|
Name |
Accession |
Description |
Interval |
E-value |
| SEC21 |
COG5240 |
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]; |
56-903 |
0e+00 |
|
Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion];
Pssm-ID: 227565 [Multi-domain] Cd Length: 898 Bit Score: 654.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 56 FQHLEKSAVLQEAR-IFNETPINPRRCLHILTKILYLLNQGEHFGTMEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMAT 134
Cdd:COG5240 15 FTTLTERTLLQDMNeSFNKSPVSTRSARKLLSNLFYLLSTGELFPEATATNLFFAILKLFQHKDLYLRQCVYSAIKELSK 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 135 ISEDVIIVTSSLTKDM-TGKEDVYRGPAIRALCRITDGTMLQAVERYMKQAIVDKVSSVASSALVSSLHMMKISYDVVKR 213
Cdd:COG5240 95 LTEDVLMGTSSIMKDLnGGVPDDVKPMAIRSLFSVIDGETVYDFERYLNQAFVSTSMARRSAALVVAYHLLPNNFNQTKR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 214 WINEAQEAASS----------------DNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTK-SGLKSQFAYCMLIRIASRL 276
Cdd:COG5240 175 WLNETQEAVLDlkqfpnqhgnegyepnGNPISQYHALGLLYQSKRTDKMAQLKLVEHFRGnASMKNQLAGVLLVRATVEL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 277 LKESEDGHeSPLFDFIESCLRNKHEMVIYEAASAIIHLP--NCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMK 354
Cdd:COG5240 255 LKENSQAL-LQLRPFLNSWLSDKFEMVFLEAARAVCALSeeNVGSQFVDQTVSSLRTFLKSTRVVLRFSAMRILNQLAMK 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 355 HPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCHKYPRKHSVM 434
Cdd:COG5240 334 YPQKVSVCNKEVESLISDENRTISTYAITTLLKTGTEETIDRLVNLIPSFVHDMSDGFKIIAIDALRSLSLLFPSKKLSY 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 435 MTFLSNMLRDDGGFEYKKAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRTPVPSKYIRFIF 514
Cdd:COG5240 414 LDFLGSSLLQEGGLEFKKYMVDAISDAMENDPDSKERALEVLCTFIEDCEYHQITVRILGILGREGPRAKTPGKYVRHIY 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 515 NRVVLENEAVRAAAVSALAKFGAQNES--LLPSILVLLQRCMMDTDDEVRDRATFYLNVLQQRQmALNATYIFNGLTvSI 592
Cdd:COG5240 494 NRLILENNIVRSAAVQALSKFALNISDvvSPQSVENALKRCLNDQDDEVRDRASFLLRNMRLSD-ACEPLFSSDELG-DI 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 593 PGMEKALHQYTLEPS-EKPFDMKSIPLAMAPVF----------EQKSEITLVTPKPE---KLAPSRQDIFQEQLAAIPEF 658
Cdd:COG5240 572 PSLELELIGYISEDSfATAFDVNQVRKFTEDEMkainlkrkksETTLDTTESVPKEDansKADPNIKTKYADELLSIEQI 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 659 MNLGPLFKSSEPVQLTEAETEYFVRCVKHMFTDHIVFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLCCIPAPSLPYNQPG 738
Cdd:COG5240 652 KPFGQLVNSSREIILTEPEAEFVVKVVKHVFKDRLVLQFLLENTLEGIQLSNGIVVLTPTGGDKKEESIKVDQIDSSEGT 731
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 739 ICYTLVRLPDEDPtaVAGTFSCTMKFTVRDCDPNTGVPDEDGYDDEYVLEDLEVTVSDHIQKILKPNFAAAWeevgDAFE 818
Cdd:COG5240 732 LSIVRFKKLDWDI--EEGYVVNGLFFTTKEIEGDTSEPEDEGFQDEYSIDPFQITAGDFVRPVRIKNFPATF----DRLK 805
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 819 KEETFAL--SSTKTLEEAVNNIITFLGMQPCErSDKVPENKNSHSLYLAGVYRGGYDLLVRSRLA--LADGVTMQVTVRS 894
Cdd:COG5240 806 REITFVLqgDIYASGKKILDKILLNSMKIPTE-ETETPNDSNTHVMKLNGKAYHGTKVSIRVKMVysMACGCTVKVYCDG 884
|
....*....
