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Conserved domains on  [gi|1436051976|ref|YP_009500636|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Ernolatia moorei]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 3-336 8.03e-95

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 284.79  E-value: 8.03e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976   3 FINNSNKMFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKIS 82
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  83 LMKNFEMNnISIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSYYFNKNFLIIVIIMNLLIGAL 162
Cdd:MTH00160   81 NLMLFNNI-SSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 163 GGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLF-INNMNFYIKLNLLIN 241
Cdd:MTH00160  160 GGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFnSNNKSKKIKFLLFLN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 242 FLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFMFNYFKMKWMNFFIKNKFILLINLFS 321
Cdd:MTH00160  240 LLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLS 319

                         330
                  ....*....|....*
gi 1436051976 322 FFSITSMILSTFIFL 336
Cdd:MTH00160  320 FISLFGLILSSLLFL 334
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 3-336 8.03e-95

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 284.79  E-value: 8.03e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976   3 FINNSNKMFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKIS 82
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  83 LMKNFEMNnISIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSYYFNKNFLIIVIIMNLLIGAL 162
Cdd:MTH00160   81 NLMLFNNI-SSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 163 GGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLF-INNMNFYIKLNLLIN 241
Cdd:MTH00160  160 GGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFnSNNKSKKIKFLLFLN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 242 FLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFMFNYFKMKWMNFFIKNKFILLINLFS 321
Cdd:MTH00160  240 LLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLS 319

                         330
                  ....*....|....*
gi 1436051976 322 FFSITSMILSTFIFL 336
Cdd:MTH00160  320 FISLFGLILSSLLFL 334
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 26-280 1.92e-21

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 92.38  E-value: 1.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  26 SNSWFGCWIGLEINLLSFIPLI-SNSNDLMSVETSLKYFLIQSLASINFLFFILM-----------KISLMKNFEMNNIS 93
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  94 IMMNSSMLM-----KMGSAPFHFWFPNIIEGISWMNN-FILMTWQKISPMILL--------SYYFNKNFLIIVIIMNLLI 159
Cdd:pfam00361  81 LLLLFLLILvgflfKSAQVPFHTWLPDAYEGAPTPVSaLLAATLVKAGGYGLIrrsllylpSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 160 GALGGLNQTSLRKLLAFSSINNLGWMIFSIMI----SENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLFINNMNFYIK 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAgtiyGIQAAIFHLLTHGLFSAGLFLCAGSVIYRRVHTRNIRDYGGLAK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1436051976 236 LN------LLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTS 280
Cdd:pfam00361 241 TMpilalvFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 12-281 2.09e-13

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 70.53  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  12 FLFILIFSTL---ISISSNSWFGCWIGLEINLLSFIPLIS-NSNDLMSVETSLKYFLIQSLASInflfFILMKISLM--- 84
Cdd:COG1007   104 FYALLLFATLgmmLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSG----FLLYGISLLyga 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  85 ----------KNFEMNNIS--------IMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSYYFNK 146
Cdd:COG1007   180 tgslnlagiaAALAAGGANspllllglVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVE 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 147 NF----------LIIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLW----LFYIIIYSFMIL---- 208
Cdd:COG1007   260 AFpglaadwqllLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGvsaaLFYLLAYLFMNLgafa 339

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1436051976 209 -MMIFLFFMLNMFFINQLF-INNMNFYIKLNLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:COG1007   340 vILLLSRKGGEAEEIEDLAgLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSV 414
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 4-281 1.38e-11

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 64.97  E-value: 1.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976   4 INNSNKMFFLFILIFSTL---ISISSNSWFGCWIGLEINLLSFIPLISNS-NDLMSVETSLKYFLIQSLASINFLFFILM 79
Cdd:TIGR01770  96 KEKINKFEFYILLLFALLgifLLVSSNDLLSIYLGLELQSLCFYVLAGLKrKSRFSTEAGLKYFILGAFSSGLLLFGISL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  80 -----------KISLMKNFEMNNIS------IMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILL-- 140
Cdd:TIGR01770 176 iygftgslnfeDLLLFLSNGMLNISllllgiVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFlr 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 141 --------SYYFNKNFLIIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENL----WLFYIIIYSFM-- 206
Cdd:TIGR01770 256 lflyilfgFSEAWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEgikaVLFYIFIYALMsl 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 207 ----ILMMIFLFFMLNMFFINQLF-INNMNFYIKLNLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:TIGR01770 336 gafgVLSLLRSYKDEWIEYISDFAgLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSV 415
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 3-336 8.03e-95

