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Conserved domains on  [gi|1631922669|ref|YP_009600534|]
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DnaB-like replicative helicase [Acinetobacter phage WCHABP12]

Protein Classification

replicative DNA helicase( domain architecture ID 11416751)

replicative DNA helicase unwinds the DNA duplex at the chromosome replication fork

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
11-420 2.10e-95

Replicative DNA helicase [Replication, recombination and repair];


:

Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 293.14  E-value: 2.10e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  11 EQYVLSFLMDDENSW--ASLDVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVEMCS 88
Cdd:COG0305     5 EQAVLGALLLDNDALdeVADILKP--EDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAELAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  89 VFAAPSATGFYIEKLKKLAECRKVEEVGKKIIELAQNTmQEDMPGIAQELASGLESVLATDTRIDIANSSaEALRVLSEK 168
Cdd:COG0305    83 NVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDE-DEDVDELLDEAEQKIFEIAEKRSSKGFVSIS-DILKEALER 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 169 IQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSRIV 248
Cdd:COG0305   161 IEELYKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 249 SAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIGCVIVDYIQLLNDPNS 328
Cdd:COG0305   241 SSEARIDSSKLRTGKLSDEDWER-LSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMSGSGR 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 329 KD--QFErISNVSTGLKRIAKDFKVPVIGLSQL---TKEAQGRKITMSDLRGSGQISQDADKIILL------SPASNEVG 397
Cdd:COG0305   319 SEnrQQE-ISEISRSLKALAKELNVPVIALSQLsraVEQRTDKRPQLSDLRESGSIEQDADVVMFLyrdeyyNPDSEDKG 397

                         410       420       430
                  ....*....|....*....|....*....|
gi 1631922669 398 VvtAE--VAKNRQGMKGEARLQ-----TRF 420
Cdd:COG0305   398 I--AEiiIAKQRNGPTGTVKLAfdgeyTRF 425
 
Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
11-420 2.10e-95

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 293.14  E-value: 2.10e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  11 EQYVLSFLMDDENSW--ASLDVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVEMCS 88
Cdd:COG0305     5 EQAVLGALLLDNDALdeVADILKP--EDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAELAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  89 VFAAPSATGFYIEKLKKLAECRKVEEVGKKIIELAQNTmQEDMPGIAQELASGLESVLATDTRIDIANSSaEALRVLSEK 168
Cdd:COG0305    83 NVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDE-DEDVDELLDEAEQKIFEIAEKRSSKGFVSIS-DILKEALER 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 169 IQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSRIV 248
Cdd:COG0305   161 IEELYKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 249 SAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIGCVIVDYIQLLNDPNS 328
Cdd:COG0305   241 SSEARIDSSKLRTGKLSDEDWER-LSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMSGSGR 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 329 KD--QFErISNVSTGLKRIAKDFKVPVIGLSQL---TKEAQGRKITMSDLRGSGQISQDADKIILL------SPASNEVG 397
Cdd:COG0305   319 SEnrQQE-ISEISRSLKALAKELNVPVIALSQLsraVEQRTDKRPQLSDLRESGSIEQDADVVMFLyrdeyyNPDSEDKG 397

                         410       420       430
                  ....*....|....*....|....*....|
gi 1631922669 398 VvtAE--VAKNRQGMKGEARLQ-----TRF 420
Cdd:COG0305   398 I--AEiiIAKQRNGPTGTVKLAfdgeyTRF 425
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 6-420 8.53e-90

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 278.92  E-value: 8.53e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSW--ASLDVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYL 83
Cdd:TIGR00665   3 HNIEAEQAVLGAILLDNEAIddVAEILKP--EDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  84 VEMCSvfAAPSAT--GFYIEKLKKLAECRKVEEVGKKIIELAQNTMQEdmpgiAQELASGLESVLatdtrIDIANSS--- 158
Cdd:TIGR00665  81 AELAS--NVPSAAniEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGD-----VEELLDEAEQKI-----FEIAESRtsk 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 159 -----AEALRVLSEKIQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLF 233
Cdd:TIGR00665 149 gfksiKEILKEAVEEIEELYERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAF 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 234 ISCEMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIG 313
Cdd:TIGR00665 229 FSLEMSAEQLVMRMLSSESRVDSQKLRTGRLSDEDWEK-LTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHG-LG 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 314 CVIVDYIQLLNDPNSKD--QFErISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGRK----ItMSDLRGSGQISQDADKII 387
Cdd:TIGR00665 307 LIVIDYLQLMSGSGRSEnrQQE-VSEISRSLKALAKELNVPVIALSQLSRSVEQREdkrpQ-LSDLRESGSIEQDADIVM 384

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1631922669 388 LL------SPASNEVGVVTAEVAKNRQGMKGEARLQ-----TRF 420
Cdd:TIGR00665 385 FLyrdeyyNPDSEDKGIAEIIIAKQRNGPTGTVKLAflgeyTRF 428
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 181-425 1.10e-73

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 231.25  E-value: 1.10e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 181 GVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSRIVSAVGRIPFDNIQ 260
Cdd:cd00984     1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 261 SGRMESDDFERWvQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSIGCVIVDYIQLLNDPNSKDQ-FERISNVS 339
Cdd:cd00984    81 TGRLDDEDWERL-TAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKRAENrQQEVAEIS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 340 TGLKRIAKDFKVPVIGLSQLTKEAQGRKI---TMSDLRGSGQISQDADKIILLS------PASNEVGVVTAEVAKNRQGM 410
Cdd:cd00984   160 RSLKALAKELNVPVIALSQLNRGVESRTDkrpMLSDLRESGSIEQDADVVIFLYrdeyydKDSEDKGIAEIIIAKNRNGP 239

                         250
                  ....*....|....*
gi 1631922669 411 KGEARLQTRFNYCQF 425
Cdd:cd00984   240 TGTVYLAFNPEYTRF 254
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 181-420 4.62e-66

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 211.51  E-value: 4.62e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 181 GVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSRIVSAVGRIPFDNIQ 260
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 261 SGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIGCVIVDYIQLLNDPNSKD--QFErISNV 338
Cdd:pfam03796  81 TGQLTDEDWEK-LAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSGGSRGEnrQQE-ISEI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 339 STGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL------SPASNEvgvVTAE--VAKNR 407
Cdd:pfam03796 158 SRSLKALAKELNVPVIALSQLSRAVEQRtdkRPQLSDLRESGAIEQDADVVMFLyrdeyyNPKEPE---GKAEiiIAKQR 234

                         250
                  ....*....|....*...
gi 1631922669 408 QGMKGEARLQ-----TRF 420
Cdd:pfam03796 235 NGPTGTVKLAflgeyTRF 252
PRK05748 PRK05748
replicative DNA helicase; Provisional
 6-425 4.95e-62

