2AF6: Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)

PDB ID: 2AF6Download
MMDB ID: 35204
PDB Deposition Date: 2005/7/25
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.01  Å
Source Organism:
Similar Structures:
Biological Unit for 2AF6: tetrameric; determined by author and by software (PQS)
Molecular Components in 2AF6
Label Count Molecule
Proteins (4 molecules)
4
Thymidylate Synthase Thyx
Molecule annotation
Chemicals and Non-standard biopolymers (21 molecules)
1
5
IODIDE IONIODIDE ION
2
4
FLAVIN-ADENINE DINUCLEOTIDEFLAVIN-ADENINE DINUCLEOTIDE
3
4
5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE
4
8
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303