gi 1907173153 895 KERTPVDVI 903
Cdd:COG5240 885 ESLYVTQLV 893
|
|
| Adaptin_N |
pfam01602 |
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ... |
60-576 |
1.23e-160 |
|
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain] Cd Length: 523 Bit Score: 480.19 E-value: 1.23e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 60 EKSAVLQE-ARIFNETPINPRRCLHILTKILYLLNQGEHFGtmeatEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISED 138
Cdd:pfam01602 1 EEKRIQQElARILNSFRDDPRKKKNAVKKLLYLIMLGEDIS-----FLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 139 V-IIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAVERYMKQAIVDKVSSVASSALVSSLHMMKISYDVVKRWINE 217
Cdd:pfam01602 76 LaILVTNSIQKDLQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 218 AQEAASSDNIMVQYHALGVLYHLRKNDRLAVsKMLNKFTK-----SGLKSQFAYCMLIRIASRLLKESEDGhESPLFDFI 292
Cdd:pfam01602 156 LKELLSDKDPGVQSAAVALLYEICKNDRLYL-KLLPLLFRrlcnlLGVLNPWLQVKILRLLTRLAPLDPLL-PKELLEDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 293 ESCLRNKHEMVIYEAASAIIHLPNCTAReLAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITD 372
Cdd:pfam01602 234 LNLLQNSNNAVLYETANTIVHLAPAPEL-IVLAVNALGRLLSSPDENLRYVALRNLNKIVMKEPKAVQHLDLIIFCLKTD 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 373 SNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISD-EFKVVVVQAISALCHKYPRKHSVMMTFLSNMLRDDGGFeYK 451
Cdd:pfam01602 313 DDISIRLRALDLLYALVNESNVKEIVKELLKYVHEIADpDFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSY-VV 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 452 KAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGPRTP---VPSKYIRFIFNRVVLENEAVRAAA 528
Cdd:pfam01602 392 DEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPngsSPPDLLRSILEVFVLESAKVRAAA 471
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1907173153 529 VSALAKFGAQN--ESLLPSILVLLQRCMM--DTDDEVRDRATFYLNVLQQRQ 576
Cdd:pfam01602 472 LTALAKLGLTSpeETTQNLIIQLLLTLATqdSLDLEVRDRAVEYLRLLSLAD 523
|
|
| COP-gamma_platf |
pfam08752 |
Coatomer gamma subunit appendage platform subdomain; COPI-coated vesicles function in ... |
646-793 |
2.76e-87 |
|
Coatomer gamma subunit appendage platform subdomain; COPI-coated vesicles function in retrograde transport from the Golgi to the ER, and in intra-Golgi transport. This is the platform subdomain of the coatomer gamma subunit appendage domain. It carries a protein-protein interaction site at UniProt:P53620, residue W776, which in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2.
Pssm-ID: 462588 Cd Length: 149 Bit Score: 274.80 E-value: 2.76e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 646 DIFQEQLAAIPEFMNLGPLFKSSEPVQLTEAETEYFVRCVKHMFTDHIVFQFDCTNTLNDQLLEKVTVQMEPSDSYEVLC 725
Cdd:pfam08752 1 QKYAEQLAAIPEFASLGPLFKSSKPVELTESETEYVVSCVKHIFKEHIVLQFNIKNTLNDQVLENVSVVMEPSEEFEDVF 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907173153 726 CIPAPSLPYNQPGICYTLVRLPD-EDPTAVAGTFSCTMKFTVRDCDPNTGVPDEDGYDDEYVLEDLEVT 793
Cdd:pfam08752 81 IIPIPSLPPNEPGSVYVSFERPDpEEEYLVSGTFSNTLKFTVKEIDPSTGEPEEEGYEDEYQLEDLELT 149
|
|
| Coatomer_g_Cpla |
pfam16381 |
Coatomer subunit gamma-1 C-terminal appendage platform; Coatomer_g_Cpla is the very C-terminal ... |
795-907 |
5.83e-48 |
|
Coatomer subunit gamma-1 C-terminal appendage platform; Coatomer_g_Cpla is the very C-terminal domain of the eukaryotic Coatomer subunit gamma-1 proteins. It acts as a platform domain to the C-terminal appendage. It carries one single protein/protein interaction site, which is the binding site for ARFGAP2 or ADP-ribosylation factor GTPase-activating protein. COPI-coated vesicles mediate retrograde transport from the Golgi back to the ER and intra-Golgi transport. The gamma-COPI is part of one of two subcomplexes that make up the heptameric coatomer complex along with the beta, delta and zeta subunits.
