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Conserved domains on  [gi|1907163286|ref|XP_036021001|]
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cyclin-D-binding Myb-like transcription factor 1 isoform X6 [Mus musculus]

Protein Classification

cyclin-D-binding Myb-like transcription factor 1( domain architecture ID 13419776)

cyclin-D-binding Myb-like transcription factor 1 (DMTF1) is a transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest

Gene Symbol:  DMTF1
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  8887674|8882580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 39-117 1.68e-23

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


:

Pssm-ID: 466737  Cd Length: 72  Bit Score: 94.03  E-value: 1.68e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907163286  39 ENDQSFEVTMTattEVADDELSEGTVTQIQILQNDQLDeispLGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 117
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 233-288 3.54e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 3.54e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907163286 233 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 187-243 1.01e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 54.62  E-value: 1.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907163286 187 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 243
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
295-348 6.68e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


:

Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 6.68e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907163286  295 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 348
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 39-117 1.68e-23

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 94.03  E-value: 1.68e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907163286  39 ENDQSFEVTMTattEVADDELSEGTVTQIQILQNDQLDeispLGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 117
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 233-288 3.54e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 3.54e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907163286 233 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 187-243 1.01e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 54.62  E-value: 1.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907163286 187 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 243
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 234-288 1.42e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 53.73  E-value: 1.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907163286 234 KWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:cd00167     1 PWTEEEDELLLEAVKKY-----GKN-----NWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
233-289 2.04e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.38  E-value: 2.04e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907163286  233 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 289
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 81-337 2.04e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.10  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163286  81 LGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNIERYLKargIKDATEIIFEMS-----KDERKDF- 154
Cdd:COG5147   189 PDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEINEYKE---KKGLSRKQFCERiwstdRDEDKFWp 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163286 155 -------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCR--- 224
Cdd:COG5147   264 niykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQELAKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyv 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163286 225 LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYL---NWKQSGGTEWTKE 301
Cdd:COG5147   336 KCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQNIRNRLQHHCRDKYGVLIsnsSPFDAGAAIWLIE 412

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1907163286 302 --------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQ 337
Cdd:COG5147   413 rysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPD 456
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
184-229 1.61e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.29  E-value: 1.61e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907163286  184 GKYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 229
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 185-227 1.98e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.87  E-value: 1.98e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907163286 185 KYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 227
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
295-348 6.68e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 6.68e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907163286  295 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 348
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 297-347 5.54e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 34.86  E-value: 5.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907163286 297 EWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIK 347
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGK-----NNWEKIAKELPG-RTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 39-117 1.68e-23

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 94.03  E-value: 1.68e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907163286  39 ENDQSFEVTMTattEVADDELSEGTVTQIQILQNDQLDeispLGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 117
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 233-288 3.54e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 3.54e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907163286 233 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 187-243 1.01e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 54.62  E-value: 1.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907163286 187 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 243
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 234-288 1.42e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 53.73  E-value: 1.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907163286 234 KWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYL 288
Cdd:cd00167     1 PWTEEEDELLLEAVKKY-----GKN-----NWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
233-289 2.04e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.38  E-value: 2.04e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907163286  233 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 289
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 81-337 2.04e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.10  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163286  81 LGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNIERYLKargIKDATEIIFEMS-----KDERKDF- 154
Cdd:COG5147   189 PDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEINEYKE---KKGLSRKQFCERiwstdRDEDKFWp 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163286 155 -------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCR--- 224
Cdd:COG5147   264 niykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQELAKLVVEHGGSWTEIGKLLGRMPNDCRDRWRdyv 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907163286 225 LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYL---NWKQSGGTEWTKE 301
Cdd:COG5147   336 KCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQNIRNRLQHHCRDKYGVLIsnsSPFDAGAAIWLIE 412

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1907163286 302 --------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQ 337
Cdd:COG5147   413 rysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPD 456
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 184-227 3.43e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 49.81  E-value: 3.43e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907163286 184 GKYTPEEIEKLKELRIKHGNDWATIGAAL-GRSASSVKDRCRLMK 227
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 235-306 5.63e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.92  E-value: 5.63e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907163286 235 WTEEEEKRLAEVVHELTSTepgdivtqgvsWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGtEWTKEDEINL 306
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-----------WKQIAKELGRRTPKQCFDRWRRKLNPKISRG-PWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
184-229 1.61e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.29  E-value: 1.61e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1907163286  184 GKYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 229
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 185-227 1.98e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.87  E-value: 1.98e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907163286 185 KYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 227
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
295-348 6.68e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 6.68e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907163286  295 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 348
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 297-347 5.54e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 34.86  E-value: 5.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907163286 297 EWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIK 347
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGK-----NNWEKIAKELPG-RTPKQCRERWRNLL 45
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 234-286 9.69e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 35.32  E-value: 9.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907163286 234 KWTEEEEKRLAEVVHEL------TSTEPGDIVTQGVSwAAVAERVGTRSEKQCRSKWLN 286
Cdd:pfam13837   3 KWTEEETLALIEIWGERlelrfqESKKRNKKLWEEIA-EKMAELGYNRSPEQCKEKWEN 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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