NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958677358|ref|XP_038948411|]
View 

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Rib_hydrolase super family cl08346
ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; ADP-ribosyl cyclase ...
 41-179 6.15e-80

ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; ADP-ribosyl cyclase (EC:3.2.2.5) synthesizes the second messenger cyclic-ADP ribose (cADPR), which in turn releases calcium from internal stores. Mammals possess two membrane proteins, CD38 and BST-1/CD157, which exhibit ADP-ribosyl cyclase activity, as well as intracellular soluble ADP-ribose cyclases. CD38 is involved in differentiation, adhesion, and cell proliferation, and has been implicated in diseases such as AIDS, diabetes, and B-cell chronic lymphocytic leukemia. The extramembrane domain of CD38 acts as a multifunctional enzyme, and can synthesize cADPR from NAD+, hydrolyze NAD+ and cADPR to ADPR, as well as catalyze the exchange of the nicotinamide group of NADP+ with nicotinic acid under acidic conditions, to yield NAADP+ (nicotinic acid-adenine dinucleotide phosphate), a metabolite involved in Ca2+ mobilization from acidic stores.


The actual alignment was detected with superfamily member pfam02267:

Pssm-ID: 471812  Cd Length: 229  Bit Score: 237.95  E-value: 6.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677358  41 TPHLQSIFLGRCAEYTTLLSLEPGNKNCTAIWEAFK-VVLDKDPCSVLPSDYDLFINLSRHAIPRDKSLFWENNHLLVMS 119
Cdd:pfam02267   1 TPHLKEIFLGRCYEYITLLNPELRDKDCEAIWEAFKsAFVSKDPCNVTPEDYDPLINLAPQTIPCNKSLFWSKTKDLVHS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677358 120 YAENTRRLMPLCDVLYGKVGDFLSWCRQENASGLDYQSCPTAEDCENNAVDAYWKSASMQ 179
Cdd:pfam02267  81 YTQVQRRFFTLEDTLLGYMADGLSWCGQEGSSGMNYQSCPTWEDCENNPVSSFWKRASKQ 140
 
Name Accession Description Interval E-value
Rib_hydrolayse pfam02267
ADP-ribosyl cyclase; ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase ...
 41-179 6.15e-80

ADP-ribosyl cyclase; ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesizes cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.


Pssm-ID: 460517  Cd Length: 229  Bit Score: 237.95  E-value: 6.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677358  41 TPHLQSIFLGRCAEYTTLLSLEPGNKNCTAIWEAFK-VVLDKDPCSVLPSDYDLFINLSRHAIPRDKSLFWENNHLLVMS 119
Cdd:pfam02267   1 TPHLKEIFLGRCYEYITLLNPELRDKDCEAIWEAFKsAFVSKDPCNVTPEDYDPLINLAPQTIPCNKSLFWSKTKDLVHS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677358 120 YAENTRRLMPLCDVLYGKVGDFLSWCRQENASGLDYQSCPTAEDCENNAVDAYWKSASMQ 179
Cdd:pfam02267  81 YTQVQRRFFTLEDTLLGYMADGLSWCGQEGSSGMNYQSCPTWEDCENNPVSSFWKRASKQ 140
Rib_hydrolase cd04759
ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; ADP-ribosyl cyclase ...
 39-180 1.76e-64

ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; ADP-ribosyl cyclase (EC:3.2.2.5) synthesizes the second messenger cyclic-ADP ribose (cADPR), which in turn releases calcium from internal stores. Mammals possess two membrane proteins, CD38 and BST-1/CD157, which exhibit ADP-ribosyl cyclase activity, as well as intracellular soluble ADP-ribose cyclases. CD38 is involved in differentiation, adhesion, and cell proliferation, and has been implicated in diseases such as AIDS, diabetes, and B-cell chronic lymphocytic leukemia. The extramembrane domain of CD38 acts as a multifunctional enzyme, and can synthesize cADPR from NAD+, hydrolyze NAD+ and cADPR to ADPR, as well as catalyze the exchange of the nicotinamide group of NADP+ with nicotinic acid under acidic conditions, to yield NAADP+ (nicotinic acid-adenine dinucleotide phosphate), a metabolite involved in Ca2+ mobilization from acidic stores.