Pssm-ID: 406717 Cd Length: 114 Bit Score: 165.85 E-value: 5.83e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 795 SDHIQKILKPNFAAAWEEVGDAFEKEETFALSSTKTLEEAVNNIITFLGMQPCERSDKVPENKNSHSLYLAGVYRGGYDL 874
Cdd:pfam16381 1 GDYIQPVFVGNFAAAWDELPSEGEASETFALSSVKSLQEAVDKLIELLGMQPLEGSDVVPENASSHTLKLSGKFVGGGKV 80
|
90 100 110
....*....|....*....|....*....|....
gi 1907173153 875 LVRSRLALAD-GVTMQVTVRSKERTPVDVILASV 907
Cdd:pfam16381 81 LVRARLAISSgGVTMKLTVRSESEEVCELVLSAV 114
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
328-423 |
4.97e-05 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 42.71 E-value: 4.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 328 VLQLFCSSPKPALRYAAVRTLnkVAMKHPSAVTAcnldLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISsfvse 407
Cdd:pfam13646 4 LLQALLRDPDPEVRAAAIRAL--GRIGDPEAVPA----LLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLR----- 72
|
90
....*....|....*.
gi 1907173153 408 iSDEFKVVVVQAISAL 423
Cdd:pfam13646 73 -DDDDDVVRAAAAEAL 87
|
|
| UNC45-central |
pfam11701 |
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ... |
362-534 |
6.92e-04 |
|
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.
Pssm-ID: 432011 Cd Length: 151 Bit Score: 40.98 E-value: 6.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 362 CNLDLEnlITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALchkYPrkhsVMMTFLSNM 441
Cdd:pfam11701 8 KFLDLR--LPESVRSLALLILSKLLEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAAL---FP----VPPDVASAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 442 LRDDGgfeykkaivdciisIVEEnpeskeagLAHLCEFIEDcehTVLATKILHLL----GKEGPRTPVPSKYIRFIFNRV 517
Cdd:pfam11701 79 FLSEG--------------FLES--------LLPLVESKKS---RKVELAALELLsaacIDKACREAISKNYVDWLEELL 133
|
170
....*....|....*..
gi 1907173153 518 VLENEAVRAAAVSALAK 534
Cdd:pfam11701 134 KSSDDEIKALAAVVLAK 150
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
303-423 |
9.77e-04 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 40.38 E-value: 9.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 303 VIYEAASAIIHLPNctarelAPAVSVLQLFCSSPKPALRYAAVRTLnkVAMKHPSAVTAcnldLENLITDSNRSIATLAI 382
Cdd:COG1413 1 VRRAAARALGRLGD------PAAVPALIAALADEDPDVRAAAARAL--GRLGDPRAVPA----LLEALKDPDPEVRAAAA 68
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1907173153 383 TTLLKTGSESSVDRLMKQissfvseISDEFKVVVVQAISAL 423
Cdd:COG1413 69 EALGRIGDPEAVPALIAA-------LKDEDPEVRRAAAEAL 102
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
473-569 |
1.24e-03 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 38.86 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 473 LAHLCEFIEDCEHTVLATKILHLLGKEGPRTPVPskyirFIFNRVVLENEAVRAAAVSALAKFGaqNESLLPsilVLLQR 552
Cdd:pfam13646 1 LPALLQALLRDPDPEVRAAAIRALGRIGDPEAVP-----ALLELLKDEDPAVRRAAAEALGKIG--DPEALP---ALLEL 70
|
90
....*....|....*..
gi 1907173153 553 CMMDTDDEVRDRATFYL 569
Cdd:pfam13646 71 LRDDDDDVVRAAAAEAL 87
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
289-389 |
3.55e-03 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 38.84 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 289 FDFIESCLRNKHEMVIYEAASAIIHLPNctarelAPAVSVLQLFCSSPKPALRYAAVRTLNKvaMKHPSAVTAcnldLEN 368
Cdd:COG1413 49 VPALLEALKDPDPEVRAAAAEALGRIGD------PEAVPALIAALKDEDPEVRRAAAEALGR--LGDPAAVPA----LLE 116
|
90 100
....*....|....*....|.
gi 1907173153 369 LITDSNRSIATLAITTLLKTG 389
Cdd:COG1413 117 ALKDPDWEVRRAAARALGRLG 137
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
340-569 |
5.10e-03 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 38.07 E-value: 5.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 340 LRYAAVRTLnkVAMKHPSAVTAcnldLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISsfvseisDEFKVVVVQA 419
Cdd:COG1413 1 VRRAAARAL--GRLGDPAAVPA----LIAALADEDPDVRAAAARALGRLGDPRAVPALLEALK-------DPDPEVRAAA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 420 ISALCHkyprkhsvmmtflsnmLRDdggfeykkaivdciisiveenpeskEAGLAHLCEFIEDcehtvlatkilhllgke 499
Cdd:COG1413 68 AEALGR----------------IGD-------------------------PEAVPALIAALKD----------------- 89
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907173153 500 gprtpvpskyirfifnrvvlENEAVRAAAVSALAKFGaqNESLLPSILVLLQrcmmDTDDEVRDRATFYL 569
Cdd:COG1413 90 --------------------EDPEVRRAAAEALGRLG--DPAAVPALLEALK----DPDWEVRRAAARAL 133
|
|
| |
