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Conserved domains on  [gi|1236517386|ref|YP_009412866|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Microcebus rufus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.99e-81

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 238.16  E-value: 1.99e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386   1 MAYTIFLLSIIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  81 TWGSNIIIWGALLSGVLMELLLMVWLLEHDGVEMVVGFNSLEDWIMFMDKGFNVIREDSLGVSALYSYASWLMVAAGWAL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1236517386 161 FVSVLIVIEIIR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.99e-81

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 238.16  E-value: 1.99e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386   1 MAYTIFLLSIIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  81 TWGSNIIIWGALLSGVLMELLLMVWLLEHDGVEMVVGFNSLEDWIMFMDKGFNVIREDSLGVSALYSYASWLMVAAGWAL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1236517386 161 FVSVLIVIEIIR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 1.57e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.58  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  21 SKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAM-ATEEYPETWGSNIIIWGALLSGVLME 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1236517386 100 LLLMVWLLEHDGVEMVVGfnsledwimfmdkGFNVIREDSLGVsALYSYASWLMVAAGWALFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAA-------------APDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.99e-81

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 238.16  E-value: 1.99e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386   1 MAYTIFLLSIIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  81 TWGSNIIIWGALLSGVLMELLLMVWLLEHDGVEMVVGFNSLEDWIMFMDKGFNVIREDSLGVSALYSYASWLMVAAGWAL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1236517386 161 FVSVLIVIEIIR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.87e-34

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 118.80  E-value: 1.87e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386   1 MAYTIFLLSIIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  81 TWGSniiiWGALLSGVLMELLLMVWLLehdgveMVVGFNSLEDWIMFMDKGFNVIREDSLGVSALYSYASWLMVAAGWAL 160
Cdd:MTH00065   81 AWGS----WSVLVYVLFYLLLLIVGYI------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|..
gi 1236517386 161 FVSVLIVIEIIR 172
Cdd:MTH00065  151 LLTLFVVLEVTR 162
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 9.59e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 114.47  E-value: 9.59e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386   1 MAYTIFLLSIIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  81 TWGSNIIIWGALLSGVLmeLLLMVWLLEHDGVEMvvgfnsleDWIMFMD-KGFNVIREDSLGVSALYSYASWLMVAAGWA 159
Cdd:MTH00138   81 SWGSWSVLGYVVGYLVG--VVLAAGLFWGGWYEG--------SWVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                         170
                  ....*....|...
gi 1236517386 160 LFVSVLIVIEIIR 172
Cdd:MTH00138  151 LLLTLFVVLELTR 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 6.02e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 97.13  E-value: 6.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386   1 MAYTIFLLSIIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  81 TWGSniiiWGALLSGVLMELLLMVWllehdGVEMVVGFNSLEDWIMFMDK-GFNVIREDSLGVSALYSYASWLMVAAGWA 159
Cdd:MTH00115   81 AWGD----WGVVGYVVGFVLVVVVV-----GVVVGGLWGMEGVGVVTVDSgGLFVVRLDFSGVSLFYSSGGGGLLVCGWG 151

                         170
                  ....*....|...
gi 1236517386 160 LFVSVLIVIEIIR 172
Cdd:MTH00115  152 LLLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 8.01e-15

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 68.09  E-value: 8.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386   1 MAYTIFLLSIIFVLGFMSFSSKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  81 TWGSniiiwgallsgVLMELLLMVWLLehdGVEMVVGFNSLEDWIMFMDKGFNVIREDSLGVSALYSYASWLMVAAGWAL 160
Cdd:MTH00214   81 SWGG-----------WSVLLFFLFYLL---GLGFVGFYFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|..
gi 1236517386 161 FVSVLIVIEIIR 172
Cdd:MTH00214  147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-170 7.28e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 57.61  E-value: 7.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386   1 MAYTIFLLSIIFVLGFMSFSSkpSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPe 80
Cdd:MTH00045    1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  81 twgsniiIWGALLSGVLMELLLMVWllehdgvemvvGFNSLEDWIMFMDKGFNVIREDSL-GVSALYSYASWLMVAAGWA 159
Cdd:MTH00045   78 -------SVSNLGEVLVLSLLLSLW-----------VFISFDNFLELSNNNWSLVSLSDLvGSSELYNSGGLYLLLGGFI 139

                         170
                  ....*....|.
gi 1236517386 160 LFVSVLIVIEI 170
Cdd:MTH00045  140 LLVALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 1.57e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.58  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236517386  21 SKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAM-ATEEYPETWGSNIIIWGALLSGVLME 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1236517386 100 LLLMVWLLEHDGVEMVVGfnsledwimfmdkGFNVIREDSLGVsALYSYASWLMVAAGWALFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAA-------------APDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 5-78 3.37e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 39.22  E-value: 3.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1236517386   5 IFLLSIIFVLGFMsFSSKPSPIYGGVGLIVSGAVGCSIIMGFGVSFMGLMVFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212    4 SLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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