3T3M: A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS

PDB ID: 3T3MDownload
MMDB ID: 98336
PDB Deposition Date: 2011/7/25
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Mus musculus▼
Similar Structures:
Biological Unit for 3T3M: tetrameric; determined by author
Molecular Components in 3T3M
Label Count Molecule
Proteins (4 molecules)
1
Integrin Alpha-iib
Molecule annotation
1
Integrin Beta-3
Molecule annotation
1
Monoclonal Antibody 10e5 Heavy Chain
Molecule annotation
1
Monoclonal Antibody 10e5 Light Chain
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
9
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
beta-D-mannopyranosebeta-D-mannopyranose
3
3
alpha-D-mannopyranosealpha-D-mannopyranose
4
6
CALCIUM IONCALCIUM ION
5
1
N-{3-[5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl]phenyl}glycinamideN-{3-[5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl]phenyl}glycinamide
6
4
SULFATE IONSULFATE ION
7
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303