3GZN: Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924

PDB ID: 3GZNDownload
MMDB ID: 79727
PDB Deposition Date: 2009/4/7
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 3GZN: trimeric; determined by author and by software (PISA)
Molecular Components in 3GZN
Label Count Molecule
Proteins (3 molecules)
1
Nedd8-activating Enzyme E1 Regulatory Subunit
(Gene symbol: NAE1)
Molecule annotation
1
Nedd8-activating Enzyme E1 Catalytic Subunit
(Gene symbol: UBA3)
Molecule annotation
1
Nedd8
(Gene symbol: NEDD8)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
ZINC IONZINC ION
2
1
[(1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate[(1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303