NCBI
National Center for
Biotechnology Information
Search
4IEH:
Crystal Structure of human Bcl-2 in complex with a small molecule inhibitor targeting Bcl-2 BH3 domain interactions
PDB ID:
4IEH
Download
MMDB ID:
111655
PDB Deposition Date:
2012/12/13
Updated in MMDB:
2014/10
Experimental Method:
x-ray diffraction
Resolution:
2.1 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4IEH: monomeric; determined by author and by software (PISA)
Molecular Components in 4IEH
Label
Count
Molecule
Protein (1 molecule)
A
1
Apoptosis Regulator Bcl-2, Bcl-2-like Protein 1 Chimera
(Gene symbol:
BCL2
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-(6-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-1,1-dioxido-1,2-benzothiazol-3-yl)-4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303