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Conserved domains on  [gi|1907157395|ref|XP_036020355|]
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type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tmemb_55A super family cl18555
Transmembrane protein 55A; Members of this family catalyze the hydrolysis of the 4-position ...
 19-147 9.02e-59

Transmembrane protein 55A; Members of this family catalyze the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, in the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.


The actual alignment was detected with superfamily member pfam09788:

Pssm-ID: 462901  Cd Length: 248  Bit Score: 182.61  E-value: 9.02e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157395  19 RRIINLGPVmlisEEQPAQPalPIQPEGTRVVCGHCGNTFLWMELRfNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMI 98
Cdd:pfam09788 127 KRIINLGPV----HPGPVSP--EPQPGGCRVICGHCHNTFLWTELT-NTLARCPHCRKVSSVGRRYPRKRCLCCFLLGLI 199

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907157395  99 CIFIAVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVS 147
Cdd:pfam09788 200 FLAIAAGLTLGTWKYAQDYGGIYVSWALLFLLALLCLGRAIYWACMKVS 248
 
Name Accession Description Interval E-value
Tmemb_55A pfam09788
Transmembrane protein 55A; Members of this family catalyze the hydrolysis of the 4-position ...
 19-147 9.02e-59

Transmembrane protein 55A; Members of this family catalyze the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, in the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.


Pssm-ID: 462901  Cd Length: 248  Bit Score: 182.61  E-value: 9.02e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157395  19 RRIINLGPVmlisEEQPAQPalPIQPEGTRVVCGHCGNTFLWMELRfNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMI 98
Cdd:pfam09788 127 KRIINLGPV----HPGPVSP--EPQPGGCRVICGHCHNTFLWTELT-NTLARCPHCRKVSSVGRRYPRKRCLCCFLLGLI 199

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907157395  99 CIFIAVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVS 147
Cdd:pfam09788 200 FLAIAAGLTLGTWKYAQDYGGIYVSWALLFLLALLCLGRAIYWACMKVS 248
 
Name Accession Description Interval E-value
Tmemb_55A pfam09788
Transmembrane protein 55A; Members of this family catalyze the hydrolysis of the 4-position ...
 19-147 9.02e-59

Transmembrane protein 55A; Members of this family catalyze the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, in the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.


Pssm-ID: 462901  Cd Length: 248  Bit Score: 182.61  E-value: 9.02e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157395  19 RRIINLGPVmlisEEQPAQPalPIQPEGTRVVCGHCGNTFLWMELRfNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMI 98
Cdd:pfam09788 127 KRIINLGPV----HPGPVSP--EPQPGGCRVICGHCHNTFLWTELT-NTLARCPHCRKVSSVGRRYPRKRCLCCFLLGLI 199

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907157395  99 CIFIAVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVS 147
Cdd:pfam09788 200 FLAIAAGLTLGTWKYAQDYGGIYVSWALLFLLALLCLGRAIYWACMKVS 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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