3MP3: Crystal Structure of Human Lyase in complex with inhibitor HG-CoA

PDB ID: 3MP3Download
MMDB ID: 82837
PDB Deposition Date: 2010/4/24
Updated in MMDB: 2010/11
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 3MP3: dimeric; determined by author and by software (PISA)
Molecular Components in 3MP3
Label Count Molecule
Proteins (2 molecules)
2
Hydroxymethylglutaryl-coa Lyase
(Gene symbol: HMGCL)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
3-HYDROXYPENTANEDIOIC ACID3-HYDROXYPENTANEDIOIC ACID
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
(3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide(3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303