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Conserved domains on  [gi|2116748543|ref|XP_044233261|]
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zinc finger protein 271-like isoform X2 [Thunnus albacares]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-654 3.18e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 231 KPFSCNTCGRRFSEKAKVNRHMRTHTGEKPHSCN--SCEKRFSRLGALKVHMRVHTELPQHhvckvekvladqqlcNQER 308
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD---------------LNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 309 NSSLDQEDREPPQIKEEQEEPYTSLDGEQLVLKQETGTFMLTATCEESDNGEDQILD--LSPVETQSAAEKEHVVSMSVK 386
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGnnSSSVNTPQSNSLHPPLPANSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 387 SSVVPDPNSVDQLLSHISHLAESQDhiggkqgdsgstrNAETKAQKRHDRSKNHTSNEDSSTTLKIHSNTYIGKrcfkch 466
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSE-------------NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP------ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 467 tcgKSFKCKYNLQTHLRFHTGERP--YPCNTCEKRFSQPSDLKLHMRVHTG-EKPYPCNTCGKGFCRMADLKTHMR--IH 541
Cdd:COG5048   238 ---KSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 542 TGE--KPYPC--NICWKRFSDRTTVKRHIRTHTGEKPYPC--NTCGKRFGRM------AYLKNHIRVHTGEKPYPCDS-C 608
Cdd:COG5048   315 SGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNsC 394

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2116748543 609 EKRFSELGILKVHMKIHTGEKPYNCE--TCGKDFRLGHQLKIHMRTHT 654
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-654 3.18e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 231 KPFSCNTCGRRFSEKAKVNRHMRTHTGEKPHSCN--SCEKRFSRLGALKVHMRVHTELPQHhvckvekvladqqlcNQER 308
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD---------------LNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 309 NSSLDQEDREPPQIKEEQEEPYTSLDGEQLVLKQETGTFMLTATCEESDNGEDQILD--LSPVETQSAAEKEHVVSMSVK 386
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGnnSSSVNTPQSNSLHPPLPANSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 387 SSVVPDPNSVDQLLSHISHLAESQDhiggkqgdsgstrNAETKAQKRHDRSKNHTSNEDSSTTLKIHSNTYIGKrcfkch 466
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSE-------------NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP------ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 467 tcgKSFKCKYNLQTHLRFHTGERP--YPCNTCEKRFSQPSDLKLHMRVHTG-EKPYPCNTCGKGFCRMADLKTHMR--IH 541
Cdd:COG5048   238 ---KSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 542 TGE--KPYPC--NICWKRFSDRTTVKRHIRTHTGEKPYPC--NTCGKRFGRM------AYLKNHIRVHTGEKPYPCDS-C 608
Cdd:COG5048   315 SGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNsC 394

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2116748543 609 EKRFSELGILKVHMKIHTGEKPYNCE--TCGKDFRLGHQLKIHMRTHT 654
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-272 1.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.20e-04
                          10        20
                  ....*....|....*....|....
gi 2116748543 249 NRHMRTHTGEKPHSCNSCEKRFSR 272
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-654 3.18e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 231 KPFSCNTCGRRFSEKAKVNRHMRTHTGEKPHSCN--SCEKRFSRLGALKVHMRVHTELPQHhvckvekvladqqlcNQER 308
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD---------------LNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 309 NSSLDQEDREPPQIKEEQEEPYTSLDGEQLVLKQETGTFMLTATCEESDNGEDQILD--LSPVETQSAAEKEHVVSMSVK 386
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGnnSSSVNTPQSNSLHPPLPANSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 387 SSVVPDPNSVDQLLSHISHLAESQDhiggkqgdsgstrNAETKAQKRHDRSKNHTSNEDSSTTLKIHSNTYIGKrcfkch 466
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSE-------------NSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP------ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 467 tcgKSFKCKYNLQTHLRFHTGERP--YPCNTCEKRFSQPSDLKLHMRVHTG-EKPYPCNTCGKGFCRMADLKTHMR--IH 541
Cdd:COG5048   238 ---KSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNH 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 542 TGE--KPYPC--NICWKRFSDRTTVKRHIRTHTGEKPYPC--NTCGKRFGRM------AYLKNHIRVHTGEKPYPCDS-C 608
Cdd:COG5048   315 SGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNsC 394

