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Conserved domains on  [gi|529217304|ref|YP_008379019|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Hapalemur griseus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 4.34e-77

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.38  E-value: 4.34e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   1 MYAMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  81 WGSNVVIWGVVLLGVGMELFMVAWMVEHGGLGVGGMFGCVEDWMIFESKEDGVIREDSLGVASLYGKASWFAAIAGWSLF 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|.
gi 529217304 161 ISVLIVIEIIR 171
Cdd:MTH00109 163 IGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 4.34e-77

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.38  E-value: 4.34e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   1 MYAMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  81 WGSNVVIWGVVLLGVGMELFMVAWMVEHGGLGVGGMFGCVEDWMIFESKEDGVIREDSLGVASLYGKASWFAAIAGWSLF 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|.
gi 529217304 161 ISVLIVIEIIR 171
Cdd:MTH00109 163 IGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
20-169 1.06e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.96  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   20 SKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVIWGVVLLGVGMeL 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-L 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  100 FMVAWMVEHGGLGVGGMFGcvedwmifeskEDGVIREDSLGVAsLYGKASWFAAIAGWSLFISVLIVIEI 169
Cdd:pfam00499  84 ALLLLVLLSASLTPAAAAA-----------APDVGNIEAIGEL-LFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-171 4.34e-77

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 227.38  E-value: 4.34e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   1 MYAMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  81 WGSNVVIWGVVLLGVGMELFMVAWMVEHGGLGVGGMFGCVEDWMIFESKEDGVIREDSLGVASLYGKASWFAAIAGWSLF 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|.
gi 529217304 161 ISVLIVIEIIR 171
Cdd:MTH00109 163 IGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-171 1.14e-34

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 119.48  E-value: 1.14e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   1 MYAMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00138   2 TYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  81 WGSN----VVIWGVVLLGVGMELFMVAWMvehgglgvggmfgcVEDWMIF-ESKEDGVIREDSLGVASLYGKASWFAAIA 155
Cdd:MTH00138  82 WGSWsvlgYVVGYLVGVVLAAGLFWGGWY--------------EGSWVVVdELKEFSVLRGDVGGVALMYSSGGGMLVIC 147

                        170
                 ....*....|....*.
gi 529217304 156 GWSLFISVLIVIEIIR 171
Cdd:MTH00138 148 AWVLLLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-171 4.34e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 110.32  E-value: 4.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   1 MYAMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00065   2 MYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  81 WGSNVVIWGVVLLGVGMelfMVAWMVehgglgvGGMFGCVEDWMIFESKEDGVIREDSLGVASLYGKASWFAAIAGWSLF 160
Cdd:MTH00065  82 WGSWSVLVYVLFYLLLL---IVGYIL-------FGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLL 151

                        170
                 ....*....|.
gi 529217304 161 ISVLIVIEIIR 171
Cdd:MTH00065 152 LTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-171 9.17e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 99.05  E-value: 9.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   1 MYAMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00115   2 MYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  81 WGSNVVIWGVVllGVGMELFMVAWMVEHGGLGVGGMFGCVEDWMIFeskedgVIREDSLGVASLYGKASWFAAIAGWSLF 160
Cdd:MTH00115  82 WGDWGVVGYVV--GFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLF------VVRLDFSGVSLFYSSGGGGLLVCGWGLL 153

                        170
                 ....*....|.
gi 529217304 161 ISVLIVIEIIR 171
Cdd:MTH00115 154 LTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-171 1.53e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 72.71  E-value: 1.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   1 MYAMFLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00214   2 LYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  81 WGSNVVIWGVVLLGVGMELFMVawmvehgglgvggmFGCVEDWMIFESKEDGVIREDSLGVASLYGKASWFAAIAGWSLF 160
Cdd:MTH00214  82 WGGWSVLLFFLFYLLGLGFVGF--------------YFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVLF 147

                        170
                 ....*....|.
gi 529217304 161 ISVLIVIEIIR 171
Cdd:MTH00214 148 LVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 5-78 1.02e-08

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 51.44  E-value: 1.02e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 529217304   5 FLLSILLVLGFVSISSKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYP 78
Cdd:MTH00045   4 YLFLILMLFGSTLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP 77
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
20-169 1.06e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.96  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304   20 SKPSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVIWGVVLLGVGMeL 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-L 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217304  100 FMVAWMVEHGGLGVGGMFGcvedwmifeskEDGVIREDSLGVAsLYGKASWFAAIAGWSLFISVLIVIEI 169
Cdd:pfam00499  84 ALLLLVLLSASLTPAAAAA-----------APDVGNIEAIGEL-LFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 1-77 1.03e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 43.46  E-value: 1.03e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529217304   1 MYAMFLLSILLVLGFVSISSKpSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEY 77
Cdd:MTH00212   1 MLLSLLLSLLLLLMLLFPLSA-HPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-73 7.81e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 37.94  E-value: 7.81e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529217304   1 MYAMFLLSILLVLGFVSISSKpSPIYGGVGLIVSGAVGCGIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMA 73
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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