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Conserved domains on  [gi|219524097|ref|YP_002456249|]
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NADH dehydrogenase subunit 3 (mitochondrion) [Deracantha onos]

Protein Classification

NADH dehydrogenase subunit 3( domain architecture ID 10009596)

NADH dehydrogenase subunit 3 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 16-116 2.80e-37

NADH dehydrogenase subunit 3; Provisional


:

Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 122.19  E-value: 2.80e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  16 SFIVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISA 95
Cdd:MTH00161  13 SIILMILASLLSKKSIMDREKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFKTSNMMSWLITSS 92

                         90       100
                 ....*....|....*....|.
gi 219524097  96 FFLLILLLGLYHEWNQGALEW 116
Cdd:MTH00161  93 FFILILLLGLYYEWNQGALEW 113
 
Name Accession Description Interval E-value
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 16-116 2.80e-37

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 122.19  E-value: 2.80e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  16 SFIVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISA 95
Cdd:MTH00161  13 SIILMILASLLSKKSIMDREKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFKTSNMMSWLITSS 92

                         90       100
                 ....*....|....*....|.
gi 219524097  96 FFLLILLLGLYHEWNQGALEW 116
Cdd:MTH00161  93 FFILILLLGLYYEWNQGALEW 113
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
20-71 4.82e-16

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 67.45  E-value: 4.82e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 219524097   20 MLLASILSKKSINdREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVE 71
Cdd:pfam00507   1 LLLSRLLGPKRPN-PEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVE 51
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 17-71 1.71e-13

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 61.68  E-value: 1.71e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 219524097  17 FIVMLLASILSKKSiNDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVE 71
Cdd:COG0838   20 LAMLLLSRLLGPKR-PNPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVE 73
 
Name Accession Description Interval E-value
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 16-116 2.80e-37

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 122.19  E-value: 2.80e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  16 SFIVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISA 95
Cdd:MTH00161  13 SIILMILASLLSKKSIMDREKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFKTSNMMSWLITSS 92

                         90       100
                 ....*....|....*....|.
gi 219524097  96 FFLLILLLGLYHEWNQGALEW 116
Cdd:MTH00161  93 FFILILLLGLYYEWNQGALEW 113
ND3 MTH00148
NADH dehydrogenase subunit 3; Provisional
 16-117 9.29e-31

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214433 [Multi-domain]  Cd Length: 117  Bit Score: 105.71  E-value: 9.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  16 SFIVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISA 95
Cdd:MTH00148  15 SPVLLLLGLVLSKRSYSDREKSSPFECGFDPISSARSPFSLRFFLLAILFLVFDVEIVLLFPVLQSLGSSFSVWSLTSLF 94

                         90       100
                 ....*....|....*....|..
gi 219524097  96 FFLLILLLGLYHEWNQGALEWA 117
Cdd:MTH00148  95 IFLLILILGLFHEWNEGSLDWV 116
ND3 MTH00202
NADH dehydrogenase subunit 3; Provisional
 16-118 1.64e-27

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214455 [Multi-domain]  Cd Length: 117  Bit Score: 97.37  E-value: 1.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  16 SFIVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISA 95
Cdd:MTH00202  15 SSLLFLVSWMLSFRSLMDREKSSPFECGFDPKESARLPFSMRFFLLAVIFLVFDIEIALLLPLPLVLKSSWSKGGLLGGT 94

                         90       100
                 ....*....|....*....|...
gi 219524097  96 FFLLILLLGLYHEWNQGALEWAY 118
Cdd:MTH00202  95 IFLLILIGGLIHEWKEGSLDWVK 117
ND3 MTH00012
NADH dehydrogenase subunit 3; Validated
 18-117 7.93e-25

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164588 [Multi-domain]  Cd Length: 117  Bit Score: 90.69  E-value: 7.93e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  18 IVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISAFF 97
Cdd:MTH00012  17 LVLGAAWVLAARSTADREKTSPFECGFDPHKTARIPFSLRFFLLAIIFIVFDIEIVLLMPVPTILMTSTSKTVVYTSILF 96

                         90       100
                 ....*....|....*....|
gi 219524097  98 LLILLLGLYHEWNQGALEWA 117
Cdd:MTH00012  97 LLILVIGLIHEWREGSLDWS 116
ND3 MTH00113
NADH dehydrogenase subunit 3; Provisional
 16-117 9.85e-21

