3FXV: Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist

PDB ID: 3FXVDownload
MMDB ID: 70843
PDB Deposition Date: 2009/1/21
Updated in MMDB: 2021/11
Experimental Method:
x-ray diffraction
Resolution: 2.26  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 3FXV: dimeric; determined by author and by software (PISA)
Molecular Components in 3FXV
Label Count Molecule
Proteins (2 molecules)
1
Nr1h4 Protein
Molecule annotation
1
12-meric Peptide From Nuclear Receptor Coactivator 1
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303