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Conserved domains on  [gi|1842004006|ref|YP_009791397|]
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dehydrogenase [Synechococcus phage Bellamy]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11481539)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.-
Gene Ontology:  GO:0004345
SCOP:  4000091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 7-429 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


:

Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 520.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   7 TLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWL----DSLGKYYE--------ADFSLKLDYHR 74
Cdd:PRK05722   11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFRevvrEALKEFARtpfdeevwERFLSRLYYVS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  75 CDLSDVDS---LRSIPVSDDMT--------FFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDLESANHLQSV 143
Cdd:PRK05722   91 GDVTDPESyerLKELLEELDEErgtggnrvFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASARELNDQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 144 VAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHMLQ 223
Cdd:PRK05722  171 VGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLLQ 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 224 ILSLIAMDAPCRNDAKEIRREKVKVLAATR------LGHKVVFGQYES----------YKSEEGVDTFSETPTYVAGDIY 287
Cdd:PRK05722  251 LLALVAMEPPASLDADSIRDEKVKVLRALRpitpedVKENTVRGQYTAgwiggkpvpgYREEEGVNPDSTTETFVALKLE 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 288 IDNWRWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHE---FNDRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATL 364
Cdd:PRK05722  331 IDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAeelGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPVKL 410

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 365 T----HPYPEGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLLCVGDKcpIRTAPFIYT-GGWGP 429
Cdd:PRK05722  411 DfsysEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEA--DGGPPPPYPaGTWGP 478
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 7-429 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 520.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   7 TLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWL----DSLGKYYE--------ADFSLKLDYHR 74
Cdd:PRK05722   11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFRevvrEALKEFARtpfdeevwERFLSRLYYVS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  75 CDLSDVDS---LRSIPVSDDMT--------FFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDLESANHLQSV 143
Cdd:PRK05722   91 GDVTDPESyerLKELLEELDEErgtggnrvFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASARELNDQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 144 VAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHMLQ 223
Cdd:PRK05722  171 VGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLLQ 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 224 ILSLIAMDAPCRNDAKEIRREKVKVLAATR------LGHKVVFGQYES----------YKSEEGVDTFSETPTYVAGDIY 287
Cdd:PRK05722  251 LLALVAMEPPASLDADSIRDEKVKVLRALRpitpedVKENTVRGQYTAgwiggkpvpgYREEEGVNPDSTTETFVALKLE 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 288 IDNWRWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHE---FNDRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATL 364
Cdd:PRK05722  331 IDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAeelGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPVKL 410

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 365 T----HPYPEGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLLCVGDKcpIRTAPFIYT-GGWGP 429
Cdd:PRK05722  411 DfsysEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEA--DGGPPPPYPaGTWGP 478
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 1-429 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 520.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   1 MELPTK----TLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWL----DSLGKYYEAD------- 65
Cdd:COG0364     1 MTQMRPaepcDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFReevrEALEEFSRKPfdeevwe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  66 -FSLKLDYHRCDLSD----------VDSLRSIPVSDDMTFFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDL 134
Cdd:COG0364    81 rFLERLHYVSGDFTDpegyerlkelLEELDEERTPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 135 ESANHLQSVVAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVR 214
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 215 DMLQNHMLQILSLIAMDAPCRNDAKEIRREKVKVLAATR------LGHKVVFGQYES----------YKSEEGVDTFSET 278
Cdd:COG0364   241 DMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRpitpedVAENTVRGQYTAgwiggepvpgYREEPGVAPDSTT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 279 PTYVAGDIYIDNWRWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHEFN---DRIVMRFQPNPHLDIRIDMKSPGL 355
Cdd:COG0364   321 ETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 356 DDKVQTATLTHPY----PEGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDdllcvgdkcPI-------RTAPFIYT 424
Cdd:COG0364   401 GMRLRPVSLDFSYsdafGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVD---------PIleawaeePEPPPPYP 471


                  ....*.
gi 1842004006 425 -GGWGP 429
Cdd:COG0364   472 aGSWGP 477
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 8-438 4.58e-157

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 453.31  E-value: 4.58e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   8 LVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARR----ENTRQSWLDSLGKYYEADFSLKLD-------YHRCD 76
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRdwsvEEFRKVVREAIIKFETDEIDEQWDefaqrlsYVSGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  77 LSDVDSL-----------RSIPVSDDMTFFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDLESANHLQSVVA 145
Cdd:TIGR00871  85 VDDDESYdslaelleqldKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELNKALR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 146 GCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHMLQIL 225
Cdd:TIGR00871 165 AVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 226 SLIAMDAPCRNDAKEIRREKVKVLAATRL----GHKVVFGQYES----------YKSEEGVDTFSETPTYVAGDIYIDNW 291
Cdd:TIGR00871 245 ALVAMEPPVSFDADSIRDEKVKVLKALRPidpdDNNTVRGQYGAgeiggvsvpgYLEEEGVDKDSNTETFAALKLEIDNW 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 292 RWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHE----FNDRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATLTHP 367
Cdd:TIGR00871 325 RWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANErdanPRNALVIRIQPDEGVYLKFNAKKPGLNFETRPVKLDFS 404

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1842004006 368 YP----EGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLLCVGDKCPIRTAPFIYTGGWGPTHKTQFITK 438
Cdd:TIGR00871 405 YAsrfgELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPSPPNYPAGSWGPKEADELIRK 479
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
169-429 6.71e-112

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 330.94  E-value: 6.71e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 169 LATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHMLQILSLIAMDAPCRNDAKEIRREKVKV 248
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 249 LAATR------LGHKVVFGQY----------ESYKSEEGVDTFSETPTYVAGDIYIDNWRWKGVPFHFMSGKKMPYTCTE 312
Cdd:pfam02781  81 LRSLRpitpedVEDNVVRGQYgagwiggepvPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 313 VVIKLKAPPIGLFDGHEF--NDRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATLTHPYPEG----AIDGYVKLFYDSLNG 386
Cdd:pfam02781 161 IRIQFKDVPHNLFRDPGTlpPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRfgerIPEAYERLLLDVMRG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1842004006 387 DQSHFVHAEEVLESWRIVDDLLcvgdKCPIRTAPFIYT-GGWGP 429
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPIL----EAWDEEKPPPYPaGSWGP 280
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 7-429 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 520.46  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   7 TLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWL----DSLGKYYE--------ADFSLKLDYHR 74
Cdd:PRK05722   11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFRevvrEALKEFARtpfdeevwERFLSRLYYVS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  75 CDLSDVDS---LRSIPVSDDMT--------FFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDLESANHLQSV 143
Cdd:PRK05722   91 GDVTDPESyerLKELLEELDEErgtggnrvFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLASARELNDQ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 144 VAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHMLQ 223
Cdd:PRK05722  171 VGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLLQ 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 224 ILSLIAMDAPCRNDAKEIRREKVKVLAATR------LGHKVVFGQYES----------YKSEEGVDTFSETPTYVAGDIY 287
Cdd:PRK05722  251 LLALVAMEPPASLDADSIRDEKVKVLRALRpitpedVKENTVRGQYTAgwiggkpvpgYREEEGVNPDSTTETFVALKLE 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 288 IDNWRWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHE---FNDRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATL 364
Cdd:PRK05722  331 IDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAeelGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPVKL 410

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 365 T----HPYPEGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLLCVGDKcpIRTAPFIYT-GGWGP 429
Cdd:PRK05722  411 DfsysEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEA--DGGPPPPYPaGTWGP 478
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 1-429 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 520.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   1 MELPTK----TLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWL----DSLGKYYEAD------- 65
Cdd:COG0364     1 MTQMRPaepcDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFReevrEALEEFSRKPfdeevwe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  66 -FSLKLDYHRCDLSD----------VDSLRSIPVSDDMTFFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDL 134
Cdd:COG0364    81 rFLERLHYVSGDFTDpegyerlkelLEELDEERTPGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 135 ESANHLQSVVAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVR 214
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 215 DMLQNHMLQILSLIAMDAPCRNDAKEIRREKVKVLAATR------LGHKVVFGQYES----------YKSEEGVDTFSET 278
Cdd:COG0364   241 DMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRpitpedVAENTVRGQYTAgwiggepvpgYREEPGVAPDSTT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 279 PTYVAGDIYIDNWRWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHEFN---DRIVMRFQPNPHLDIRIDMKSPGL 355
Cdd:COG0364   321 ETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 356 DDKVQTATLTHPY----PEGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDdllcvgdkcPI-------RTAPFIYT 424
Cdd:COG0364   401 GMRLRPVSLDFSYsdafGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVD---------PIleawaeePEPPPPYP 471


                  ....*.
gi 1842004006 425 -GGWGP 429
Cdd:COG0364   472 aGSWGP 477
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
4-443 1.93e-167

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 479.40  E-value: 1.93e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   4 PTKTLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWLDSLGKYYEADFSLKLD------------ 71
Cdd:PRK12853    7 PPCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFGADGFDdavwdrlaarls 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  72 YHRCDLSDVDSL----RSIPVSDDMTFFLSVPPDRYSDAIQNLKSAGLVddPEKSRVIIEKPFGTDLESANHLQSVVAGC 147
Cdd:PRK12853   87 YVQGDVTDPADYarlaEALGPGGNPVFYLAVPPSLFAPVVENLGAAGLL--PEGRRVVLEKPFGHDLASARALNATLAKV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 148 LREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHMLQILSL 227
Cdd:PRK12853  165 FDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLLQLLAL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 228 IAMDAPCRNDAKEIRREKVKVLAATRL---GH-KVVFGQYES----------YKSEEGVDTFSETPTYVAGDIYIDNWRW 293
Cdd:PRK12853  245 VAMEPPASFDADAVRDEKAKVLRAIRPldpDDvHTVRGQYTAgtvggepvpgYREEPGVDPDSRTETFVALKLEIDNWRW 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 294 KGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHEFN--DRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATL--THPYP 369
Cdd:PRK12853  325 AGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTGVEppNRLVIRLQPDEGISLELNVKRPGPGMRLRPVELdaDYADD 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 370 EGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLL--CVGDKCPIRTAPfiyTGGWGPTHKTQFITK----WDYPA 443
Cdd:PRK12853  405 ERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLdaWAADPVPPHEYP---AGSWGPAAADALLARdgrgWREPA 481
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 8-438 4.58e-157

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 453.31  E-value: 4.58e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   8 LVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARR----ENTRQSWLDSLGKYYEADFSLKLD-------YHRCD 76
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRdwsvEEFRKVVREAIIKFETDEIDEQWDefaqrlsYVSGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  77 LSDVDSL-----------RSIPVSDDMTFFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDLESANHLQSVVA 145
Cdd:TIGR00871  85 VDDDESYdslaelleqldKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELNKALR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 146 GCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHMLQIL 225
Cdd:TIGR00871 165 AVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 226 SLIAMDAPCRNDAKEIRREKVKVLAATRL----GHKVVFGQYES----------YKSEEGVDTFSETPTYVAGDIYIDNW 291
Cdd:TIGR00871 245 ALVAMEPPVSFDADSIRDEKVKVLKALRPidpdDNNTVRGQYGAgeiggvsvpgYLEEEGVDKDSNTETFAALKLEIDNW 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 292 RWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHE----FNDRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATLTHP 367
Cdd:TIGR00871 325 RWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANErdanPRNALVIRIQPDEGVYLKFNAKKPGLNFETRPVKLDFS 404

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1842004006 368 YP----EGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLLCVGDKCPIRTAPFIYTGGWGPTHKTQFITK 438
Cdd:TIGR00871 405 YAsrfgELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPSPPNYPAGSWGPKEADELIRK 479
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 3-429 8.07e-124

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 368.21  E-value: 8.07e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   3 LPTKTLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWLDSL---------GKYYEAD---FSLKL 70
Cdd:PRK12854    9 APPTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHArdaldefgaRKLDDGEwarFAKRL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  71 DYHRCDLSD---------VDSLRSIPVSD-DMTFFLSVPPDRYSDAIQNLKSAGLVddpEKSRVIIEKPFGTDLESANHL 140
Cdd:PRK12854   89 RYVPGGFLSagpgalaaaVAAARAELGGDaRLVHYLAVPPSAFLDVTRALGEAGLA---EGSRVVMEKPFGTDLASAEAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 141 QSVVAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNH 220
Cdd:PRK12854  166 NAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTH 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 221 MLQILSLIAMDAPCRNDAKEIRREKVKVLAATRL--GHKVVFGQYESYKSEEGVDTFSETPTYVAGDIYIDNWRWKGVPF 298
Cdd:PRK12854  246 LFQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPldPAEVVRGQYSGYRDEPGVAPDSTTETFVALKVWIDNWRWAGVPF 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 299 HFMSGKKMPYTCTEVVIKLKAPPIGLFDGHEFN----DRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATLTHPYPE---- 370
Cdd:PRK12854  326 YLRTGKRMAEGQRIISIAFREPPYSMFPAGSVGaqgpDHLTFDLADNSKVSLSFYGKRPGPGMRLDKLSLQFSLKDtgpk 405

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 371 -GAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLLcvGDKCPIRTAPfiyTGGWGP 429
Cdd:PRK12854  406 gDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLL--EDPPPVKPYA---PGSWGP 460
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
169-429 6.71e-112

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 330.94  E-value: 6.71e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 169 LATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHMLQILSLIAMDAPCRNDAKEIRREKVKV 248
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 249 LAATR------LGHKVVFGQY----------ESYKSEEGVDTFSETPTYVAGDIYIDNWRWKGVPFHFMSGKKMPYTCTE 312
Cdd:pfam02781  81 LRSLRpitpedVEDNVVRGQYgagwiggepvPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 313 VVIKLKAPPIGLFDGHEF--NDRIVMRFQPNPHLDIRIDMKSPGLDDKVQTATLTHPYPEG----AIDGYVKLFYDSLNG 386
Cdd:pfam02781 161 IRIQFKDVPHNLFRDPGTlpPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRfgerIPEAYERLLLDVMRG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1842004006 387 DQSHFVHAEEVLESWRIVDDLLcvgdKCPIRTAPFIYT-GGWGP 429
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPIL----EAWDEEKPPPYPaGSWGP 280
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 7-438 6.34e-107

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 327.09  E-value: 6.34e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   7 TLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQS-W-LDSLGKYYE---------ADFSLKLDYHRC 75
Cdd:PTZ00309   56 TIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVErWkKETLARFFKrlddrechlEQFLKHISYISG 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  76 DLSDVDSL--------------RSIPVSDDMTFFLSVPPDRYSDAIQNLKSaGLVDDPEKSRVIIEKPFGTDLESANHLQ 141
Cdd:PTZ00309  136 SYDEDEDFkrlnkliermeeafQGPEKGGNRLFYLALPPSVFASVCEGIHR-GCMSKNGWVRVIVEKPFGRDLESSEELS 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 142 SVVAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHM 221
Cdd:PTZ00309  215 NQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHL 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 222 LQILSLIAMDAPCRNDAKEIRREKVKVLAATRLGHK--VVFGQYE--------SYKSEEGVDTFSETPTYVAGDIYIDNW 291
Cdd:PTZ00309  295 LQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMeeCVLGQYTasadgsipGYLEDEGVPKDSTTPTFAAAVLHINND 374

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 292 RWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHEFN-DRIVMRFQPNPHLDIRIDMKSPGLDDKV-QTA---TLTH 366
Cdd:PTZ00309  375 RWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDDTQrNELVIRAQPSEAMYLKITAKVPGLSNDLhQTEldlTYKT 454

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1842004006 367 PYPEGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLLCVGDKCPIRTAPFIYtGGWGPTHKTQFITK 438
Cdd:PTZ00309  455 RYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPF-GSRGPKEADELIKK 525
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 7-441 9.41e-92

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 286.23  E-value: 9.41e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   7 TLVIFGATGDLCRRKLIPALETLHKKGLL-PDNFKIIGAARRENTRQSWLDSLGKYYEAD----------FSLKLDYHRC 75
Cdd:PLN02539   19 SIIVLGASGDLAKKKTFPALFNLYRQGFLpPDEVHIFGYARSKITDEELRDRIRGYLKDEknapaeavskFLQLIKYVSG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  76 DLSDVDSLRSI--------------PVSDDMTFFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDLESANHLQ 141
Cdd:PLN02539   99 AYDSEEGFRRLdkeiseheisknsaEGSSRRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGKDLESAEELS 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 142 SVVAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQNHM 221
Cdd:PLN02539  179 SQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 222 LQILSLIAMDAPCRNDAKEIRREKVKVLAATR-LGHK-VVFGQYESYKSEEGVDTFSETPTYVAGDIYIDNWRWKGVPFH 299
Cdd:PLN02539  259 LQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEpIKDEeVVLGQYEGYRDDPTVPDDSNTPTFASVVLRINNERWEGVPFI 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 300 FMSGKKMPYTCTEVVIKLKAPPIGLFD-----GHEFndriVMRFQPNPHLDIRIDMKSPGLDDKVQTATL----THPYPE 370
Cdd:PLN02539  339 LKAGKALDSRKAEIRVQFKDVPGDIFKcqkqgRNEF----VIRLQPSEAMYMKLTVKQPGLEMSTVQSELdlsyGQRYQD 414

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1842004006 371 GAI-DGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLLCVGDKCPIRTAPFIYtGGWGPTHKTQFITKWDY 441
Cdd:PLN02539  415 VVIpEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQ-GSRGPAEADELLEKAGY 485
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 5-408 2.08e-87

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 277.28  E-value: 2.08e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   5 TKTLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWLDSLGK------------------------ 60
Cdd:PLN02640   88 TLSITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISStltcridqrencgdkmdqflkrcf 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  61 YYEADFSLKLDYHRCDlSDVDSLRSIPVSDDMtFFLSVPPDRYSDAIqnlKSAGLVDDPEK--SRVIIEKPFGTDLESAN 138
Cdd:PLN02640  168 YHSGQYDSEEDFAELN-KKLKEKEAGKLSNRL-FYLSIPPNIFVDVV---RCASLRASSENgwTRVIVEKPFGRDSESSG 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 139 HLQSVVAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRDMLQ 218
Cdd:PLN02640  243 ELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQ 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 219 NHMLQILSLIAMDAPCRNDAKEIRREKVKVLAATR--LGHKVVFGQYE----------SYKSEEGVDTFSETPTYVAGDI 286
Cdd:PLN02640  323 NHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMKplQLEDVIVGQYKghskggksypAYTDDPTVPKHSLTPTFAAAAL 402

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 287 YIDNWRWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLF------DGHEFNDRIVMRFQPNPHLDIRIDMKSPGLDDKVQ 360
Cdd:PLN02640  403 FINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYkrnfgtDLDKATNELVLRVQPDEAIYLKINNKVPGLGMRLD 482

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1842004006 361 TATLT----HPYPEGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLL 408
Cdd:PLN02640  483 RSDLNllyrARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLL 534
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 2-408 1.85e-86

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 275.70  E-value: 1.85e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   2 ELPTKTLVIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAAR----------------------RENTRQSWLDSLG 59
Cdd:PLN02333  114 DESTVSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARskmtdaelrnmvsktltcridkRENCGEKMEEFLK 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  60 K--YYEADFSLKLDYHRCD--LSDVDSLRsipVSDDMtFFLSVPPDRYSDAIQnLKSAGLVDDPEKSRVIIEKPFGTDLE 135
Cdd:PLN02333  194 RcfYHSGQYDSQEHFAELDkkLKEHEGGR---VSNRL-FYLSIPPNIFVDAVK-CASSSASSVNGWTRVIVEKPFGRDSE 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 136 SANHLQSVVAGCLREKQVYRIDHYLGKDTVNNILATRFSNTLLEPLWNRNYIEEVQIFATETIGCEGRSQYYDGAGVVRD 215
Cdd:PLN02333  269 SSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRD 348

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 216 MLQNHMLQILSLIAMDAPCRNDAKEIRREKVKVLAATR--LGHKVVFGQYES----------YKSEEGVDTFSETPTYVA 283
Cdd:PLN02333  349 IMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRpiQLEDVVIGQYKShtkggvtypaYTDDKTVPKGSLTPTFAA 428

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006 284 GDIYIDNWRWKGVPFHFMSGKKMPYTCTEVVIKLKAPPIGLFDGHEFNDR------IVMRFQPNPHLDIRIDMKSPGLDD 357
Cdd:PLN02333  429 AALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYNRNFGTDLdqatneLVIRVQPDEAIYLKINNKVPGLGM 508

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1842004006 358 KVQTATL----THPYPEGAIDGYVKLFYDSLNGDQSHFVHAEEVLESWRIVDDLL 408
Cdd:PLN02333  509 RLDRSNLnllyAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLL 563
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
9-167 1.17e-63

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 203.04  E-value: 1.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006   9 VIFGATGDLCRRKLIPALETLHKKGLLPDNFKIIGAARRENTRQSWLDSLGKYYE----------ADFSLKLDYHRCDLS 78
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKefkeldeekwDRFLERLHYVSGDFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842004006  79 DVDS---LRS-IPVSDDMT-----FFLSVPPDRYSDAIQNLKSAGLVDDPEKSRVIIEKPFGTDLESANHLQSVVAGCLR 149
Cdd:pfam00479  81 DPESyekLKErLEEHEDETrgnrlFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESARELNDQLAKVFK 160

                         170
                  ....*....|....*...
gi 1842004006 150 EKQVYRIDHYLGKDTVNN 167
Cdd:pfam00479 161 EEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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