1HVY: Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation

PDB ID: 1HVYDownload
MMDB ID: 15302
PDB Deposition Date: 2001/1/8
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 1HVY: dimeric; determined by author and by software (PISA)
Molecular Components in 1HVY
Label Count Molecule
Proteins (2 molecules)
2
Thymidylate Synthase
(Gene symbol: TYMS)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
TOMUDEXTOMUDEX
2
2
2'-DEOXYURIDINE 5'-MONOPHOSPHATE2'-DEOXYURIDINE 5'-MONOPHOSPHATE
3
2
BETA-MERCAPTOETHANOLBETA-MERCAPTOETHANOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303