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 207.11  E-value: 4.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSW--ASLDVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYL 83
Cdd:PRK05748   12 QSIEAEQAVLGAIFLDPDALitVSEYLSP--DDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDLEEVGGLSYL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  84 VEMCSvfAAPSAT--GFYIEKLKKLAECRKVEEVGKKIIELAQNTMQEdmpgiAQELASGLESVLatdtrIDIANSSA-- 159
Cdd:PRK05748   90 AELAN--SVPTAAniEYYAKIVAEKAMLRRLIRTATEIANDAYEPEDD-----ADEILDEAEKKI-----FEVSERRNks 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 160 ------EALRVLSEKIQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLF 233
Cdd:PRK05748  158 gfknikDVLVKAYDRIEMLHNQTGDITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNVAI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 234 ISCEMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERWvqTTA-HELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSI 312
Cdd:PRK05748  238 FSLEMGAESLVMRMLCAEGNIDAQRLRTGQLTDDDWPKL--TIAmGSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHGGL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 313 GCVIVDYIQLL--NDPNSKDQFERISNVSTGLKRIAKDFKVPVIGLSQLTK---EAQGRKITMSDLRGSGQISQDADKII 387
Cdd:PRK05748  316 GLILIDYLQLIqgSGRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRgveQRQDKRPVMSDIRESGSIEQDADIVA 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1631922669 388 LL------SPASNEVGVVTAEVAKNRQGMKGEARLQTRFNYCQF 425
Cdd:PRK05748  396 FLyrddyyDEETENKNTIEIIIAKQRNGPVGTVELAFQKEYNKF 439
 
Name Accession Description Interval E-value
DnaB COG0305
Replicative DNA helicase [Replication, recombination and repair];
11-420 2.10e-95

Replicative DNA helicase [Replication, recombination and repair];


Pssm-ID: 440074 [Multi-domain]  Cd Length: 429  Bit Score: 293.14  E-value: 2.10e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  11 EQYVLSFLMDDENSW--ASLDVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVEMCS 88
Cdd:COG0305     5 EQAVLGALLLDNDALdeVADILKP--EDFYRPAHRLIFEAILDLYERGEPIDLVTVAEELEKRGELEEVGGAAYLAELAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  89 VFAAPSATGFYIEKLKKLAECRKVEEVGKKIIELAQNTmQEDMPGIAQELASGLESVLATDTRIDIANSSaEALRVLSEK 168
Cdd:COG0305    83 NVPSAANIEYYARIVKEKALLRRLIEAGTEIVELAYDE-DEDVDELLDEAEQKIFEIAEKRSSKGFVSIS-DILKEALER 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 169 IQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSRIV 248
Cdd:COG0305   161 IEELYKNGGGITGVPTGFTDLDKLTGGLQPGDLIILAARPSMGKTAFALNIARNAAIKEGKPVAIFSLEMSAEQLVMRLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 249 SAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIGCVIVDYIQLLNDPNS 328
Cdd:COG0305   241 SSEARIDSSKLRTGKLSDEDWER-LSSAAGELSEAPIYIDDTPGLTIAEIRAKARRLKREHG-LGLIVIDYLQLMSGSGR 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 329 KD--QFErISNVSTGLKRIAKDFKVPVIGLSQL---TKEAQGRKITMSDLRGSGQISQDADKIILL------SPASNEVG 397
Cdd:COG0305   319 SEnrQQE-ISEISRSLKALAKELNVPVIALSQLsraVEQRTDKRPQLSDLRESGSIEQDADVVMFLyrdeyyNPDSEDKG 397

                         410       420       430
                  ....*....|....*....|....*....|
gi 1631922669 398 VvtAE--VAKNRQGMKGEARLQ-----TRF 420
Cdd:COG0305   398 I--AEiiIAKQRNGPTGTVKLAfdgeyTRF 425
DnaB TIGR00665
replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein ...
 6-420 8.53e-90

replicative DNA helicase; This model describes the helicase DnaB, a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. An intein of > 400 residues is found at a conserved location in DnaB of Synechocystis PCC6803, Rhodothermus marinus (both experimentally confirmed), and Mycobacterium tuberculosis. The intein removes itself by a self-splicing reaction. The seed alignment contains inteins so that the model built from the seed alignment will model a low cost at common intein insertion sites. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273206 [Multi-domain]  Cd Length: 432  Bit Score: 278.92  E-value: 8.53e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSW--ASLDVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYL 83
Cdd:TIGR00665   3 HNIEAEQAVLGAILLDNEAIddVAEILKP--EDFYRPAHRLIFQAILDLYEKGEPIDLVTVAEELEKDGELEEVGGLAYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  84 VEMCSvfAAPSAT--GFYIEKLKKLAECRKVEEVGKKIIELAQNTMQEdmpgiAQELASGLESVLatdtrIDIANSS--- 158
Cdd:TIGR00665  81 AELAS--NVPSAAniEYYAEIVKEKAILRRLIQAGTEIVELAYDPTGD-----VEELLDEAEQKI-----FEIAESRtsk 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 159 -----AEALRVLSEKIQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLF 233
Cdd:TIGR00665 149 gfksiKEILKEAVEEIEELYERKGGITGVPTGFTDLDKLTSGLQPSDLIILAARPSMGKTAFALNIAENAAIKEGKPVAF 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 234 ISCEMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIG 313
Cdd:TIGR00665 229 FSLEMSAEQLVMRMLSSESRVDSQKLRTGRLSDEDWEK-LTEAAGELSEAPLYIDDTPGLTITELRAKARRLKREHG-LG 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 314 CVIVDYIQLLNDPNSKD--QFErISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGRK----ItMSDLRGSGQISQDADKII 387
Cdd:TIGR00665 307 LIVIDYLQLMSGSGRSEnrQQE-VSEISRSLKALAKELNVPVIALSQLSRSVEQREdkrpQ-LSDLRESGSIEQDADIVM 384

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1631922669 388 LL------SPASNEVGVVTAEVAKNRQGMKGEARLQ-----TRF 420
Cdd:TIGR00665 385 FLyrdeyyNPDSEDKGIAEIIIAKQRNGPTGTVKLAflgeyTRF 428
DnaB_C cd00984
C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase ...
 181-425 1.10e-73

C-terminal domain of DnaB helicase; DnaB helicase C-terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 410864 [Multi-domain]  Cd Length: 256  Bit Score: 231.25  E-value: 1.10e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 181 GVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSRIVSAVGRIPFDNIQ 260
Cdd:cd00984     1 GLPTGFTDLDKLTGGLQPGDLIIIAARPSMGKTAFALNIAENIALDEGLPVLFFSLEMSAEQLAERLLSSESGVSLSKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 261 SGRMESDDFERWvQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSIGCVIVDYIQLLNDPNSKDQ-FERISNVS 339
Cdd:cd00984    81 TGRLDDEDWERL-TAAMGELSELPLYIDDTPGLTVDEIRAKARRLKREHGGLGLIVIDYLQLIRGSKRAENrQQEVAEIS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 340 TGLKRIAKDFKVPVIGLSQLTKEAQGRKI---TMSDLRGSGQISQDADKIILLS------PASNEVGVVTAEVAKNRQGM 410
Cdd:cd00984   160 RSLKALAKELNVPVIALSQLNRGVESRTDkrpMLSDLRESGSIEQDADVVIFLYrdeyydKDSEDKGIAEIIIAKNRNGP 239

                         250
                  ....*....|....*
gi 1631922669 411 KGEARLQTRFNYCQF 425
Cdd:cd00984   240 TGTVYLAFNPEYTRF 254
DnaB_C pfam03796
DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 181-420 4.62e-66

DnaB-like helicase C terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.


Pssm-ID: 427509 [Multi-domain]  Cd Length: 254  Bit Score: 211.51  E-value: 4.62e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 181 GVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSRIVSAVGRIPFDNIQ 260
Cdd:pfam03796   1 GLPTGFTDLDRLTGGLQPGDLIIIAARPSMGKTAFALNIARNAAVKHKKPVAIFSLEMSAEQLVMRLLASEAGVDSQKLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 261 SGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIGCVIVDYIQLLNDPNSKD--QFErISNV 338
Cdd:pfam03796  81 TGQLTDEDWEK-LAKAAGRLSEAPLYIDDTPGLSIAEIRAKARRLKREHG-LGLIVIDYLQLMSGGSRGEnrQQE-ISEI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 339 STGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL------SPASNEvgvVTAE--VAKNR 407
Cdd:pfam03796 158 SRSLKALAKELNVPVIALSQLSRAVEQRtdkRPQLSDLRESGAIEQDADVVMFLyrdeyyNPKEPE---GKAEiiIAKQR 234

                         250
                  ....*....|....*...
gi 1631922669 408 QGMKGEARLQ-----TRF 420
Cdd:pfam03796 235 NGPTGTVKLAflgeyTRF 252
PRK05748 PRK05748
replicative DNA helicase; Provisional
 6-425 4.95e-62

replicative DNA helicase; Provisional


Pssm-ID: 180232 [Multi-domain]  Cd Length: 448  Bit Score: 207.11  E-value: 4.95e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSW--ASLDVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYL 83
Cdd:PRK05748   12 QSIEAEQAVLGAIFLDPDALitVSEYLSP--DDFYRHAHRLIFRAMLKLSDRGEPIDVVTVTEILDDQGDLEEVGGLSYL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  84 VEMCSvfAAPSAT--GFYIEKLKKLAECRKVEEVGKKIIELAQNTMQEdmpgiAQELASGLESVLatdtrIDIANSSA-- 159
Cdd:PRK05748   90 AELAN--SVPTAAniEYYAKIVAEKAMLRRLIRTATEIANDAYEPEDD-----ADEILDEAEKKI-----FEVSERRNks 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 160 ------EALRVLSEKIQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLF 233
Cdd:PRK05748  158 gfknikDVLVKAYDRIEMLHNQTGDITGIPTGFTDLDKMTSGLQPNDLIIVAARPSVGKTAFALNIAQNVATKTDKNVAI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 234 ISCEMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERWvqTTA-HELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSI 312
Cdd:PRK05748  238 FSLEMGAESLVMRMLCAEGNIDAQRLRTGQLTDDDWPKL--TIAmGSLSDAPIYIDDTPGIKVTEIRARCRRLAQEHGGL 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 313 GCVIVDYIQLL--NDPNSKDQFERISNVSTGLKRIAKDFKVPVIGLSQLTK---EAQGRKITMSDLRGSGQISQDADKII 387
Cdd:PRK05748  316 GLILIDYLQLIqgSGRSGENRQQEVSEISRSLKALAKELKVPVIALSQLSRgveQRQDKRPVMSDIRESGSIEQDADIVA 395

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1631922669 388 LL------SPASNEVGVVTAEVAKNRQGMKGEARLQTRFNYCQF 425
Cdd:PRK05748  396 FLyrddyyDEETENKNTIEIIIAKQRNGPVGTVELAFQKEYNKF 439
PRK08006 PRK08006
replicative DNA helicase DnaB;
6-432 1.96e-61

replicative DNA helicase DnaB;


Pssm-ID: 181193 [Multi-domain]  Cd Length: 471  Bit Score: 206.40  E-value: 1.96e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSWASLDVKPCLDDFYSDRHKEIFKaiENQRML--GKPFDQITMLEVFKDLGKLDLIGGEEYL 83
Cdd:PRK08006   29 HSIEAEQSVLGGLMLDNERWDDVAERVVADDFYTRPHRHIFT--EMARLQesGSPIDLITLAESLERQGQLDSVGGFAYL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  84 VEMCSVFAAPSATGFYIEKLKKLAECRKVEEVGKKIIELA---QNTMQEDMPGIAQelaSGLESVLATDTRIDIANSSAE 160
Cdd:PRK08006  107 AELSKNTPSAANISAYADIVRERAVVREMISVANEIADAGydpQGRTSEDLLDLAE---SRVFQIAESRANKDEGPKNIA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 161 alRVLSEKIQ-----HKTSKDGLAyGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFIS 235
Cdd:PRK08006  184 --DILDATVArieqlFQQPHDGVT-GVNTGYDDLNKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMLQDKPVLIFS 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 236 CEMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERWVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSIGCV 315
Cdd:PRK08006  261 LEMPGEQIMMRMLASLSRVDQTRIRTGQLDDEDWARISGTMGILLEKRNMYIDDSSGLTPTEVRSRARRIFREHGGLSLI 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 316 IVDYIQLLNDPN-SKDQFERISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL-- 389
Cdd:PRK08006  341 MIDYLQLMRVPSlSDNRTLEIAEISRSLKALAKELQVPVVALSQLNRSLEQRadkRPVNSDLRESGSIEQDADLIMFIyr 420

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1631922669 390 ----SPASNEVGVVTAEVAKNRQGMKGEARLQ-----TRFNycQFAAPKIED 432
Cdd:PRK08006  421 devyHENSDLKGIAEIIIGKQRNGPIGTVRLTfngqwSRFD--NYAGPQYDD 470
PRK08760 PRK08760
replicative DNA helicase; Provisional
 6-425 8.02e-61

replicative DNA helicase; Provisional


Pssm-ID: 181547 [Multi-domain]  Cd Length: 476  Bit Score: 204.77  E-value: 8.02e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSWASLDVKPCLDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVE 85
Cdd:PRK08760   35 HSVEAEQAVLGGLMLAPDALDRVNDQLTENDFYRRDHRLIYRAIRELSEKDRPFDAVTLGEWFESQGKLEQVGDGAYLIE 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  86 MCSVFAAPSATGFYIEKLKKLAECRKVEEVGKKIIelaQNTMQEDMPGIAQELASGLESVLA-----TDTRIDIANSSAe 160
Cdd:PRK08760  115 LASTTPSAANIAAYAEIVRDKAVLRQLIEVGTTIV---NDGFQPEGRESIELLASAEKAVFKiaeagARGRTDFVAMPG- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 161 ALRVLSEKIQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAH 240
Cdd:PRK08760  191 ALKDAFEELRNRFENGGNITGLPTGYNDFDAMTAGLQPTDLIILAARPAMGKTTFALNIAEYAAIKSKKGVAVFSMEMSA 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 241 YELTSRIVSAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHgSIGCVIVDYI 320
Cdd:PRK08760  271 SQLAMRLISSNGRINAQRLRTGALEDEDWAR-VTGAIKMLKETKIFIDDTPGVSPEVLRSKCRRLKREH-DLGLIVIDYL 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 321 QLLNDP-NSKDQFERISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL------- 389
Cdd:PRK08760  349 QLMSVPgNSENRATEISEISRSLKGLAKELNVPVIALSQLNRSLETRtdkRPVMADLRESGAIEQDADMIVFIyrddyyn 428

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1631922669 390 SPASNEVGVVTAEVAKNRQGMKGEARLQTRFNYCQF 425
Cdd:PRK08760  429 KENSPDKGLAEIIIGKHRGGPTGSCKLKFFGEYTRF 464
PRK08840 PRK08840
replicative DNA helicase; Provisional
 6-432 1.17e-59

replicative DNA helicase; Provisional


Pssm-ID: 181562 [Multi-domain]  Cd Length: 464  Bit Score: 201.37  E-value: 1.17e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSWASLDVKPCLDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVE 85
Cdd:PRK08840   22 HSLEAEQSVIGGLLLDNERWDTVAEKVVASDFYSRPHRLIFEGVKSILEAGKPLDLITLSEHLERREQLEDVGGFAYLAD 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  86 MCSVFAAPSATGFYIEKLKKLAECRKVEEVGKKIIELA---QNTMQEDMP--------GIAQELASGLESVLATDTridI 154
Cdd:PRK08840  102 LAKNTPSAANINAYADIVAERALVRNLIGVANEIADAGydpQGRTSEDLLdmaeskvfAIAEARTSENEGPQNVDS---I 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 155 ANSSAEALRVLsekiqHKTSKDGLAyGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFI 234
Cdd:PRK08840  179 LEKTLERIELL-----YKTPQDGVT-GVDTGFTDLNKKTAGLQGSDLIIVAARPSMGKTTFAMNLCENAAMDQDKPVLIF 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 235 SCEMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERWVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSIGC 314
Cdd:PRK08840  253 SLEMPAEQLMMRMLASLSRVDQTKIRTGQLDDEDWARISSTMGILMEKKNMYIDDSSGLTPTEVRSRARRIAREHGGLSM 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 315 VIVDYIQLLNDPNSKD-QFERISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL- 389
Cdd:PRK08840  333 IMVDYLQLMRVPALSDnRTLEIAEISRSLKALAKELNVPVVALSQLNRSLEQRadkRPVNSDLRESGSIEQDADLIMFIy 412

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1631922669 390 -----SPASNEVGVVTAEVAKNRQGMKGEARLQTRFNYCQF---AAPKIED 432
Cdd:PRK08840  413 rdevyNPDSPLKGTAEIIIGKQRNGPIGSVRLTFQGQYSRFdnyAGPAFDD 463
PRK06904 PRK06904
replicative DNA helicase; Validated
 6-425 1.07e-56

replicative DNA helicase; Validated


Pssm-ID: 136106 [Multi-domain]  Cd Length: 472  Bit Score: 194.06  E-value: 1.07e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSWASLDVKPCLDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVE 85
Cdd:PRK06904   25 HSIEAEQAVLGGIMLDNRHWDSVAERVIADDFYTFEHRIIFQEMELLFRQNTPIDLLTLDQALKTKGKSDEVGGFAYLAE 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  86 MCSvfAAPSATGF--YIEKLKKLAECRKVEEVGKKIIELAQNTMQEDMPGIAQELASGLESVLATDTR--------IDIA 155
Cdd:PRK06904  105 LSN--NTPSAANIlaYADIVREKAILRELISVGNNIAKNAYSPKGQDIKDILDEAERDVFSIAEKRTTanegpqnvINLL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 156 NSSAEALRVLSekiqhKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFIS 235
Cdd:PRK06904  183 ENTIDKIENLA-----ATPTNNGVTGVTTGFTDLDKKTAGLQPSDLIIVAARPSMGKTTFAMNLCENAAMASEKPVLVFS 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 236 CEMAHYELTSRIVSAVGRIPFDNIQSGRMESD-DFERWVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSIGC 314
Cdd:PRK06904  258 LEMPAEQIMMRMLASLSRVDQTKIRTGQNLDQqDWAKISSTVGMFKQKPNLYIDDSSGLTPTELRSRARRVYRENGGLSL 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 315 VIVDYIQLLNDPNSKDQFE-RISNVSTGLKRIAKDFKVPVIGLSQL--TKEAQG-RKITMSDLRGSGQISQDADKIILL- 389
Cdd:PRK06904  338 IMVDYLQLMRAPGFEDNRTlEIAEISRSLKALAKELKVPVVALSQLnrTLENRGdKRPVNSDLRESGSIEQDADLIMFIy 417

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1631922669 390 ------SPASNEVGVVTAEVAKNRQGMKGEARLQTRFNYCQF 425
Cdd:PRK06904  418 rdevynETTEDNKGVAEIIIGKQRNGPIGRVRLAFQGQYSRF 459
PRK07773 PRK07773
replicative DNA helicase; Validated
 6-419 2.52e-54

replicative DNA helicase; Validated


Pssm-ID: 236093 [Multi-domain]  Cd Length: 886  Bit Score: 193.81  E-value: 2.52e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVL-SFLMDDEnswASLDVKPCL--DDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEY 82
Cdd:PRK07773   26 QDLAAEQSVLgGMLLSKE---AIARVLERLrpGAFYRPAHQNIYDAILDLYGRGEPADLVTVAAELDRRGLLERIGGAPY 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  83 LVEMCSVFAAPSATGFYIEKLKKLAECRKVEEVGKKIIELAQNTMQeDMPGIAQELASGLESVLATDTRIDIAnSSAEAL 162
Cdd:PRK07773  103 LHTLISTVPTAANADYYARIVAEKALLRRLIEAGTRIVQYGYAEGA-DVAEVVDRAQAEIYDVTDRRLSEDFV-ALEDLL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 163 RVLSEKIQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYE 242
Cdd:PRK07773  181 QPTFDEIDAIASSGGLARGVPTGFTELDAMTNGLHPGQLIIVAARPSMGKTTFGLDFARNCAIRHRLAVAIFSLEMSKEQ 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 243 LTSRIVSAVGRIPFDNIQSGRMESDDFERWVQtTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHgSIGCVIVDYIQL 322
Cdd:PRK07773  261 LVMRLLSAEAKIKLSDMRSGRMSDDDWTRLAR-AMGEISEAPIFIDDTPNLTVMEIRAKARRLRQEA-NLGLIVVDYLQL 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 323 LNDPNSKDQFER-ISNVSTGLKRIAKDFKVPVIGLSQLTK--EAQGRKITM-SDLRGSGQISqdADKIILLSPASNEV-- 396
Cdd:PRK07773  339 MTSGKKYENRQQeVSEISRHLKLLAKELEVPVVALSQLSRgvEQRTDKRPMlSDLRESGCLT--GDTLILRADTGAEVpi 416

                         410       420
                  ....*....|....*....|....*...
gi 1631922669 397 ----GVVTAEV-AKNRQGMKGEARLQTR 419
Cdd:PRK07773  417 gelvGERPFAVwALDERTLRLVAAPVSN 444
PRK09165 PRK09165
replicative DNA helicase; Provisional
 6-384 8.07e-52

replicative DNA helicase; Provisional


Pssm-ID: 181676 [Multi-domain]  Cd Length: 497  Bit Score: 181.62  E-value: 8.07e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSWASLD--VKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYL 83
Cdd:PRK09165   23 HNIEAEQALLGAILINNRALDRVSdfLKP--EHFFEPLHQRIYEAIAKIIRKGKLATPVTLKTFLENDEALGELGGVQYL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  84 V----EMCSVFAAPSatgfYIEKLKKLAECRKVEEVGKKIIELAQNTmQEDMPGIAQ---------ELAsglESVLATDT 150
Cdd:PRK09165  101 AklatEAVTIINARD----YGRIIYDLALRRELINIGEDVVNNAYDA-PVDVAPQEQiedaeqklyELA---ETGRYEGG 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 151 RIDIANSSAEALRVLSEKIQhktSKDGLAyGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKR---- 226
Cdd:PRK09165  173 FQSFGTAITEAVDMANAAFK---RDGHLS-GISTGLRDLDSKLGGLHPSDLIILAGRPSMGKTALATNIAFNAAKAyrre 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 227 ---------NDVPCL-FISCEMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERWVqTTAHELQKYKLDIVDKAGITIN 296
Cdd:PRK09165  249 aqpdgskkaVNGGVVgFFSLEMSAEQLATRILSEQSEISSSKIRRGKISEEDFEKLV-DASQELQKLPLYIDDTPALSIS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 297 EIRGEIKKSIAKHGsIGCVIVDYIQLLNdPNSKDQFE----RISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KIT 369
Cdd:PRK09165  328 QLRARARRLKRQHG-LDLLVVDYLQLIR-GSSKRSSDnrvqEISEITQGLKALAKELNIPVIALSQLSRQVEQRddkRPQ 405

                         410
                  ....*....|....*
gi 1631922669 370 MSDLRGSGQISQDAD 384
Cdd:PRK09165  406 LSDLRESGSIEQDAD 420
PRK05595 PRK05595
replicative DNA helicase; Provisional
 6-430 2.25e-49

replicative DNA helicase; Provisional


Pssm-ID: 235525 [Multi-domain]  Cd Length: 444  Bit Score: 173.86  E-value: 2.25e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSWASLDVKPCLDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVE 85
Cdd:PRK05595   10 QSIEAEQSVLGAMIIDKTSIAEAAEVLKSEDFYRDSHKVIFSAIIELYQKDIAVDMLTLTENLKSTDKLEAAGGVTYITE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  86 MCSVFAAPSATGFYIEKLKKLAECRKVEEVGKKIIELAQNTmQEDMPGIaqelasglesVLATDTRI-DIAN----SSAE 160
Cdd:PRK05595   90 LSNSIVSTANIQSYIKIVKDKSTLRRLIKSSTEIIENSYNN-QDDVEKV----------IDSAEKKIfDISEkrttSDFE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 161 ALRVLSEK----IQHKTSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISC 236
Cdd:PRK05595  159 PLSNVLERgfeqIENLFNNKGETTGVASGFRELDAKTSGFQKGDMILIAARPSMGKTTFALNIAEYAALREGKSVAIFSL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 237 EMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIGCVI 316
Cdd:PRK05595  239 EMSKEQLAYKLLCSEANVDMLRLRTGNLEDKDWEN-IARASGPLAAAKIFIDDTAGVSVMEMRSKCRRLKIEHG-IDMIL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 317 VDYIQLLN-DPNSKDQFERISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL--- 389
Cdd:PRK05595  317 IDYLQLMSgGKGSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRadhRPMLSDLRESGSIEQDADVVMFLyrd 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1631922669 390 ---SPASNEVGVVTAEVAKNRQGMKGEARLQTRFNYCQFAAPKI 430
Cdd:PRK05595  397 eyyNKETEDKNVAECIIAKQRNGPTGTVKLAWLGQYSKFGNLDV 440
PRK06321 PRK06321
replicative DNA helicase; Provisional
 35-426 5.00e-48

replicative DNA helicase; Provisional


Pssm-ID: 180528 [Multi-domain]  Cd Length: 472  Bit Score: 170.79  E-value: 5.00e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  35 DDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVEMcSVFAAPSAtgfYIEKLkklAECRKVEE 114
Cdd:PRK06321   47 DDFYFLEHKIIFRVLQDAFKSDKPIDVHLAGEELKRRNQLNVIGGPSYLITL-AEFAGTSA---YIEEY---AEIIRSKS 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 115 VGKKIIELAQ----NTMQEdmpgiAQELASGLESVLATDTRIDIANSSAEALrVLSEKIQHKTSKDGLAY---------- 180
Cdd:PRK06321  120 ILRKMIQTAKeiekKALEE-----PKDVATALDEAQNLLFKISQTTNLAQYV-LVADKLKGLTSSKDKPFllqlqerqea 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 181 --------------GVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSR 246
Cdd:PRK06321  194 fqqsaqgdsspmisGIPTHFIDLDKMINGFSPSNLMILAARPAMGKTALALNIAENFCFQNRLPVGIFSLEMTVDQLIHR 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 247 IVSAVGRIPFDNIQSGRMESDDFERWVqTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIGCVIVDYIQLL--- 323
Cdd:PRK06321  274 IICSRSEVESKKISVGDLSGRDFQRIV-SVVNEMQEHTLLIDDQPGLKITDLRARARRMKESYD-IQFLIIDYLQLLsgs 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 324 -NDPNSKDQFERISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL------SPaS 393
Cdd:PRK06321  352 gNLRNSESRQTEISEISRMLKNLARELNIPILCLSQLSRKVEDRanhRPMMSDLRESGSIEQDSDLVMFLlrreyyDP-N 430

