NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958757284|ref|XP_038954684|]
View 

probable E3 ubiquitin-protein ligase HERC4 isoform X4 [Rattus norvegicus]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18804227)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 588-934 2.84e-158

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 468.58  E-value: 2.84e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 588 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 666
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 667 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 743
Cdd:cd00078    81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 744 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 822
Cdd:cd00078   159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 823 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPV 900
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1958757284 901 SHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFS 934
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-338 9.28e-86

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 278.78  E-value: 9.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284   3 CWGNASYGQLGLGgiDEEIVLEPRKSDFFVNkkVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184    21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLqGSEECIRVPRNI-KSLSDiqIVQVACGYYHSLALSKASEVF 159
Cdd:COG5184    97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPVQVdAGLSG--VVAIAAGGYHTCALKSDGTVW 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 160 CWGQNKYGQLGLGIECQkQTSPQLIKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Cdd:COG5184   172 CWGANSYGQLGDGTTTD-RPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 240 rsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGRIYSF 319
Cdd:COG5184   249 --TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCA-LLTDGTVWCW 323

                         330
                  ....*....|....*....
gi 1958757284 320 GLGGNGQLGTGSTSNRKSP 338
Cdd:COG5184   324 GDNAYGQLGDGTTTDRSTP 342
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 588-934 2.84e-158

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 468.58  E-value: 2.84e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 588 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 666
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 667 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 743
Cdd:cd00078    81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 744 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 822
Cdd:cd00078   159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 823 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPV 900
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1958757284 901 SHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFS 934
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 614-933 2.97e-124

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 379.27  E-value: 2.97e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  614 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSD----LFHLIGVICGLAIYNFT 689
Cdd:smart00119   4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEehlsYFRFIGRVLGKALYDNR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  690 IVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQL-LDYPEDDIEEtfcLNFTITVEN-FGATEVKELVLNGADTAV 767
Cdd:smart00119  84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSNIPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  768 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 847
Cdd:smart00119 161 TEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQT 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  848 IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQ 925
Cdd:smart00119 241 IKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLLL 320


                   ....*...
gi 1958757284  926 AIDHNEGF 933
Cdd:smart00119 321 AINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 638-936 4.93e-116

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 356.92  E-value: 4.93e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 638 LLIMRELLDPKYGMFRY-YEDSRLIWFSDKTFED-----SDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLD 711
Cdd:pfam00632   1 TLLSKELFDPNYGLFEYeTEDDRTYWFNPSSSESpdlelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 712 DLKELMPDVGRSMQQLLDYpEDDIEETFCLNFTITVenFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASL 791
Cdd:pfam00632  81 DLESIDPELYKSLKSLLNM-DNDDDEDLGLTFTIPV--FGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 792 FDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLT 871
Cdd:pfam00632 158 LEAFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVT 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958757284 872 GSDRIPILGMKSL-KLVIQSTGG-GESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 936
Cdd:pfam00632 238 GSSRLPVGGFKSLpKFTIVRKGGdDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
411-936 8.97e-101

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 334.81  E-value: 8.97e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 411 LSYPSGRFPVEIANEIDGTFSSSGClngsFLAVSNDDHYRTGTRFSGVDMNAARLLFHRLIQPDhPQISQQVNErTGQLI 490
Cdd:COG5021   330 LEETLGESTSFLVVNNDDSSSIKDL----PHQVGSNPFLEAHPEFSELLKNQSRGTTRDFRNKP-TGWSSSIED-LGQFL 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 491 QYDKFyiHEVQELIDIRND-----------YINWVQQQAYGVDVSHGITELADIPVTICTYpfvFDAQAKTTLLQTD--- 556
Cdd:COG5021   404 FSDFL--TSSSTYEDLRREqlgresdesfyVASNVQQQRASREGPLLSGWKTRLNNLYRFY---FVEHRKKTLTKNDsrl 478

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 557 --AVLQMQMAIDQ---AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGG 631
Cdd:COG5021   479 gsFISLNKLDIRRikeDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGG 558

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 632 VRKEFFLLIMRELLDPKYGMFRYYEDSRLIW----FSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRK 707
Cdd:COG5021   559 LTREWLFLLSKEMFNPDYGLFEYITEDLYTLpinpLSSINPEHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKP 638

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 708 PSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKS 787
Cdd:COG5021   639 VSLVDLESLDPELYRSLVWLLNNDID--ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKR 716

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 788 VASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGeYWAEHPTIKIFWEVFHELPLEKKKQF 866
Cdd:COG5021   717 VEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKL 795

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958757284 867 LLFLTGSDRIPILGMKSL-------KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 936
Cdd:COG5021   796 LQFVTGTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-338 9.28e-86

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 278.78  E-value: 9.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284   3 CWGNASYGQLGLGgiDEEIVLEPRKSDFFVNkkVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184    21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLqGSEECIRVPRNI-KSLSDiqIVQVACGYYHSLALSKASEVF 159
Cdd:COG5184    97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPVQVdAGLSG--VVAIAAGGYHTCALKSDGTVW 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 160 CWGQNKYGQLGLGIECQkQTSPQLIKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Cdd:COG5184   172 CWGANSYGQLGDGTTTD-RPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 240 rsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGRIYSF 319
Cdd:COG5184   249 --TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCA-LLTDGTVWCW 323

