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Conserved domains on  [gi|66818145|ref|XP_642745|]
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hypothetical protein DDB_G0277149 [Dictyostelium discoideum AX4]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 708416)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 118-287 2.92e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.08  E-value: 2.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 118 LESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYSTALY 197
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 198 CLEEVLLNAPinfvfyiKYAEPLYCLG----GNENYNSAVQYYTHALELNsptemdkldhpPTFLPAIYGIIMSIYSLCE 273
Cdd:COG3914 168 ALRRALELDP-------DNAEALNNLGnalqDLGRLEEAIAAYRRALELD-----------PDNADAHSNLLFALRQACD 229

                       170
                ....*....|....*
gi 66818145 274 -EGYQLKESQLKLME 287
Cdd:COG3914 230 wEVYDRFEELLAALA 244
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 118-287 2.92e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.08  E-value: 2.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 118 LESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYSTALY 197
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 198 CLEEVLLNAPinfvfyiKYAEPLYCLG----GNENYNSAVQYYTHALELNsptemdkldhpPTFLPAIYGIIMSIYSLCE 273
Cdd:COG3914 168 ALRRALELDP-------DNAEALNNLGnalqDLGRLEEAIAAYRRALELD-----------PDNADAHSNLLFALRQACD 229

                       170
                ....*....|....*
gi 66818145 274 -EGYQLKESQLKLME 287
Cdd:COG3914 230 wEVYDRFEELLAALA 244
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 87-247 5.43e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 5.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145    87 GDHTNPKKLFEQlKSKFGKDSVRVQRIHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLN 166
Cdd:TIGR02917 411 GDPSEAIADLET-AAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFE 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145   167 AYLQIYMCDLEAWLELSSFHISYLSYSTALYCLEEVLLNAPINFVFYIKYAEpLYCLGGNEnyNSAVQYYTHALELNsPT 246
Cdd:TIGR02917 490 KALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAG-LYLRTGNE--EEAVAWLEKAAELN-PQ 565


                  .
gi 66818145   247 E 247
Cdd:TIGR02917 566 E 566
StaR_like cd05804
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member ...
 113-152 1.84e-03

StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.


Pssm-ID: 100115 [Multi-domain]  Cd Length: 355  Bit Score: 39.57  E-value: 1.84e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 66818145 113 IHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIF 152
Cdd:cd05804  48 VEALSAWIAGDLPKALALLEQLLDDYPRDLLALKLHLGAF 87
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 118-287 2.92e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.08  E-value: 2.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 118 LESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYSTALY 197
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 198 CLEEVLLNAPinfvfyiKYAEPLYCLG----GNENYNSAVQYYTHALELNsptemdkldhpPTFLPAIYGIIMSIYSLCE 273
Cdd:COG3914 168 ALRRALELDP-------DNAEALNNLGnalqDLGRLEEAIAAYRRALELD-----------PDNADAHSNLLFALRQACD 229

                       170
                ....*....|....*
gi 66818145 274 -EGYQLKESQLKLME 287
Cdd:COG3914 230 wEVYDRFEELLAALA 244
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
115-243 2.01e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 115 ALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYST 194
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 66818145 195 ALYCLEEVLLNAPINFVFYIKYAEPLYCLGgneNYNSAVQYYTHALELN 243
Cdd:COG0457  95 ALEDYDKALELDPDDAEALYNLGLALLELG---RYDEAIEAYERALELD 140
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 87-243 2.03e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 2.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145  87 GDHTNPKKLFEQLKSKfGKDSVRVQRIHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLN 166
Cdd:COG2956  90 GLLDRAEELLEKLLEL-DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALE 168

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66818145 167 AYLQIYMCDLEAWLELSSFHISYLSYSTALYCLEEVLLNAPINFVFYIKYAEPLYCLGgneNYNSAVQYYTHALELN 243
Cdd:COG2956 169 KALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLG---DPEEALELLRKALELD 242
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 106-243 2.85e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.88  E-value: 2.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 106 DSVRVQRIHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSF 185
Cdd:COG2956  40 ETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66818145 186 HISYLSYSTALYCLEEVLLNAPINFVFYIKYAEplyCLGGNENYNSAVQYYTHALELN 243
Cdd:COG2956 120 YEQEGDWEKAIEVLERLLKLGPENAHAYCELAE---LYLEQGDYDEAIEALEKALKLD 174
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 115-243 4.09e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.65  E-value: 4.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 115 ALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYST 194
Cdd:COG4783  11 AQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 66818145 195 ALYCLEEVLLNAPINFVFYIKYAEPLYCLGgneNYNSAVQYYTHALELN 243
Cdd:COG4783  91 ALALLEKALKLDPEHPEAYLRLARAYRALG---RPDEAIAALEKALELD 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
115-241 1.72e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 1.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 115 ALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYST 194
Cdd:COG0457  49 GLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 66818145 195 ALYCLEEVLLNAPINFVFYIKYAEPLYCLGgneNYNSAVQYYTHALE 241
Cdd:COG0457 129 AIEAYERALELDPDDADALYNLGIALEKLG---RYEEALELLEKLEA 172
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 114-246 2.72e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.84  E-value: 2.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 114 HALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYS 193
Cdd:COG3914 118 LGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLE 197

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 66818145 194 TALYCLEEVLLNAPINFVFYIKYAEPLYCLGGNENYnSAVQYYTHALELNSPT 246
Cdd:COG3914 198 EAIAAYRRALELDPDNADAHSNLLFALRQACDWEVY-DRFEELLAALARGPSE 249
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 115-243 5.45e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 5.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 115 ALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYST 194
Cdd:COG2956  15 GLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDR 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 66818145 195 ALYCLEEVLLNAPinfvfyiKYAEPLYCLGG----NENYNSAVQYYTHALELN 243
Cdd:COG2956  95 AEELLEKLLELDP-------DDAEALRLLAEiyeqEGDWEKAIEVLERLLKLG 140
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 94-243 3.89e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 3.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145  94 KLFEQLkSKFGKDSVRVQRIHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYM 173
Cdd:COG2956 131 EVLERL-LKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDP 209

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 174 CDLEAWLELSSFHISYLSYSTALYCLEEVLLNAPINFVfYIKYAEPLYCLGGNEnynSAVQYYTHALELN 243
Cdd:COG2956 210 DYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL-LLALADLLERKEGLE---AALALLERQLRRH 275
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 116-208 3.93e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 3.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 116 LCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYSTA 195
Cdd:COG5010  62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEA 141

                        90
                ....*....|...
gi 66818145 196 LYCLEEVLLNAPI 208
Cdd:COG5010 142 KAALQRALGTSPL 154
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 87-247 5.43e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 5.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145    87 GDHTNPKKLFEQlKSKFGKDSVRVQRIHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLN 166
Cdd:TIGR02917 411 GDPSEAIADLET-AAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFE 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145   167 AYLQIYMCDLEAWLELSSFHISYLSYSTALYCLEEVLLNAPINFVFYIKYAEpLYCLGGNEnyNSAVQYYTHALELNsPT 246
Cdd:TIGR02917 490 KALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAG-LYLRTGNE--EEAVAWLEKAAELN-PQ 565


                  .
gi 66818145   247 E 247
Cdd:TIGR02917 566 E 566
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 106-171 5.59e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.52  E-value: 5.59e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66818145 106 DSVRVQRIHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQI 171
Cdd:COG3914 144 DFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
117-207 1.39e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 117 CLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQvLNAYLQIYMCDLEAWLELSSFHISYLSYSTAL 196
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                        90
                ....*....|.
gi 66818145 197 YCLEEVLLNAP 207
Cdd:COG3063  80 AYLERALELDP 90
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 81-207 1.84e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 1.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145  81 VACLDCGDHTNPKKLFEQLKSKFgKDSVRVQRIHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSK 160
Cdd:COG4783  12 QALLLAGDYDEAEALLEKALELD-PDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 66818145 161 AIQVLNAYLQIYMCDLEAWLELSSFHISYLSYSTALYCLEEVLLNAP 207
Cdd:COG4783  91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
StaR_like cd05804
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member ...
 113-152 1.84e-03

StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.


Pssm-ID: 100115 [Multi-domain]  Cd Length: 355  Bit Score: 39.57  E-value: 1.84e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 66818145 113 IHALCLESNNQLAEALQIFESILKKYPSDALSMKRQVAIF 152
Cdd:cd05804  48 VEALSAWIAGDLPKALALLEQLLDDYPRDLLALKLHLGAF 87
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 124-243 1.93e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 1.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 124 LAEALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYSTALYCLEEVL 203
Cdd:COG5010  36 NTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKAL 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 66818145 204 LNAPINFVFYIKYAEPLYCLGgneNYNSAVQYYTHALELN 243
Cdd:COG5010 116 ALSPDNPNAYSNLAALLLSLG---QDDEAKAALQRALGTS 152
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 93-251 2.82e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145    93 KKLFEQLKSKFGKDSVRVQRIHALCLESNNqLAEALQIFESILKKYPSDALSMKrQVAIFKGQGNLSKAIQVLNAYLQIY 172
Cdd:TIGR02917 689 KKIAKSLQKQHPKAALGFELEGDLYLRQKD-YPAAIQAYRKALKRAPSSQNAIK-LHRALLASGNTAEAVKTLEAWLKTH 766

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145   173 MCDLEAWLELSSFHISYLSYSTALYCLEEVLLNAPINFVFYIKYAeplYCLGgnENYNS-AVQYYTHALEL--NSPTEMD 249
Cdd:TIGR02917 767 PNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLA---WLYL--ELKDPrALEYAERALKLapNIPAILD 841


                  ..
gi 66818145   250 KL 251
Cdd:TIGR02917 842 TL 843
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 87-172 5.02e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.12  E-value: 5.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145  87 GDHTNPKKLFEQLKSKFGKDSVR--VQRIHALCLESNNQLAEALQIFESILKKYPSDAL---SMKRQVAIFKGQGNLSKA 161
Cdd:COG1729   7 GDYDEAIAAFKAFLKRYPNSPLApdALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGDYDKA 86

                        90
                ....*....|.
gi 66818145 162 IQVLNAYLQIY 172
Cdd:COG1729  87 RATLEELIKKY 97
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 126-245 8.95e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 35.75  E-value: 8.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66818145 126 EALQIFESILKKYPSDALSMKRQVAIFKGQGNLSKAIQVLNAYLQIYMCDLEAWLELSSFHISYLSYSTALYCLEEVLLN 205
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 66818145 206 APINfvfyikyAEPLYCLG----GNENYNSAVQYYTHALELNSP 245
Cdd:COG4235  81 DPDN-------PEALYLLGlaafQQGDYAEAIAAWQKLLALLPA 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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