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1631922669 394 NEVGVVTAEVAKNRQGMKGEARLQTRFNYCQFA 426
Cdd:PRK06321  431 DKPGTAELIVAKNRHGSIGSVPLVFEKEFARFR 463
PRK08506 PRK08506
replicative DNA helicase; Provisional
 4-388 1.39e-46

replicative DNA helicase; Provisional


Pssm-ID: 236278 [Multi-domain]  Cd Length: 472  Bit Score: 166.72  E-value: 1.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   4 NLHSIPYEQYVLSFLMDDENSWASL--DVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDliggEE 81
Cdd:PRK08506    3 ELYDLDIERAVLSSILFSPDKFEEIasVLEP--KDFYLPAHQDIFEAMLKLHNEDEPIDEEFIRKKLPKDKKID----EE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  82 YLVEmcsVFAAPS--ATGFYIEKLKKLAECRKVEEVGKKIIELAQNtmqEDMPG--IAQELASGLESvLATDTRIDIANS 157
Cdd:PRK08506   77 ILLE---ILATNPidNIEAYVEEIKEKSIKRELLSLANTIPEQAVE---EDQKSsdILDEVERELYS-ITNGSNSEDFKD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 158 SAEALRVLSEKIQHKTSKDGLAY-GVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFiSC 236
Cdd:PRK08506  150 SKEVIESTMEHIKKQKRLGNKDIiGLDTGFVELNKMTKGFNKGDLIIIAARPSMGKTTLCLNMALKALNQDKGVAFF-SL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 237 EMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSIGCVI 316
Cdd:PRK08506  229 EMPAEQLMLRMLSAKTSIPLQNLRTGDLDDDEWER-LSDACDELSKKKLFVYDSGYVNIHQVRAQLRKLKSQHPEIGLAV 307

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1631922669 317 VDYIQLLN-DPNSKDQFERISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADkIIL 388
Cdd:PRK08506  308 IDYLQLMSgSGNFKDRHLQISEISRGLKLLARELDIPIIALSQLNRSLESRadkRPMLSDLRESGAIEQDAD-IIL 382
PRK07004 PRK07004
replicative DNA helicase; Provisional
 6-425 2.01e-46

replicative DNA helicase; Provisional


Pssm-ID: 235907 [Multi-domain]  Cd Length: 460  Bit Score: 166.24  E-value: 2.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   6 HSIPYEQYVLSFLMDDENSWASLDVKPCLDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVE 85
Cdd:PRK07004   17 HSIEAEQSVLGGLLLDNAAWDRIADFLSQSDFYRYDHRIIFEHIGRLIAATRPADVITVYEALTTSGKAEEVGGLAYLNA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  86 MCSvfAAPSATGF--YIEKLKKLAECRKVEEVGKKIIELAQNTMQEDMPGIAQELASGLESVLATDTR-----IDIANSS 158
Cdd:PRK07004   97 LAQ--NTPSAANIrrYAEIVRDRAVLRRLVSVADEISADAFNPQGKEVRQLLDEAESKVFSIAEEGARgtqgfLEIGPLL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 159 AEALRVLSEKIQHKTSKDglAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEM 238
Cdd:PRK07004  175 TQVVERIDTLYHTANPSD--VTGTPTGFVDLDRMTSGMHGGELIIVAGRPSMGKTAFSMNIGEYVAVEYGLPVAVFSMEM 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 239 AHYELTSRIVSAVGRIPFDNIQSGRMESDDFERwVQTTAHELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSIGCVIVD 318
Cdd:PRK07004  253 PGTQLAMRMLGSVGRLDQHRMRTGRLTDEDWPK-LTHAVQKMSEAQLFIDETGGLNPMELRSRARRLARQCGKLGLIIID 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 319 YIQLLN-DPNSKDQFERISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL----- 389
Cdd:PRK07004  332 YLQLMSgSSQGENRATEISEISRSLKSLAKELDVPVIALSQLNRGLEQRpnkRPVMSDLRESGAIEQDADVILFIyrdev 411

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1631922669 390 -SPASNEVGVVTAEVAKNRQGMKGEARLQTRFNYCQF 425
Cdd:PRK07004  412 yNPDSPDKGTAEIIIGKQRNGPIGPVRLTFLGQYTKF 448
PRK05636 PRK05636
replicative DNA helicase; Provisional
 11-425 4.66e-44

replicative DNA helicase; Provisional


Pssm-ID: 180177 [Multi-domain]  Cd Length: 505  Bit Score: 160.77  E-value: 4.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  11 EQYVLSFLMDDENswASLDVKPCL--DDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEYLVEMCS 88
Cdd:PRK05636   77 EQGVLGAMLLSPD--TVIDIVEVLtpEDFYRPAHQLIFQAIIDLFSDNKEIDPVIVAGRLDRTNDLERVGGAPYLHTLIQ 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  89 VFAAPSATGFYIEKLKKLAECRKVEEVGKKIIELAQ------------NTMQEDMPGIAQELASGLESVLAtdtriDIAN 156
Cdd:PRK05636  155 SVPTAANARYYAEIVSEKAVLRRLVDAGTRVVQLGYegdegaeidsviDRAQQEVFAVSQKNQSEDYAVLA-----DILD 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 157 SSAEALRVLSekiqhktSKDGLAYGVNTGLHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISC 236
Cdd:PRK05636  230 PTMDELEMLS-------SQGGIATGIPTGFKDLDDLTNGLRGGQMIIVAARPGVGKSTLALDFMRSASIKHNKASVIFSL 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 237 EMAHYELTSRIVSAVGRIPFDNIQSGRMESDDFERWVQTTAhELQKYKLDIVDKAGITINEIRGEIKKSIAKHGsIGCVI 316
Cdd:PRK05636  303 EMSKSEIVMRLLSAEAEVRLSDMRGGKMDEDAWEKLVQRLG-KIAQAPIFIDDSANLTMMEIRSKARRLKQKHD-LKLIV 380

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 317 VDYIQLLNDPN---SKDQfeRISNVSTGLKRIAKDFKVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL- 389
Cdd:PRK05636  381 VDYLQLMSSGKrveSRQQ--EVSEFSRQLKLLAKELDVPLIAISQLNRGPESRtdkRPQLADLRESGSLEQDADMVMLLy 458

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1631922669 390 SPASNE-----VGVVTAEVAKNRQGMKGEARLQTRFNYCQF 425
Cdd:PRK05636  459 RPDSQDkdderAGEADIILAKHRGGPIDTVQVAHQLHYSRF 499
PRK06749 PRK06749
replicative DNA helicase; Provisional
 42-417 3.85e-38