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 284.79  E-value: 8.03e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976   3 FINNSNKMFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKIS 82
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  83 LMKNFEMNnISIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSYYFNKNFLIIVIIMNLLIGAL 162
Cdd:MTH00160   81 NLMLFNNI-SSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAIIGAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 163 GGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLF-INNMNFYIKLNLLIN 241
Cdd:MTH00160  160 GGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFnSNNKSKKIKFLLFLN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 242 FLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFMFNYFKMKWMNFFIKNKFILLINLFS 321
Cdd:MTH00160  240 LLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFLS 319

                         330
                  ....*....|....*
gi 1436051976 322 FFSITSMILSTFIFL 336
Cdd:MTH00160  320 FISLFGLILSSLLFL 334
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 9-281 6.21e-56

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 185.41  E-value: 6.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976   9 KMFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKISLMKNFE 88
Cdd:MTH00112    6 KLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWNTGQWD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  89 MNNIS-----IMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILL---SYYFNKNFLIIVIIMNLLIG 160
Cdd:MTH00112   86 ITQLTnptscTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLlmtSNSLNPTLLLTLAILSTLIG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 161 ALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLFIN-NMNFYIKLNLL 239
Cdd:MTH00112  166 GWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSwTKSPTLNTTLM 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1436051976 240 INFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:MTH00112  246 LTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSL 287
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 10-315 5.23e-49

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 167.33  E-value: 5.23e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  10 MFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKISLMKNFEM 89
Cdd:MTH00105    7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMYSGQWTI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  90 NNI-----SIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILL---SYYFNKNFLIIVIIMNLLIGA 161
Cdd:MTH00105   87 TKLtnptaSTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILyqiSPSINPNLLLTLAILSILIGG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 162 LGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQL-FINNMNFYIKLNLLI 240
Cdd:MTH00105  167 WGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLsHTWNKTPLMTSLILL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 241 NFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFM-----FNYFKMKWMNFFIKNKFIL 315
Cdd:MTH00105  247 TLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLtmfpsTNNMKMKWQFENTKPMTLL 326
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 13-281 2.64e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 165.48  E-value: 2.64e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  13 LFILIFS----TLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKISLMKNFE 88
Cdd:MTH00070    6 LSILLSSlalgTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWFTGEWT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  89 MNNI-----SIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILL---SYYFNKNFLIIVIIMNLLIG 160
Cdd:MTH00070   86 IMNMqtplpTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLiqiSHLLNSNLLIIMGLLSTLIG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 161 ALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLFINNM-NFYIKLNLL 239
Cdd:MTH00070  166 GWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSkNPTLTSMMM 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1436051976 240 INFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:MTH00070  246 LTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSAL 287
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 11-261 3.86e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 159.97  E-value: 3.86e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  11 FFLFILIFS----TLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKISLMKN 86
Cdd:MTH00135    4 YVLTILLFSlglgTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWLTGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  87 FEMNNISIMMNSSMLM-----KMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLS--YYFNKNFLIIVIIMNLLI 159
Cdd:MTH00135   84 WDIQQMSHPLPTTMITlalalKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILqiAPTNPTLLITLGLTSTLV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 160 GALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLFINNMNFYI--KLN 237
Cdd:MTH00135  164 GGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAltALT 243

                         250       260
                  ....*....|....*....|....
gi 1436051976 238 LLInFLSLGGLPPFLGFMPKWIII 261
Cdd:MTH00135  244 PLI-LLSLGGLPPLTGFMPKWLIL 266
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 7-330 8.01e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 150.81  E-value: 8.01e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976   7 SNKMFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMkisLMKN 86
Cdd:MTH00144    4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLI---MYNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  87 FEMNNISIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSYYFNKNFLIIVI----IMNLLIGAL 162
Cdd:MTH00144   81 SFSWFSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLcvisVLSALVGSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 163 GGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLFINNMNFYIKLNLLINF 242
Cdd:MTH00144  161 GGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIISLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 243 LSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFMFNYFKMKWMNFFIKNKFILLINLFSF 322
Cdd:MTH00144  241 LSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNLLGG 320


                  ....*...
gi 1436051976 323 FSITSMIL 330
Cdd:MTH00144  321 LLFLLLYL 328
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 10-329 1.28e-41

