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Conserved domains on  [gi|166851902|ref|YP_001661366|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Eulemur mongoz]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.19e-77

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 228.92  E-value: 1.19e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   1 MMYVMFLLSILLVLGFVSISSKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  81 TWGSNVVIWGVVLLGVGVELLMVMWMVEHGGLGVESVFGGVEDWVSFESKGGGVVREDCLGVASLYDSASWFVAVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 166851902 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.19e-77

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 228.92  E-value: 1.19e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   1 MMYVMFLLSILLVLGFVSISSKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  81 TWGSNVVIWGVVLLGVGVELLMVMWMVEHGGLGVESVFGGVEDWVSFESKGGGVVREDCLGVASLYDSASWFVAVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 166851902 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 9.30e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 51.35  E-value: 9.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   21 SKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVIWGVVLLGVGveL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLL--L 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  101 LMVMWMVEHGGLGVESVFGGVEDWVSFESKGggvvredclgvASLYDSASWFVAVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  83 LALLLLVLLSASLTPAAAAAAPDVGNIEAIG-----------ELLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.19e-77

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 228.92  E-value: 1.19e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   1 MMYVMFLLSILLVLGFVSISSKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  81 TWGSNVVIWGVVLLGVGVELLMVMWMVEHGGLGVESVFGGVEDWVSFESKGGGVVREDCLGVASLYDSASWFVAVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 166851902 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 4.78e-36

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 122.94  E-value: 4.78e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   1 MMYVMFLLSILLVLGFVSISSKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  81 TWGSNVVIWGVVLLGVGVELLMVMWmvehGGLGVESVFGGVEDWVSFeskggGVVREDCLGVASLYDSASWFVAVAGWSL 160
Cdd:MTH00138  81 SWGSWSVLGYVVGYLVGVVLAAGLF----WGGWYEGSWVVVDELKEF-----SVLRGDVGGVALMYSSGGGMLVICAWVL 151

                        170
                 ....*....|..
gi 166851902 161 FVSVLIVIEIIR 172
Cdd:MTH00138 152 LLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 2.01e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 111.09  E-value: 2.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   1 MMYVMFLLSILLVLGFVSISSKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  81 TWGSNVVIWGVVLLGVgveLLMVMWMVEHGGLGVESVFGGVedwvsfeSKGGGVVREDCLGVASLYDSASWFVAVAGWSL 160
Cdd:MTH00065  81 AWGSWSVLVYVLFYLL---LLIVGYILFGCNFSLEFLFTNY-------DTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 166851902 161 FVSVLIVIEIIR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 1.35e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 98.67  E-value: 1.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   1 MMYVMFLLSILLVLGFVSISSKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  81 TWGSnvviWGVVLLGVGVELLMVMWMVEHGGLGVESVFGGvedwVSFESKGGGVVREDCLGVASLYDSASWFVAVAGWSL 160
Cdd:MTH00115  81 AWGD----WGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGV----VTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 166851902 161 FVSVLIVIEIIR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 4.87e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 71.17  E-value: 4.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   1 MMYVMFLLSILLVLGFVSISSKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  81 TWGSNVVIWGVVLLGVGVELLMVMWMVEHGGLGVESVfggvedwvsfeskgGGVVREDCLGVASLYDSASWFVAVAGWSL 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGV--------------DEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|..
gi 166851902 161 FVSVLIVIEIIR 172
Cdd:MTH00214 147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-170 2.28e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 58.76  E-value: 2.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   1 MMYVMFLLSILLVLGFVSISSkpSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  81 TWGSNVVIwgvvllgvGVELLMVMWmvehgglgvesVFGGVEDWVSFESKGGG-VVREDCLGVASLYDSASWFVAVAGWS 159
Cdd:MTH00045  79 VSNLGEVL--------VLSLLLSLW-----------VFISFDNFLELSNNNWSlVSLSDLVGSSELYNSGGLYLLLGGFI 139

                        170
                 ....*....|.
gi 166851902 160 LFVSVLIVIEI 170
Cdd:MTH00045 140 LLVALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 9.30e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 51.35  E-value: 9.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   21 SKPSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVIWGVVLLGVGveL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLL--L 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902  101 LMVMWMVEHGGLGVESVFGGVEDWVSFESKGggvvredclgvASLYDSASWFVAVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  83 LALLLLVLLSASLTPAAAAAAPDVGNIEAIG-----------ELLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 2-78 4.44e-06

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 44.23  E-value: 4.44e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 166851902   2 MYVMFLLSILLVLGFVSISSKpSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   1 MLLSLLLSLLLLLMLLFPLSA-HPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 2-118 1.42e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 37.17  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166851902   2 MYVMFLLSILLVLGFVSISSKpSPIYGGVGLIISGALGCGIVMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEeypET 81
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLSPN---PL 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 166851902  82 WGSNVVIWGVVLLGVGVELLMVMWMVEHGGLGVESVF 118
Cdd:MTH00152  77 FGSNFKFVFFSLTLFGFLGLFFFFLYLYSSGGLSLSS 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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