replicative DNA helicase; Provisional


Pssm-ID: 168658 [Multi-domain]  Cd Length: 428  Bit Score: 143.17  E-value: 3.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669  42 HKEIFKAIENQRMLGKPFDQITMLEVFkDLGKLDLIGGEEYLVEMCSVfaAPSATGF-YIEKLKKLA-ECRKVEEVGKKI 119
Cdd:PRK06749   38 HKSIFQLMRKMEDEGQPIDLVTFTSRV-DPNFLKGIGGMEYFIGLMDG--VPTTSNFsYYEGLVRGAwKMYQAGVLGHKM 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 120 IELAQNTMQEDMPGIAQELASGLESVLATDtRIDIAnssaEALRVLSEKIqHKTSKDglAYGVNTGLHNLDALLGDIEPS 199
Cdd:PRK06749  115 GERLIAEKSEKIIGETITALCELEEKDCVC-EFDLK----DALVDLYEEL-HQDAKE--ITGIETGYTSLNKMTCGLQEG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 200 HFCVIAAAPGGGKTTMAQMIALNAVKRNDVPCLFiSCEMAHYELTSRIVSAVGripfdNIQSGRMES-------DDFERW 272
Cdd:PRK06749  187 DFVVLGARPSMGKTAFALNVGLHAAKSGAAVGLF-SLEMSSKQLLKRMASCVG-----EVSGGRLKNpkhrfamEDWEKV 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 273 VQTTAhELQKYKLDIVDKAGITINEIRGEIKKSIAKHGSIGC-VIVDYIQLL-NDPNSK-DQFERISNVSTGLKRIAKDF 349
Cdd:PRK06749  261 SKAFA-EIGELPLEIYDNAGVTVQDIWMQTRKLKRKHGDKKIlIIVDYLQLItGDPKHKgNRFQEISEISRKLKLLAREL 339

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1631922669 350 KVPVIGLSQLTKEAQGR---KITMSDLRGSGQISQDADKIILL------SPASNEVGVVTAEVAKNRQGMKGEARLQ 417
Cdd:PRK06749  340 NVCVVALSQLSRSVESRqdkRPLLSDLRETGQIEQDADVIMLMyredyyDKETMQKEMTEIHVAKHRNGPVGSFKLR 416
DnaB pfam00772
DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at ...
 5-104 1.63e-16

DnaB-like helicase N terminal domain; The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity.


Pssm-ID: 395624 [Multi-domain]  Cd Length: 103  Bit Score: 74.58  E-value: 1.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669   5 LHSIPYEQYVLSFLMDDENSW--ASLDVKPclDDFYSDRHKEIFKAIENQRMLGKPFDQITMLEVFKDLGKLDLIGGEEY 82
Cdd:pfam00772   3 PHNIEAEQAVLGALLLDPEAIdeVADILKP--EDFYDPAHRLIFEAILDLYDKGEPIDPVTVAEELEKKGKLEDVGGIAY 80

                          90       100
                  ....*....|....*....|..
gi 1631922669  83 LVEMCSVFAAPSATGFYIEKLK 104
Cdd:pfam00772  81 LAELAANVPSAANIEYYARIVK 102
RecA-like_Gp4D_helicase cd19483
RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the ...
 203-414 2.37e-12

RecA-like domain of Escherichia coli bacteriophage T7 Gp4D helicase; This family includes the RecA-like domain of the Gp4D fragment of the Gene4 helicase-primase (Gp4) from bacteriophage T7. Gp4D (residues 241-566) is the minimal fragment of the Gp4 that forms hexameric rings, it contains the helicase domain and the linker connecting the helicase and primase domains. Helicases are ring-shaped oligomeric enzymes that unwind DNA at the replication fork; they couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410891 [Multi-domain]  Cd Length: 231  Bit Score: 66.05  E-value: 2.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 203 VIAAAPGGGKTTMAQMIALNAVKRNDVPCLFISCEMAHYELTSRIVSAvgripFDNIQSGRMESDDFERWvqtTAHELQK 282
Cdd:cd19483     2 TIGAGSGIGKSTIVRELAYHLITEHGEKVGIISLEESVEETAKGLAGK-----HLGKPEPLELPRDDITE---EEEDDAF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 283 YKLDIVDK-------AGITINEIRGEIKKSIAKHGsigC--VIVDYIQ-LLNDPNSKDQFERISNVSTGLKRIAKDFKVP 352
Cdd:cd19483    74 DNELGSGRfflydhfGSLDWDNLKEKIRYMVKVLG---CkvIVLDHLTiLVSGLDSSDERKELDEIMTELAALVKELGVT 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1631922669 353 VIGLSQLTKEA------QGRKITMSDLRGSGQISQDADKIILL-----SPASNEVGVVTAEVAKNRQ-GMKGEA 414
Cdd:cd19483   151 IILVSHLRRPGggkgheEGGEVSESDLRGSSAIAQLSDYVIGLernkqADDPVERNTTRVRVLKNRFtGETGIA 224
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
182-390 8.99e-10

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 58.39  E-value: 8.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 182 VNTGLHNLDALLGD-IEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDvPCLFISCEmahyELTSRIVSAVGRIPFdniq 260
Cdd:COG0467     2 VPTGIPGLDELLGGgLPRGSSTLLSGPPGTGKTTLALQFLAEGLRRGE-KGLYVSFE----ESPEQLLRRAESLGL---- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 261 sgrmesdDFERWVqttahelQKYKLDIVD----KAGITINEIRGEIKKSIAKHGsIGCVIVD----YIQLLNDPnskdqf 332
Cdd:COG0467    73 -------DLEEYI-------ESGLLRIIDlspeELGLDLEELLARLREAVEEFG-AKRVVIDslsgLLLALPDP------ 131

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1631922669 333 ERISNVSTGLKRIAKDFKVPVIGLSQLTkeaqgrkiTMSDLRGSGQISQDADKIILLS 390
Cdd:COG0467   132 ERLREFLHRLLRYLKKRGVTTLLTSETG--------GLEDEATEGGLSYLADGVILLR 181
RepA COG3598
RecA-family ATPase [Replication, recombination and repair];
196-409 3.57e-08

RecA-family ATPase [Replication, recombination and repair];


Pssm-ID: 442817 [Multi-domain]  Cd Length: 313  Bit Score: 54.91  E-value: 3.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 196 IEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNDVP--------CLFISCEMAHYELTSRIvSAVGR---IPFDNIQSgrm 264
Cdd:COG3598    10 LPEGGVTLLAGPPGTGKSFLALQLAAAVAAGGPWLgrrvppgkVLYLAAEDDRGELRRRL-KALGAdlgLPFADLDG--- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 265 esddferwvqttahelqkyKLDIVDKAGITIN-EIRGEIKKSIAKHGsIGCVIVDYIQLLN--DPNSKDQferISNVSTG 341
Cdd:COG3598    86 -------------------RLRLLSLAGDLDDtDDLEALERAIEEEG-PDLVVIDPLARVFggDENDAEE---MRAFLNP 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1631922669 342 LKRIAKDFKVPVIGLSQLTKeAQGRKITMSDLRGSGQISQDADKIILLSPASNEvGVVTAEVAKNRQG 409
Cdd:COG3598   143 LDRLAERTGAAVLLVHHTGK-GGAGKDSGDRARGSSALRGAARSVLVLSREKGE-DLRVLTRAKSNYG 208
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 182-409 9.14e-08

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 52.65  E-value: 9.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 182 VNTGLHNLDALL-GDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRnDVPCLFISCEmahyELTSRIVSavgripfdniQ 260
Cdd:cd01124     1 VKTGIPGLDELLgGGIPKGSVTLLTGGPGTGKTLFGLQFLYAGAKN-GEPGLFFTFE----ESPERLLR----------N 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 261 SGRMESdDFErwvqttAHELQKyKLDIVDKAGIT-----INEIRGEIKKSIAKHGsIGCVIVDYIQLLNdpNSKDQFERI 335
Cdd:cd01124    66 AKSFGW-DFD------EMEDEG-KLIIVDAPPTEagrfsLDELLSRILSIIKSFK-AKRVVIDSLSGLR--RAKEDQMRA 134

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1631922669 336 SNVSTGLKRIAKDFKVPVIGLSQLtkeaqgRKITMSDLRGSGQISQDADKIILLSPASNEVGVV-TAEVAKNRQG 409
Cdd:cd01124   135 RRIVIALLNELRAAGVTTIFTSEM------RSFLSSESAGGGDVSFIVDGVILLRYVEIEGELRrTIRVLKMRGT 203
AAA_25 pfam13481
AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.
 194-364 4.44e-06

AAA domain; This AAA domain is found in a wide variety of presumed DNA repair proteins.