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 147.51  E-value: 1.28e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  10 MFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMkiSLMKNFEM 89
Cdd:MTH00197    1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSL--SFSNLYLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  90 NNISIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSY-YFNKNFLIIVIIMNLLIGALGGLNQT 168
Cdd:MTH00197   79 LLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFnSSSFMGLLICSVLSSLIGGIGGMNQS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 169 SLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQ-LFINNMNFYIKLNLLINFLSLGG 247
Cdd:MTH00197  159 NIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQqYSNPESMSSNLVFLGLSFLSLGG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 248 LPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFMFNYF---KMKWMNFFIKNKFILLINLFSFFS 324
Cdd:MTH00197  239 LPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWminFLMKINLLYSGLFILLMMMLPLLM 318


                  ....*
gi 1436051976 325 ITSMI 329
Cdd:MTH00197  319 IFTMI 323
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 5-281 2.73e-41

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 147.00  E-value: 2.73e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976   5 NNSNKMFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKI--- 81
Cdd:MTH00041    2 NRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAwls 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  82 -SLMKNFEMNNI-SIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSY---YFNKNFLIIVIIMN 156
Cdd:MTH00041   82 gSWSINGPLNTLsSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISisnLLNSNILILCGILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 157 LLIGALGGLNQTSLRKLLAFSSINNLGWMI----FSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINqlfINNMNF 232
Cdd:MTH00041  162 VLVGGWGGLNQTQTRKILAFSSIAHLGWIIitsaYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNK---LSQLNP 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1436051976 233 YIKLNLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:MTH00041  239 ISAFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSL 287
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 10-296 3.78e-37

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 135.68  E-value: 3.78e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  10 MFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKISlMKNFEM 89
Cdd:MTH00011    9 FLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWS-FPSLLK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  90 NNISIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSYYFN---KNFLIIVIIMNLLIGALGGLN 166
Cdd:MTH00011   88 NITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTShniLPMMTSMAAMSALAGGLGGMN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 167 QTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMIL-MMIFLFFMLNMFFINQLFINNMNFYIKLNLLINFLSL 245
Cdd:MTH00011  168 QTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTpLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSL 247

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1436051976 246 GGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFM 296
Cdd:MTH00011  248 GGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMY 298
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 10-330 4.39e-37

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 135.87  E-value: 4.39e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  10 MFFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILMKISLMKN--- 86
Cdd:MTH00200    7 PLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQwgi 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  87 --FEMNNISIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILL---SYYFNKNFLIIVIIMNLLIGA 161
Cdd:MTH00200   87 seMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLiqlAPALNSNILLLLGLLSVLVGG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 162 LGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQL-FINNMNFYIKLNLLI 240
Cdd:MTH00200  167 WGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLsSSKTKNPILSMLLGL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 241 NFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFMFNYFKMKWMNFFIKNKFILLINLF 320
Cdd:MTH00200  247 TLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSNSNLLVG 326

                         330
                  ....*....|
gi 1436051976 321 SFFSITSMIL 330
Cdd:MTH00200  327 LLLLLSILGL 336
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 15-280 2.20e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 96.25  E-value: 2.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  15 ILIFSTLISISSNSWFGCWIGLEINLLSFIPLI-SNSNDLMSVETSLKYFLIQSLASINFLFFILMKISLMKNFEMNNIS 93
Cdd:MTH00196    1 MVALGILCLISSSNWLSVYLAIELQTLSLFILIaQNRGSGYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGGLHLSYIN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  94 IMMNS------------------SMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPM-ILLSYYFNKNFLIIVII 154
Cdd:MTH00196   81 LVLNSgqsfssvsvpigylliivALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFsILVSIGLNVNILLIGGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 155 MNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMI----SENLWLFYIIIYSFM---ILMMIFLFFMLNMFFINQLFI 227
Cdd:MTH00196  161 FSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIgsfeSIQASLVYLFIYIIMsicVFSIILALNVYKNLIIEFSGL 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1436051976 228 NNMNFYIKLNLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTS 280
Cdd:MTH00196  241 SRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCS 293
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 15-280 6.61e-22

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 95.85  E-value: 6.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  15 ILIFSTLISISSNSWFGCWIGLEINLLS-FIPLISNSNDLMSVETSLKYFLIQSLASINFLF--FILMKISLMKNFEMNN 91
Cdd:MTH00199  105 IVALGSLLLVSSINWLSIYLAIELQTLTlFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFgcALLYGLTGETSIQGIN 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  92 I-------SIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPM-ILLSYYFNKNFLIIVIIMNLLIGALG 163
Cdd:MTH00199  185 SiltgdvgKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFsILVQIGPVTNVVLICAVLSIIYGAIG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 164 GLNQTSLRKLLAFSSINNLGWMIFSIMISEN----LWLFYIIIYSFM---ILMMIFLFFMLNMFFINQLFINNMNFYIKL 236
Cdd:MTH00199  265 ALNQTKIKRLLAYSGIGHMGFILFGVAIGSFesiqASLIYMIIYVIMsicSFSIILSLKLTKGLIVEVSGLSRKNPVIAL 344

