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4NCG:
Discovery of Doravirine, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
PDB ID:
4NCG
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MMDB ID:
117524
PDB Deposition Date:
2013/10/24
Updated in MMDB:
2022/10
Experimental Method:
x-ray diffraction
Resolution:
2.58 Å
Source Organism:
HIV-1 M:B_HXB2R
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4NCG: dimeric; determined by author and by software (PISA)
Molecular Components in 4NCG
Label
Count
Molecule
Proteins (2 molecules)
A
1
Reverse Transcriptase/ribonuclease H
(Gene symbol:
gag-pol
)
B
1
P51 RT
(Gene symbol:
gag-pol
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303