3EWH: Crystal structure of the VEGFR2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole inhibitor

PDB ID: 3EWHDownload
MMDB ID: 76218
PDB Deposition Date: 2008/10/15
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 3EWH: monomeric; determined by author and by software (PISA)
Molecular Components in 3EWH
Label Count Molecule
Protein (1 molecule)
1
Vascular Endothelial Growth Factor Receptor 2
(Gene symbol: KDR)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
N-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amineN-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine
2
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303