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1436051976 237 NLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTS 280
Cdd:MTH00199  345 TLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSS 388
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 26-280 1.92e-21

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 92.38  E-value: 1.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  26 SNSWFGCWIGLEINLLSFIPLI-SNSNDLMSVETSLKYFLIQSLASINFLFFILM-----------KISLMKNFEMNNIS 93
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIgYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLmynytgtlsfdELSKALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  94 IMMNSSMLM-----KMGSAPFHFWFPNIIEGISWMNN-FILMTWQKISPMILL--------SYYFNKNFLIIVIIMNLLI 159
Cdd:pfam00361  81 LLLLFLLILvgflfKSAQVPFHTWLPDAYEGAPTPVSaLLAATLVKAGGYGLIrrsllylpSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 160 GALGGLNQTSLRKLLAFSSINNLGWMIFSIMI----SENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLFINNMNFYIK 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAgtiyGIQAAIFHLLTHGLFSAGLFLCAGSVIYRRVHTRNIRDYGGLAK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1436051976 236 LN------LLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTS 280
Cdd:pfam00361 241 TMpilalvFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 12-281 2.09e-13

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 70.53  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  12 FLFILIFSTL---ISISSNSWFGCWIGLEINLLSFIPLIS-NSNDLMSVETSLKYFLIQSLASInflfFILMKISLM--- 84
Cdd:COG1007   104 FYALLLFATLgmmLMASANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSG----FLLYGISLLyga 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  85 ----------KNFEMNNIS--------IMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSYYFNK 146
Cdd:COG1007   180 tgslnlagiaAALAAGGANspllllglVLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVE 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 147 NF----------LIIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLW----LFYIIIYSFMIL---- 208
Cdd:COG1007   260 AFpglaadwqllLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGvsaaLFYLLAYLFMNLgafa 339

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1436051976 209 -MMIFLFFMLNMFFINQLF-INNMNFYIKLNLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:COG1007   340 vILLLSRKGGEAEEIEDLAgLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSV 414
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 21-261 1.10e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 68.73  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  21 LISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSV---------ETSLKYFLIQSLASINFLFFILMKISLMKN----- 86
Cdd:MTH00198  202 LLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCALYFGFTGNegmlg 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  87 ------FEMNNISIMMNS--------SMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILL-SYYFNKNFLII 151
Cdd:MTH00198  282 tilsatLETTNIELRQGSlgylfitvAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLtSLVITSKLLLS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 152 VIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMIS-----ENLWLfYIIIY------SFMILMMI--------- 211
Cdd:MTH00198  362 VAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFILIGVSAGtyeslQASWT-YAVTYlvsalaSFTVICTLeefgtrtpt 440

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1436051976 212 -------FLFFMLNMFFINQLFINNMNFYIKLNLLINFLSLGGLPPFLGFMPKWIII 261
Cdd:MTH00198  441 srqrdgsFGNYNLVRRLVDLTILSRGQPYIAFSLAIVFLSLAGIPPLLGFLGKWFIL 497
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 4-281 1.38e-11

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 64.97  E-value: 1.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976   4 INNSNKMFFLFILIFSTL---ISISSNSWFGCWIGLEINLLSFIPLISNS-NDLMSVETSLKYFLIQSLASINFLFFILM 79
Cdd:TIGR01770  96 KEKINKFEFYILLLFALLgifLLVSSNDLLSIYLGLELQSLCFYVLAGLKrKSRFSTEAGLKYFILGAFSSGLLLFGISL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  80 -----------KISLMKNFEMNNIS------IMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILL-- 140
Cdd:TIGR01770 176 iygftgslnfeDLLLFLSNGMLNISllllgiVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFlr 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 141 --------SYYFNKNFLIIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENL----WLFYIIIYSFM-- 206
Cdd:TIGR01770 256 lflyilfgFSEAWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEgikaVLFYIFIYALMsl 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 207 ----ILMMIFLFFMLNMFFINQLF-INNMNFYIKLNLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:TIGR01770 336 gafgVLSLLRSYKDEWIEYISDFAgLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSV 415
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
11-281 3.25e-10