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177175 [Multi-domain]  Cd Length: 114  Bit Score: 79.92  E-value: 9.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  16 SFIVMLLASILSKKSiNDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISA 95
Cdd:MTH00113  14 STILTTLNFWLTQTK-PDNEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWAINLTTPTTTLTWAT 92

                         90       100
                 ....*....|....*....|..
gi 219524097  96 FFLLILLLGLYHEWNQGALEWA 117
Cdd:MTH00113  93 IILTLLTLGLIYEWLQGGLEWA 114
ND3 MTH00069
NADH dehydrogenase subunit 3; Provisional
 18-117 2.94e-20

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177141 [Multi-domain]  Cd Length: 114  Bit Score: 78.88  E-value: 2.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  18 IVMLLASILSKKSIN----------DREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHL 87
Cdd:MTH00069   4 LMLLISTILSLILITisfwlplnnpDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPTPWASQLNTP 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 219524097  88 LSWSIISAFFLLILLLGLYHEWNQGALEWA 117
Cdd:MTH00069  84 TNTLFWSTLILILLTLGLIYEWIQGGLEWA 113
ND3 MTH00042
NADH dehydrogenase subunit 3; Validated
 18-117 3.16e-20

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 177117 [Multi-domain]  Cd Length: 116  Bit Score: 78.87  E-value: 3.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  18 IVMLLASILSKKSInDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISAFF 97
Cdd:MTH00042  17 LLLLAGHFLPSRSP-DLEKSSPYECGFDPLNSARLPFSFRFFLVAILFLLFDLEIALLFPLPPATLITNPSTLLPISLIF 95

                         90       100
                 ....*....|....*....|
gi 219524097  98 LLILLLGLYHEWNQGALEWA 117
Cdd:MTH00042  96 LIILTIGLVYEWVNGGLEWA 115
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 35-117 3.31e-20

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 78.83  E-value: 3.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  35 EKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISAFFLLILLLGLYHEWNQGAL 114
Cdd:MTH00106  32 EKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTNNLNTMLTMALLLISLLALSLAYEWTQKGL 111


                 ...
gi 219524097 115 EWA 117
Cdd:MTH00106 112 EWT 114
ND3 MTH00136
NADH dehydrogenase subunit 3; Provisional
 33-117 1.79e-19

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177194 [Multi-domain]  Cd Length: 116  Bit Score: 76.88  E-value: 1.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  33 DREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQW-SHLLSWSIISAFFLLILLLGLYhEWNQ 111
Cdd:MTH00136  31 DHEKLSPYECGFDPLGSARLPFSLRFFLVAILFLLFDLEIALLLPLPWGDQLpSPLLTFFWATAVLILLTLGLIY-EWLQ 109


                 ....*.
gi 219524097 112 GALEWA 117
Cdd:MTH00136 110 GGLEWA 115
ND3 MTH00203
NADH dehydrogenase subunit 3; Provisional
 16-116 1.40e-17

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214456 [Multi-domain]  Cd Length: 112  Bit Score: 71.85  E-value: 1.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  16 SFIVMLLASILSK--KSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSII 93
Cdd:MTH00203  12 LLLSLILLFIAFWlpKVNPDGEKLSPYECGFDPLGSARLPFSLQFFLVALSFLLFDLEIALLLPLPWSNQLSSLSLLLAF 91

                         90       100
                 ....*....|....*....|...
gi 219524097  94 saFFLLILLLGLYHEWNQGALEW 116
Cdd:MTH00203  92 --LFLILLTLGLIYEWLQGGLEW 112
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
20-71 4.82e-16

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 67.45  E-value: 4.82e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 219524097   20 MLLASILSKKSINdREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVE 71
Cdd:pfam00507   1 LLLSRLLGPKRPN-PEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVE 51
PRK06602 PRK06602
NADH:ubiquinone oxidoreductase subunit A; Validated
 18-117 1.66e-13

NADH:ubiquinone oxidoreductase subunit A; Validated


Pssm-ID: 180638 [Multi-domain]  Cd Length: 121  Bit Score: 61.80  E-value: 1.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  18 IVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPiiiimqWS---HLLSW-SII 93
Cdd:PRK06602  23 ILLLVAGKLLGPRAPDREKNSPYESGFEAFGDARMKFDVRFYLVAILFVIFDLEAAFLFP------WAvsfREIGWlGFV 96

                         90       100
                 ....*....|....*....|....*
gi 219524097  94 SA-FFLLILLLGLYHEWNQGALEWA 117
Cdd:PRK06602  97 EAmIFILVLLVGLVYLWRKGALDWE 121
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 17-71 1.71e-13