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2116748543 609 EKRFSELGILKVHMKIHTGEKPYNCE--TCGKDFRLGHQLKIHMRTHT 654
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
188-621 4.48e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 4.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 188 NSTSLKIHSNTYTGKKSLKCDSCGKTFKCKSKLHTHMRVHTGEKPFSCNTCGR--RFSEKAKVNRHMRTHTGEKPHSCNS 265
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 266 C-----EKRFSRLGALKVHMRVHTELPQHHVCKVEKVLADQQLCNQERNSSLDQEDREPPQIKEEQEEPYTSLDGEQLVL 340
Cdd:COG5048    97 SlplsnSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 341 KQETGTFMLTATCEESDNGEDQILDLSPVETQSAAEKEHvvsmsvkSSVVPDPNSVDQLLSHISHLaeSQDHIggkqgDS 420
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSS-------SDQNLENSSSSLPLTTNSQL--SPKSL-----LS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 421 GSTRNAETKAQKRHDRSKNHTSNEDSSTTLKIHSNTYIGKRC-----FKCHTCGKSFKCKYNLQTHLR--FHTGE--RPY 491
Cdd:COG5048   243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 492 PC--NTCEKRFSQPSDLKLHMRVHTGEKPYPCNTCGKGF--------CRMADLKTHMRIHTGEKPYPC-NICWKRFSDRT 560
Cdd:COG5048   323 SCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSkfspllnnEPPQSLQQYKDLKNDKKSETLsNSCIRNFKRDS 402

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2116748543 561 TVKRHIRTHTGEKP--YPCNTCGKRFGRMAYLKNHIRVHTgEKPYPCDSCEKRFSELGILKVH 621
Cdd:COG5048   403 NLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-272 1.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.20e-04
                          10        20
                  ....*....|....*....|....
gi 2116748543 249 NRHMRTHTGEKPHSCNSCEKRFSR 272
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
563-584 1.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.68e-04
                          10        20
                  ....*....|....*....|..
gi 2116748543 563 KRHIRTHTGEKPYPCNTCGKRF 584
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
477-502 1.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.73e-04
                          10        20
                  ....*....|....*....|....*.
gi 2116748543 477 NLQTHLRFHTGERPYPCNTCEKRFSQ 502
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
589-613 1.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.74e-04
                          10        20
                  ....*....|....*....|....*
gi 2116748543 589 YLKNHIRVHTGEKPYPCDSCEKRFS 613
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
618-640 2.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.85e-04
                          10        20
                  ....*....|....*....|...
gi 2116748543 618 LKVHMKIHTGEKPYNCETCGKDF 640
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-528 4.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.30e-04
                          10        20
                  ....*....|....*....|....
gi 2116748543 505 DLKLHMRVHTGEKPYPCNTCGKGF 528
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
533-557 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*
gi 2116748543 533 DLKTHMRIHTGEKPYPCNICWKRFS 557
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
437-522 1.51e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 437 SKNHTSNEDSSTTLKIHSNTyigKRCFKCHTCGKSFKCKYNLQTHLRFHTGERPYPCN--TCEKRFSQPSDLKLHMRVHT 514
Cdd:COG5048    11 SNNSVLSSTPKSTLKSLSNA---PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHH 87


                  ....*...
gi 2116748543 515 GEKPYPCN 522
Cdd:COG5048    88 NNPSDLNS 95
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 585-654 2.95e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 585 GRMAYLKnhirvhtGEKPYPCD--SCEKRFSELGILKVHMK-------------------IHTGEKPYNCETCGKDFRLG 643
Cdd:COG5189   339 SRMLKVK-------DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNL 411

                          90
                  ....*....|.
gi 2116748543 644 HQLKIHmRTHT 654
Cdd:COG5189   412 NGLKYH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 491-513 4.30e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.30e-03
                          10        20
                  ....*....|....*....|...
gi 2116748543 491 YPCNTCEKRFSQPSDLKLHMRVH 513
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-243 5.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.47e-03
                          10        20
                  ....*....|....*....|.
gi 2116748543 223 HMRVHTGEKPFSCNTCGRRFS 243
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 487-570 7.25e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2116748543 487 GERPYPCNT--CEKRFSQPSDLKLHMRV-HTGEKPYPcntcgkgfcrMADLKTHMRIHTGEKPYPCNICWKRFSDRTTVK 563
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 2116748543 564 RHiRTHT 570
Cdd:COG5189   416 YH-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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