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Conserved domains on  [gi|1907172887|ref|XP_036022117|]
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electron transfer flavoprotein beta subunit lysine methyltransferase isoform X3 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10008106)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens electron transfer flavoprotein beta subunit lysine methyltransferase

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 1-128 2.55e-22

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 87.25  E-value: 2.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172887   1 MSGASKILANDIDPIAGMAITLNCKLNGLnPFPVLTKNILNTQ-QGKFDLIVLGDMFYDEDLADSLHLWLQNyFWTHGTR 79
Cdd:COG3897    90 KAGAADVTATDYDPEALAALRLNAALNGV-AITTRLGDWRDPPaAGGFDLILGGDVLYERDLAEPLLPFLDR-LAAPGGE 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907172887  80 VLIGDPGRPQFsgHSIRHQLYQLVEYTLPEPTQQENNGLTTSAVWDFHP 128
Cdd:COG3897   168 VLIGDPGRGYL--PAFRERLEALAGYEVVTRELEDTEKVKRGRVLRLRR 214
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 1-128 2.55e-22

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 87.25  E-value: 2.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172887   1 MSGASKILANDIDPIAGMAITLNCKLNGLnPFPVLTKNILNTQ-QGKFDLIVLGDMFYDEDLADSLHLWLQNyFWTHGTR 79
Cdd:COG3897    90 KAGAADVTATDYDPEALAALRLNAALNGV-AITTRLGDWRDPPaAGGFDLILGGDVLYERDLAEPLLPFLDR-LAAPGGE 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907172887  80 VLIGDPGRPQFsgHSIRHQLYQLVEYTLPEPTQQENNGLTTSAVWDFHP 128
Cdd:COG3897   168 VLIGDPGRGYL--PAFRERLEALAGYEVVTRELEDTEKVKRGRVLRLRR 214
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
 2-50 2.33e-05

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 42.21  E-value: 2.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907172887   2 SGASKILANDIDPIAGMAITLNCKLNGLNPFPVLTK--NILNTQQGKFDLI 50
Cdd:PRK04338   79 TGVEKVTLNDINPDAVELIKKNLELNGLENEKVFNKdaNALLHEERKFDVV 129
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 3-51 6.78e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.71  E-value: 6.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907172887   3 GASKILANDIDPIAGMAITLNCKLNGLNP-FPVltKNILNTQQGKFDLIV 51
Cdd:pfam06325 183 GAKKVVGVDIDPVAVRAAKENAELNGVEArLEV--YLPGDLPKEKADVVV 230
 
Name Accession Description Interval E-value
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 1-128 2.55e-22

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 87.25  E-value: 2.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172887   1 MSGASKILANDIDPIAGMAITLNCKLNGLnPFPVLTKNILNTQ-QGKFDLIVLGDMFYDEDLADSLHLWLQNyFWTHGTR 79
Cdd:COG3897    90 KAGAADVTATDYDPEALAALRLNAALNGV-AITTRLGDWRDPPaAGGFDLILGGDVLYERDLAEPLLPFLDR-LAAPGGE 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1907172887  80 VLIGDPGRPQFsgHSIRHQLYQLVEYTLPEPTQQENNGLTTSAVWDFHP 128
Cdd:COG3897   168 VLIGDPGRGYL--PAFRERLEALAGYEVVTRELEDTEKVKRGRVLRLRR 214
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
 2-50 2.33e-05

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 42.21  E-value: 2.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907172887   2 SGASKILANDIDPIAGMAITLNCKLNGLNPFPVLTK--NILNTQQGKFDLI 50
Cdd:PRK04338   79 TGVEKVTLNDINPDAVELIKKNLELNGLENEKVFNKdaNALLHEERKFDVV 129
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 3-51 6.78e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.71  E-value: 6.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907172887   3 GASKILANDIDPIAGMAITLNCKLNGLNP-FPVltKNILNTQQGKFDLIV 51
Cdd:pfam06325 183 GAKKVVGVDIDPVAVRAAKENAELNGVEArLEV--YLPGDLPKEKADVVV 230
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
3-51 1.49e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 36.67  E-value: 1.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907172887   3 GASKILANDIDPIAGMAITLNCKLNGlnpfpVLTKNILNTQQGKFDLIV 51
Cdd:PRK00517  141 GAKKVLAVDIDPQAVEAARENAELNG-----VELNVYLPQGDLKADVIV 184
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
 6-50 2.08e-03

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 36.39  E-value: 2.08e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1907172887   6 KILANDIDPIAGMAITLNCKLNGLNPFPVLTKN---ILNTQQGKFDLI 50
Cdd:COG1867    82 KVTLNDIDPEAVELIRENLELNGLEDVEVYNRDanaLLHELGRRFDVV 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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