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Conserved domains on  [gi|1907161037|ref|XP_036020776|]
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mismatch repair endonuclease PMS2 isoform X3 [Mus musculus]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
86-336 3.43e-41

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 152.03  E-value: 3.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037  86 YEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRN 165
Cdd:COG4642    81 GGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPH 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 166 GFGMFkcgTQP--VSYIGHWCHGKRHGKGSIYYnqegtswyegdwvynikkgwgircyKSGNIYEGQWENNMRHGEGRMR 243
Cdd:COG4642   161 GQGTL---TYAdgDRYEGEFKNGKRHGQGTLTY-------------------------ANGDVYEGEFKNGQRHGQGTYT 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 244 WlttneeytghwekgiQNGFgthtwflkripnsqyplrnEYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQGRGRMT 323
Cdd:COG4642   213 Y---------------ADGD-------------------RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMT 258

                         250
                  ....*....|...
gi 1907161037 324 FKNGHVYEGLFSN 336
Cdd:COG4642   259 YADGSVYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
86-336 3.43e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 152.03  E-value: 3.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037  86 YEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRN 165
Cdd:COG4642    81 GGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPH 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 166 GFGMFkcgTQP--VSYIGHWCHGKRHGKGSIYYnqegtswyegdwvynikkgwgircyKSGNIYEGQWENNMRHGEGRMR 243
Cdd:COG4642   161 GQGTL---TYAdgDRYEGEFKNGKRHGQGTLTY-------------------------ANGDVYEGEFKNGQRHGQGTYT 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 244 WlttneeytghwekgiQNGFgthtwflkripnsqyplrnEYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQGRGRMT 323
Cdd:COG4642   213 Y---------------ADGD-------------------RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMT 258

                         250
                  ....*....|...
gi 1907161037 324 FKNGHVYEGLFSN 336
Cdd:COG4642   259 YADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 106-405 2.22e-28

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 121.86  E-value: 2.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 106 GNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRNGFGMFkCGTQPVSYIGHWCH 185
Cdd:PLN03185    8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTY-TGTDGTTYKGRWRL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 186 GKRHGKGsiYYNQEGTSWYEGDWVYNIKKGWGIRCYKSGNIYEGQWENNMRHGEGRMRWlTTNEEYTGHWEKGIQNGFGT 265
Cdd:PLN03185   87 NLKHGLG--YQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTW-VSGDSYEGQWLDGMMHGFGV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 266 HTWflkriPNSQYplrneYIGEFVNGFRHGQGKFYYA-SGAMYEGEWASNKKQGRGRM--TFKNGHVYEGLFSNDHIAQF 342
Cdd:PLN03185  164 YTW-----SDGGC-----YVGTWTRGLKDGKGVFYPAgSRVPAVQEFYLNALRKRGVLpdLRRQNQVLSSHNSEQLSRGV 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907161037 343 fetemdysqSLDRWSDASQRS-RQPRGSSVSAVREpetlRKLDGSESRsVLGTSIELDLTLLLD 405
Cdd:PLN03185  234 ---------SSDKLSKGSLLPlEQSRNRNVSLERR----WSLEVSIEK-VIGHDYSGSSSAVLD 283
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
225-244 1.08e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.63  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|
gi 1907161037  225 NIYEGQWENNMRHGEGRMRW 244
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTY 20
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 284-306 1.67e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 39.31  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|...
gi 1907161037 284 YIGEFVNGFRHGQGKFYYASGAM 306
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
86-336 3.43e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 152.03  E-value: 3.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037  86 YEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRN 165
Cdd:COG4642    81 GGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPH 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 166 GFGMFkcgTQP--VSYIGHWCHGKRHGKGSIYYnqegtswyegdwvynikkgwgircyKSGNIYEGQWENNMRHGEGRMR 243
Cdd:COG4642   161 GQGTL---TYAdgDRYEGEFKNGKRHGQGTLTY-------------------------ANGDVYEGEFKNGQRHGQGTYT 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 244 WlttneeytghwekgiQNGFgthtwflkripnsqyplrnEYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQGRGRMT 323
Cdd:COG4642   213 Y---------------ADGD-------------------RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMT 258

                         250
                  ....*....|...
gi 1907161037 324 FKNGHVYEGLFSN 336
Cdd:COG4642   259 YADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
64-339 4.98e-37

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 140.09  E-value: 4.98e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037  64 MEQSEEETQYEEPILTKLIVESYEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNiPMN 143
Cdd:COG4642     1 GGSVAEDGAGGGGDATALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAG-GGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 144 HGVYTWPDGSTYEGEVTNGMRNGFGMFKCGTQPVSYIGhwchgkrhgkgsiYYNQEGTSWYEGDWVYNIKKGWGIRCYKS 223
Cdd:COG4642    80 GGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGG-------------VLEGDDGGGYGGGTADGGRGGGGIYTFPN 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 224 GNIYEGQWENNMRHGEGRMRWlTTNEEYTGHWEKGIQNGFGTHTWflkriPNSqyplrNEYIGEFVNGFRHGQGKFYYAS 303
Cdd:COG4642   147 GDVYEGEFKNGKPHGQGTLTY-ADGDRYEGEFKNGKRHGQGTLTY-----ANG-----DVYEGEFKNGQRHGQGTYTYAD 215

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1907161037 304 GAMYEGEWASNKKQGRGRMTFKNGHVYEGLFSNDHI 339
Cdd:COG4642   216 GDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
68-233 5.41e-36