                         330
                  ....*....|....*....
gi 1958757284 320 GLGGNGQLGTGSTSNRKSP 338
Cdd:COG5184   324 GDNAYGQLGDGTTTDRSTP 342
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 8.37e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 72.16  E-value: 8.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958757284 208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 588-934 2.84e-158

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 468.58  E-value: 2.84e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 588 LILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDS-RLIWFSDK 666
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 667 TFEDSD---LFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNF 743
Cdd:cd00078    81 SFADEDhlkLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGD--EDDLELTF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 744 TITVEN-FGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG 822
Cdd:cd00078   159 TIELDSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 823 NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPV 900
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLnpKFTIRRVGSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1958757284 901 SHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFS 934
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGFG 352
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 614-933 2.97e-124

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 379.27  E-value: 2.97e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  614 KKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSD----LFHLIGVICGLAIYNFT 689
Cdd:smart00119   4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEehlsYFRFIGRVLGKALYDNR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  690 IVDLHFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQL-LDYPEDDIEEtfcLNFTITVEN-FGATEVKELVLNGADTAV 767
Cdd:smart00119  84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEELD---LTFSIVLTSeFGQVKVVELKPGGSNIPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  768 NKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT 847
Cdd:smart00119 161 TEENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQT 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  848 IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQ 925
Cdd:smart00119 241 IKWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALspKFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREKLLL 320


                   ....*...
gi 1958757284  926 AIDHNEGF 933
Cdd:smart00119 321 AINEGKGF 328
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 638-936 4.93e-116

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 356.92  E-value: 4.93e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 638 LLIMRELLDPKYGMFRY-YEDSRLIWFSDKTFED-----SDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRKPSLD 711
Cdd:pfam00632   1 TLLSKELFDPNYGLFEYeTEDDRTYWFNPSSSESpdlelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 712 DLKELMPDVGRSMQQLLDYpEDDIEETFCLNFTITVenFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASL 791
Cdd:pfam00632  81 DLESIDPELYKSLKSLLNM-DNDDDEDLGLTFTIPV--FGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 792 FDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLT 871
Cdd:pfam00632 158 LEAFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVT 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958757284 872 GSDRIPILGMKSL-KLVIQSTGG-GESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 936
Cdd:pfam00632 238 GSSRLPVGGFKSLpKFTIVRKGGdDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGFGLS 304
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
411-936 8.97e-101

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 334.81  E-value: 8.97e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 411 LSYPSGRFPVEIANEIDGTFSSSGClngsFLAVSNDDHYRTGTRFSGVDMNAARLLFHRLIQPDhPQISQQVNErTGQLI 490
Cdd:COG5021   330 LEETLGESTSFLVVNNDDSSSIKDL----PHQVGSNPFLEAHPEFSELLKNQSRGTTRDFRNKP-TGWSSSIED-LGQFL 403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 491 QYDKFyiHEVQELIDIRND-----------YINWVQQQAYGVDVSHGITELADIPVTICTYpfvFDAQAKTTLLQTD--- 556
Cdd:COG5021   404 FSDFL--TSSSTYEDLRREqlgresdesfyVASNVQQQRASREGPLLSGWKTRLNNLYRFY---FVEHRKKTLTKNDsrl 478

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 557 --AVLQMQMAIDQ---AHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGG 631
Cdd:COG5021   479 gsFISLNKLDIRRikeDKRRKLFYSLKQKAKIFDPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGG 558

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 632 VRKEFFLLIMRELLDPKYGMFRYYEDSRLIW----FSDKTFEDSDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRK 707
Cdd:COG5021   559 LTREWLFLLSKEMFNPDYGLFEYITEDLYTLpinpLSSINPEHLSYFKFLGRVIGKAIYDSRILDVQFSKAFYKKLLGKP 638

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 708 PSLDDLKELMPDVGRSMQQLLDYPEDdiEETFCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKS 787
Cdd:COG5021   639 VSLVDLESLDPELYRSLVWLLNNDID--ETILDLTFTVEDDSFGESRTVELIPNGRNISVTNENKKEYVKKVVDYKLNKR 716

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 788 VASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGeYWAEHPTIKIFWEVFHELPLEKKKQF 866
Cdd:COG5021   717 VEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAYHG-YTEDSPIIVWFWEIISEFDFEERAKL 795

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958757284 867 LLFLTGSDRIPILGMKSL-------KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSLI 936
Cdd:COG5021   796 LQFVTGTSRIPINGFKDLqgsdgvrKFTIEKGGTDDDRLPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGFGLL 872
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-338 9.28e-86