Pssm-ID: 463892 [Multi-domain]  Cd Length: 193  Bit Score: 46.99  E-value: 4.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 194 GDIEPSHFCVIAAAPGGGKTTMAQMIALnAVKRND-----------VPCLFISCEMAHYELTSRIVSAVGRIPfdniqsg 262
Cdd:pfam13481  28 GLLPAGGLGLLAGAPGTGKTTLALDLAA-AVATGKpwlggprvpeqGKVLYVSAEGPADELRRRLRAAGADLD------- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 263 rmesDDFERWVQTTAHELQkykLDIVDKAGITINEIRGEIKKSIAKHGSIGCVIVDYIQ--LLNDPNSKDQFERISNvst 340
Cdd:pfam13481 100 ----LPARLLFLSLVESLP---LFFLDRGGPLLDADVDALEAALEEVEDPDLVVIDPLAraLGGDENSNSDVGRLVK--- 169

                         170       180
                  ....*....|....*....|....
gi 1631922669 341 GLKRIAKDFKVPVIGLSQLTKEAQ 364
Cdd:pfam13481 170 ALDRLARRTGATVLLVHHVGKDGA 193
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 204-371 1.15e-05

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 45.81  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 204 IAAAPGGGKTTMAQMIALNAVKRNDVpCLFISCEmaHYELTSRIVSAVGRIPfdniQSGRMESDDFER--WVQTTAHELQ 281
Cdd:cd01393     6 IYGPPGSGKTQLALQLAANALLLGGG-VVWIDTE--GAFPPSRLVQILEASP----SSELELAEALSRllYFRPPDTLAH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 282 kykLDIVDKAgitineirgeiKKSIAKHGSIGCVIVDYI----------QLLNDPNSKDQFERISNVSTGLKRIAKDFKV 351
Cdd:cd01393    79 ---LLALDSL-----------PESLFPPPNTSLVVVDSVsalfrkafprGGDGDSSSSLRARLLSQLARALQKLAAQFNL 144

                         170       180
                  ....*....|....*....|.
gi 1631922669 352 PVIGLSQL-TKEAQGRKITMS 371
Cdd:cd01393   145 AVVVTNQVtTKIRGGSGASLV 165
41 PHA02542
41 helicase; Provisional
 203-411 1.13e-04

41 helicase; Provisional


Pssm-ID: 222864 [Multi-domain]  Cd Length: 473  Bit Score: 44.28  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 203 VIAAAPGGGKTT-MAQMIALNAVKRNDVpcLFISCEMAHYELTSRIVSAVGRIPFDNIQSgrMESDDFERWVQTTAhelQ 281
Cdd:PHA02542  194 VLLAGVNVGKSLgLCSLAADYLQQGYNV--LYISMEMAEEVIAKRIDANLLDVSLDDIDD--LSKAEYKAKMEKLR---S 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 282 KYKLDIVDK----AGITINEIRGEIKKSIAKHGSI-GCVIVDYIQLLNDPN----SKDQFERISNVSTGLKRIAKDFKVP 352
Cdd:PHA02542  267 KTQGKLIIKqyptGGAHAGHFRALLNELKLKKNFKpDVIIVDYLGICASSRlrvsSENSYTYVKAIAEELRGLAVEHDVV 346

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631922669 353 VIGLSQLTKEAQGRK-ITMSDLRGSGQISQDADKII-LLSPAS-NEVGVVTAEVAKNRQGMK 411
Cdd:PHA02542  347 VWTAAQTTRSGWDSSdVDMSDTAESAGLPATADFMLaVIETEElAQMGQQLVKQLKSRYGDK 408
Twinkle_C cd01122
C-terminal domain of Twinkle; Twinkle ( T7 gp4-like protein with intramitochondrial nucleoid ...
 186-407 2.28e-03

C-terminal domain of Twinkle; Twinkle ( T7 gp4-like protein with intramitochondrial nucleoid localization, also known as C10orf2, PEO1, SCA8, ATXN8, IOSCA, PEOA3 or SANDO) is a homohexameric DNA helicases which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. Mutations in the human gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. This group also contains viral GP4-like and related bacterial helicases.


Pssm-ID: 410867  Cd Length: 266  Bit Score: 39.53  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 186 LHNLDALLGDIEPSHFCVIAAAPGGGKTTMAQMIALNAVKRNdVPCLFISCEMAHYELTSRIVSAVGRIPFDNIQSGRME 265
Cdd:cd01122    30 FPSLNKLLKGHRRGELTIFTGPTGSGKTTFLSEYSLDLCMQG-VNTLWGSFEIKNVRLAKTMLTQFAGKNLEDNLREFDE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631922669 266 -SDDFERWVQ--TTAHELQKYKlDIVDKagitineirgeIKKSIAKHGsIGCVIVDYIQLL--NDPNSKDQFERISNVST 340
Cdd:cd01122   109 wADKFELLPMyfMKFHGSTDID-EVLDA-----------MEHAVYVYD-IQHIVIDNLQFMmgTQASGSDRFELQDLIIG 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1631922669 341 GLKRIAKDFKVPVIGLSQLTKEAQGRKITMSDLRGSGQISQDADKIILL--SPASNEVGVVTAEVAKNR 407
Cdd:cd01122   176 KFRRFATNNNVHITLVIHPRKEDDDNELTTSSIFGSAKATQEADNVLILqdKRLISGEGKKFLQIKKNR 244
KaiC-like_N cd19488
N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 182-243 5.89e-03

N-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410896 [Multi-domain]  Cd Length: 225  Bit Score: 38.10  E-value: 5.89e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1631922669 182 VNTGLHNLDALL-GDIEPSHFCVIAAAPGGGKTTMA-QMIALNAvkRNDVPCLFISCEMAHYEL 243
Cdd:cd19488     1 ISTGIPGLDDILrGGLPPRRLYLVEGAPGTGKTTLAlQFLLEGA--ANGETGLYITLSETEQEL 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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