5EMJ: Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin

PDB ID: 5EMJDownload
MMDB ID: 136753
PDB Deposition Date: 2015/11/6
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.273  Å
Source Organism:
Similar Structures:
Biological Unit for 5EMJ: octameric; determined by author and by software (PISA)
Molecular Components in 5EMJ
Label Count Molecule
Proteins (8 molecules)
4
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
4
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
4
SINEFUNGINSINEFUNGIN
2
4
(2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol(2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol
3
16
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303