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Conserved domains on  [gi|1842033245|ref|YP_009820168|]
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hypothetical protein HOV20_gp18 [Escherichia phage NC-A]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TA_inhibitor super family cl10214
Inhibitor of toxin/antitoxin system (Gp4.5); This is a family of prokaryotic toxin-antitoxin ...
 1-89 2.53e-49

Inhibitor of toxin/antitoxin system (Gp4.5); This is a family of prokaryotic toxin-antitoxin (TA) systems inhibitors, found in Podoviridae such as Enterobacteria phage T7. Family members such as Gene product 4.5 have been shown to neutralize TA-system-mediated abortive infection by inhibiting the Lon protease activity, thus preventing antitoxin degradation and toxin activation.


The actual alignment was detected with superfamily member pfam17574:

Pssm-ID: 353062  Cd Length: 89  Bit Score: 150.73  E-value: 2.53e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842033245  1 MSQVAETIRLSDTADQWNRRVHINVRNGKATMVYRWKDSKSSKNHTQRMTLTDEQALRLVNALTKAAVTAIHEAGRVNEA 80
Cdd:pfam17574  1 MSNVAETIRLSDTADQWNRRVHINVRNGKATMVYRWKDSKSSKNHTQRMTLTDEQALRLVNALTKAAVTAIHEAGRVNEA 80


                 ....*....
gi 1842033245 81 MAILDKIDS 89
Cdd:pfam17574 81 MAILDKIDN 89
 
Name Accession Description Interval E-value
TA_inhibitor pfam17574
Inhibitor of toxin/antitoxin system (Gp4.5); This is a family of prokaryotic toxin-antitoxin ...
 1-89 2.53e-49

Inhibitor of toxin/antitoxin system (Gp4.5); This is a family of prokaryotic toxin-antitoxin (TA) systems inhibitors, found in Podoviridae such as Enterobacteria phage T7. Family members such as Gene product 4.5 have been shown to neutralize TA-system-mediated abortive infection by inhibiting the Lon protease activity, thus preventing antitoxin degradation and toxin activation.


Pssm-ID: 340289  Cd Length: 89  Bit Score: 150.73  E-value: 2.53e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842033245  1 MSQVAETIRLSDTADQWNRRVHINVRNGKATMVYRWKDSKSSKNHTQRMTLTDEQALRLVNALTKAAVTAIHEAGRVNEA 80
Cdd:pfam17574  1 MSNVAETIRLSDTADQWNRRVHINVRNGKATMVYRWKDSKSSKNHTQRMTLTDEQALRLVNALTKAAVTAIHEAGRVNEA 80


                 ....*....
gi 1842033245 81 MAILDKIDS 89
Cdd:pfam17574 81 MAILDKIDN 89
PHA00446 PHA00446
hypothetical protein
 1-89 3.22e-42

hypothetical protein


Pssm-ID: 177281  Cd Length: 89  Bit Score: 132.67  E-value: 3.22e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842033245  1 MSQVAETIRLSDTADQWNRRVHINVRNGKATMVYRWKDSKSSKNHTQRMTLTDEQALRLVNALTKAAVTAIHEAGRVNEA 80
Cdd:PHA00446   1 IKFVANTIRLSDTADQWARRVHINVRNGKVTMVYRWKDHKSSKAHTQRMTLDDEQAGRLLAALTVAATVAVGDNKVRNVA 80


                 ....*....
gi 1842033245 81 MAILDKIDS 89
Cdd:PHA00446  81 LGKGVKEII 89
 
Name Accession Description Interval E-value
TA_inhibitor pfam17574
Inhibitor of toxin/antitoxin system (Gp4.5); This is a family of prokaryotic toxin-antitoxin ...
 1-89 2.53e-49

Inhibitor of toxin/antitoxin system (Gp4.5); This is a family of prokaryotic toxin-antitoxin (TA) systems inhibitors, found in Podoviridae such as Enterobacteria phage T7. Family members such as Gene product 4.5 have been shown to neutralize TA-system-mediated abortive infection by inhibiting the Lon protease activity, thus preventing antitoxin degradation and toxin activation.


Pssm-ID: 340289  Cd Length: 89  Bit Score: 150.73  E-value: 2.53e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842033245  1 MSQVAETIRLSDTADQWNRRVHINVRNGKATMVYRWKDSKSSKNHTQRMTLTDEQALRLVNALTKAAVTAIHEAGRVNEA 80
Cdd:pfam17574  1 MSNVAETIRLSDTADQWNRRVHINVRNGKATMVYRWKDSKSSKNHTQRMTLTDEQALRLVNALTKAAVTAIHEAGRVNEA 80


                 ....*....
gi 1842033245 81 MAILDKIDS 89
Cdd:pfam17574 81 MAILDKIDN 89
PHA00446 PHA00446
hypothetical protein
 1-89 3.22e-42

hypothetical protein


Pssm-ID: 177281  Cd Length: 89  Bit Score: 132.67  E-value: 3.22e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1842033245  1 MSQVAETIRLSDTADQWNRRVHINVRNGKATMVYRWKDSKSSKNHTQRMTLTDEQALRLVNALTKAAVTAIHEAGRVNEA 80
Cdd:PHA00446   1 IKFVANTIRLSDTADQWARRVHINVRNGKVTMVYRWKDHKSSKAHTQRMTLDDEQAGRLLAALTVAATVAVGDNKVRNVA 80


                 ....*....
gi 1842033245 81 MAILDKIDS 89
Cdd:PHA00446  81 LGKGVKEII 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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