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 61.68  E-value: 1.71e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 219524097  17 FIVMLLASILSKKSiNDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVE 71
Cdd:COG0838   20 LAMLLLSRLLGPKR-PNPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVE 73
ND3 MTH00018
NADH dehydrogenase subunit 3; Validated
 18-116 5.81e-13

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164592 [Multi-domain]  Cd Length: 113  Bit Score: 60.08  E-value: 5.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  18 IVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISAFF 97
Cdd:MTH00018  15 ALFSGASYFLGVKQPDREKVSAYECGFDPFGFPGRPFSIRFFLIGILFLIFDLEISFLFPWCVLYNQIAPFGFWTMVGFL 94

                         90
                 ....*....|....*....
gi 219524097  98 LLILLLGLYhEWNQGALEW 116
Cdd:MTH00018  95 FILTLGLIY-EWIKGGLEW 112
ND3 MTH00055
NADH dehydrogenase subunit 3; Provisional
 33-116 4.12e-12

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177128 [Multi-domain]  Cd Length: 118  Bit Score: 58.18  E-value: 4.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  33 DREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISAFFLLILLLGLYhEWNQG 112
Cdd:MTH00055  35 DSEKVSVYECGFDPFESSRIPFSVRFFLVGILFLIFDLEISFLFPWCVVYNQIGLFGFWVMYLFLIILTIGLIY-EWVKG 113


                 ....
gi 219524097 113 ALEW 116
Cdd:MTH00055 114 GLEW 117
ND3 MTH00030
NADH dehydrogenase subunit 3; Provisional
 33-116 7.68e-11

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 164603 [Multi-domain]  Cd Length: 123  Bit Score: 54.94  E-value: 7.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  33 DREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIIIMQWSHLLSWSIISAFFLLILLLGLYhEWNQG 112
Cdd:MTH00030  40 DSEKSSIYECGFDPFGKIRTPFTIKFVLVGILFMIFDIEISFLFPWSIVFNQLNLFSFWIVYTFLIVLAIGLAY-EWIKG 118


                 ....
gi 219524097 113 ALEW 116
Cdd:MTH00030 119 GLEW 122
ndhC CHL00022
NADH dehydrogenase subunit 3
 35-116 6.78e-05

NADH dehydrogenase subunit 3


Pssm-ID: 176964 [Multi-domain]  Cd Length: 120  Bit Score: 39.20  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  35 EKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVEIALLLPIIiiMQWSHLLSWSIISAF-FLLILLLGLYHEWNQGA 113
Cdd:CHL00022  39 EKLSSYESGIEPMGDAWLQFRIRYYMFALVFVVFDVETVFLYPWA--MSFDVLGVSAFIEALiFVLILIVGLVYAWRKGA 116


                 ...
gi 219524097 114 LEW 116
Cdd:CHL00022 117 LEW 119
PRK07756 PRK07756
NADH-quinone oxidoreductase subunit A;
18-71 3.08e-04

NADH-quinone oxidoreductase subunit A;


Pssm-ID: 169084 [Multi-domain]  Cd Length: 122  Bit Score: 37.41  E-value: 3.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 219524097  18 IVMLLASILSKKSINDREKASPFECGFDPKSSARLPFSLRFFLIAVIFLIFDVE 71
Cdd:PRK07756  24 VVALTLGRMLRPNKPSAAKATTYESGIEPFHDANIRFHARYYIFALLFVIFDVE 77
PRK07928 PRK07928
NADH dehydrogenase subunit A; Validated
 20-116 7.07e-04

NADH dehydrogenase subunit A; Validated


Pssm-ID: 181171 [Multi-domain]  Cd Length: 119  Bit Score: 36.57  E-value: 7.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219524097  20 MLLASILSKKSINdREKASPFECGFDPKSSARLP--FSLRFFLIAVIFLIFDVEIALLLPIIiiMQWSHLLSWSIIS-AF 96
Cdd:PRK07928  22 VVVASLVGPKRYN-RAKLEAYECGIEPTPQPAGGgrFPVKYYLTAMLFIVFDIEIVFLYPWA--VSFDALGVFGLVEmAL 98

                         90       100
                 ....*....|....*....|
gi 219524097  97 FLLILLLGLYHEWNQGALEW 116
Cdd:PRK07928  99 FMLTVFVAYAYVWRRGGLEW 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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