2Q8G: Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug AZD7545

PDB ID: 2Q8GDownload
MMDB ID: 54147
PDB Deposition Date: 2007/6/10
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 2Q8G: dimeric; determined by author and by software (PISA,PQS)
Molecular Components in 2Q8G
Label Count Molecule
Proteins (2 molecules)
2
[pyruvate Dehydrogenase [lipoamide]] Kinase Isozyme 1
(Gene symbol: PDK1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
POTASSIUM IONPOTASSIUM ION
2
2
4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303