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 278.78  E-value: 9.28e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284   3 CWGNASYGQLGLGgiDEEIVLEPRKSDFFVNkkVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVA 80
Cdd:COG5184    21 CWGDNSYGQLGDG--TTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGdgTTTDRTTPVKVPG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  81 LDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLqGSEECIRVPRNI-KSLSDiqIVQVACGYYHSLALSKASEVF 159
Cdd:COG5184    97 LT--GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-GTTTNRLTPVQVdAGLSG--VVAIAAGGYHTCALKSDGTVW 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 160 CWGQNKYGQLGLGIECQkQTSPQLIKSLLGIpfMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSL 239
Cdd:COG5184   172 CWGANSYGQLGDGTTTD-RPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 240 rsQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGRIYSF 319
Cdd:COG5184   249 --TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCA-LLTDGTVWCW 323

                         330
                  ....*....|....*....
gi 1958757284 320 GLGGNGQLGTGSTSNRKSP 338
Cdd:COG5184   324 GDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 37-343 6.92e-82

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 268.38  E-value: 6.92e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  37 RDVGCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDG 114
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGdgTTTDRSTPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 115 QLGlQGSEECIRVPRNIKSLSDiqIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGiECQKQTSPQLIKSLLGiPFMQ 194
Cdd:COG5184    79 QLG-DGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQVDAGLS-GVVA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 195 VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSqkIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Cdd:COG5184   154 IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQL 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958757284 275 GHNSTSHEINPRKVFELMGsiVTQIACGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Cdd:COG5184   232 GDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCA-LKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG 297
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 1-172 6.40e-42

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 157.06  E-value: 6.40e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284   1 MLCWGNASYGQLGLGGIDEEIVlePRKSDFFVNkkVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE--KSRKKPEQV 78
Cdd:COG5184   170 VWCWGANSYGQLGDGTTTDRPT--PVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGttTDRATPVQV 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284  79 VALDaqNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGlQGSEECIRVPRNIKSLSDiqIVQVACGYYHSLALSKASEV 158
Cdd:COG5184   246 AGLT--GVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLG-DGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTV 320

                         170
                  ....*....|....
gi 1958757284 159 FCWGQNKYGQLGLG 172
Cdd:COG5184   321 WCWGDNAYGQLGDG 334
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 194-375 3.67e-33

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 131.25  E-value: 3.67e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRsqKIVYICCGEDHTAALTKEGGVFTFGAGGYGQ 273
Cdd:COG5184     2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLS--NVVAVAAGGDHTCALKADGTVWCWGNNSYGQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958757284 274 LGHNSTSHEINPRKVFELmgSIVTQIACGRQHTSAfVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVkgnwfsyngqcp 353
Cdd:COG5184    80 LGDGTTTDRTTPVKVPGL--TGVVAVAAGYYHSCA-LKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV------------ 144

                         170       180
                  ....*....|....*....|..
gi 1958757284 354 qDIGSEDyfcVKRIFSGGDQSF 375
Cdd:COG5184   145 -DAGLSG---VVAIAAGGYHTC 162
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
208-257 8.37e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 72.16  E-value: 8.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958757284 208 SGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
102-152 4.48e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 69.85  E-value: 4.48e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958757284 102 KGQVYAWGLDSDGQLGLqGSEECIRVPRNIKSLSDIQIVQVACGYYHSLAL 152
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGL-GTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
52-99 4.36e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.46  E-value: 4.36e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958757284  52 DGTVYTCGCNDLGQLGH--EKSRKKPEQVVALDAQNIVAVSCGEAHTLAL 99
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLgtTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
260-308 4.54e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 64.46  E-value: 4.54e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958757284 260 EGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSA 308
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
157-205 9.81e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 63.31  E-value: 9.81e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958757284 157 EVFCWGQNKYGQLGLGIEcQKQTSPQLIKSLLGIPFMQVAAGGAHSFVL 205
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
139-168 2.67e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.20  E-value: 2.67e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958757284 139 IVQVACGYYHSLALSKASEVFCWGQNKYGQ 168
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
3-49 3.65e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 50.21  E-value: 3.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958757284   3 CWGNASYGQLGLGgiDEEIVLEPRKSDFFVNKKVRDVGCGLRHTVFV 49
Cdd:pfam00415   6 TWGRNDYGQLGLG--TTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
86-115 6.10e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 49.34  E-value: 6.10e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958757284  86 IVAVSCGEAHTLALNDKGQVYAWGLDSDGQ 115
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
36-65 1.97e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.80  E-value: 1.97e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958757284  36 VRDVGCGLRHTVFVLDDGTVYTCGCNDLGQ 65
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
194-221 2.81e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 44.34  E-value: 2.81e-06
                          10        20
                  ....*....|....*....|....*...
gi 1958757284 194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQ 221
Cdd:pfam13540   3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
313-343 1.91e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 42.50  E-value: 1.91e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958757284 313 SGRIYSFGLGGNGQLGTGSTSNRKSPFTVKG 343
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG 31
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
244-273 2.40e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.03  E-value: 2.40e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1958757284 244 IVYICCGEDHTAALTKEGGVFTFGAGGYGQ 273
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
296-326 1.00e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.40  E-value: 1.00e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958757284 296 VTQIACGRQHTsAFVPSSGRIYSFGLGGNGQ 326
Cdd:pfam13540   1 VVSVAAGDNHT-LALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH