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Conserved domains on  [gi|1907069131|ref|XP_036021299|]
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opticin isoform X5 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
193-324 2.98e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 193 DLENIPPLPQMT--TYLYARFNHISHIQAgDFKGLTKLRRIDLSGNSISSIhNDALRLLPALQDLILPENQLAALPV--- 267
Cdd:COG4886   102 DLSGNEELSNLTnlESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEelg 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 268 -LPSgIEFLDVRLNRLQSsgiQPEAFVALKKLQFLYLANNMLDSIPGPLPL--SLRSLHL 324
Cdd:COG4886   180 nLTN-LKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDL 235
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
193-324 2.98e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 193 DLENIPPLPQMT--TYLYARFNHISHIQAgDFKGLTKLRRIDLSGNSISSIhNDALRLLPALQDLILPENQLAALPV--- 267
Cdd:COG4886   102 DLSGNEELSNLTnlESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEelg 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 268 -LPSgIEFLDVRLNRLQSsgiQPEAFVALKKLQFLYLANNMLDSIPGPLPL--SLRSLHL 324
Cdd:COG4886   180 nLTN-LKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDL 235
LRR_8 pfam13855
Leucine rich repeat;
205-262 4.73e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 4.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907069131 205 TYLYARFNHISHIQAGDFKGLTKLRRIDLSGNSISSIHNDALRLLPALQDLILPENQL 262
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 188-325 1.08e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 188 YCDDADLENIPPLPQMT--TYLYARFNHISHIQagDFKGLTKLRRIDLSGNSISSIHNdaLRLLPALQDLILpENQlaal 265
Cdd:cd21340    30 YLYDNKITKIENLEFLTnlTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHI-ENQ---- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 266 pVLPSG--IEF--------------LDVRLNRLQSsgiqPEAFVALKKLQFLYLANNMLDSIPGPLPL-----SLRSLHL 324
Cdd:cd21340   101 -RLPPGekLTFdprslaalsnslrvLNISGNNIDS----LEPLAPLRNLEQLDASNNQISDLEELLDLlsswpSLRELDL 175


                  .
gi 1907069131 325 Q 325
Cdd:cd21340   176 T 176
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
190-322 2.95e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 2.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 190 DDADLENIPP-LPQMTTYLYARFNHISHIQAG--DfkgltKLRRIDLSGNSISSIHNdalRLLPALQDLILPENQLAALP 266
Cdd:PRK15370  207 DNNELKSLPEnLQGNIKTLYANSNQLTSIPATlpD-----TIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLP 278

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907069131 267 -VLPSGIEFLDVRLNRLQSsgiQPEAFVAlkKLQFLYLANNMLDSIPGPLPLSLRSL 322
Cdd:PRK15370  279 eNLPEELRYLSVYDNSIRT---LPAHLPS--GITHLNVQSNSLTALPETLPPGLKTL 330
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
193-324 2.98e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 193 DLENIPPLPQMT--TYLYARFNHISHIQAgDFKGLTKLRRIDLSGNSISSIhNDALRLLPALQDLILPENQLAALPV--- 267
Cdd:COG4886   102 DLSGNEELSNLTnlESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEelg 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 268 -LPSgIEFLDVRLNRLQSsgiQPEAFVALKKLQFLYLANNMLDSIPGPLPL--SLRSLHL 324
Cdd:COG4886   180 nLTN-LKELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDL 235
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
185-324 4.83e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 4.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 185 SSVYCDDADLENIPP-LPQMT--TYLYARFNHISHIQAgDFKGLTKLRRIDLSGNSISSIhNDALRLLPALQDLILPENQ 261
Cdd:COG4886   116 ESLDLSGNQLTDLPEeLANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907069131 262 LAALPVL---PSGIEFLDVRLNRLQSsgiQPEAFVALKKLQFLYLANNMLDSIP--GPLPlSLRSLHL 324
Cdd:COG4886   194 ITDLPEPlgnLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDL 257
LRR_8 pfam13855
Leucine rich repeat;
205-262 4.73e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 4.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907069131 205 TYLYARFNHISHIQAGDFKGLTKLRRIDLSGNSISSIHNDALRLLPALQDLILPENQL 262
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 188-325 1.08e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 188 YCDDADLENIPPLPQMT--TYLYARFNHISHIQagDFKGLTKLRRIDLSGNSISSIHNdaLRLLPALQDLILpENQlaal 265
Cdd:cd21340    30 YLYDNKITKIENLEFLTnlTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHI-ENQ---- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 266 pVLPSG--IEF--------------LDVRLNRLQSsgiqPEAFVALKKLQFLYLANNMLDSIPGPLPL-----SLRSLHL 324
Cdd:cd21340   101 -RLPPGekLTFdprslaalsnslrvLNISGNNIDS----LEPLAPLRNLEQLDASNNQISDLEELLDLlsswpSLRELDL 175


                  .
gi 1907069131 325 Q 325
Cdd:cd21340   176 T 176
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
190-322 2.95e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 2.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 190 DDADLENIPP-LPQMTTYLYARFNHISHIQAG--DfkgltKLRRIDLSGNSISSIHNdalRLLPALQDLILPENQLAALP 266
Cdd:PRK15370  207 DNNELKSLPEnLQGNIKTLYANSNQLTSIPATlpD-----TIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLP 278

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907069131 267 -VLPSGIEFLDVRLNRLQSsgiQPEAFVAlkKLQFLYLANNMLDSIPGPLPLSLRSL 322
Cdd:PRK15370  279 eNLPEELRYLSVYDNSIRT---LPAHLPS--GITHLNVQSNSLTALPETLPPGLKTL 330
LRR_8 pfam13855
Leucine rich repeat;
226-308 2.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 226 TKLRRIDLSGNSISSIHNDALRLLPALQDLILPENQLaalpvlpsgiefldvrlnrlqsSGIQPEAFVALKKLQFLYLAN 305
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL----------------------TTLSPGAFSGLPSLRYLDLSG 58


                  ...
gi 1907069131 306 NML 308
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
104-322 2.12e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 104 IEDYNEVIDL-----SNYEELAdygdqipeAKISNLTLPTRTSPtSTVAQKTLSPNLTMAVPTTtgllnsqsshgLPTCL 178
Cdd:PRK15370  205 ILDNNELKSLpenlqGNIKTLY--------ANSNQLTSIPATLP-DTIQEMELSINRITELPER-----------LPSAL 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 179 VCVclgsSVYCDDadLENIPP-LPQMTTYLYARFNHISHIQAGDFKGLTKLrridlsgnsisSIHNDALRLLPA-----L 252
Cdd:PRK15370  265 QSL----DLFHNK--ISCLPEnLPEELRYLSVYDNSIRTLPAHLPSGITHL-----------NVQSNSLTALPEtlppgL 327

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907069131 253 QDLILPENQLAALPV-LPSGIEFLDVRLNRLQssgIQPEAFVAlkKLQFLYLANNMLDSIPGPLPLSLRSL 322
Cdd:PRK15370  328 KTLEAGENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPAALQIM 393
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
191-323 3.54e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.54  E-value: 3.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 191 DADLENIPPLPQMTTYLYARFNHISHIQAGDfkglTKLRRIDLSGNSISSihndaLRLLPA-LQDLILPENQLAALPVLP 269
Cdd:PRK15387  351 DNQLASLPTLPSELYKLWAYNNRLTSLPALP----SGLKELIVSGNRLTS-----LPVLPSeLKELMVSGNRLTSLPMLP 421

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907069131 270 SGIEFLDVRLNRLQSsgiQPEAFVALKKLQFLYLANNmldsipgplPLSLRSLH 323
Cdd:PRK15387  422 SGLLSLSVYRNQLTR---LPESLIHLSSETTVNLEGN---------PLSERTLQ 463
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
191-295 4.41e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 4.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 191 DADLENIPPLPQMTTYLYARFNHISHIQAGDfkglTKLRRIDLSGNSISSI------------HNDALRLLPAL----QD 254
Cdd:PRK15387  311 DNQLASLPALPSELCKLWAYNNQLTSLPTLP----SGLQELSVSDNQLASLptlpselyklwaYNNRLTSLPALpsglKE 386

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1907069131 255 LILPENQLAALPVLPSGIEFLDVRLNRLQSSGIQPEAFVAL 295
Cdd:PRK15387  387 LIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSL 427
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
186-327 7.89e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 7.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 186 SVYCDDADLENIPPLPQMT--TYLYARFNHISHIqaGDFKGLTKLRRIDLSGNSISSIHNDALRLLPALQDLILPENQLA 263
Cdd:COG4886   232 TLDLSNNQLTDLPELGNLTnlEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907069131 264 ALPVLPSGIEFLDVRLNRLQSSGIQPEAFVALKKLQFLYLANNMLDSIPGPLPLSLRSLHLQLH 327
Cdd:COG4886   310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
194-322 1.91e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 194 LENIPPLPQMTTYLYARFNHISHIQAGDfKGLTKLRridLSGNSISSIHndalRLLPALQDLILPENQLAALPVLPSGIE 273
Cdd:PRK15387  254 LTSLPVLPPGLLELSIFSNPLTHLPALP-SGLCKLW---IFGNQLTSLP----VLPPGLQELSVSDNQLASLPALPSELC 325

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907069131 274 FLDVRLNRLQSSGIQPEAfvalkkLQFLYLANNMLDSIPgPLPLSLRSL 322
Cdd:PRK15387  326 KLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLP-TLPSELYKL 367
LRR_8 pfam13855
Leucine rich repeat;
275-325 8.60e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 8.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907069131 275 LDVRLNRLQSsgIQPEAFVALKKLQFLYLANNMLDSIPG----PLPlSLRSLHLQ 325
Cdd:pfam13855   6 LDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLS 57
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
225-322 8.36e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 37.83  E-value: 8.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069131 225 LTKLRRIDLSGNSISSIHNDALRLLP-----ALQDLILPENQLAALPVLPSGIEFLDVRLNRLQSSGIQPEAFVAL---- 295
Cdd:PRK15387  192 VQKMRACLNNGNAVLNVGESGLTTLPdclpaHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELsifs 271

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1907069131 296 ----------KKLQFLYLANNMLDSIPgPLPLSLRSL 322
Cdd:PRK15387  272 nplthlpalpSGLCKLWIFGNQLTSLP-VLPPGLQEL 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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