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 60.99  E-value: 3.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  11 FFLFILiFSTL---ISISSNSWFGCWIGLEINLLSFIPLIS-NSNDLMSVETSLKYFLIQSLASINFLFFILM------- 79
Cdd:PRK05777  105 FYLLVL-FALLgmmVMVSANDLLTLFLGLELLSLPLYALAAlRRDRRRSLEAAIKYFVLGALASGFLLYGMSLlygatgs 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  80 ----KISLMKNFEMNNIS------IMMNSSMLMKMGSAPFHFWFPNIIEG-----ISWMNN------FILMTwqKISPMI 138
Cdd:PRK05777  184 lsfaGIAKALADGSGNSLlllfglVFLLVGLAFKLSAVPFHMWTPDVYEGaptpvTAFLATapkiaaFAVLL--RLLVVA 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 139 LLSYYF-NKNFLIIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENL----WLFYIIIYSFM-----IL 208
Cdd:PRK05777  262 FGGLSEdWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEgysaVLFYLLAYLFMtlgafGV 341

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1436051976 209 MMIFLFFMLNMFFINQLF-INNMNFYIKLNLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:PRK05777  342 ISLLRRKGGEAESISDFAgLSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSA 415
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 87-309 2.48e-08

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 54.11  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  87 FEMNNISIMMNSSMLMKMGSAPFHFWFPNIIEGISWMNNFILMTWQKISPMILLSYYFNKNFLIIvIIMNLLIGALGGLN 166
Cdd:MTH00091   54 FLLFSFGYFQFLILMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFL-LLFGLLICFFQMFL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 167 QTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFmlnmffinqlfINNMNFYIKLNLLINFLSlg 246
Cdd:MTH00091  133 LKSYKNLLILSSTESFNWLILSFFFSFFNVFFLFFYYFLLMLFLIPKFN-----------NVNKLNFVSWETLLVFMN-- 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1436051976 247 gLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSLIIIYYYIQIIYSSFMFNYFKMKWMNFFI 309
Cdd:MTH00091  200 -LPFSVTFFVKIFSLSEILKVLGFFLLFLLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFF 261
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 11-281 3.22e-07

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 51.69  E-value: 3.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  11 FFLFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLFFILM----------- 79
Cdd:COG0651   111 PLFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLlygatgtlnma 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  80 ----KISLMKNFEMNNISIMMNSSMLMKMGSAPFHFWFPN-----------IIEGIswMNNF----ILMTWQKISPMILL 140
Cdd:COG0651   191 dlaaRLAELDPGLLLAAFALLLVGFGIKAALFPLHFWLPDaypaapspvsaLLSGL--LTKVgvyaILRVLTLLFGADPA 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 141 SYYfnKNFLIIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMF 220
Cdd:COG0651   269 LFL--GTLLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNHALAKALLFLAAGA 346

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 221 FINQLFINNMNFY---------IKLNLLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:COG0651   347 IERATGTRDLDKLgglgkrmplTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSL 416
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 13-260 5.24e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 44.70  E-value: 5.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  13 LFILIFSTLISISSNSWFGCWIGLEINLLSFIPLISNSNDL-MSVETSLKYFLIQSLASINFLFFILMKISLMKNFEMNN 91
Cdd:PRK08376  127 ILLLELGMLGMAITGDLFNFFVFLEIMSIASYALVAFRNDTwEAIEAGIKYMFVGSLASSMVLLGIALLYGQYGTLNMAY 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  92 ISIMMNSSM---------------LMKMGSAPFHFWFPN----IIEGISWMNNFILMTWQKISPMILLSYY---FNKNFL 149
Cdd:PRK08376  207 LAVKMSENPtvvakialalfiaglAMKSGAVPVHMWLPDaypaAPSSISAMLLVIKQAGLYALARVLFSIYgpaINLATV 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 150 ----IIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSI----------------MISENLWLFYIIIYSfmilM 209
Cdd:PRK08376  287 gwviIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYMLLGLgvglaalgdpamasygEIALAGGIYHIVNHA----L 362

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 210 MIFLFFMLNMFFINQLFINNMNF---------YIKLNLLINFLSLGGLPPFLGFMPKWII 260
Cdd:PRK08376  363 YKALLFLTAGAVIYETGTRNLNElgglartmpKTTIAFLIGAAAIVGLPPFNGFASKWLI 422
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
52-257 7.45e-05