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 137.39  E-value: 5.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037  68 EEETQYEEPILTKLIVESYEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVY 147
Cdd:COG4642   109 KGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 148 TWPDGSTYEGEVTNGMRNGFGMFKC--GTQpvsYIGHWCHGKRHGKGsIYYNQEGTsWYEGDWVYNIKKGWGIRCYKSGN 225
Cdd:COG4642   189 TYANGDVYEGEFKNGQRHGQGTYTYadGDR---YEGEFKNGKRHGQG-TLTYADGD-RYEGEFKNGKRHGQGTMTYADGS 263


                  ....*...
gi 1907161037 226 IYEGQWEN 233
Cdd:COG4642   264 VYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 106-405 2.22e-28

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 121.86  E-value: 2.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 106 GNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRNGFGMFkCGTQPVSYIGHWCH 185
Cdd:PLN03185    8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTY-TGTDGTTYKGRWRL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 186 GKRHGKGsiYYNQEGTSWYEGDWVYNIKKGWGIRCYKSGNIYEGQWENNMRHGEGRMRWlTTNEEYTGHWEKGIQNGFGT 265
Cdd:PLN03185   87 NLKHGLG--YQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTW-VSGDSYEGQWLDGMMHGFGV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 266 HTWflkriPNSQYplrneYIGEFVNGFRHGQGKFYYA-SGAMYEGEWASNKKQGRGRM--TFKNGHVYEGLFSNDHIAQF 342
Cdd:PLN03185  164 YTW-----SDGGC-----YVGTWTRGLKDGKGVFYPAgSRVPAVQEFYLNALRKRGVLpdLRRQNQVLSSHNSEQLSRGV 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907161037 343 fetemdysqSLDRWSDASQRS-RQPRGSSVSAVREpetlRKLDGSESRsVLGTSIELDLTLLLD 405
Cdd:PLN03185  234 ---------SSDKLSKGSLLPlEQSRNRNVSLERR----WSLEVSIEK-VIGHDYSGSSSAVLD 283
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 86-265 9.77e-22

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 100.68  E-value: 9.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037  86 YEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRN 165
Cdd:PLN03185   34 YEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQE 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 166 GFGMFKCGTQPVsYIGHWCHGKRHGKGSIyynqegtSWyegdwvynikkgwgircyKSGNIYEGQWENNMRHGEGRMRWl 245
Cdd:PLN03185  114 GPGKYTWANGNV-YLGDMKGGKMSGKGTL-------TW------------------VSGDSYEGQWLDGMMHGFGVYTW- 166

                         170       180
                  ....*....|....*....|
gi 1907161037 246 TTNEEYTGHWEKGIQNGFGT 265
Cdd:PLN03185  167 SDGGCYVGTWTRGLKDGKGV 186
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 86-170 1.40e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 81.03  E-value: 1.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037  86 YEGEKVRGLYEGEGFAVFQGGNTYHGMFSEGLMHGQGTYIWADGLKYEGDFVKNIPMNHGVYTWPDGSTYEGEVTNGMRN 165
Cdd:PLN03185  103 FEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKD 182


                  ....*
gi 1907161037 166 GFGMF 170
Cdd:PLN03185  183 GKGVF 187
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 271-339 4.69e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 56.77  E-value: 4.69e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907161037 271 KRIPNSQYplrneYIGEFVNGFRHGQGKFYYASGAMYEGEWASNKKQGRGRMTFKNGHVYEGLFSNDHI 339
Cdd:PLN03185    3 LVLSNGDF-----YSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYM 66
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
153-337 2.89e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 45.06  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 153 STYEGEVTNGMRNGFGMFKCGTQPVSYIGHWCHGKRHGKGSIYYNQEGTSWYEGDWVYNIKKGWgircYKSGNI-YEGQW 231
Cdd:COG2849    10 SKYLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTY----YPNGQLkSEGTY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907161037 232 ENNMRHGEgrmrwlttneeYTGHWEKGIQngfgthtwflkripnsqyplrnEYIGEFVNGFRHGQGKFYYASGA-MYEGE 310
Cdd:COG2849    86 KNGKLEGE-----------WKEYYENGKL----------------------KSEGNYKNGKLHGEWKEYYENGKlKEEGN 132

                         170       180
                  ....*....|....*....|....*...
gi 1907161037 311 WASNKKQGRGRMTFKNGH-VYEGLFSND 337
Cdd:COG2849   133 YKNGKKDGVWKYYDENGKlVKEEEYKNG 160
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
225-244 1.08e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.63  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|
gi 1907161037  225 NIYEGQWENNMRHGEGRMRW 244
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTY 20
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 284-306 1.67e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 39.31  E-value: 1.67e-04
                          10        20
                  ....*....|....*....|...
gi 1907161037 284 YIGEFVNGFRHGQGKFYYASGAM 306
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 109-129 2.38e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.54  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|.
gi 1907161037 109 YHGMFSEGLMHGQGTYIWADG 129
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
107-128 2.87e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 38.48  E-value: 2.87e-04
                           10        20
                   ....*....|....*....|..
gi 1907161037  107 NTYHGMFSEGLMHGQGTYIWAD 128
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
282-302 1.06e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.93  E-value: 1.06e-03
                           10        20
                   ....*....|....*....|.
gi 1907161037  282 NEYIGEFVNGFRHGQGKFYYA 302
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 132-154 2.02e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 36.23  E-value: 2.02e-03
                          10        20
                  ....*....|....*....|...
gi 1907161037 132 YEGDFVKNIPMNHGVYTWPDGST 154
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 227-244 4.22e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.08  E-value: 4.22e-03
                          10
                  ....*....|....*...
gi 1907161037 227 YEGQWENNMRHGEGRMRW 244
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTW 18
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
305-326 8.62e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.24  E-value: 8.62e-03
                           10        20
                   ....*....|....*....|..
gi 1907161037  305 AMYEGEWASNKKQGRGRMTFKN 326
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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