NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2026149040|ref|YP_010038038|]
View 

endolysin [Pseudomonas phage Persinger]

Protein Classification

lysozyme( domain architecture ID 10091405)

lysozyme, also called endolysin or muramidase, hydrolyzes (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins; similar to Salmonella virus P22 endolysin

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 7-145 3.69e-61

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


:

Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 185.03  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040   7 GIAVMHYFESCRLTAYPDPGSkdgtPWTIGWGHTGPE-VRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVPVTQGQFDA 85
Cdd:cd00737     1 GLDLIKEFEGLRLKAYRDPAG----VWTIGYGHTGGVvVKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040  86 LVSFAYNLGLGNLRSSTLLRLLNEGKTAEAAQQFKRWVKNDGKVMRGLVRRRAAEQCLFL 145
Cdd:cd00737    77 LVSFAFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 7-145 3.69e-61

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 185.03  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040   7 GIAVMHYFESCRLTAYPDPGSkdgtPWTIGWGHTGPE-VRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVPVTQGQFDA 85
Cdd:cd00737     1 GLDLIKEFEGLRLKAYRDPAG----VWTIGYGHTGGVvVKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040  86 LVSFAYNLGLGNLRSSTLLRLLNEGKTAEAAQQFKRWVKNDGKVMRGLVRRRAAEQCLFL 145
Cdd:cd00737    77 LVSFAFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
1-146 5.67e-58

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 177.34  E-value: 5.67e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040   1 MRTSAHGIAVMHYFESCRLTAYPDPGSKdgtpWTIGWGHTGPEVRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVPVTQ 80
Cdd:COG3772     2 MKTSAAGLALIKEFEGFRLKAYRDPAGV----WTIGYGHTGKDVKPGDTITEEEAEALLAADLAKAEAAVRRLVKVPLTQ 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2026149040  81 GQFDALVSFAYNLGLGNLRSSTLLRLLNEGKTAEAAQQFKRWVKNDGKVMRGLVRRRAAEQCLFLG 146
Cdd:COG3772    78 NQFDALVSFAYNVGAGAFCRSTLLRKLNAGDYAGACDELLRWVYAGGKVLPGLVRRREAERALCLG 143
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 33-138 8.43e-20

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 78.93  E-value: 8.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040  33 WTIGWGHTGPEVRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVP-VTQGQFDALVSFAYNLGLGNLRSSTLLRLLNEGK 111
Cdd:pfam00959   2 WTIGIGHNGKDVSPHPRATKSEAAGRLQIDLDTAERCINQYHKVKdFNPNQQDALVSLAFNVGCGKRGFSTLLRAGNIGQ 81

                          90       100
                  ....*....|....*....|....*..
gi 2026149040 112 TAEAAQQFKRWVKnDGKVMRGLVRRRA 138
Cdd:pfam00959  82 WIKACSAIWKSLK-AGKVYNGLVNRRE 107
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 7-145 3.69e-61

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 185.03  E-value: 3.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040   7 GIAVMHYFESCRLTAYPDPGSkdgtPWTIGWGHTGPE-VRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVPVTQGQFDA 85
Cdd:cd00737     1 GLDLIKEFEGLRLKAYRDPAG----VWTIGYGHTGGVvVKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040  86 LVSFAYNLGLGNLRSSTLLRLLNEGKTAEAAQQFKRWVKNDGKVMRGLVRRRAAEQCLFL 145
Cdd:cd00737    77 LVSFAFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
1-146 5.67e-58

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 177.34  E-value: 5.67e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040   1 MRTSAHGIAVMHYFESCRLTAYPDPGSKdgtpWTIGWGHTGPEVRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVPVTQ 80
Cdd:COG3772     2 MKTSAAGLALIKEFEGFRLKAYRDPAGV----WTIGYGHTGKDVKPGDTITEEEAEALLAADLAKAEAAVRRLVKVPLTQ 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2026149040  81 GQFDALVSFAYNLGLGNLRSSTLLRLLNEGKTAEAAQQFKRWVKNDGKVMRGLVRRRAAEQCLFLG 146
Cdd:COG3772    78 NQFDALVSFAYNVGAGAFCRSTLLRKLNAGDYAGACDELLRWVYAGGKVLPGLVRRREAERALCLG 143
endolysin_R21-like cd16900
endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria ...
 5-145 2.95e-36

endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria phage P21 has an N-terminal SAR (signal-arrest-release) domain that anchors the endolysin to the membrane in an inactive form, which act to prevent premature lysis of the infected bacterium. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381619 [Multi-domain]  Cd Length: 142  Bit Score: 122.28  E-value: 2.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040   5 AHGIAVMHYFESCRLTAYPDPGskdgTPWTIGWGHTGPEVRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVPVTQGQFD 84
Cdd:cd16900     6 LAAAALVGPWEGLRLTAYRDPV----GVWTVCYGHTGGDVKPGMRYTPAECDALLAKDLQEAAAAVDRCVKVPLPDPQRA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2026149040  85 ALVSFAYNLGLGNLRSSTLLRLLNEGKTAEAAQQFKRWVKNDGKVMRGLVRRRAAEQCLFL 145
Cdd:cd16900    82 ALASFAYNVGVGAFCRSTLLRKLNAGDRRGACDELTRWVYAGGRVLRGLVNRREAERALCL 142
lyz_P1 cd16901
P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the ...
 2-143 3.98e-31

P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the Escherichia coli periplasm where it is membrane bound and inactive. Activation involves the release from the membrane, an intramolecular thiol-disulfide isomerization and extensive structural rearrangement of the N-terminal region. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381620 [Multi-domain]  Cd Length: 140  Bit Score: 108.85  E-value: 3.98e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040   2 RTSAHGIAVMHYFESCRLTAYPDPGSKdgtpWTIGWGHTGpEVRKGLVWTQAQADAAFVKDLRRFESGVLEMVQ-VPVTQ 80
Cdd:cd16901     1 RTSAAGLELIANAEGCRRDPYKCPAGV----PTIGIGSTH-GVKPGDRYTDEQAAKRLAKDIKKAERCVNRCFNgVPLPQ 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2026149040  81 GQFDALVSFAYNLGLGNLRSSTLLRLLNEGKTAEAAQQFKRWVKNDGKVMRGLVRRRAAE--QCL 143
Cdd:cd16901    76 GEFDAYVSFAFNVGCGAFCKSTIYKKLQAGDYAAACNQLPRWVYAGGKVLPGLVTRRQKEraLCL 140
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 33-138 8.43e-20

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 78.93  E-value: 8.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040  33 WTIGWGHTGPEVRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVP-VTQGQFDALVSFAYNLGLGNLRSSTLLRLLNEGK 111
Cdd:pfam00959   2 WTIGIGHNGKDVSPHPRATKSEAAGRLQIDLDTAERCINQYHKVKdFNPNQQDALVSLAFNVGCGKRGFSTLLRAGNIGQ 81

                          90       100
                  ....*....|....*....|....*..
gi 2026149040 112 TAEAAQQFKRWVKnDGKVMRGLVRRRA 138
Cdd:pfam00959  82 WIKACSAIWKSLK-AGKVYNGLVNRRE 107
T4-like_lys cd00735
bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1, ...
 13-97 7.53e-06

bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.


Pssm-ID: 381597  Cd Length: 146  Bit Score: 43.13  E-value: 7.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2026149040  13 YFESCRLTAYPDpgSKDGtpWTIGWGHT---GPEVRKGLVWTQAQADAAFVKDLRRFESGVLEMVQVPVTQGQF-----D 84
Cdd:cd00735     8 QDEGYRLKAYKD--TEGY--PTIGIGHLigkKGASLTNGTITKDEAEALFEQDVDRAVRDMLRNPKLAPVYAQLnaarrM 83

                          90
                  ....*....|...
gi 2026149040  85 ALVSFAYNLGLGN 97
Cdd:cd00735    84 ALINMAFQMGVGG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH