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Conserved domains on  [gi|2217305536|ref|XP_047289904|]
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telomere repeats-binding bouquet formation protein 1 isoform X1 [Homo sapiens]

Protein Classification

telomere repeats-binding bouquet formation protein 1( domain architecture ID 10184727)

telomere repeats-binding bouquet formation protein 1 (TERB1) is a meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis

CATH:  1.20.58.1880
Gene Symbol:  TERB1
Gene Ontology:  GO:0003677|GO:0070197|GO:0045141
PubMed:  8882580|24413433
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 674-718 1.73e-18

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 212556  Cd Length: 46  Bit Score: 79.37  E-value: 1.73e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2217305536 674 FTEEEVNYLFNGVKKMGNHWNSILWSFPFQQGRKAVDLAHKYHKL 718
Cdd:cd11658     1 WTKEETDYLFDLVKRFDLRWNVILDRYPFQKGRSVEDLKEKYYHL 45
 
Name Accession Description Interval E-value
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 674-718 1.73e-18

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212556  Cd Length: 46  Bit Score: 79.37  E-value: 1.73e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2217305536 674 FTEEEVNYLFNGVKKMGNHWNSILWSFPFQQGRKAVDLAHKYHKL 718
Cdd:cd11658     1 WTKEETDYLFDLVKRFDLRWNVILDRYPFQKGRSVEDLKEKYYHL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 671-718 1.18e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 37.10  E-value: 1.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2217305536 671 RKNFTEEEVNYLFNGVKKMGNHWNSILWSFPfqqGRKAVDLAHKYHKL 718
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLP---GRTDNQCKNRWQNY 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
671-718 8.62e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 34.89  E-value: 8.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217305536  671 RKNFTEEEVNYLFNGVKKMG-NHWNSILWSFPfqqGRKAVDLAHKYHKL 718
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELP---GRTAEQCRERWRNL 46
 
Name Accession Description Interval E-value
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 674-718 1.73e-18

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212556  Cd Length: 46  Bit Score: 79.37  E-value: 1.73e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2217305536 674 FTEEEVNYLFNGVKKMGNHWNSILWSFPFQQGRKAVDLAHKYHKL 718
Cdd:cd11658     1 WTKEETDYLFDLVKRFDLRWNVILDRYPFQKGRSVEDLKEKYYHL 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 672-720 2.00e-06

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 45.25  E-value: 2.00e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217305536 672 KNFTEEEVNYLFNGVKKMGN-HWNSILWSFPFQQGRKAVDLAHKYHKLTK 720
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVgNWAKILKDYFFVNNRTSVDLKDKWRNLKK 50
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 671-718 1.18e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 37.10  E-value: 1.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2217305536 671 RKNFTEEEVNYLFNGVKKMGNHWNSILWSFPfqqGRKAVDLAHKYHKL 718
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLP---GRTDNQCKNRWQNY 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
671-718 8.62e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 34.89  E-value: 8.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2217305536  671 RKNFTEEEVNYLFNGVKKMG-NHWNSILWSFPfqqGRKAVDLAHKYHKL 718
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELP---GRTAEQCRERWRNL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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