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 44.27  E-value: 7.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  52 DLMSVETSLKYFLIQSLASINFLF--FILMKISLMK-NFEMNNISIMMNSSMLM-------------KMGSAPFHFWFPN 115
Cdd:PRK02504  156 DPRSNEAALKYLLIGAASSAIFLYgsSLLYGLSGGStQLSAIALALITSPSLGLalalvfviagiafKISAVPFHQWTPD 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 116 IIEGI-----------SWMNNFILmtwqkisPMILLSYYFN------KNFLIIVIIMNLLIGALGGLNQTSLRKLLAFSS 178
Cdd:PRK02504  236 VYEGSptpvvaflsvgSKAAGFAL-------AIRLLVTAFPsfdeqwKLLFTALAILSMVLGNVVALAQTSMKRMLAYSS 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 179 INNLGW-MI---------FSIMIsenlwlFYIIIYSFMILMMIFLFFMLNMFFINQLFINNMNFYIK-----LNLLINFL 243
Cdd:PRK02504  309 IGQAGFvMIglvagteagYASMV------FYLLAYLFMNLGAFACVILFSLRTGTDQISDYAGLYQKdplltLGLSLCLL 382

                         250
                  ....*....|....
gi 1436051976 244 SLGGLPPFLGFMPK 257
Cdd:PRK02504  383 SLGGIPPLAGFFGK 396
PRK12665 PRK12665
putative monovalent cation/H+ antiporter subunit D; Reviewed
 147-203 1.68e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237165 [Multi-domain]  Cd Length: 521  Bit Score: 43.03  E-value: 1.68e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1436051976 147 NFLIIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIY 203
Cdd:PRK12665  274 TLLMVVALLTMVVGILGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTVAGLSGAIYY 330
PRK12650 PRK12650
DUF4040 family protein;
108-189 2.19e-04

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 43.11  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 108 PFHFWFPNIIEGISWMNNFI---LMTWQKISPMILLSYYFNKN-----FLIIVIIMNLLIGALGGLNQTSLRKLLAFSSI 179
Cdd:PRK12650  226 PFHFWLPEAMAAITPVSAFLhaaAVVKAGIYLLLRFSPVFHDVavwnwLLIIVGMITALMGAVFAVQKTDLKKLTAYSTV 305

                          90
                  ....*....|
gi 1436051976 180 NNLGWMIFSI 189
Cdd:PRK12650  306 SQLGWIVATI 315
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
149-281 3.28e-03

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 39.16  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 149 LIIVIIMNLLIGALGGLNQTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSF--MILMMIFLFFMLNMFFINQLF 226
Cdd:PRK12663  275 LATMAAITMVIGALGALAYKDIRRIAGYQVISSIGFILLGLALGTPAGINGAIFYLVhdMVVKTALFLIAGSLVRLTGYR 354

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1436051976 227 -INNMNFYIKLN------LLINFLSLGGLPPFLGFMPKWIIINFLMINKFYFLTFIFVMTSL 281
Cdd:PRK12663  355 sLQYLGGLYRKEplfgalFLILIFAIGGLPPFSGFWGKVLLVQGALDNGAYILLALMLITSL 416
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 36-261 5.89e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 38.32  E-value: 5.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976  36 LEINLLSFIPLISNSNDLMSVETSLKYFLIQSLASINFLF-------------FILMKISLMKNFEMNNISIMMNSSMLM 102
Cdd:PRK08375  135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIgvgllygvtgtlnMADLAGALAENPTVVTAFGFVLLALAL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 103 KMGSAPFHFWFPN-----------IIEGIS-----WMNNFILMTWQKISPMILLSYyfnKNFLIIVIIMNLLIGALGGLN 166
Cdd:PRK08375  215 KAAVFPLHTWLPRaypaappvvtaLLSGLVtkvavYALIRIYFTVFGGDFRFALGL---GWLLAVLALLSMLVGSLAALG 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1436051976 167 QTSLRKLLAFSSINNLGWMIFSIMISENLWLFYIIIYSFMILMMIFLFFMLNMFFINQLFINNMNFYIKLN-----LLIN 241
Cdd:PRK08375  292 QDDVKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLLHHALMKGALFLAAGAIEVTYGTRRLSELSGLGrrmplTAAA 371

                         250       260
                  ....*....|....*....|....
gi 1436051976 242 F----LSLGGLPPFLGFMPKWIII 261
Cdd:PRK08375  372 FavasLSLIGVPPTSGFVSKWYLV 395
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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