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Conserved domains on  [gi|1907157829|ref|XP_036020446|]
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BTB/POZ domain-containing protein 19 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 82-154 2.84e-33

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


:

Pssm-ID: 350569  Cd Length: 73  Bit Score: 115.10  E-value: 2.84e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157829  82 DVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 154
Cdd:cd18494     1 SVETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73
 
Name Accession Description Interval E-value
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 82-154 2.84e-33

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 115.10  E-value: 2.84e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157829  82 DVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 154
Cdd:cd18494     1 SVETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 90-186 4.30e-10

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 55.43  E-value: 4.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157829   90 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVD-ETELVQAARSWARVGaavlEQPVAEV 168
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHD----PEKRREH 80

                           90
                   ....*....|....*...
gi 1907157829  169 AAPVVRELRLALLAPAEL 186
Cdd:smart00875  81 LPELLEHVRLPLLSPDYL 98
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 86-186 2.21e-09

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 53.32  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157829  86 VCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCV-DETELVQAARSWARVGAAVLEQP 164
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 1907157829 165 VAEvaapVVRELRLALLAPAEL 186
Cdd:pfam07707  81 LPE----LLSAVRLPLLSPQYL 98
 
Name Accession Description Interval E-value
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 82-154 2.84e-33

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 115.10  E-value: 2.84e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157829  82 DVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 154
Cdd:cd18494     1 SVETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 81-186 1.03e-12

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 62.25  E-value: 1.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157829  81 LDVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARVgaav 160
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEH---- 76

                          90       100
                  ....*....|....*....|....*.
gi 1907157829 161 lEQPVAEVAAPVVRELRLALLAPAEL 186
Cdd:cd14822    77 -NPDSKEDAKEILEAVRLPLMSLTEL 101
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 90-186 4.30e-10

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 55.43  E-value: 4.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157829   90 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVD-ETELVQAARSWARVGaavlEQPVAEV 168
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHD----PEKRREH 80

                           90
                   ....*....|....*...
gi 1907157829  169 AAPVVRELRLALLAPAEL 186
Cdd:smart00875  81 LPELLEHVRLPLLSPDYL 98
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 86-186 2.21e-09

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 53.32  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157829  86 VCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCV-DETELVQAARSWARVGAAVLEQP 164
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 1907157829 165 VAEvaapVVRELRLALLAPAEL 186
Cdd:pfam07707  81 LPE----LLSAVRLPLLSPQYL 98
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 82-136 5.06e-07

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 45.34  E-value: 5.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907157829  82 DVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRS 136
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_BTBD3 cd18524
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); ...
 81-156 5.40e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.


Pssm-ID: 350599  Cd Length: 95  Bit Score: 43.95  E-value: 5.40e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907157829  81 LDVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARV 156
Cdd:cd18524     1 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEV 76
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 101-154 9.56e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 43.12  E-value: 9.56e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907157829 101 LQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 154
Cdd:cd18488    21 LMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWA 74
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 90-155 1.17e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 42.31  E-value: 1.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907157829  90 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCV-DETELVQAARSWAR 155
Cdd:cd18480    10 LSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVpDEEAVLKAVLRWTK 76
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 87-155 6.20e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 40.57  E-value: 6.20e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157829  87 CEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKL-CVDETELVQAARSWAR 155
Cdd:cd18474     7 LALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLaVRSEEVVLEAALRWVD 76
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 90-153 7.09e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 39.87  E-value: 7.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907157829  90 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCV-DETELVQAARSW 153
Cdd:cd18493     9 LQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVeDEYTLFQAVEKW 73
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 100-154 2.17e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350562  Cd Length: 95  Bit Score: 39.26  E-value: 2.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907157829 100 SLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 154
Cdd:cd18487    20 QLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWA 74
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 83-156 3.42e-04

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 38.26  E-value: 3.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907157829  83 VELVCEALQVAVTF----GLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARV 156
Cdd:cd18507     2 VDTVCALLASAERYdqykCTKTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWSRK 79
BACK_BTBD6 cd18525
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...
 81-154 3.55e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350600  Cd Length: 95  Bit Score: 38.91  E-value: 3.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907157829  81 LDVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 154
Cdd:cd18525     1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWA 74
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 88-154 2.17e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 35.83  E-value: 2.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907157829  88 EALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELV-QAARSWA 154
Cdd:cd18472     8 ELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVfEAAVRWL 75
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 81-153 4.63e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 35.65  E-value: 4.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907157829  81 LDVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKL-CVDETELVQAARSW 153
Cdd:cd18465     1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLkNCSEIDLFRAAIRW 74
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 90-154 8.65e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 34.96  E-value: 8.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907157829  90 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 154
Cdd:cd18523    10 LTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWA 74
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 81-155 9.61e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 34.71  E-value: 9.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157829  81 LDVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTR----GFLELSATALLPVLRSDKLC-VDETELVQAARSWAR 155
Cdd:cd18473     1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPrVKESRLLTLVLEWLN 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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