGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNPIH 252
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLhrlnwqrvWTLSPD------KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVH 74

                          90
                  ....*....|....*
gi 1907068596 253 VLKgteGHQGPLTCV 267
Cdd:pfam12894  75 HFS---AGSDLITCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-244 1.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.75e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907068596  209 CKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 244
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 247-287 2.21e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.21e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907068596  247 QGNPIHVLKGtegHQGPLTCVATNQDGSLILTGSVDCQAKL 287
Cdd:smart00320   1 SGELLKTLKG---HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
248-287 4.47e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907068596 248 GNPIHVLKGtegHQGPLTCVATNQDGSLILTGSVDCQAKL 287
Cdd:pfam00400   1 GKLLKTLEG---HTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-428 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907068596  390 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 428
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
210-244 3.05e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907068596 210 KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 244
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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