Pssm-ID: 212498  Cd Length: 244  Bit Score: 199.44  E-value: 1.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677358  39 GTTPHLQSIFLGRCAEYTTLLSLEPGNKNCTAIWEAF-KVVLDKDPCSVLPSDYDLFINLSRHAIPRDKSLFWENNHLLV 117
Cdd:cd04759     1 GTTPNLKEIFLGRCYDYQALHNPEEREVDCSKLWNAFeKAFAFKDPCNVTPEDYDPFFNLAPQTIPCDKTLFWSGTYDLV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958677358 118 MSYAENTRRLMPLCDVLYGKVGDFLSWCRQENASGLDYQSCPTAEDCENNAVDAYWKSASMQL 180
Cdd:cd04759    81 HSYTKVLRRFFTLEDTLPGYLLNGLTWCGQKDSSGINYTSCPTWEECSNNAVDAFWKRASARF 143
 
Name Accession Description Interval E-value
Rib_hydrolayse pfam02267
ADP-ribosyl cyclase; ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase ...
 41-179 6.15e-80

ADP-ribosyl cyclase; ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose hydrolase or CD38) synthesizes cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.


Pssm-ID: 460517  Cd Length: 229  Bit Score: 237.95  E-value: 6.15e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677358  41 TPHLQSIFLGRCAEYTTLLSLEPGNKNCTAIWEAFK-VVLDKDPCSVLPSDYDLFINLSRHAIPRDKSLFWENNHLLVMS 119
Cdd:pfam02267   1 TPHLKEIFLGRCYEYITLLNPELRDKDCEAIWEAFKsAFVSKDPCNVTPEDYDPLINLAPQTIPCNKSLFWSKTKDLVHS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677358 120 YAENTRRLMPLCDVLYGKVGDFLSWCRQENASGLDYQSCPTAEDCENNAVDAYWKSASMQ 179
Cdd:pfam02267  81 YTQVQRRFFTLEDTLLGYMADGLSWCGQEGSSGMNYQSCPTWEDCENNPVSSFWKRASKQ 140
Rib_hydrolase cd04759
ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; ADP-ribosyl cyclase ...
 39-180 1.76e-64

ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; ADP-ribosyl cyclase (EC:3.2.2.5) synthesizes the second messenger cyclic-ADP ribose (cADPR), which in turn releases calcium from internal stores. Mammals possess two membrane proteins, CD38 and BST-1/CD157, which exhibit ADP-ribosyl cyclase activity, as well as intracellular soluble ADP-ribose cyclases. CD38 is involved in differentiation, adhesion, and cell proliferation, and has been implicated in diseases such as AIDS, diabetes, and B-cell chronic lymphocytic leukemia. The extramembrane domain of CD38 acts as a multifunctional enzyme, and can synthesize cADPR from NAD+, hydrolyze NAD+ and cADPR to ADPR, as well as catalyze the exchange of the nicotinamide group of NADP+ with nicotinic acid under acidic conditions, to yield NAADP+ (nicotinic acid-adenine dinucleotide phosphate), a metabolite involved in Ca2+ mobilization from acidic stores.


Pssm-ID: 212498  Cd Length: 244  Bit Score: 199.44  E-value: 1.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677358  39 GTTPHLQSIFLGRCAEYTTLLSLEPGNKNCTAIWEAF-KVVLDKDPCSVLPSDYDLFINLSRHAIPRDKSLFWENNHLLV 117
Cdd:cd04759     1 GTTPNLKEIFLGRCYDYQALHNPEEREVDCSKLWNAFeKAFAFKDPCNVTPEDYDPFFNLAPQTIPCDKTLFWSGTYDLV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958677358 118 MSYAENTRRLMPLCDVLYGKVGDFLSWCRQENASGLDYQSCPTAEDCENNAVDAYWKSASMQL 180
Cdd:cd04759    81 HSYTKVLRRFFTLEDTLPGYLLNGLTWCGQKDSSGINYTSCPTWEECSNNAVDAFWKRASARF 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH